A dual-network supramolecular hydrogel dressing encapsulating Cu/EGCG nanoenzyme and glucose oxidase for closed cascade catalytic therapy of diabetic wounds.

Poor diabetic wound healing represents a significant threat to public health. Key obstacles include heightened oxidative stress resulting from the hyperglycemic microenvironment and increased susceptibility to bacterial infections. These factors synergistically exacerbate one another, creating a self-perpetuating cycle that hampers healing.

Plasma biomarkers of dairy intake and gut microbiome, and their association with incident carotid plaque: a prospective cohort study.

Background: This study aimed to investigate the prospective association of dairy biomarkers of odd-chain saturated fatty acids (OCFA) with incident carotid artery plaque (CAP) and to explore the potential role of gut microbiota and related metabolites in the above associations.

Methods: In the Guangzhou Nutrition and Health Study (GNHS, n = 1211; baseline mean age: 58.7 ± 6.

NO-Driven Self-Propelled Nanomotors Augment Chemo-Immunotherapy and Transcatheter Arterial Embolization.

Chemo-immunotherapy is often deemed a first-line treatment for clinical cancer patients. However, the major challenges of poor tumor penetration, multidrug resistance, and T-cell-related immune escape are still unresolved in clinical translation. Herein, we describe a nitric oxide (NO)-driven nanomotor that integrates bioinspired self-propulsion and immunosuppression alleviation for augmented chemo-immunotherapy.

Pseudohypoxia-Stabilized HIF2α Transcriptionally Inhibits , a Druggable Target in MELAS.

The mitochondrial regulator MNRR1 is reduced in several pathologies, including the mitochondrial heteroplasmic disease MELAS, and genetic restoration of its level normalizes the pathological phenotype. Here, we investigate the upstream mechanism that reduces MNRR1 levels. We have identified the hypoxic regulator HIF2α to bind the MNRR1 promoter and inhibit transcription by competing with RBPJκ.

Photodynamic therapy promotes hypoxia-activated nitrogen mustard drug release.

Photodynamic therapy (PDT) has become a promising method for tumor treatment due to its non-invasive and high spatiotemporal selectivity. However, PDT is still hindered by reactive oxygen species deficiency, because solid tumors feature a hypoxic microenvironment. PDT combined with hypoxia-activated chemotherapy drugs can effectively induce tumor death, overcoming the limitations of the sole PDT for the fight against hypoxia.

Serine/threonine/tyrosine kinase 1 drives pancreatic carcinogenesis via GSK3β sequestration-mediated Wnt/β-catenin pathway hyperactivation.

The Wnt/β-catenin pathway is strongly relevant to pancreatic cancer progression, poor prognostic outcomes, and elevated cancer-related mortality. However, the mechanism underlying continuously activated Wnt/β-catenin signaling in pancreatic cancer, a context in which adenomatous polyposis coli (APC) mutations are rarely observed, remains poorly understood. In this study, we investigated the role of STYK1 in regulating canonical Wnt/β-catenin signaling and pancreatic cancer tumorigenesis using the LSL-Kras; Trp53; Pdx1 mouse model.

The optimization of compound enzyme process for enzymatic hydrolyzate from black soldier fly (Hermetia illucens): Antioxidant and immune activity investigation in vitro and in vivo.

The black soldier fly (BSF) is a promising edible insect, recognized for its high nutritional value and beneficial health effects. This study was the first time to investigate the optimal conditions for the enzymatic hydrolysis of BSF (EBSF) by compound enzyme method and EBSF's reparative effects on hepatic injuries. The findings indicated a ratio of alkaline proteinase, trypsin, and papain of 1:1:1, with an enzyme concentration of 6 %, a substrate concentration of 20 %, a temperature of 63 °C, and a hydrolysis time of 5 h, yielded the highest amount of EBSF peptides.

Aerobic Exercise Upregulates Renal-Derived ELABELA to Improve Myocardial Fibrosis by Activating APJ-AMPK-Sirt1 and Inhibiting TGFβ1-Smad2/3 Signaling Pathways in Myocardial Infarction Mice.

ELABELA (ELA) has been identified as a potential cardiovascular protective factor. However, the source of endogenous ELA and its molecular mechanism in myocardial fibrosis inhibition remain incompletely understood. Herein, we found that aerobic exercise significantly improved renal apoptosis caused by MI, inhibited inflammation, attenuated structural damage, enhanced renal function, and increased expression and secretion levels of renal ELA.

Bright-light treatment ameliorates motor and non-motor deficits through distinct visual circuits in a mouse model of Parkinson's disease.

Light has a profound impact on non-visual functions, and clinical evidence suggests bright-light therapy's effectiveness in alleviating motor and non-motor symptoms of Parkinson's disease (PD). However, the neural mechanisms underlying these effects remain unclear. Here, we demonstrate that bright-light treatment alleviates PD symptoms in mice via distinct visual circuits.

Association of plasma n-3 polyunsaturated fatty acid with gut mycobiome and implications for glucose homeostasis.

The pivotal role of gut fungi (i.e., mycobiome) in host health is increasingly recognized.

Comprehensive genetic analysis and genotype-phenotype correlations in pediatric patients with atypical hemolytic uremic syndrome.

Background: Atypical hemolytic uremic syndrome (aHUS) is a rare disease caused by the dysregulation of the alternative pathway. The objective of this study was to evaluate the genetic background and genotype-phenotype correlations in pediatric patients with aHUS.

Methods: This retrospective study enrolled 116 pediatric patients from 2013 to 2023 in China.

Correction: Shu et al. Relationship between Circulating 25-Hydroxyvitamin D and Metabolic Syndrome in Chinese Adults: A Large Nationwide Longitudinal Study. 2024, , 1480.

The following two errors were identified in the main text [1]: In the Results section (3 [...

Enhancing blending efficiency and in vitro aerosol performance of low-dose inhalable dry powders with spray freeze dried microparticles.

Carrier-based dry powder inhaler (DPI) products deliver low-dose drugs to the lungs by blending micronized drug particles with carriers. Traditional methods for obtaining fine particles, such as milling or spray drying, are not suitable for high-value, heat-sensitive drugs. Hence, we propose a novel strategy for preparing carrier-based DPI products based on spray freeze dried (SFD) particles.

Targeting mixed lineage kinase domain-like protein's non-necroptosis role: A new horizon in anti-inflammatory therapy for alcoholic liver disease.

Although mixed lineage kinase domain-like protein (MLKL) is widely recognized as a critical effector in the necroptotic signaling pathway, MLKL plays broader regulatory roles beyond programmed necroptosis. Notably, Xuan Yuan demonstrated that CPD4, an ATP-binding pocket inhibitor of MLKL, significantly reduces liver inflammation and improves liver function by inhibiting NF-κB signaling, suggesting its use as a potential therapeutic candidate for alcoholic liver disease. However, the pharmacokinetic properties and long-term toxicity of CPD4 require further evaluation.

Epigenetically Reprogrammed Nanovesicles as Inverse Vaccines for Antigen-Specific Immune Tolerance in Autoimmune Diseases.

The development of antigen-specific immunotherapy for autoimmune diseases constitutes an important unmet clinical need. Here we present an innovative inverse vaccine platform leveraging epigenetic reprogramming to induce durable antigen-specific immune tolerance. This inverse vaccine (mDCNVreg) is constructed using artificial cell membrane nanovesicles derived from IFN-γ-primed regulatory dendritic cells subjected to epigenetic modulation.

Exerkine-mediated organ interactions: A new interpretation of exercise on cardiovascular function improvement.

Cardiovascular diseases impair the structure and function of distal organs, including the liver, skeletal muscle, kidney, and adipose tissue. Exercise stimulates the interaction between the cardiovascular system and distal organs that is important for disease rehabilitation and organ health. However, the mechanisms by which exercise improves cardiovascular function through exerkine-mediated organ crosstalk remain incompletely elucidated.

A novel molecular classification system for head and neck squamous cell carcinoma: predicting treatment response and metastatic potential through multi-omics analysis.

Background: Head and neck squamous cell carcinoma (HNSCC) demonstrates significant heterogeneity, necessitating improved molecular classification for precision treatment.

Methods: We integrated single-cell and bulk RNA sequencing data from 59,376 cells across ten datasets using Scissor and scSTAR packages. Molecular subtyping was performed through ssGSEA and WGCNA analysis, with immune infiltration evaluated using CIBERSORT.

The association between C-reactive protein-albumin-lymphocyte index and depression in adults with type 2 diabetes mellitus: A cross-sectional study from NHANES.

Objective: Inflammation and nutrition are interrelated, and both are related to depression. This study explored the association between the C-reactive protein (CRP)-albumin-lymphocyte (CALLY) index, a novel immunonutrition scoring system, and depression in patients with type 2 diabetes mellitus (T2DM).

Methods: We included 3517 patients with T2DM from the National Health and Nutrition Examination Survey 2005-2010 and 2015-2018.

Chloride intracellular channel 6 inhibits hepatocellular carcinoma progression by modulating immune cell balance and promoting tumor cell apoptosis.

Objective: Chloride intracellular channel 6 (CLIC6) is essential for the development of cancer, and it is widely studied for the treatment of various cancers. This study aimed to explore the potential mechanisms of CLIC6 in the treatment of hepatocellular carcinoma (HCC).

Material And Methods: Initially, a subcutaneous xenograft model of HCC was established.

Association of middle cerebral artery aneurysms and variation of the A1 segment.

Objective: The disturbance of blood flow caused by variations in the circle of Willis is an important factor in the occurrence and development of aneurysms. Previous studies have confirmed that a fetal-type posterior cerebral artery(PCA) is closely related to posterior communicating artery (PcoA) aneurysms, while anatomical variations of the anterior cerebral artery (ACA) appear to correlate with the prevalence of aneurysms in the anterior communicating artery (ACoA). However, the relationship between variations in the circle of Willis and middle cerebral artery(MCA) aneurysms remains controversial.

SP7 transcription factor ameliorates bone defect healing in low-density lipoprotein receptor-related protein 5 (LRP5)-dependent osteoporosis mice.

Loss-of-function variants of low-density lipoprotein receptor-related protein 5 (LRP5) can lead to reduced bone formation, culminating in diminished bone mass. Our previous study reported transcription factor osterix (SP7)‍-binding sites on the promoter and its pivotal role in upregulating LRP5 expression during implant osseointegration. However, the potential role of SP7 in ameliorating LRP5-dependent osteoporosis remained unknown.

Increased circulating apolipoprotein Cs are implicated in the association between elevated serum retinol and retinol-binding protein 4 and adverse progression of metabolic syndrome in adults: A prospective study.

Prior research has highlighted the significant roles of circulating retinol, retinol-binding protein 4 (RBP4), and apolipoprotein C (ApoC) in metabolic health. This study investigates the joint association of retinol and RBP4 with metabolic syndrome (MetS) and examines the potential mediating role of ApoCs in these relationships. This prospective study included 3,009 and 2,724 participants with baseline serum retinol and RBP4 data, respectively.