Biomimetic membrane nanotechnology in cerebral ischemic stroke:a promising technology for therapeutic treatment and diagnosis.

Cerebral ischemic stroke (CIS) is a severe cerebrovascular disease that poses numerous challenges in diagnosis and treatment, primarily attributed to blood-brain barrier (BBB) constraints and inherent drug targeting limitations. Biomimetic membrane nanotechnology, as an emerging therapeutic approach, offers a novel therapeutic strategy by emulating biological membrane structures and functions. This review comprehensively examines biomimetic nanomedicines (BMNPs) in CIS management, encompassing preparation methodologies, material characterization, and specific diagnostic/therapeutic applications.

Ferroptosis and aging: Inducing and catalyzing neurodegenerative diseases.

Ferroptosis is a newly recognized form of programmed cell death characterized by iron overload-dependent lipid peroxidation. These pathological phenomena are often observed in neurodegenerative diseases. Aging is an irreversible process characterized by the deterioration of tissue and cell function.

Characterization of the antimicrobial activity and mechanism of the peptide Squ8 isolated from fermented mulberry leaves.

This study identifies a novel antimicrobial peptide, Squ8, from fermented mulberry leaves via LC-MS. The peptide (amino acid sequence RMGAGMAK, 820 Da) features an α-helical structure, +2 net charge, 50 % hydrophobicity, and antibacterial activity against Gram-negative/positive bacteria. Unlike many antimicrobial peptides that are easily inactivated under extreme temperatures or pH conditions, Squ8 retains its activity under such circumstances and has a low hemolysis rate, thus demonstrating excellent stability and safety.

Examining the after-school study burden of Chinese secondary school students following burden reduction policies: a sociological analysis.

Background: To address the significant issue of students' heavy after-school study burden, many countries have enacted relevant policies. However, the effects of policy implementation are not always desirable. This study is informed by an analysis of how dominant social imaginaries and discourses in China-emphasizing accountability, performativity, competitiveness, and capital accrual-contribute to students' burdens.

Prognostic factors for metastatic gastrointestinal stromal tumors treated with cytoreductive surgery: a retrospective cohort study.

Background: Cytoreductive surgery (CRS) may benefit patients with metastatic gastrointestinal stromal tumors (GISTs) treated with tyrosine kinase inhibitors (TKIs). However, there is insufficient evidence on prognostic factors for metastatic GISTs undergoing CRS.

Methods: This study reviewed metastatic GISTs that underwent CRS after receiving TKIs in our center from April 2014 to December 2023.

Prognostic Impact of Non-Impacted Third Molar Extraction on Non-Surgical Periodontal Therapy for Adjacent Second Molars: A Prospective Split-Mouth Study.

Aims: To compare the outcomes of non-surgical periodontal therapy (NSPT) alone and NSPT plus adjacent non-impacted third molar (N-M3) removal on second molars (M2s).

Materials And Methods: In this prospective split-mouth study, 40 patients with periodontitis who had N-M3s on both sides of the same jaw were enrolled. For each patient, a full-mouth NSPT was performed, with one N-M3 extracted (N-M3-) and the other N-M3 retained (N-M3+).

ASH2L-K312-Lac Stimulates Angiogenesis in Tumors to Expedite the Malignant Progression of Hepatocellular Carcinoma.

Hepatocellular carcinoma (HCC) is a common malignant tumor. However, the role of lactic acid-modified proteins in its pathogenesis is unclear. This study determines the distribution of a novel post-translational modification-protein lactylation-in HCC to identify potential targets and obtain mechanistic insights into this disease.

Study on the role and mechanism of intermittent theta burst stimulation (iTBS) induced N-acetylaspartylglutamate (NAAG) in suppressing ferroptosis in ischemic stroke.

This study investigates the mechanism through which intermittent theta burst stimulation (iTBS) inhibits ferroptosis in ischemic stroke by inducing N-acetylaspartylglutamate (NAAG). In SD rats subjected to middle cerebral artery occlusion (MCAO), iTBS treatment significantly decreased ischemia-reperfusion (I/R) injury, improving motor, coordination, spatial memory abilities and Cognitive Impairment by enhancing synaptic function and neuronal repair. Western blot analysis showed that in MCAO rats treated with iTBS, GPX4 protein expression increased, while ACSL4, TFRC, and DMT1 protein levels decreased.

Small intestinal γδ T17 cells promote SAE through STING/C1q-induced microglial synaptic pruning in male mice.

Sepsis is a severe global health issue with high mortality rates, and sepsis-associated encephalopathy (SAE) further exacerbates this risk. While recent studies have shown the migration of gut immune cells to the lungs after sepsis, their impact on the central nervous system remains unclear. Our research demonstrates that sepsis could induce the migration of IL-7R CD8 γδ T17 cells from the small intestine to the meninges, where they secrete IL-17A, impairing mitochondrial function in microglia and activating the cGAS-STING-C1q pathway in male mice.

Global research trends of neuroinflammation in perioperative neurocognitive dysfunction: a bibliometric analysis.

Perioperative neurocognitive dysfunction (PND) is a significant complication in elderly surgical patients, characterized by cognitive decline and often linked to neuroinflammation. This study conducted a bibliometric analysis of 744 publications on PND-related neuroinflammation from 1999 to 2023, using the Web of Science Core Collection (WoSCC) database. Tools such as VOSviewer, CiteSpace, and Microsoft Excel were employed to analyze publication trends, geographical distribution, and key research areas.

mPEG-NH/2-FPBA/TubA exerts anti-hepatocellular carcinoma activity by targeting ABCF1-K430la through the KDM3A-H3K9me2-HIF1A axis.

Few systematic investigations have explored the use of polymeric micelles for the delivery of lactylated proteomic-modified drugs. A small-molecule drug Tubuloside A (TubA), which targets lactate modified at lysine 430 of ABCF1 and effectively inhibits hepatocellular carcinoma (HCC) progression, was identified in previous study. In this study, we selected a nanomaterial, mPEG-NH+ 2-FPBA, as a drug carrier, which not only efficiently encapsulated the drug, but also facilitated targeted release within tumor tissues.

Novel insight into the Warburg effect: Sweet temptation.

Metabolic reprogramming is an important feature of tumors, and reprogramming of glucose metabolism was the earliest identified marker of metabolic alterations in tumors. The Warburg effect describes the propensity of tumor cells to preferentially metabolize glucose through glycolysis, even in the presence of oxygen, rather than relying on oxidative phosphorylation. This unique metabolic phenotype empowers cancer cells to proliferate and invade indefinitely, inducing metabolic adaptations that provide cancer cells with a survival advantage in hypoxic and nutrient-poor environments.

Achieving synergy between pollution reduction and carbon mitigation in the eco-industrial park: a multi-objective optimization framework.

Eco-Industrial Parks (EIPs) have emerged as a strategic approach to reconcile industrial development with environmental responsibility. However, optimizing their industrial structure remains complex due to the intertwined goals of economic growth, energy efficiency, and ecological sustainability. This study aims to develop a multi-objective optimization framework that systematically balances economic benefits, energy consumption, and waste management within EIPs.

The safety and feasibility of transoral thyroidectomy vestibular approach in the treatment of thyroid disorders: An overview of systematic reviews.

Objective: Many systematic reviews (SRs) and meta-analyses (MAs) have recently assessed the short-term outcomes of the transoral thyroidectomy vestibular approach (TOTVA) compared with conventional open thyroidectomy (COT) and non-transoral endoscopic thyroidectomy (NTET). However, their conclusions remain controversial. This overview aimed to evaluate the safety and feasibility of TOTVA by appraising the quality of existing SRs/MAs.

Accurate stochastic simulation algorithm for multiscale models of infectious diseases.

In the infectious disease literature, significant effort has been devoted to studying dynamics at a single scale. For example, compartmental models describing population-level dynamics are often formulated using differential equations. In cases where small numbers or noise play a crucial role, these differential equations are replaced with memoryless Markovian models, where discrete individuals can be members of a compartment and transition stochastically.

Lidocaine as a Potential Therapeutic Agent in Colorectal Cancer: A Study of Gene Expression and Prognosis.

Background: Colorectal cancer (CRC) is a significant contributor to cancer-related mortality globally. Despite the availability of treatments such as surgery, chemotherapy, and radiotherapy, these interventions are often accompanied by severe side effects and suboptimal patient outcomes. Recent studies have suggested that lidocaine, a widely used local anesthetic, may possess anti-tumor properties in various cancer types.

polysaccharide alleviates liver fibrosis through the TGF‑β/Smad signaling pathway and reduces collagen.

Liver fibrosis (LF) is a liver condition that represents a serious health risk to humans, and effective therapeutic options are limited. polysaccharide (PSP), derived from the roots of Red, has been demonstrated to exert anti‑inflammatory, antioxidant and antibacterial effects. However, its potential therapeutic impact on LF remains unexplored.

Overexpression of promotes colorectal cancer growth.

Background: Research has revealed that long non-coding RNAs (lncRNAs) are intimately associated with the occurrence, development, and metastasis of tumors through their regulation of gene expression. The lncRNA is important for colorectal cancer (CRC) occurrence and development. Our research aimed to explore the roles of in CRC progression.

Heterogeneity of tumor-associated macrophages in colorectal cancer: Origins, classification, and immunotherapeutic implications.

Tumor microenvironment (TME) plays an important role in the occurrence, progression, and therapeutic response of malignant tumor. As the main immune cells in TME, tumor-associated macrophages (TAMs) are considered to be potential key targets for cancer diagnosis and treatment. However, the functional roles and clinical significance of TAMs in colorectal cancer (CRC) remains controversial.

Primary cardiac angiosarcoma: a case report.

Primary cardiac tumors are extremely rare, with an incidence rate ranging from only 0.17% to 0.33%.

Tryptophan Suppresses FTH1-Driven Ferritinophagy, a Key Correlate of Prognosis in Hepatocellular Carcinoma.

Hepatocellular carcinoma (HCC) remains a lethal malignancy with limited therapeutic options. Ferritinophagy, an autophagy-dependent process regulating iron metabolism, has emerged as a key contributor to ferroptosis and tumour progression. This study hypothesised that the ferritinophagy-related gene FTH1 drives HCC pathogenesis by modulating tryptophan metabolism and reactive oxygen species (ROS)-dependent ferroptosis.

Metabolomics-Based Identification and Validation of the Creatine Precursor Guanidinoacetic Acid for Frailty in Older Adults.

Backgound: Subtle biological changes related to frailty may be undetected by standard clinical methods, and reliable biomarkers for frailty are still under investigation. This study was conducted to profile plasma metabolite patterns associated with frailty and validate the most significant metabolite for identifying and predicting frailty in cross-sectional and longitudinal analyses.

Methods: The "Fujian Prospective Aging Cohort" (ChiCTR 2000032949) enrolled 2,265 community-dwelling individuals aged 60 and above in 2020.

A Highly Efficient and Biocompatible Cupper-Based Single-Atom Nanocatalyst with Unsaturated Coordination Structure for Efficient Diabetic Wound Healing.

The unsaturated coordination alters the electronic structure of metal atoms, exposing more active sites, and thereby demonstrating high catalytic activity. It is extremely difficult to precisely regulate the unsaturated coordination environment of single-atom catalysts due to the thermodynamically unstable structure. Herein, a facile "micelle-confined oxidative crosslinking and coupled coordination" strategy is proposed to construct a copper single-atom catalyst with an unsaturated Cu-N coordination structure in a confined silica-carbon framework (Cu SA@MCSN), which demonstrate unique pH-dependent multiple-enzymatic activity (peroxidase (POD)-like activity in an acidic environment with a low K of 6.

Siliconizing-Driven Layer-by-Layer Growth of 2D Tellurides with Controlled Crystallization.

2D transition metal tellurides (TMTs) possess fascinating properties for applications in ferroelectrics and optoelectronics. Nevertheless, it is still challenging to grow high-quality 2D TMTs with the desired phase (especially high-temperature phase) because of the weak bonding between the transition metal and Te as compared to S and Se atoms. Here, a strategy of siliconizing-driven layer-by-layer growth is reported to synthesize 2D ZrTe and ZrTe crystals with high crystallinity and desired thickness.