The G-allele of rs10830963 in Exerts Stage-Specific Effects Across the Trajectory of Type 2 Diabetes: A Multi-State Analysis.

Although the single nucleotide polymorphism rs10830963 has been strongly associated with the onset of type 2 diabetes (T2D), its association with the progression and prognosis of T2D has been understudied. We conducted this prospective analysis based on the UK Biobank cohort study. Microvascular complications (MIC) of T2D in this study included diabetic retinopathy, diabetic neuropathy, and diabetic kidney disease.

Fast Screening of Circulating Tumor Cells in Blood Samples by Sialic Acid Recognition and Microfluidic Chip-Single-Cell ICP-MS: A Breakthrough in Non-invasive Cancer Diagnosis.

Circulating tumor cells (CTCs) hold promise for non-invasive cancer diagnostics, but current detection methods face challenges like white blood cell (WBC) interference, high false negative rates, low throughput, and operational complexity. To overcome these, we developed a simple, fast, and universal CTCs analysis method by the integrating sialic acid (SA) recognition strategy, microfluidic cell sorting, and online single-cell inductively coupled plasma mass spectrometry (SC-ICP-MS) detection. Cells from lysed blood sample were labeled by phenylboronic acid-functionalized gold nanoparticles (PBA-AuNPs) via PBA-SA recognition.

An Ethylene-Response Factor LlERF092 Coordinates With LlETO1 to Improve Thermotolerance by Activating LlMBF1c in Lily.

Multiprotein bridging factor 1c (MBF1c) has been shown to play a critical role in plant responses to heat stress. Previous studies have implicated MBF1c roles in ethylene-mediated thermotolerance; however, the upstream regulatory mechanisms linking MBF1c to this process remain unclear. In this study, an ethylene-response factor (ERF), LlERF092, was identified as a potential regulator of LlMBF1c through a yeast one-hybrid screening assay.

Early-life exposure to tobacco, inflammation, and risk of rheumatic diseases: a prospective cohort study.

Background: Tobacco smoke exposure was associated with inflammation and adverse health outcomes. However, the impact of early-life tobacco exposure on rheumatic diseases, including rheumatoid arthritis, osteoarthritis, gout, and spondyloarthritis, and the potential modifying role of inflammation are unclear.

Methods: A prospective analysis of over 200 000 participants without rheumatic diseases at baseline in the UK Biobank was conducted.

Sll1725, an ABC transporter in Synechocystis sp. PCC 6803 for the detoxification of cadmium ion stress.

Cadmium threatens eco-environmental security and human health, but the interaction between cadmium and microalgae cells remains unknown. This research examined the molecular detoxification mechanism of Synechocystis sp. to cadmium.

High-Entropy V-Based Null Matrix Alloys─Short/Long-Range Structural Features, Chemical Stabilities, and Mechanical Properties.

Null matrix alloys are special types of alloys with no peaks in the neutron diffraction patterns. These types of materials have tremendous applications in the neutron scattering community as main components for manufacturing advanced reaction vessels for measurements. In the literature, null matrix alloys are often reported to be composed of two different elements/isotopes.

Therapeutic Effect and Mechanism of Da-Huang-Zhe-Chong Pills on Uterine Fibroids Using Liquid Chromatography Combined With Mass Spectrometry Metabolomics.

Da-Huang-Zhe-Chong Pills (DHZCPs) have demonstrated efficacy in treating uterine fibroids (UFs), but the mechanisms underlying their action remain unclear. In this study, untargeted serum metabolomic analysis was employed to investigate the therapeutic effects of DHZCP in a rat model of UFs utilizing advanced ultra-performance liquid chromatography tandem quadrupole time-of-flight mass spectrometry (UPLC-Q-TOF/MS) and pattern recognition. Histopathological examination through H&E staining revealed significant improvements in uterine morphology following DHZCP administration.

The LoMYB26/LoJAZ4-LoCOMT module regulates anther dehiscence via Jasmonic acid-mediated endothecium lignification in lily.

Introduction: Timely anther dehiscence is a key step for successful sexual reproduction in plants. Secondary cell wall thickening of anther endothecium is a vital process during anther dehiscence that provides an indispensable mechanical force for successful dehiscence. Anther dehiscence depends on anther lignification, and it is a timely and sophisticated process regulated by phytohormones and transcription factors.

Residential greenness exposure and repeatedly measured hyperglycemic markers in women with gestational diabetes mellitus: A birth cohort study in Foshan, China.

Objectives: To investigate the association between residential greenness exposure and repeatedly measured hemoglobin A1c (HbA1c) levels during pregnancy in women with gestational diabetes mellitus (GDM).

Study Design: This was a cohort study.

Methods: This study was conducted in Foshan City, Southern China from January 1, 2016 to August 31, 2022.

Facile Cascaded Negative Magnetophoresis Chip Combined with ICP-MS for Efficient Sorting and Online Detection of Circulating Tumor Cells.

The isolation and detection of circulating tumor cells (CTCs) play a significant role in early cancer diagnosis and prognosis. Negative magnetophoresis sorting is a label-free method, providing easy access to enrich intact and viable CTCs, but it struggles to meet the demands of high-throughput separation and direct downstream analysis. In this work, a facile cascaded negative magnetophoresis microfluidic chip was fabricated and online coupled to inductively coupled plasma mass spectrometry (ICP-MS) for the rapid separation and detection of rare CTCs in blood samples.

LoBLH6 interacts with LoMYB65 to regulate anther development through feedback regulation of gibberellin synthesis in lily.

The homeostasis of gibberellin (GA) is crucial for the normal development of anthers, but its underlying regulatory mechanisms are not clear. The GA-induced v-Myb myeloblastosis viral oncogene homolog (MYB) transcription factor LoMYB65 is involved in anther development. In this study, we screened and identified an interacting protein of LoMYB65, Oriental Hybrids BEL1-Like Homeodomain6 (LoBLH6).

Case report: Successful treatment of hyperbaric oxygen for radiation-induced hemorrhagic cystitis in a 95-year-old patient with bladder cancer.

Background: Severe radiation-induced hemorrhagic cystitis (RHC) may ultimately require radical cystectomy. High-quality clinical evidence exists regarding the impact of hyperbaric oxygen therapy (HBOT) on RHC. However, there is a lack of reported data addressing the applicability of HBOT in very elderly patients (over 90 years old) with severe bleeding necessitating multiple blood transfusions.

3D Printed All-in-One Sample Introduction System for ICP-MS: Integrating Chip-Based Array Monolithic Microextraction, Microvalve Control, and Microflow Nebulizer.

Three-dimensional printing (3DP) technology was applied to fabricate an all-in-one sample introduction system for inductively coupled plasma mass spectrometry (ICP-MS) analysis of ultratrace rare-earth elements (REEs) in cells. The developed 3DP all-in-one sample introduction system comprised a microfluidic chip integrating cell lysis and monolithic microextraction array, a microvalve control unit, and a microflow total consumption high-efficiency nebulizer (MTHEN). It made full use of the advantages of 3DP in preparing user-customized three-dimensional structures.

3D printed clear resin stir bar sorptive extraction coupled with high performance liquid chromatography for trace chlorophenols analysis in environmental water samples.

3D printing is an additive manufacturing technology based on digital model files. 3D printing has become a popular manufacturing tool in various fields. Stereolithography offers a series of advantages compared to its counterparts, such as smooth prints, appropriate resolution in all the axes, acceptable organic solvent compatibility and sufficient tightness to the flowing of solutions/solvents at moderate/high pressure.

Binary Metal Alloy Electrocatalyst Synergistically Accelerates the Bidirectional Polysulfide Conversions in Lithium-Sulfur Batteries.

The sluggish redox kinetics of polysulfides and the resulting shuttle effect remain significant challenges for the practical utilization of lithium-sulfur (Li-S) batteries. To address the unidirectional catalytic limitations of conventional electrocatalysts, we herein report a binary metal (CoNi) alloy embedded in a carbon matrix on carbon nanofibers (CoNi@C-CNFs) as a highly efficient electrocatalyst to accelerate bidirectional polysulfide conversions. Time-of-flight secondary ion mass spectrometry (TOF-SIMS) reveals a significantly improved catalytic effect of the CoNi alloy toward polysulfide conversions after introducing the Ni component.

Synergistic Effect and Mechanism of Combined Astaxanthin and Curcumin Administration on Ovarian Function in PCOS Mice.

To investigate the synergistic effect of astaxanthin and curcumin on ovarian function in polycystic ovary syndrome (PCOS) mice and to elucidate the underlying mechanisms, fifty 4-week-old female mice were randomly divided into five groups: (i) normal control group; (ii) PCOS model group; (iii) PCOS + astaxanthin group; (iv) PCOS + curcumin group; and (v) PCOS + astaxanthin-curcumin. Throughout the study, various parameters were meticulously evaluated, including serum levels of key reproductive hormones (testosterone (T), estradiol (E2), follicle-stimulating hormone (FSH), luteinizing hormone (LH), and anti-Müllerian hormone (AMH)), as well as monitoring alterations in the estrous cycle, follicle development, and ovulation rates. Additionally, markers of oxidative stress and inflammation were measured.

Dual-Amplification Single-Particle ICP-MS Strategy Based on Strand Displacement Amplification-CRISPR/Cas12a Amplification for Homogeneous Detection of miRNA.

MicroRNAs (miRNAs) regulate a myriad of biological processes and thus have been regarded as useful biomarkers in biomedical research and clinical diagnosis. The specific and highly sensitive detection of miRNAs is of significant importance. Herein, a sensitive and rapid dual-amplification elemental labeling single-particle inductively coupled plasma-mass spectrometry (spICP-MS) analytical method based on strand displacement amplification (SDA) and CRISPR/Cas12a was developed for miRNA-21 detection.

Hierarchically porous covalent organic framework doped monolithic column for on-line chip-based array microextraction of nonsteroidal anti-inflammatory drugs in microlitre volume of blood.

Background: Traditional blood drug analysis involves large blood consumption and complicated operations and a further reduction in blood consumption is urgently needed. Chip-based monolithic column microextraction is a good strategy for the pretreatment of small-volume samples, and new monolithic materials is the critical factor. Covalent organic frameworks (COFs) are good adsorbents due to large specific surface area and rich conjugated structure.

Spectrally selective and thermally insulating hybrid nanofiber aerogel coolers for building energy conservation.

With the advancement of worldwide carbon neutralization, passive radiative cooling (PRC) has attracted tremendous interest in energy conservation by dissipating heat into the ultracold outer space without any electricity consumption. Despite some progress has been made in tailoring spectral properties for PRC, it still remains a crucial challenge in fabricating efficient and low-cost coolers for building energy saving. Herein, hierarchical cellulose-based aerogel coolers consisting of beads-on-string structural electrospun nanofibers are manufactured for all-day and all-region energy saving by combining radiative cooling and thermal insulation in one design.

Viscoelastic Fluid Focusing Chip-ICP-MS Single-Cell Analysis Enables Elucidating the Effect of Extracellular Polymeric Substances on Bioaccumulation of Hg/HgS in Cell.

Understanding the interactions between mercury and microalgae, especially the interactions between inorganic mercury (IHg) and extracellular polymeric substances (EPS, a protective barrier between cells and their external environment), is essential for elucidating mercury's toxicological mechanisms. Given the inherent cell heterogeneity, a novel analysis system of an online viscoelastic fluid focusing chip-time-resolved analysis inductively coupled plasma mass spectrometry has been developed to investigate the bioaccumulation of HgS nanoparticles and Hg in single () cells, exploring the interaction mechanisms between HgS/Hg accumulation in algal cells and EPS. The single-cell analysis results reveal minimal bioavailability of HgS within algal cells, with mercury's toxicity to being species-dependent.

Research on Efficient Electromagnetic Shielding Performance and Modulation Mechanism of Aero/Organo/Hydrogels with Gravity-Induced Asymmetric Gradient Structure.

To eliminate electromagnetic pollution, it is a challenging task to develop highly efficient electromagnetic shielding materials that integrate microwave absorption (MA) performance with high shielding capability and achieve tunability in shielding performance. Asymmetrically structured aero/organo/hydrogels with a progressively changing concentration gradient of liquid metal nanoparticles (LMNPs), induced by gravity, are prepared by integrating the conductive fillers TiCT MXene and LMNPs into a dual-network structure composed of polyvinyl alcohol and cellulose nanofibers. Benefiting from the unique structure, which facilitates the absorption-reflection-reabsorption process of electromagnetic waves along with conductive fillers and the porous structure, three types of gels demonstrate efficient shielding performance.

Latest progress and challenges associated with lithium-ion semi-solid flow batteries: a critical review.

Since the proposal of the concept of semi-solid flow batteries (SSFBs), SSFBs have gained increased attention as an alternative for large-scale energy storage applications. As a new type of high energy density flow battery system, lithium-ion semi-solid flow batteries (Li-SSFBs) combine the features of both flow batteries and lithium-ion batteries and show the advantages of decoupling power and capacity. Moreover, Li-SSFBs typically can achieve much higher energy density while maintaining a lower cost.

Thiol-functionalized MOF modified 3D printed monolithic microextraction array for analysis of trace Cd and Pb in human urine.

Controlling the position, size, and shape of pores is a limitation of traditional monolithic preparation methods. The application of 3D printing technology offers high customizability, allowing the precise printing of pore positions, sizes, and shapes according to the designer's 3D model. Herein, by using Projection Microstereolithography (PμSL), we prepared a 3D-printed monolithic array with post-modification of thiol-functionalized metal-organic framework (MOF), and combined it with inductively coupled plasma mass spectrometry (ICP-MS) for the online analysis of trace Cd and Pb in human urine.

Trace rare earth elements analysis in atmospheric particulates and cigar smoke by ICP-MS after pretreatment with magnetic polymers.

Background: Some heavy metals could be ingested into human body through breathing besides diet and drinking. Atmospheric particulates and smoke are main sources of this kind for the metals' exposure to human. Compared with environmental water, the methodologies for trace metals in particulates and smoke samples with more complex matrix are much less.

An Integrated Inertial-Magnetophoresis Microfluidic Chip Online-Coupled with ICP-MS for Rapid Separation and Precise Detection of Circulating Tumor Cells.

Circulating tumor cells (CTCs) are recognized as promising targets for liquid biopsy, which play an important role in early diagnosis and efficacy monitoring of cancer. However, due to the extreme scarcity of CTCs and partial size overlap between CTCs and white blood cells (WBCs), the separation and detection of CTCs from blood remain a big challenge. To address this issue, we fabricated a microfluidic chip by integrating a passive contraction-expansion array (CEA) inertial sorting zone and an active magnetophoresis zone with the trapezoidal groove and online coupled it with inductively coupled plasma mass spectrometry (ICP-MS) for rapid separation and precise detection of MCF-7 cells (as a model CTC) in blood samples.