The G-allele of rs10830963 in Exerts Stage-Specific Effects Across the Trajectory of Type 2 Diabetes: A Multi-State Analysis.

Although the single nucleotide polymorphism rs10830963 has been strongly associated with the onset of type 2 diabetes (T2D), its association with the progression and prognosis of T2D has been understudied. We conducted this prospective analysis based on the UK Biobank cohort study. Microvascular complications (MIC) of T2D in this study included diabetic retinopathy, diabetic neuropathy, and diabetic kidney disease.

Early-life exposure to tobacco, inflammation, and risk of rheumatic diseases: a prospective cohort study.

Background: Tobacco smoke exposure was associated with inflammation and adverse health outcomes. However, the impact of early-life tobacco exposure on rheumatic diseases, including rheumatoid arthritis, osteoarthritis, gout, and spondyloarthritis, and the potential modifying role of inflammation are unclear.

Methods: A prospective analysis of over 200 000 participants without rheumatic diseases at baseline in the UK Biobank was conducted.