[Analysis of transurethral water vapor thermal therapy for the treatment of benign prostatic hyperplasia].

Objective: To investigate the efficacy and safety of transurethral water vapor thermal therapy (WVTT) using the Rezūm system for benign prostatic hyperplasia (BPH) in the real world.

Methods: A total of 181 patients with BPH were recruited from the Second Affiliated Hospital of Nanjing Medical University from August 2022 to December 2023, of whom 173 patients were treated with WVTT using the Rezūm system, while 8 patients were treated with WVTT combined with TURP. They were followed up at 1, 3, and 6 months postoperatively to assess changes in the IPSS, QoL, Qmax, IIEF-5, and the occurrence of any complications.

Effects of Maternal Iodine Deficiency in Women with Mild Thyroid Dysfunction During Early Pregnancy on Mental and Motor Growth of Their Offspring During Levothyroxine Treatment.

The relationship between maternal thyroid function and intellectual development of offspring is controversial. Iodine may be an important confounding factor. This study investigated whether maternal iodine status could affect the efficacy of levothyroxine (LT4) treatment during early pregnancy on the intellectual growth of progeny.

An Integrated System for Comprehensive Mouse Peripheral Vestibular Function Evaluation Based on Vestibulo-ocular Reflex.

Purpose: In the fields of both vestibular and auditory research, reliable vestibular function tests are essential. However, unlike the auditory function tests, which use standard Auditory Brainstem Response (ABR) equipment, there is no equivalent widely adopted apparatus for vestibular tests. Vestibulo-ocular reflexes (VORs) are the compensatory ocular reflexes that ensure stable vision during head motion.

Enhancement effect of biochar on the immobilization of heavy metals and anions in MSWI fly ash/bottom ash-coal fly ash-based cementitious materials: Risk assessment model and mechanisms.

The preparation of solidified materials using biochar (BC) and MSWI fly ash (FA) promotes pollutant remediation and the resource utilization of solid waste. However, studies on the quantitative risk assessment of BC-enhanced MSWI FA/bottom ash (BA)-coal FA-based cementitious materials (CBFM) and the synchronous immobilization mechanisms of heavy metals and anions are still limited. This study used multiple leaching methods and the RAC/OPTI model to evaluate the leaching behavior and environmental risk of MSWI FA/CBFM under various pH conditions.

Determining the Dipole Orientation of Second Harmonic Generation in 3R-MoS for Enhanced Nonlinear Susceptibility.

As an efficient two-dimensional nonlinear optical crystal, 3R-MoS exhibits intrinsic bulk second-order nonlinearity with substantial second harmonic generation (SHG) due to the interfacial charge transfer induced interlayer dipole and intralayer intrinsic asymmetric dipole. However, how these dipoles determine the SHG emission dipole orientation and intensity in 3R-MoS has not been clearly resolved. Here, we accurately determine the coexistence of in-plane and out-of-plane SHG emission dipoles in few-layer 3R-MoS through radial-/azimuthal-polarization excitation SHG measurements and back focal plane (BFP) imaging combined with numerical simulations, where the SHG emission dipole orientation () in real space for 3L, 4L, 5L, and 6L 3R-MoS is determined to be ∼8°, ∼16°, ∼20°, and ∼32°, respectively.

The oxidizing characteristics of plasma-activated water induced by long-lived species generated by dielectric barrier discharges with bubbling diffusion and its use in decomposition of oxytetracycline.

The application of low-temperature plasma as an advanced oxidation technology in the field of water treatment has attracted more attention as it introduces no additional chemical ingredients and is environmentally friendly. The core of this technology refers to reactive species (mainly the reactive oxygen species and reactive nitrogen species) generated by the discharge, reacting with water content to form plasma-activated water (PAW). An improved PAW generation configuration was proposed to enhance the mass transfer progress of plasma-generated reactive species in the liquid phase.

Hypobaric hypoxia aggravates neuroinflammation in ligature-induced periodontitis mice via the STAT3 signaling pathway.

Background And Purpose: Studies have shown that inflammation is a key risk factor for altitude sickness in hypobaric hypoxia environments. Periodontitis, a common oral disease, is prevalent among many individuals. This study aimed to investigate the onset and progression of neuroinflammation in mice with ligature-induced periodontitis under hypobaric hypoxia and to explore the potential underlying mechanisms.

Discovery of multi-target anti-gout agents from Eurycoma longifolia Jack through phenotypic screening and structural optimization.

Developing anti-gout medications that simultaneously reduce uric acid and exert anti-inflammatory effects represents a critical breakthrough for managing gout progression. Natural products with polypharmacological properties offer promising leads for drug discovery. In this study, β-carboline-1-propionic acid, a bioactive constituent of Eurycoma longifolia Jack, served as the starting point for drug design.

SAP30BP aggravates mitochondrial-related ferroptosis in diabetic cardiomyopathy by regulating MFN2-ACSL4 axis.

Ferroptosis is characterized by iron overload and uncontrolled lipid peroxidation, which plays a substantial role in the development of diabetic cardiomyopathy (DCM). However, the exact factor responsible for inducing ferroptosis in DCM has not been fully elucidated. SAP30 binding protein (SAP30BP), a member of the HCNGP family, functions as a transcription regulator.

Cold Stress Regulates Muscle Development and Promotes Muscle Fiber Transformation by Regulating Mib1/Notch Pathway.

Background: In mammals, skeletal muscle typically constitutes approximately 55% of body weight. The thermogenesis of skeletal muscle increases with increased cold stress, and skeletal muscle maintains the animal's body temperature through the heat generated by shivering. However, less attention has been paid to investigating the impact of cold stress on the fiber type makeup of skeletal muscle, especially the gastrocnemius.

Deletion of METTL14, a key methylation regulator, attenuates vascular ageing.

Background And Aims: Vascular ageing often accompanies inflammation, contributing to the onset of local or systemic vascular diseases. Nevertheless, limited research focuses on pivotal factors triggering chronic vascular inflammation and associated pathological changes. This study aimed to investigate the role of methyltransferase-like protein 14 (METTL14) in inflammation in the pathogenesis of vascular ageing.

Plasma membrane CYBDOM proteins catalyse apoplastic AsA regeneration and interact with RbohD to activate autophagy and drought tolerance in plants.

Autophagy and apoplastic ascorbic acid (AsA) play important roles in plant drought tolerance. However, the trans-plasma membrane transport of AsA and its association with autophagy during drought stress are unclear. Here we report an AsA-induced autophagy pathway in plants, wherein plasma-membrane-located cytochrome b561 and DOMON domain (CYBDOM) proteins play positive roles.

OTDR Development Based on Single-Mode Fiber Fault Detection.

With the large-scale application and high-quality development demands of optical fiber cables, higher requirements have been placed on the corresponding measurement technologies. In recent years, optical fiber testing has played a crucial role in evaluating cable performance, as well as in the deployment, operation, maintenance, fault repair, and upgrade of optical networks. The Optical Time-Domain Reflectometer (OTDR) is a fiber fault diagnostic tool recommended by standards such as the International Telecommunication Union and the International Electrotechnical Commission.

Effects of Nitro-Oxidative Stress on Biomolecules: Part 2-Reactive Molecular Dynamics Simulations.

In this review article, statistical mechanisms of oxidative modification reactions in various organic compounds under the influence of reactive oxygen species (ROS) generated by cold atmospheric plasma (CAP) are investigated and analyzed based on reactive molecular dynamics (MD) simulations. As an efficient and hygienic advanced oxidation technology, CAP demonstrates tremendous potential in fields such as biomedicine and environmental protection. Through simulations, this paper provides a detailed analysis of the interaction mechanisms between ROS and components of biological tissues and environmental toxins.

Associations between sleep problems, cortical morphometry, and structural brain network organization in preschool children with autism: a retrospective observational study.

Unlabelled: Sleep problems are highly prevalent in autism spectrum disorder (ASD) and may contribute to behavioral challenges and atypical brain development. However, the neuroanatomical mechanisms linking sleep problems and ASD during early childhood remain underexplored. This retrospective observational study included 183 preschool children with ASD, grouped by sleep problem status using the Children's Sleep Habits Questionnaire (CSHQ).

Leveraging hypoxia-related genes signature for predicting the prognosis of bladder cancer.

Background: Hypoxia is common in solid tumors, facilitating tumor growth and treatment resistance, and is crucial for optimizing patient outcomes, but research on the mechanism of hypoxia in bladder cancer (BC) remains limited. This study aims to explore the functional role of hypoxia-related genes (HRGs) in BC.

Methods: The HRGs were obtained from GeneCards, and the hypoxia score in BC patients was evaluated by single-sample gene set enrichment analysis (ssGSEA).

Inhibiting CD36 palmitoylation improves cardiac function post-infarction by regulating lipid metabolic homeostasis and autophagy.

Alterations in myocardial energy substrate metabolism and mitochondrial injury following myocardial infarction (MI) lead to structural and functional abnormalities of the heart. The fatty acid translocase CD36 (CD36) plays a pivotal role in regulating lipid homeostasis and mitochondrial metabolism. Here, we demonstrate that inhibiting the palmitoylation of CD36 and the resulting alteration in its subcellular localization alleviates lipid metabolism disorders and mitochondrial dysfunction in cardiomyocytes of male mice post-MI.

Bangerter filter's role in regulating ocular axial length: a novel application of an established therapy.

Key Messages: What is known Occlusion with Bangerter filters designed with different translucent microscopic diffusers is an effective treatment for anisometropic amblyopia. What is new Bangerter filters were found to show an effect on slowing down ocular axial length (AL) growth. When rapid hyperopic reduction occurs in the non-amblyopic eye combined with persistently widening interocular AL differences, Bangerter filter application represents a more preferable alternative to patching for managing anisometropic amblyopia.

Latent profile analysis of social participation among adults with cardiovascular disease based on the CHARLS.

Social participation is recognized as a critical factor in reducing mortality and promoting healthy aging in middle-aged and older adults with cardiovascular disease (CVD). However, the determinants influencing social participation within this demographic remain poorly understood. The present study sought to assess the social participation status of middle-aged and older individuals with CVD and identify the factors influencing their participation levels.

Multi-Time Point Transcriptome Analysis and Functional Validation Revealed Negatively Regulates Black Rot Resistance in Cabbage.

4-coumarate-CoA ligase (4CL) plays a crucial role in the phenylpropanoid metabolic pathway and is a key enzyme involved in plant growth and stress responses. Black rot, caused by pv. () is a major bacterial disease affecting the production of global cruciferous crop-like cabbage ( var.

Tunable magnetic anisotropy and phase transitions in 2D Janus transition-metal chalcogenide halides.

Two-dimensional (2D) magnetic semiconductors have received increasing interest for spintronic applications due to their tunable magnetic properties. Using first-principles calculations, we design a series of 2D novel ferromagnetic semiconductors, including VSBr and Janus MSBrX (M = Cr/V, X = F, Cl, I), which exhibit various exotic properties. We realize an indirect-to-direct bandgap transition in CrSBrF, a giant perpendicular magnetic anisotropy in VSBrI, and a significant enhancement in both VSBrF and VSBrI.

Brain age prediction model based on electroencephalogram signal and its application in children with autism spectrum disorders.

Background: There is a lack of objective biomarkers for brain developmental abnormalities of autism spectrum disorder (ASD). We used EEG and deep learning to conduct a brain aging study in ASD.

Methods: (1) A total of 659 healthy children and 98 ASD patients were retrospectively recruited.

Sex-Specific effects of vitamin D on autistic behavior and gastrointestinal symptoms in rats via the regulation of serotonin metabolism.

Vitamin D (VitD) deficiency (VDD) during prenatal and early brain development may be an environmental risk factor for autism spectrum disorder (ASD). While supplementation with high-dose VitD can improve core ASD symptoms, its mechanism is unclear. In addition, VitD regulates the serotonin (5-HT) pathway, which has been shown to be closely related to ASD.