Functional connectivity signatures of olfactory networks linked to cognitive risk: A functional MRI study in subjective cognitive decline at risk for Alzheimer's disease.

BackgroundIndividuals with subjective cognitive decline (SCD) are at high risk of preclinical Alzheimer's disease (AD). While olfactory dysfunction is evident in AD and mild cognitive impairment (MCI), its presence and neural mechanism in SCD remain unclear.ObjectiveThis study examined functional connectivity (FC) alterations across olfactory networks and their mediating role between olfactory and cognitive functions in SCD and MCI.

Serum Pepsinogen as a Biomarker of Gastrointestinal Stromal Tumors (GIST) in Stomach.

Background: Gastric GISTs (GG) are significant mesenchymal tumors. No biomarker has been identified for GG detection. We first observed mucosal atrophy surrounding GG tumors, leading to the hypothesis that localized atrophy may alter serum pepsinogen (PG) levels.

CNO induced Ca store and glutamate-dependent nonspecific Ca signalling in DREADD-free brain slices.

DREADD (design receptors exclusively activated by designer drugs) is a widely used powerful tool designed to study specific cellular functions. However, off-target effects of chemogenetic activators, including clozapine N-oxide (CNO) and deschloroclozapine (DCZ), have been reported. In our study, we demonstrated the direct off-target effects of CNO and DCZ on basal Ca levels in the locus coeruleus nucleus in both neurons and astrocytes by combining viral microinjection, Ca imaging and electrophysiology.

Integrated DNA methylome and transcriptome analysis reveals the epigenetic regulatory mechanisms underlying maize response to copper stress.

DNA methylation plays a crucial role in plants' adaptation to environmental stresses. However, the precise role of DNA methylation in regulating the response of maize (Zea mays L.) to copper stress remains incompletely understood.

Pulmonary Benign Metastasizing Leiomyoma: A Retrospective Analysis of Seven Cases Including a Rare Coexistence with In Situ Mucinous Adenocarcinoma.

Pulmonary benign metastasizing leiomyoma (PBML) is a rare condition characterized by histologically benign smooth muscle tumors occurring at extrauterine sites, often in women with a history of uterine leiomyoma. While PBML generally exhibits indolent behavior, its pathogenesis, management, and malignant potential remain unclear. This study retrospectively analyzes the clinical characteristics, imaging features, diagnostic approaches, pathological findings, treatment strategies, and outcomes of seven patients with PBML treated at our institution between January 2016 and May 2025.

Research on mechanical properties of a new type of composite floor slab with split joint.

At present, the commonly used composite floor of steel bar truss in prefabricated buildings has the problem that the overhanging bent steel bars in the prefabricated floor collide with the reserved steel bars in other prefabricated components, which reduces the subsequent construction efficiency. In order to solve this problem, a new type of composite floor slab with split joints was designed. The bent steel bars are distributed centrally in the middle of the stitching edge of the prefabricated bottom plate, while the ends of the bottom plate are not reinforced, which reduces the contact with the reserved steel bars of other structures.

Atherogenic index of plasma combined with carotid crouse score predicts coronary artery disease in young and middle-aged adults.

This retrospective study included 642 patients aged 18-59 years who underwent carotid ultrasound and coronary angiography. Patients were grouped by coronary artery disease (CAD) status and median Gensini score. Clinical characteristics, the atherogenic index of plasma (AIP), and carotid Crouse scores were compared.

Acupotomy for Military Training-Induced Lumbar Radiculopathy with Sciatica: Protocol of a Randomized Controlled Trial.

Background: Military personnel face elevated risks of chronic sciatica due to repetitive mechanical loading during combat training. Conventional therapies, such as nonsteroidal anti-inflammatory drugs (NSAIDs) and physical therapy, often fall short in addressing the urgent need for rapid functional recovery. Acupotomy, a minimally invasive technique that integrates acupuncture with microsurgical dissection, has the potential to alleviate both central and peripheral nerve compression; however, its efficacy within military populations remains inadequately studied.

Fibroblast growth factor receptor inhibitors ameliorate metabolic dysfunction-associated steatohepatitis by modulating the glycine-glutathione-gut microbiota axis.

Metabolic dysfunction-associated steatohepatitis (MASH) is a chronic liver disease characterized by hepatic steatosis, inflammation, and fibrosis. Dysregulation of fibroblast growth factor receptor (FGFR) signaling is closely associated with various liver diseases, but its role in hepatic metabolism remains unclear. In this study, we developed a small-molecule FGFR inhibitor, CP0813, and evaluated its therapeutic potential in three diet-induced MASH mouse models.

The Role of Advance Care Planning on Community Dwelling Adults' Coping Abilities and Death Attitudes: A Sequential Mixed-Methods Study.

Aim: To (1) examine the attitudes of community-dwelling adults towards death and their ability to cope with death, as well as (2) understand the influence of advance care planning on community-dwelling adults' death attitudes and coping with death.

Design: A sequential explanatory mixed-methods study was conducted in Singapore.

Methods: In Phase I, a case-control study was conducted to examine the differences in death attitudes and coping with death ability between community-dwelling adults who have completed advance care planning and those who have not.

Photonic crystal microring resonators on a hybrid silicon nitride-on-lithium niobate platform.

Photonic crystal resonators (PhCRs) have been widely used in nonlinear integrated photonics for frequency engineering applications. A microwave-assisted frequency converter based on PhCRs provides precisely controlled bidirectional frequency conversion. Using a hybrid silicon nitride-on-lithium niobate-on-insulator platform, we demonstrate a high-quality PhCR for the first time, to the best of our knowledge, for voltage-driven flexible frequency conversion using the electro-optic effect (0.

Examining the after-school study burden of Chinese secondary school students following burden reduction policies: a sociological analysis.

Background: To address the significant issue of students' heavy after-school study burden, many countries have enacted relevant policies. However, the effects of policy implementation are not always desirable. This study is informed by an analysis of how dominant social imaginaries and discourses in China-emphasizing accountability, performativity, competitiveness, and capital accrual-contribute to students' burdens.

scPEGSSC:Proximity Enhanced Graph Convolutional Sparse Subspace Clustering Method for scRNA-seq Data.

The identification of cell types by clustering singlecell RNA sequencing (scRNA-seq) data is a fundamental step in the downstream analysis of single-cell data. However, great challenges remain owing to the inherent characteristics of scRNAseq data, including high dimensionality, high noise, and high sparsity. In this study, we propose a proximity enhanced graph convolutional sparse subspace clustering method scPEGSSC for scRNA-seq data.

Collaborative Attention Contrast Learning for Cancer Subtype Identification Based on Multi-Omics Data.

Identification of cancer subtypes plays an important role in revealing useful insights into disease pathogenesis and advancing personalized therapy. This endeavor significantly relies on multi-omics data, whose pivotal role in subtype classification has been widely recognized and applied in current biomedical research and clinical practice. Intricate high-dimensional data in each omics contain significant number of discriminative features as well as noise information.

Polarization Textures in Moiré Patterns of van der Waals Homo- and Heterostructures via Sliding Ferroelectrics.

Ferroelectricity can emerge in moiré patterns formed by stacking nonferroelectric monolayers, such as graphene and hexagonal boron nitride, in specific configurations. This moiré-induced ferroelectricity not only extends the scope of two-dimensional (2D) ferroelectrics but also deepens our understanding of ferroelectric mechanisms in low-dimensional systems. Here, we present a general framework for analyzing polarization in moiré superlattices by decomposing them into fundamental structural components.

Small-world network properties and cortical responses of Tai Chi Yunshou: Insights from fNIRS.

Objective: This study aims to characterize the time-domain features and functional network properties from Tai Chi Yunshou across four states (rest, observation, imagination, and motion) using functional near-infrared spectroscopy (fNIRS), thereby discriminating the neural mechanisms underlying the mental regulation and integrative body-mind harmony of Tai Chi Yunshou.

Methods: 100 healthy participants were included and administered with rest, observation, imagination and motion states of Tai Chi Yunshou. The forty-channel wearable fNIRS system was utilized to evaluate the real-time cortical responses during four states.

Efficacy and safety of drug-coated balloon angioplasty in proximal LAD stenosis with distal myocardial bridge: a 12-month comparative study with drug-eluting stents.

Introduction: Myocardial bridge (MB), particularly involving the distal left anterior descending artery (LAD), presents unique challenges in percutaneous coronary intervention (PCI) when coexisting with proximal LAD stenosis. Drug-coated balloon (DCB) represents a "leave nothing behind" strategy that may offer advantages over drug-eluting stents (DES) in these anatomically complex lesions.

Methods: In this retrospective single-center study, 231 patients with proximal LAD stenosis and distal MB underwent PCI using either DCB ( = 83) or DES ( = 148).

Impact of myocardial bridge on lesion morphology and clinical outcomes in patients undergoing IVUS-guided PCI for LAD CTO.

Introduction: Myocardial bridge (MB) is increasingly recognized for its potential role in coronary artery disease. However, its impact on lesion morphology and clinical outcomes in patients with left anterior descending (LAD) chronic total occlusion (CTO) undergoing intravascular ultrasound (IVUS)-guided percutaneous coronary intervention (PCI) remains unclear.

Methods: This single-center retrospective study analyzed 256 patients who underwent IVUS-guided PCI for LAD CTO between 2016 and 2022.

Risk factors and clinical consequences of side branch occlusion in left anterior descending bifurcation percutaneous coronary intervention: a validation study of the V-RESOLVE score.

Background/purpose: Side branch occlusion (SBO) remains a prevalent and clinically significant complication during percutaneous coronary intervention (PCI) for bifurcation lesions, particularly those involving the left anterior descending (LAD) artery. This retrospective study aimed to assess the incidence, identify independent predictors, and evaluate the clinical consequences of SBO in the context of LAD bifurcation PCI.

Methods: We conducted a retrospective analysis of 553 patients who underwent PCI targeting LAD bifurcation lesions between 2018 and 2023.

Prognostic impact of early and late newly diagnosed atrial fibrillation in acute myocardial infarction treated with percutaneous coronary intervention.

Background: Atrial fibrillation (AF) is a common arrhythmic complication in individuals presenting with acute myocardial infarction (AMI); however, the distinct clinical features of AF when it manifests at different stages—either early or late during hospitalization—remain insufficiently characterized.

Objective: This study aimed to investigate the clinical characteristics, 2-year outcomes, and predictive determinants of early versus late newly diagnosed atrial fibrillation (NDAF) in patients with AMI undergoing percutaneous coronary intervention (PCI).

Methods: A total of 2,345 consecutive AMI patients treated with PCI were retrospectively reviewed and stratified into three categories: early NDAF, late NDAF, and no NDAF.

Acupuncture for cognitive impairment in type 2 diabetes mellitus: a systematic review and Bayesian network meta-analysis protocol.

Background: The global prevalence of diabetes mellitus (DM) has exceeded 589 million, with the proportion of type 2 diabetes mellitus (T2DM) patients with comorbid cognitive impairment (CI) as high as 49.1%, which has a serious impact on disease management and quality of life. While acupuncture has been shown to improve cerebral glucose metabolism and synaptic plasticity, existing clinical trials are plagued by critical limitations: small sample sizes (often <100 participants) fail to detect subtle treatment effects, methodological heterogeneity in acupuncture protocols (e.

Isolation, Identification, and Antibiotic Resistance, CRISPR System Analysis of from Forest Musk Deer in Western China.

() is an opportunistic pathogen widely distributed in nature, and multi-drug resistance (MDR) has been widely recognized as a critical reservoir of resistance genes, posing severe health threats to humans and animals. A total of 288 strains were isolated and purified from fresh fecal samples of forest musk deer collected from farms in Sichuan, Shaanxi, and Yunnan Provinces of China between 2013 and 2023. This study aimed to conduct antibiotic susceptibility testing and resistance gene detection on the isolated forest musk deer-derived , analyze the correlations between them, investigate the presence of CRISPR systems within the strains, and perform bioinformatics analysis on the CRISPR systems carried by the strains.

Reducing driveline infection risk in durable mechanical circulatory support devices with ultra-flexible wires for energy transfer.

Background: Driveline infections (DLIs) pose a burden to heart failure patients supported by durable mechanical circulatory support devices (dMCSs). A major factor to DLI comes from the low mechanical compliance of drivelines, affecting wound healing. New drivelines that mitigate mechanical stress on skin may reduce the risk of DLI.

Measurement properties of the Edmonton Frail Scale in older adults: A systematic review and meta-analysis.

Background: Frailty is a clinical condition characterised by heightened vulnerabilities to stressors and negative health consequences. The Edmonton Frail Scale is a prominent multidimensional tool for assessing frailty across various settings.

Objectives: This review aimed to synthesise and evaluate the certainty of evidence and the quality of Edmonton Frail Scale in older adults aged 60 and above with respect to its reliability (test-retest, inter-rater) and construct validity (convergent, known-group).

A predictive model for heart failure with preserved ejection fraction following acute myocardial infarction: the HFpEF-AMI score.

Background: Heart failure with preserved ejection fraction (HFpEF) is a common yet under-recognized complication following acute myocardial infarction (AMI), particularly after primary percutaneous coronary intervention (PCI). Early identification of at-risk patients remains a clinical challenge.

Methods: We retrospectively analyzed 458 first-episode AMI patients who underwent emergency PCI at a single center.