Dual-plasmonic metals functionalized MXene synergistic enhanced SERS biosensor for sensitive and selective detection of S. aureus in milk.

A multifunctional surface-enhanced Raman scattering (SERS) sensor was initially developed by integrating MXene with Au nanoparticles (MXene/Au) and plasmonic metal composite (Au@Ag NFs) as the substrate, combined with aptamers (apt) and signal molecules (4-MBA) for sensitively recognizing S. aureus in milk products. Firstly, MXene possesses the characteristic of a large specific surface area.

Fatty acid desaturase 2 (FAD2) is functionally involved in regulation of synthesis of fatty acid derivatives in Chrysanthemum indicum var. aromaticum.

The fatty acid desaturase 2 (FAD2) is an important functional gene in the fatty acid metabolism pathway of aromatic plants, which can significantly affect the biosynthesis of volatile compounds and the aroma characteristics. However, the possible mechanism of action of FAD2 in Chrysanthemum indicum var. aromaticum (Ci.

Neighborhood structure enhancement and denoising method for multi-behavior recommendation.

Traditional recommender systems often assume that there is only one type of interaction between a user and an item, which does not reflect the complexity of real-life users engaging in multiple behaviors such as browsing, clicking, adding to cart, and purchasing. Recent multi-behavioral recommendation methods have demonstrated their effectiveness, while they still suffer from two limitations: (1) Unbalanced user interaction data and sparse node neighbor information pose challenges to user preference modeling. (2) Direct transfer of information from the auxiliary behavior to the target behavior introduces noise.

Energy metabolism dysfunction and therapeutic strategies for treating temporomandibular disorders.

Temporomandibular disorders (TMD) are prevalent and multifactorial conditions affecting the temporomandibular joint (TMJ). Recent studies have highlighted the central role of energy metabolism in their pathogenesis. This review focuses on how disturbances in glucose, lipid, and mitochondrial energy pathways contribute to TMJ dysfunction and degeneration.

Low-triggering-potential electrochemiluminescence biosensor based on hydrogen-bonded organic framework and luminol-derived carbon dots for α-glucosidase detection.

Low-triggering-potential can decrease electrochemical interference and cross talk of electrochemiluminescence (ECL), significantly improving long-term stability of working electrode. Herein, we develop a ratiometric ECL biosensor with hydrogen organic framework (HOF) and luminol derived carbon dots (Lu-CDs) as the emitters for sensitive detection of α-glucosidase (α-Glu) at a low positive potential range of 0.1-1.

Lidocaine as a Potential Therapeutic Agent in Colorectal Cancer: A Study of Gene Expression and Prognosis.

Background: Colorectal cancer (CRC) is a significant contributor to cancer-related mortality globally. Despite the availability of treatments such as surgery, chemotherapy, and radiotherapy, these interventions are often accompanied by severe side effects and suboptimal patient outcomes. Recent studies have suggested that lidocaine, a widely used local anesthetic, may possess anti-tumor properties in various cancer types.

NIR-II Plastic Particles for Monitoring Intestinal Motility and Microplastic Deposition in Mice.

Plastic products are widely used in daily life, leading to the pervasive presence of microplastics, which have posed great threats to human health. However, the relative lack of methods to observe the movement and distribution of microplastics in living animals has retarded the understanding of their biological effects. Fluorescence imaging in the near-infrared II (NIR-II) window with good tissue penetration has greatly expanded its scope for living animals.

Near-infrared II cyanine fluorophores with large stokes shift engineered by regulating respective absorption and emission.

Fluorescence bioimaging in the near-infrared II window is a promising area due to its deep tissue penetration and high contrast. However, efficient design strategies for near-infrared II fluorophores with large Stokes shifts are still scarce. Here, we develop a series of near-infrared II fluorophores (termed VIPIs) with large Stokes shifts (167-260 nm in chloroform) by conjugating p-aminostyryl to hemicyanines.

Image drift compensation in scanning electron microscopy facilitated by an external scanning and imaging system.

Microstructures significantly influence the physical properties of materials. Characterizing the evolution of materials' microstructures is helpful for exploring the processing techniques and understanding the thermodynamic properties of materials. However, the in-situ experiments based on the scanning electron microscope (SEM) often suffer from non-uniform image drift distortion, which severely interferes with the imaging and characterization.

Understanding the role of NOTCH2 mutation in centronuclear myopathy.

NOTCH2 is a widely expressed protein that plays a crucial role in the normal development and function of various tissues, including skeletal muscle. This study focused on a pedigree with centronuclear myopathy, primarily characterized by muscle weakness and centralized nuclei, and identified the autosomal recessive NOTCH2 p.I1689F mutation through whole-exome sequencing.

Indacenodithienothiophene-based A-D-A-type phototheranostics for immuno-phototherapy.

The development of phototherapeutics with high photothermal conversion efficiency (PCE) and strong ability to generate reactive oxygen species under single near-infrared (NIR) laser irradiation for immuno-phototherapy applications remains a significant challenge. Herein, we optimally selected the molecule IT-4 F with an acceptor-donor-acceptor (A-D-A) strucssture to prepare water-dispersible nanoparticles (NPs) by assembly with DSPE-PEG-NH. Such NPs have NIR absorption and fluorescence peaks at 728 and 817 nm, respectively.

Ratio Fluorescence Sensor Based on Bimetal MOFs for the Detection of Hgand HO.

In this work, a dual-emission material based on lanthanide metals was synthesized and used as a ratio fluorescence sensor to respond to Hg and HO, respectively. Tb-BDC-NH as a bimetal MOFs had double ligands and exhibited double fluorescence emission peaks at 550 nm and 450 nm. The two emission peaks of Tb-BDC-NH can be quenched by Hg and HO respectively, forming a built-in calibration signal for ratio fluorescence detection.

Cellular Membrane Protein GRINA is Highly Expressed and Associated with Survival Outcomes in Liver Cancer Patients.

Objective: Hepatocellular carcinoma (HCC), a lethal cancer with high global mortality, may be targeted through ferroptosis, an iron-dependent form of cell death. Despite its potential, the prognostic value of ferroptosis in HCC is underexplored.

Methods: Our study leveraged single-cell and bulk sequencing datasets to identify ferroptosis-related genes and developed a prognostic model via Cox and LASSO regression analyses.

Predicting the Impact of Climate Change on the Distribution of North China Leopards () in Gansu Province Using MaxEnt Modeling.

Climate change has a profound impact on the phenology and growth of vegetation, which in turn influences the distribution and behavior of animal communities, including prey species. This dynamic shift significantly affects predator survival and activities. This study utilizes the MaxEnt model to explore how climate change impacts the distribution of the North China leopard () in the Ziwuling region of Gansu Province, China.

NIR-II Cyazulene Fluorophores with Adjustable Cycloalkenes and Spectroscopic Properties for Imaging Applications.

NIR-II fluorescence imaging has shown broad application prospects in life science because of its deeper tissue penetration and higher spatiotemporal resolution. Developing NIR-II fluorophores with special spectroscopic properties and analytical functions has become a cutting-edge but challenging topic in this field. Herein, a series of azulene-based NIR-II fluorophores (called cyazulenes) with adjustable cycloalkenes and spectroscopic properties for imaging applications is reported.

A multidimensional pan-cancer analysis of NDUFA4L2 and verification of the oncogenic value in colon cancer.

NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 4-like 2 (NDUFA4L2) protein is located in the mitochondria and can regulate cell proliferation. Some studies have shown that the high NDUFA4L2 expression is linked with poor prognosis and cancer progression in various patients with cancers. However, the correlation between NDUFA4L2 and pan-cancer is unknown.

Deep learning model for automated detection of fresh and old vertebral fractures on thoracolumbar CT.

Purpose: To develop a deep learning system for automatic segmentation of compression fracture vertebral bodies on thoracolumbar CT and differentiate between fresh and old fractures.

Methods: We included patients with thoracolumbar fractures treated at our Hospital South Campus from January 2020 to December 2023, with prospective validation from January to June 2024, and used data from the North Campus from January to December 2023 for external validation. Fresh fractures were defined as back pain lasting less than 4 weeks, with MRI showing bone marrow edema (BME).

Relationship Between Paraspinal Sarcopenia and Lumbar Alignment and Facet Joint Osteoarthritis in Patients with Degenerative Lumbar Spinal Stenosis.

Study Design: Retrospective study analysis.

Objective: To explore association between degenerative spinal conditions and paraspinal sarcopenia in patients with severe degenerative lumbar spinal stenosis (DLSS).

Background: Paraspinal muscles plays an essential role in stabilizing the spine.

Resveratrol alleviates heart failure by activating foxo3a to counteract oxidative stress and apoptosis.

Resveratrol has been extensively studied for its multifaceted health benefits. Nonetheless, the pharmacological mechanisms of resveratrol for heart failure remain elusive, especially the cardioprotective effects. To address this knowledge gap, we performed high-throughput drug screening using zebrafish and discovered that resveratrol significantly alleviated heart failure, including rescuing abnormalities in heart rate, blood flow, cardiac output, and nppb overexpression.

Ultrabright silicon nanoparticles combined with o-phenylenediamine for ratiometric fluorescence and smartphone imaging dual-mode detection of nitrite.

Nitrite (NO) is widely present in the natural environment and human daily life. Excessive NO can cause harm to the environment and human health. Herein, silicon nanoparticles (SiNPs) with a fluorescence quantum yield of up to 70 % were synthesised using a one-pot hydrothermal method and combined with the common and inexpensive o-phenylenediamine (OPD) to achieve the detection of NO.