The ceRNA Regulatory Network in Vitiligo: Evidence from Bioinformatics Analysis.

Background: Vitiligo is an acquired depigmentary disorder caused by the loss of functional melanocytes. Increasing evidence suggests that competing endogenous RNA (ceRNA) interactions participate in this process, yet their global architecture in vitiligo remains unclear.

Objective: To delineate a long non-coding RNA (lncRNA)-microRNA (miRNA)-mRNA ceRNA network associated with vitiligo and to identify blood-borne RNA markers with diagnostic potential.

Enhancement of High-Temperature Triboelectric Performance of Polyimide Nanofibers by Introducing Fluorinated Monomers.

Triboelectric nanogenerators (TENGs) are typically constrained to operate below 200 °C due to the thermionic emission effect and material degradation at high temperatures. Herein, high-temperature-resistant fluorinated polyimide nanofibers (4,4'-(hexafluoroisopropylidene) diphthalic anhydride-4,4'-oxidianiline/2,2″-bis(trifluoromethyl)benzidine, 6FDA-ODA/TFDB) were designed to mitigate the thermionic emission effect through the introduction of trifluoromethyl (-CF) groups. 6FDA-ODA/TFDB nanofibers exhibited a fine fiber structure and a large highest occupied molecular orbital-lowest unoccupied molecular orbital (HOMO-LUMO) gap, which enhanced its effective contact area and maintained more localized states for charge transfer.

MODE: high-resolution digital dissociation with deep multimodal autoencoder.

In single cell biology, the complexity of tissues may hinder lineage cell mapping or tumor microenvi-ronment decomposition, requiring digital dissociation of bulk tissues. Many deconvolution methods focus on transcriptomic assay, not easily applicable to other omics due to ambiguous cell markers and reference-to-target difference. Here, we present MODE, a multimodal autoencoder pipeline linking multi-dimensional features to jointly predict personalized multi-omic profiles and cellular compositions, using pseudo-bulk data constructed by internal non-transcriptomic reference and external scRNA-seq data.

Associations between Life's Essential 8 scores and systemic immune-inflammation index among American-adult populations without cardiovascular disease.

Background: Cardiovascular health (CVH) profoundly impacts human health and quality of life. Increasing evidence suggests a close association between cardiovascular disease (CVD) and systemic immune-inflammatory levels. This study explores the potential correlation between Life's Essential 8 (LE8) scores and the systemic immune-inflammation index (SII), a novel immune-inflammatory index among US adults.

Genetic variation in the FMO and GSTO gene clusters impacts arsenic metabolism in humans.

Background: In Bangladesh, > 50 million individuals are chronically exposed to inorganic arsenic (iAs) through drinking water, increasing risk for cancer and other iAs-related diseases. Previous studies show that individuals' ability to metabolize and eliminate iAs, and their risk of toxicity, is influenced by genetic variation in the AS3MT and FTCD gene regions.

Methods: To identify additional loci influencing arsenic metabolism, we used data from Bangladeshi individuals to conduct genome-wide association analyses of the relative abundances of arsenic species measured in both urine (n = 6,540) and blood (n = 976).

Tire wear particles (TWPs) induced toxicity in wheat (Triticum aestivum L.) by affecting osmotic regulation, redox homeostasis, photosynthesis, and microbial density.

Tire wear particles (TWPs) are commonly found in soil environments; however, their impacts on soil ecosystems, particularly on wheat (Triticum aestivum L.) physiology, remain largely unexplored. This study aimed to investigate the effects of TWPs at concentrations of T0 (control), T1 (0.

Insulin resistance, left atrial anatomical remodeling, and recurrence in patients with atrial fibrillation undergoing radiofrequency ablation.

Background: Insulin resistance (IR) is associated with both the anatomical remodeling of the left atrium and the pathogenesis of atrial fibrillation (AF). However, the exact extent of this correlation and its influence on AF recurrence in individuals undergoing radiofrequency catheter ablation (RFCA) remains unclear.

Methods: A total of 910 patients with AF who underwent RFCA were included in this analysis.

Injectable amino-modified poly-L-lactic acid microspheres/hyaluronic acid-based hydrogel composites for soft tissue fillers.

Soft tissue fillers have received much attention for the treatment of skin aging and the restoration of missing or excised soft volumes. However, the development of fillers with both safety and applicability remains a challenge. This study presented a synergistic composite filler comprising aldehyde-modified hyaluronic acid (OHA), hydrazide-modified hyaluronic acid (NHA), amino-modified poly-L-lactic acid microspheres (NPLLA), and antioxidant copper peptide.

Characteristics of gut and lung microbiota in patients with lung masses and their relationship with clinical features.

Objectives: The exploration of how dysbiosis relates to lung masses is still nascent, with few studies focusing on the microbial characteristics across various sites. Therefore, we categorized the microbiota into feces and bronchoalveolar fluid (BALF) groups to compare microbial characteristics between benign and malignant masses, analyze their clinical correlations, and develop predictive models for lung cancer.

Methods: A total of 238 fecal samples and 34 BALF samples were collected from patients with benign and malignant masses and then analyzed by 16 SrRNA.

Predictive value of core-fucosylated low-molecular-weight kininogen levels in patients with liver fibrosis: A prospective study.

Background: Core-fucosylated low-molecular-weight kininogen (LMWK-Fc) levels are significantly elevated in patients with liver fibrosis and cirrhosis.

Aim: To assess the value of LMWK-Fc as a diagnostic biomarker for liver fibrosis.

Methods: Our study included 132 healthy people and 132 patients with liver fibrosis.

Novel three-dimensional electrical impedance tomography for noninvasive detection of lung perfusion.

Background: Non-invasive bedside detection of pulmonary ventilation and perfusion remains a challenge. Electrical impedance tomography (EIT) uses a differential imaging technique to reconstruct images of lung ventilation and perfusion. Conventional methods of perfusion signal acquisition are achieved by breath-holding and hypertonic saline injection, limiting its widespread application.

Enhanced wavelength selectivity and stability of multilayer graphene-based infrared emissivity modulator using a silicon overlayer.

Ion intercalation offers a versatile method for dynamically tuning the infrared emissivity of multilayer graphene (MLG), with great potential in various applications, such as radiative cooling and thermal camouflage. However, the practical use of MLG-based emissivity modulators is limited by poor wavelength selectivity and short operational lifespans. Herein, a silicon overlayer is introduced to address these challenges.

Climate change and ocular health: temperature-pollution synergies amplify uveitis burden.

Background: Uveitis, an inflammatory eye disease, exhibits seasonal patterns, which suggest environmental influences. This study examines the link between average temperature and uveitis outpatient visits, considering air pollution's modifying effects.

Methods: We analyzed uveitis outpatient data ( = 8,090) from a major hospital in Shanghai between 2017 and 2023, along with meteorological and air pollutant data.

From community to science to community, enhancing remote sensing of water quality in Chesapeake Bay tributaries through participatory science.

Citizen, or participatory, science provides a powerful tool to both enrich environmental datasets as well as increase public awareness of pressing environmental issues - especially in coastal regions. Here, we used rich bio-optical datasets collected by trained volunteers to develop, optimize, and validate new satellite retrievals of key water quality indicators in the economically and ecologically valuable tributaries of the Chesapeake Bay Estuary. The optimized algorithms were applied to imagery from Landsat/OLI, Sentinel-2/MSI, and Sentinel-3/OLCI, and effectively captured the temporal and spatial distribution of turbidity, chlorophyll-a concentration, and dissolved organic matter dynamics in both optically complex tributaries and the main stem of the Bay.

Global, regional, and National burden of urticaria (1990-2021), its potential risk factors, and projections to 2046.

Background: Urticaria is a common inflammatory skin disorder that causes distressing symptoms, significantly impacting the quality of life of patients and imposing a substantial burden on society.

Objective: This study aimed to enhance policymakers' awareness of the burden of urticaria and encourage the rational allocation of health resources.

Methods: We utilized data from the Global Burden of Disease (GBD) Results (2021) to obtain prevalence, incidence, and disability-adjusted life years (DALYs) for urticaria from 1990 to 2021, categorized by age, gender, and region.

Multi-ancestry polygenic risk scores for the prediction of type 2 diabetes and complications in diverse ancestries.

Background: Polygenic risk scores (PRSs) improve type 2 diabetes (T2D) prediction beyond clinical risk factors but perform poorly in non-European populations, where T2D burden is often higher, undermining their global clinical utility.

Methods: We conducted the largest global effort to date to harmonize T2D genome-wide association study (GWAS) meta-analyses across five ancestries-European (EUR), African/African American (AFR), Admixed American (AMR), South Asian (SAS), and East Asian (EAS)-including 360,000 T2D cases and 1·8 million controls (41% non-EUR). We constructed ancestry-specific and multi-ancestry PRSs in training datasets including 11,000 T2D cases and 32,000 controls, and validated their performance in independent datasets including 39,000 T2D cases and 126,000 controls of diverse ancestries.

A Retrospective Study of Pelvic Floor Muscle Training Combined with Biofeedback Stimulation versus Pelvic Floor Muscle Training Alone in the Treatment of Postpartum Stress Urinary Incontinence.

Objective: Stress urinary incontinence (SUI) is a common postpartum complication in women. This study aims to evaluate the clinical efficacy of pelvic floor muscle training (PFMT) combined with biofeedback stimulation (BS) in the treatment of postpartum SUI.

Methods: A total of patients with postpartum SUI admitted to our hospital from January 2023 to January 2024 were enrolled in the study.

Exploring the relationship between circadian syndrome, serum uric acid levels, and hyperuricemia: evidence from NHANES 2005-2018.

Hyperuricemia is closely linked to metabolic diseases and cardiovascular conditions, while circadian syndrome (CircS) plays a pivotal role in metabolic syndrome (MetS) and its related disorders. This study examines the relationship between CircS, serum uric acid (SUA) levels, and the risk of hyperuricemia using data from the National Health and Nutrition Examination Survey (NHANES) from 2005 to 2018. Weighted multivariable linear and logistic regression analyses were employed to assess the relationships between CircS, its components, SUA levels, and the risk of hyperuricemia, supplemented by subgroup analyses and interaction tests to understand the influence of other risk factors.

20E-induced expression facilitates developmental transitions depending on chromosome accessibility of enhancers.

Transcription factors and histone modification-mediated chromatin accessibility coordinately regulate spatiotemporal expression of genes that control growth and development. It is well documented that juvenile hormone-activated Kr-h1 antagonizes 20-hydroxyecdysone (20E)-induced expression of the pupal specifier to sustain larval status in holometabolous insects. Here, we revealed that during the larval-prepupal transition in , the 20E-activated axis is a prerequisite for wing disc morphogenesis.

Extracellular Vesicle Protein Panel Enables Early Lung Cancer Detection in a Large Clinical Cohort.

The early detection and diagnosis of lung cancer through extracellular vesicle (EV)-based liquid biopsy show substantial promise for enhancing clinical outcomes. Nonetheless, there is a scarcity of large-scale clinical investigations validating EV-based liquid biopsy. To evaluate the EV membrane protein panel as a diagnostic tool for early-stage cancer detection and validate its efficacy and clinical applicability, a cohort comprised of 302 individuals without cancer and 645 with lung cancer was recruited.

Energy-Efficient Resource Allocation for Near-Field MIMO Communication Networks.

With the rapid development of sixth-generation (6G) wireless networks and large-scale multiple-input multiple-output (MIMO) technology, the number of antennas deployed at base stations (BSs) has increased significantly, resulting in a high probability that users are in the near-field region. Note that it is difficult for the traditional far-field plane-wave model to meet the demand for high-precision beamforming in the near-field region. In this paper, we jointly optimize the power and the number of antennas to achieve the maximum energy efficiency for the users located in the near-field region.

Community Perceptions of Flavor Restriction Policies: A Scoping Review of Disaggregated Outcomes.

Introduction: Increasingly, U.S. states and localities are passing policies to restrict menthol and other characterizing flavors in tobacco products.

Impact of Non-Culprit Lesion TCFA on Adverse Cardiovascular Events in Patients with Diabetes Mellitus who Present with Acute Myocardial Infarction.

Aims: Patients with acute myocardial infarction (AMI) and diabetes mellitus (DM) are at higher risk of major adverse cardiovascular events (MACE) than those without DM. This study aimed to investigate whether thin-cap fibroatheroma (TCFA) in non-culprit lesions (NCLs) contributes to this increased risk in DM patients and whether NCL TCFA also adversely affects prognosis in non-DM patients.

Methods And Results: A total of 1312 AMI patients who underwent 3-vessel optical coherence tomography (OCT) were analyzed for NCL TCFA prevalence based on DM status.