Predicting Efficacy of Neoadjuvant Chemoradiotherapy for Locally Advanced Rectal Cancer Using Transrectal Contrast-Enhanced Ultrasound-Based Radiomics Model.

Background: Predicting tumor regression grade (TRG) after neoadjuvant chemoradiotherapy (NCRT) in patients with locally advanced rectal cancer (LARC) preoperatively accurately is crucial for providing individualized treatment plans. This study aims to develop transrectal contrast-enhanced ultrasound-based (TR-CEUS) radiomics models for predicting TRG.

Methods: A total of 190 LARC patients undergoing NCRT and subsequent total mesorectal excision were categorized into good and poor response groups based on pathological TRG.

The ceRNA Regulatory Network in Vitiligo: Evidence from Bioinformatics Analysis.

Background: Vitiligo is an acquired depigmentary disorder caused by the loss of functional melanocytes. Increasing evidence suggests that competing endogenous RNA (ceRNA) interactions participate in this process, yet their global architecture in vitiligo remains unclear.

Objective: To delineate a long non-coding RNA (lncRNA)-microRNA (miRNA)-mRNA ceRNA network associated with vitiligo and to identify blood-borne RNA markers with diagnostic potential.

Molecular Detection and Isolation of Species in Bats and Their Ectoparasites Along the China-Myanmar Border.

are parasitic pathogens that infect many mammals, including humans, and cause significant diseases. This study investigates the presence, genetic diversity, and tissue tropism of in bats and their ectoparasites along the China-Myanmar border. Bats and ectoparasites were collected from Yingjiang, Ruili, and Gengma Counties.

Acrylamide-Linked Water-Soluble Nitroxide Biradicals with Enhanced Electron-Electron Couplings for Dynamic Nuclear Polarization at 14.1 T.

Dynamic nuclear polarization (DNP) has emerged as a powerful technique to overcome the sensitivity limit of solid-state nuclear magnetic resonance (ssNMR) spectroscopy through polarizing agents (PAs) carrying unpaired electrons. Nitroxide biradical-based PAs have garnered great attention due to their superior DNP performance. Here, we report TJPols─water-soluble acrylamide-linked nitroxide biradicals featuring facile large-scale synthesis.

Evaluation of Poxvirus-Specific Antibody Response in Monkey Poxvirus-Negative and -Positive Cohorts.

Objectives: Understanding the antibody response in monkeypox virus (MPXV)-infected and uninfected individuals is essential for developing next-generation MPXV vaccines. This study aimed to characterize neutralizing antibody (NAb) and antibody-dependent cellular cytotoxicity (ADCC) responses in both groups, providing insights into immune protection and vaccine design.

Methods: A recombinant vaccinia Tian Tan (VTT) virus was utilized to develop high-throughput luciferase-reporter-based neutralization and ADCC assays.

The G-allele of rs10830963 in Exerts Stage-Specific Effects Across the Trajectory of Type 2 Diabetes: A Multi-State Analysis.

Although the single nucleotide polymorphism rs10830963 has been strongly associated with the onset of type 2 diabetes (T2D), its association with the progression and prognosis of T2D has been understudied. We conducted this prospective analysis based on the UK Biobank cohort study. Microvascular complications (MIC) of T2D in this study included diabetic retinopathy, diabetic neuropathy, and diabetic kidney disease.

Nano-piezoelectric BaTiO activate water to overcome pH limitations: A novel oxidase-mimicking strategy for cystathionine-γ-lyase colorimetric biosensing.

Cystathionine-γ-lyase (CSE) is a pivotal bio-enzyme that catalyzes the cleavage of cystathionine, whose expression has been linked to a myriad of severe illnesses and tumorigenic processes. The development of reliable and sensitive detection plays an important role in better understanding the physiology and pathology of CSE. Herein, we introduce a facile colorimetric assay for CSE detection in physiological media, utilizing tetragonal barium titanate (T-BTO) nanoparticles (NPs) as an innovative oxidase-like (OXD) nanozyme.

Reversible Electron Transfer in the Formation of Radical Anionic and Dianionic 1,4-Diborabutatrienes.

One- and two-electron reductions of diborylacetylene with potassium graphite (KC) yielded radical anionic and dianionic 1,4-diborabutatrienes and , respectively. X-ray diffraction, electron paramagnetic resonance, and computational studies indicated the π electron delocalization over the B-C-C-B cumulene skeleton. possesses a relatively small HOMO-LUMO gap and exhibits a significantly red-shifted UV-vis absorption at λ = 578 nm, compared to the all-carbon tetraarylbutatrienes.

The ConPET Mechanism Remains Veiled: Reply to "Unlocking the ConPeT Mechanism".

In this journal, a Correspondence by Ventura, Cozzi, and Ceroni reported time-resolved absorption spectroscopy studies in the electron transfer process from cyanoarene photocatalyst 3,4,5,6-tetrakis(diphenyl amino)phthalonitrile (4DPAPN) in the presence of tetrabutylammonium oxalate (TBAOx). This was used as a model reaction to investigate the mechanism of consecutive photoinduced electron transfer (ConPET) in our previously reported asymmetric [3+2] photocycloaddition. They proposed a new electron transfer pathway in which the electron from the excited state of the radical anion 4DPAPN* solvated in acetonitrile.

Closed-loop recycling of lead iodide precursor from waste organic solvents in the production of perovskite solar cells: Toward sustainable photovoltaics.

Perovskite solar cells (PSCs), characterized by high efficiency, have demonstrated significant potential in solar energy harvesting. However, the PSCs production process usually generates substantial waste containing polar organic solvents, i.e.

Insights into the interaction of tris (2,4-di-tert-butyl phenyl) phosphite (I 168) and its metabolites (24DP) with pepsin: Enzyme inhibition, structural impacts, and antioxidant interference.

This study investigated the interactions between pepsin (PEP) and the organophosphite antioxidant Irgafos 168 (I 168), its metabolite 2,4-di-tert-butylphenol (24DP), focusing on structural, functional, and antioxidant implications. UV-Vis absorption spectra, fluorescence lifetimes and Stern-Volmer quenching analyses show that I 168/24DP statically bursts PEP with high binding affinity. Thermodynamic parameters, molecular docking analyses and molecular dynamics simulations (e.

Vapor-phase fluorination to regulating oxygen content of silicon anode materials.

SiO is a high-potential candidate material for silicon (Si) derived anodes, owing to its high specific capacity and commendable cycling performance. However, the irreversible formation of phases during lithiation results in low Initial Coulombic Efficiency (ICE). In this work, the Si/C composite (Si@FC) with a fluorine (F) -doped bilayer structure is synthesized via "Vapor-Phase Fluorination" using Polytetrafluoroethylene (PTFE) as a source of fluorine and carbon.

Review of Self-Powered Wireless Sensors by Triboelectric Breakdown Discharge.

This review systematically examines recent advances in self-powered wireless sensing technologies based on triboelectric nanogenerators (TENGs), focusing on innovative methods that leverage breakdown discharge effects to achieve high-precision and long-distance signal transmission. These methods offer novel technical pathways and theoretical frameworks for next-generation wireless sensing systems. To address the core limitations of conventional wireless sensors, such as a restricted transmission range, high power consumption, and suboptimal integration, this analysis elucidates the mechanism of the generation of high-frequency electromagnetic waves through localized electric field ionization induced by breakdown discharge.

"It Is in the Air": Seeking and Scanning for Information About Pre-Exposure Prophylaxis Among Young-Adult Men Who Have Sex with Men in the US.

Pre-exposure prophylaxis (PrEP) is a biomedical intervention that dramatically lowers one's risk of acquiring HIV. However, PrEP uptake has been slow among young-adult men who have sex with men (YMSM) - one group highly vulnerable to HIV infection in the US. Drawing from health communication scholarship on information seeking and scanning, as well as on concepts from the health belief model, we convened individual interviews and focus groups with = 50 PrEP-eligible YMSM in the US to understand how and where YMSM acquire information about PrEP.

Long Short-Term Financial Time Series Forecasting Based on Residual Multiscale TCN Sparse Expert Network and Informer.

Due to the inherent high volatility and complexity of financial markets, traditional time series forecasting models face numerous challenges in handling both short- and long-term predictions in the stock market. Most traditional neural network-based financial prediction models are limited to short-term forecasting and struggle to capture long-term trends and global dependencies in the market fully. To address this, we propose a novel network architecture called ResMMoT-Informer.

Establishment and Validation of a C57BL/6J Mouse Model for Melasma.

Melasma is a recurrent and treatment-resistant hyperpigmentation disorder characterized by a complex and multifactorial pathogenesis. However, the lack of a stable and reliable animal model has hindered systematic investigations into its onset and progression. In this study, we established a melasma-like model in C57BL/6J mice by combining broadband UVB irradiation, intramuscular progesterone administration, and induced emotional stress.

Insights into solidification mechanism of Cr(III) and Cr(VI) in chromite ore processing residue via composite geopolymers synthesized from calcined red mud and granulated blast furnace slag.

Chromite ore processing residue (COPR), which contains soluble toxic Cr(Ⅵ), is a hazardous waste from chromium salts production process. The pre-reduced COPR was solidified using composite geopolymers synthesized from the calcined red mud (RM) and the granulated blast furnace slag (GBFS). Results indicated that higher Na₂S doses reduced the compressive strength of cured specimens but significantly enhanced chromium immobilization efficiency.

Early-life exposure to tobacco, inflammation, and risk of rheumatic diseases: a prospective cohort study.

Background: Tobacco smoke exposure was associated with inflammation and adverse health outcomes. However, the impact of early-life tobacco exposure on rheumatic diseases, including rheumatoid arthritis, osteoarthritis, gout, and spondyloarthritis, and the potential modifying role of inflammation are unclear.

Methods: A prospective analysis of over 200 000 participants without rheumatic diseases at baseline in the UK Biobank was conducted.

Association of pulmonary function with the risk of stroke based on the NHANES database.

Background: Stroke is a significant cause of morbidity and mortality worldwide, often associated with various risk factors including age, hypertension, and diabetes. This study aimed to investigate the relationship between pulmonary function and the presence of stroke, accounting for demographic and clinical factors.

Methods: A total of 6700 participants were enrolled from National Health and Nutrition Examination Survey.

Cohort profile: the Guangzhou older longitudinal dynamic health (GOLD-Health) cohort.

The Guangzhou Older Longitudinal Dynamic Health (GOLD-Health) Cohort is a prospective population-based cohort study aimed at investigating the risk factors associated with non-communicable diseases (NCDs) among adult individuals in Guangzhou, one of China's most developed and densely populated cities. From 1 Jan 2018 until 31 Dec 2020, 737,863 participants (mean age = 71.8 years, 58.

Photo- and Copper-Catalyzed Enantioselective Oxidation of Benzylic C(sp)-H Bonds.

Here, we report a photo- and copper-catalyzed enantioselective oxidation of benzylic C(sp)-H bonds using -hydroxyphthalimide as the oxygenated reagent. The reaction proceeds under mild conditions and does not require excess substrates or oxidants. The oxidation products can be readily transformed into chiral benzylic alcohols or hydroxylamines.

Interactive Rendering of Relightable and Animatable Gaussian Avatars.

Creating relightable and animatable avatars from multi-view or monocular videos is a challenging task for digital human creation and virtual reality applications. Previous methods rely on neural radiance fields or ray tracing, resulting in slow training and rendering processes. By utilizing Gaussian Splatting, we propose a simple and efficient method to decouple body materials and lighting from sparse-view or monocular avatar videos, so that the avatar can be rendered simultaneously under novel viewpoints, poses, and lightings at interactive frame rates (6.

SQSTM1/p62 Orchestrates Skin Aging via USP7 Degradation.

Skin aging is a complex process driven by intrinsic genetic factors and extrinsic environmental influences. In this study, sequestosome1 (SQSTM1/p62) was identified as a key regulator of senescence, the senescence-associated secretory phenotype (SASP), and skin aging. Notably, p62 expression is reduced in senescent cells and aging skin of both humans and mice.

: Advancing Proteomics Data Interpretation through GPT-4o Reannotated Topic Ontology and Data-Driven Analysis.

The interpretation of proteomics data often relies on functional enrichment analysis, such as Gene Ontology (GO) enrichment, to uncover the biological functions of proteins, as well as the examination of protein expression patterns across data sets like the Clinical Proteomic Tumor Analysis Consortium (CPTAC) database. However, conventional approaches to functional enrichment frequently produce extensive and redundant term lists, complicating interpretation and synthesis. Moreover, the absence of specialized tools tailored to proteomics researchers limits the efficient exploration of protein expression within specific biological contexts.