Application strategies of autologous and decellularized nerve grafts: Structural and functional recovery.

Autologous nerve transplantation is currently recognized as the gold standard for treating severe peripheral nerve injuries in clinical practice. However, challenges such as a limited supply of donors, complications in the donor area, and the formation of neuromas necessitate the optimization of existing transplantation strategies. Additionally, the development of new and promising repair methods is a critical issue in the field of peripheral nerve research.

Screening of SGLT2 inhibitors based on virtual screening and cellular experiments.

This study aims at find hit compounds as SGLT2 inhibitors through the methods of virtual screening, biological experiment, Structural similarity search and molecular docking. Computer-aided drug design techniques were used to build modelling of quantitative construct validity relationships. Three-dimensional pharmacophore model and the principle of drug properties were used to screen the compounds.

Acute thrombocytopenia and fibrinogen reduction occurring after nintedanib treatment for immune checkpoint inhibitor-related pneumonia: a case report.

Background: Nintedanib, a small molecule multi-target tyrosine kinase inhibitor, can block the fibrosis process and slow disease progression. Acute thrombocytopenia and fibrinogen reduction caused by nintedanib is a rare clinical event, with few studies reported.

Case Presentation: We report the case of an 89-year-old male diagnosed with advanced renal cell carcinoma who developed immune-related interstitial lung disease after treatment with sintilimab injection combined with axitinib.

Identification of anti-fibrotic compounds from Piper longum L via hollow fiber cell fishing and high-performance liquid chromatography with in vivo and in vitro validation.

Background: Traditional Chinese medicine (TCM) is an important source of bioactive compounds, hence enjoying a wide application in clinical treatment, while its pharmacodynamic material basis remains difficult to elucidate as it has a complex chemical composition. Piper longum L is a commonly used herbal medicine in prescriptions for chronic kidney disease (CKD), yet its key active ingredients responsible for anti-renal fibrosis effects remain unclear. This study aimed to establish a novel and efficient strategy for the screening and identification of anti-fibrotic compounds from Piper longum L.

Detection and Genetic Characteristics of Cosavirus and Salivirus in the Wastewater, China.

Cosavirus (CoSV) and Salivirus (SalV) are two novel picornaviruses that are associated with human diseases. However, epidemiological data on these viruses in China remain limited. In this study, we conducted the first simultaneous investigation of CoSV and SalV in a city of eastern China by wastewater-based epidemiology (WBE) method.

Natural polyphenol rutin inhibits ferroptosis in ulcerative colitis by regulating lipid metabolism blocking the LCN2-ALOX15 axis.

Ulcerative colitis (UC), a chronic inflammatory disorder with elevated carcinogenic risk, urgently requires multi-target therapeutic strategies. Ferroptosis, characterized by iron-dependent lipid peroxidation, emerges as a promising intervention target for intestinal barrier protection. Rutin, a natural polyphenol with established anti-inflammatory properties, holds therapeutic potential for UC, yet its mechanisms involving ferroptosis regulation and barrier enhancement remain unexplored.

Involvement of mediodorsal thalamus and its related neural circuit in pain regulation in mice.

The mediodorsal thalamus (MD) constitutes an integral component of the medial nociceptive transmission system, although its precise role and related neural pathway in pain processing remains incompletely elucidated. While anatomical studies have confirm reciprocal projections between the MD and anterior cingulate cortex (ACC), the functional contribution of ACC-MD neural circuitry to nociceptive regulation has not yet been systematically investigated. In this study, we used immunohistochemistry, pharmacogenetic manipulations, and multidimensional behavioral assessments to investigate the role of the MD and ACC-MD pathway in pain modulation.

PPI in preventing gastrointestinal injury in minor ischemic stroke or TIA patients at low risk of gastrointestinal bleeding treated with short-term dual antiplatelet therapy.

Objective: To analyse the use of prophylactic proton pump inhibitors (PPIs) and their benefits for the prevention of gastrointestinal injury and to determine the optimal course of preventive use among patients with minor ischaemic stroke (IS) and transient ischaemic attack (TIA) at low risk of gastrointestinal bleeding (GIB) treated with short-term dual-antiplatelet therapy (DAPT).

Methods: We retrospectively collected clinical data from the hospital information system (HIS) from January 2022 to December 2023. The data were collected from patients who were admitted to a tertiary hospital with a first occurrence of minor IS/TIA diagnosed within 14 days and treated with short-term DAPT.

Interparental Hostility and Cooperative Interparental Conflict Interact to Predict Chinese Adolescents' Problematic Smartphone Use Through Adolescents' Conflict Appraisals.

Interparental hostility is a risk factor for adolescents' problematic smartphone use (PSU). However, the mechanisms implicated in this association remain unclear. Using three-wave, multi-informant data from 364 Chinese parent-child dyads over the junior high school years (grades 7-9, M = 12.

[Ningmitai Capsules alleviate CP/CPPS symptoms by regulating Nrf2 and NF-κB signaling pathways].

Objective: To investigate the therapeutic effect of Ningmitai Capsules (NMT) on chronic prostatitis / chronic pelvic pain syndrome (CP/CPPS) and its action mechanism.

Methods: We equally randomized fifteen 6－8 weeks old male Wistar rats into a sham operation, a model control and an NMT group, and established a CP/CPPS model in the rats by intra-prostatic injection of complete Freund adjuvant (CFA). We treated the rats in the sham operation and model control groups by injection of aseptic phosphate buffer saline (PBS) and 50 μl complete Freund adjuvant (CFA), respectively, into the ventral lobe of the prostate followed by gavage with purified water from the second day after surgery, and those in the NMT group with 50 μl CFA injected into the ventral lobe of the prostate followed by gavage with 3 ml NMT suspension at 400 mg/kg/d from the second day after surgery.

Time-resolved photocatalytic proximity labeling uncovers ER proteome dynamics underlying UPR-to-apoptosis transition.

Apoptosis is a critical outcome of stress-induced processes, with the endoplasmic reticulum (ER) playing a central role in apoptotic protein processing and stress signal transduction. Profiling the ER proteome during stress to cell death offers valuable insights into these processes, but existing methods often suffer from a loss of in situ information or requirement of genetic manipulation. In this study, we introduce CAT-ER, a nongenetic ER proteomics system that provides in situ labeling, spatiotemporal resolution, and compatibility across diverse cell types.

Family socioeconomic status predicts adolescents' career adaptability through their self-efficacy on career goal setting and exploration: Testing the moderating roles of relationship quality with teachers, parents, and peers.

Family socioeconomic status (SES) is one key antecedent of adolescents' career adaptability; understanding the mechanisms through which family SES influences career outcomes is thus essential. Grounded in the career self-management model, this study leveraged three-wave data from a sample of 3,196 Chinese adolescents (15.56 ± .

Optimizing space heating efficiency in sustainable building design a multi criteria decision making approach with model predictive control.

Efficient space heating is vital for sustainable building design, offering opportunities to reduce energy consumption and costs while maintaining thermal comfort. This study examines the optimization of space heating in a nearly-zero energy building (nZEB) located in Oslo, Norway, under cold climatic conditions. The research question explores how advanced control strategies can balance heating costs and thermal comfort efficiently.

Intranasal administration of stem cell derivatives for the treatment of AD animal models: a systematic review and meta-analysis.

Background: Alzheimer’s disease (AD) is a neurodegenerative disorder with increasing prevalence and limited efficacy of current therapies. Stem cell-derived therapies have attracted attention for their potential neurodegenerative and reparative effects. Intranasal administration provides a non-invasive route that bypasses the blood-brain barrier and delivers stem cell derivatives directly to the brain.

Multidimensional Evaluation of Combined Anticoagulation and Venoprotective Therapy in Deep Vein Thrombosis: A Retrospective Propensity Score-Matched Cohort Study of Clinical, Economic, and Resource Utilization Outcomes.

: Deep vein thrombosis (DVT) management remains challenging despite standard anticoagulation therapy. This study evaluated the comprehensive benefits of combining rivaroxaban with Aescuven (CAV) compared to rivaroxaban monotherapy (SAT) in DVT treatment. : A retrospective analysis was conducted on DVT patients (2018-2023) using multi-method propensity score matching and ensemble weighting.

Implications of childhood psychological maltreatment and peer victimization for COVID-19 PTSD symptoms among adolescents: Mindfulness and self-compassion as explanatory mechanisms in trauma transmission.

Objective: The linking mechanisms underlying associations between early adversities and posttraumatic stress disorder (PTSD) symptoms related to major public health crises remain unclear. Grounded in the stress process model, the present study examined the potential mediating roles of mindfulness and various forms of emotion regulation strategies (general: cognitive reappraisal and expressive suppression; self-care specific: self-compassion) in the associations between victimization by family members and peers (childhood psychological maltreatment and peer victimization) and COVID-19 PTSD symptoms among adolescents.

Method: Three-wave survey data were collected from 844 Chinese junior high school students (51.

Body Mass Index and Peer Victimization From Middle Childhood Through Early Adolescence: Disaggregation of Between- and Within-Person Associations and Specificity Across Victimization Types.

Peer victimization is a prevalent problem, which is often related to high body mass index (BMI). However, prior studies largely overlooked the heterogeneity in this association varying as a function of the victimization type/form (i.e.

Sharing Task-Relevant Information in Visual Prompt Tuning by Cross-Layer Dynamic Connection.

Recent progress has shown great potential of visual prompt tuning (VPT) when adapting pre-trained vision transformers to various downstream tasks. However, most existing solutions independently optimize prompts at each layer, thereby neglecting the usage of task-relevant information encoded in prompt tokens across layers. Additionally, existing prompt structures are prone to interference from task-irrelevant noise in input images, which can adversely affect the sharing of task-relevant information.

Efficacy of Filtration Surgery and Risk Factors for Central Visual Field Deterioration in Highly Myopic Eyes with Open-Angle Glaucoma.

Prcis: This study demonstrates the effectiveness of filtration surgery in preserving the central visual field in eyes showing open-angle glaucoma with high myopia, highlighting the necessity of intraocular pressure reduction ≥30% for optimal outcomes.

Purpose: To evaluate the efficacy of filtration surgery in preserving the central visual field (VF) in eyes with open-angle glaucoma (OAG) and high myopia (HM) and identify postoperative intraocular pressure (IOP) targets and factors associated with targeted IOP reduction.

Methods: This retrospective cohort study included 55 eyes (48 patients) with OAG and HM who underwent filtration surgery and were followed up for minimum 3 years.

Investigation into the Performance of TDR and FDR Techniques for Measuring the Water Content of Biochar-Amended Loess.

Biochar has garnered considerable attention for its potential to improve soil properties due to its unique characteristics. However, the precise measurement of soil water content using electromagnetic sensors becomes challenging after biochar is incorporated. This study investigated the impact of biochar on soil water content measurement by adding biochar of varying dosages and particle sizes to a typical loess, under both room and subzero temperature conditions by using time domain reflectometry (TDR) and frequency domain reflectometry (FDR) techniques.

Early postnatal overnutrition as a contributor to metabolic dysregulation: Insights into hepatic epigenetic mechanisms.

This study evaluated the effects of postnatal overnutrition during lactation on hepatic DNA methylation patterns and their relationship with hepatic metabolic disorders. At postnatal day 3, male rats were randomly divided into normal litters (NL, 10 pups per litter) or small litters (SL, three pups per litter). Weight and insulin resistance were assessed at week 3 and week 13.

Damage control orthopaedics is associated with impaired fracture healing and delayed recovery in a rodent model of severe multiple trauma.

Aims: Polytraumatized patients with severe limb injuries often develop complications, which are influenced by the surgical treatment strategy. For the initial fracture stabilization, Early Total Care (ETC) and Damage Control Orthopedics (DCO) are competing concepts, with the treatment choice depending on the patient's condition. Clear guidance factors remain lacking.