The ceRNA Regulatory Network in Vitiligo: Evidence from Bioinformatics Analysis.

Background: Vitiligo is an acquired depigmentary disorder caused by the loss of functional melanocytes. Increasing evidence suggests that competing endogenous RNA (ceRNA) interactions participate in this process, yet their global architecture in vitiligo remains unclear.

Objective: To delineate a long non-coding RNA (lncRNA)-microRNA (miRNA)-mRNA ceRNA network associated with vitiligo and to identify blood-borne RNA markers with diagnostic potential.

Systemic lupus erythematosus with recurrent posterior reversible encephalopathy syndrome: A rare case report.

Rationale: Posterior reversible encephalopathy syndrome (PRES) is a rare but potentially life-threatening neurological condition. In patients with systemic lupus erythematosus (SLE), PRES can occur as a complication of hypertension, renal dysfunction, or immunosuppressive treatment, and is often difficult to distinguish from neuropsychiatric lupus.

Patient Concerns: A 17-year-old woman was diagnosed with SLE, presenting with fever, hypertension, and severe lower limb edema.

[Sequential therapy with carglumic acid in three cases of organic acidemia crisis].

Case 1: A 19-day-old male infant presented with poor feeding and decreased activity for 2 weeks, worsening with poor responsiveness for 3 days. At 5 days old, he developed poor feeding and poor responsiveness, was hospitalized, and was found to have elevated blood ammonia and thrombocytopenia. Whole-genome genetic analysis revealed a pathogenic homozygous mutation in the gene, NM-000282.

Establishment and Validation of a C57BL/6J Mouse Model for Melasma.

Melasma is a recurrent and treatment-resistant hyperpigmentation disorder characterized by a complex and multifactorial pathogenesis. However, the lack of a stable and reliable animal model has hindered systematic investigations into its onset and progression. In this study, we established a melasma-like model in C57BL/6J mice by combining broadband UVB irradiation, intramuscular progesterone administration, and induced emotional stress.

Quantifying carbon stocks in mangrove estuaries of two coastal cities in Tanzania.

Mangrove forests offer a wide range of ecosystem services, including coastal protection and climate regulation. These ecosystems serve as significant carbon sinks, effectively sequestering and storing carbon in their biomass and sediments. However, various human activities have an impact on carbon stocks in mangroves.

First Report of Causing Branch Blight of Walnut in Chongqing, China.

Walnut (Juglans regia L.), a key economic tree species, plays an essential role in China's forestry sector. Our previous surveys indicated that the incidence of walnut branch blight reaches up to 60% in Chengkou County and Beibei District, Chongqing City, China.

The impact of different Spartina alterniflora eradication strategies on the biological community.

The global invasive species, Spartina alterniflora has caused significant damage to coastal wetland ecosystems in China. This study evaluated the effectiveness and ecological impacts of two S. alterniflora management strategies in the Yangtze River estuary: Haloxyfop-R-methyl application and repeated mowing (once at the early flowering stage and once nine weeks later).

Construction and validation of a risk prediction model for hypoglycemia in patients with gestational diabetes mellitus.

Objective: We explored the prevalence and determinants of hypoglycemia in patients with gestational diabetes mellitus (GDM), and we developed and validated a nomogram prediction model.

Methods: We extracted data from the clinical records of 475 patients with GDM attending the tertiary class A specialized hospital in Zhuhai City between December 2021 and June 2023 for a modeling group, and we used data of another cohort of 204 GDM cases for a validation group. We conducted a logistic regression analysis to identify factors associated with hypoglycemia in patients with GDM and generated a risk prediction model presented as a nomogram.

Application of metagenomic next-generation sequencing in pathogen detection of lung infections.

Background: Metagenomic next-generation sequencing (mNGS) has been widely reported to provide crucial information for the diagnosis and treatment of infectious diseases. In this study, we aimed to evaluate mNGS in pathogens diagnosis of lung infections.

Methods: A total of 188 patients who were suspected of pulmonary infection and received medical treatment at the Second Affiliated Hospital of Nanchang University from August 2022 to December 2023 were enrolled in this study.

Norepinephrine promotes oxidative stress in vascular adventitial fibroblasts via PKC/NFκB-mediated NOX2 upregulation.

Background: Sympathetic overactivity is closely associated with vascular remodeling. Sympathetic fibers dominantly innervate the adventitia of arteries rather than tunica media. Vascular adventitial fibroblasts (VAFs) play crucial roles in vascular remodeling.

A Comparative Study on the Sensitivity of Establishing Melasma-Like Models in Different Strains of Mice.

Background: Melasma is a common disease that is difficult to treat, with no recognized animal model for mechanism research or drug screening.

Objectives: To develop a novel, standardized mouse model of melasma.

Materials And Methods: Three different strains of mice (C57BL/6J, BALB/c, and KM) were used to create a melasma-like model across various body regions.

Identification and characterization of aldo-keto reductase responsible for patulin degradation in Saccharomyces cerevisiae.

Patulin (PAT) is a hazardous mycotoxin that contaminates fruits and their products, causing significant economic losses. An aldo-keto reductase from Saccharomyces cerevisiae (ScAKR) was expressed in Escherichia coli in this study. The purified ScAKR converted PAT to E-ascladiol with NADPH as a cofactor.

Intraspecific Variation on Thermal Acclimation of Phragmites australis, a Widespread Wetland Plant Species in Response to Multiple Time-Scale Temperature Changes.

The temperature sensitivity of photosynthesis remains a significant uncertainty in wetland plants, critically impacting predictions of vegetation dynamics and ecosystem functions under global warming scenarios. This study investigates the photosynthetic responses of Phragmites australis, a model wetland plant with a broad geographic distribution, to temperature variations across three distinct temporal scales. We analysed short-term responses using net photosynthesis rate temperature curves, medium-term acclimation across three growth temperature regimes, and long-term adaptation of phylogeographical groups to their genotypic origins' climate.

Realization of 2D metals at the ångström thickness limit.

Two-dimensional (2D) metals are appealing for many emergent phenomena and have recently attracted research interests. Unlike the widely studied 2D van der Waals (vdW) layered materials, 2D metals are extremely challenging to achieve, because they are thermodynamically unstable. Here we develop a vdW squeezing method to realize diverse 2D metals (including Bi, Ga, In, Sn and Pb) at the ångström thickness limit.

Patulin Detoxification by Evolutionarily Divergent Reductases of ATCC 621.

The mycotoxin patulin in processed apple juice poses a significant threat to food safety, driving the need for effective detoxification strategies. ATCC 621 can detoxify patulin to ascladiol using either the short-chain dehydrogenases/reductases (SDRs)─GOX0525, GOX1899, and GOX0716─or the aldo-keto reductase (AKR) GOX1462. While GOX0525 and GOX1899 have been previously characterized, this study focuses on GOX0716 and GOX1462, evaluating their optimal pH, thermostability, thermoactivity, and substrate specificity, thereby completing the characterization of all four reductases.

YlRax1 and YlRax2 Play a Partial and Functionally Interdependent Role in Regulating Bipolar Budding in the Yeast Yarrowia lipolytica.

Rax1 and Rax2 proteins provide the spatial landmark signal during the bipolar budding of Saccharomyces cerevisiae for the proper assembly of the new bud. The nonconventional yeast Yarrowia lipolytica also undergoes bipolar budding, and its genome encodes YlRax1 (YALI0E10329) and YlRax2 (YALI0A04609), the orthologs of Rax1 and Rax2, respectively. In this study, we explored the roles of YlRax1 and YlRax2 in the bipolar budding of Y.

Ensartinib for advanced or metastatic non-small-cell lung cancer with exon 14 skipping mutations (EMBRACE): a multi-center, single-arm, phase 2 trial.

Background: exon14 skipping mutations (ex14) is an established actionable driver oncogene of non-small-cell lung cancer (NSCLC). While ensartinib is a known second-generation tyrosine kinase inhibitor with primary activity against translocation, it is also classified as a type Ia MET inhibitor. We have previously shown anti-tumor activity against ex14 positive NSCLC both and .

Sliding ferroelectric memories and synapses based on rhombohedral-stacked bilayer MoS.

Recent advances have uncovered an exotic sliding ferroelectric mechanism, which endows to design atomically thin ferroelectrics from non-ferroelectric parent monolayers. Although notable progress has been witnessed in understanding the fundamental properties, functional devices based on sliding ferroelectrics remain elusive. Here, we demonstrate the rewritable, non-volatile memories at room-temperature with a two-dimensional (2D) sliding ferroelectric semiconductor of rhombohedral-stacked bilayer MoS.

Medium-scale flexible integrated circuits based on 2D semiconductors.

Two-dimensional (2D) semiconductors, combining remarkable electrical properties and mechanical flexibility, offer fascinating opportunities for flexible integrated circuits (ICs). Despite notable progress, so far the showcased 2D flexible ICs have been constrained to basic logic gates and ring oscillators with a maximum integration scale of a few thin film transistors (TFTs), creating a significant disparity in terms of circuit scale and functionality. Here, we demonstrate medium-scale flexible ICs integrating both combinational and sequential elements based on 2D molybdenum disulfide (MoS).

Latexin (LXN) enhances tumor immune surveillance in mice by inhibiting Treg cells through the macrophage exosome pathway.

Latexin (LXN) is a secreted protein with a molecular weight of 29 KD, which is considered a tumor suppressor and plays an important role in the inflammatory immune response. LXN is highly expressed in macrophages and regulates macrophage polarity and tumor immune escape, demonstrating excellent clinical potential. However, its mechanism is still unclear.

Prioritizing landscapes for mitigating the impacts of onshore wind farms on multidimensional waterbird diversity in the Yellow Sea.

Ongoing wind energy developments play a key role in mitigating the global effects of climate change and the energy crisis; however, they have complex ecological consequences for many flying animals. The Yellow Sea coast is considered as an ecological bottleneck for migratory waterbirds along the East Asian-Australasian flyway (EAAF), and is also an important wind farm base in China. However, the effects of large-scale onshore wind farms along the EAAF on multidimensional waterbird diversity, and how to mitigate these effects, remain unclear.

Effects of salinity on iron-organic carbon binding in the rhizosphere of Kandelia obovata: Insights from root exudate analysis.

Iron (Fe) oxides in wetland soils are crucial for stabilizing soil organic carbon (SOC) by forming stable Fe-OC complexes, thus protecting SOC from microbial breakdown and aiding its preservation. This study delves into the response of Fe (hydr-)oxides to salt stress, a relatively unexplored area, by examining Kandelia obovata, a key mangrove species. Through controlled climate chamber experiments, we investigated how salt stress affects the interactions between Fe (hydr-)oxides and SOC in root exudates (REs) and rhizosphere soils.

Inhibitory potential of 7-hydroxycoumarin-3-carboxylic acid against tyrosinase and its effect on the preservation of fresh-sliced apples.

Excessive tyrosinase expression leads to pigmented diseases in humans and browning in plants, necessitating effective tyrosinase inhibitors. This study investigated the inhibitory effect and mechanism of 7-hydroxycoumarin-3-carboxylic acid (7-HC-3-CA) on tyrosinase. Using UV-visible absorption spectroscopy, we found that 7-HC-3-CA effectively inhibited tyrosinase activity, with an IC value of 364 ± 1.

The construction of an inflammation classification model for HDPCs applied in guiding pulpotomy based on single-cell Raman spectroscopy.

The immune defense and the repair function of the pulp tissue serve as the biological foundation of pulpotomy. The precise evaluation of the pulp inflammation extent and determining its reversibility are essential for the success of pulpotomy. The objective of this study was to classify the molecular-level of dental pulp cell physiology and inflammatory state based on the biochemical changes obtained by single-cell Raman spectroscopy.

Graded Nanotexturing Architectural Wearable Triboelectric Sensor for Programmable Haptic Exploration.

Emulating biological perception mechanisms to construct intelligent sensing devices and systems represents a paradigm for promoting human-computer interaction in the Internet of Everything era. Nonetheless, developing highly sensitive, real-time sensing and rapidly integrated intelligent interaction units remains a challenging and time-consuming endeavor. This study employs a low-temperature glow discharge technique to rapidly fabricate graded nanotexturing architectural triboelectric nanopaper, upon which wearable triboelectric sensors for real-time tactile detection are designed.