Latent profile analysis of healthcare-related regret coping among Master of Nursing specialist students during clinical internships: A multi-center cross-sectional study.

Background: Healthcare-related regret (HRR) is frequently encountered by healthcare professionals, even in the early clinical stages. Effective coping strategies are essential for mental well-being, professional performance, and career satisfaction. However, the specific coping mechanisms used by Master of Nursing specialist (MNS) students during clinical internships are not well understood.

Association of lactate-albumin ratio with native liver survival in paediatric acute liver failure: a 10-year retrospective study.

Background: Paediatric acute liver failure (PALF) is a severe life-threatening condition with complex aetiologies and high mortality rates. Prognostic research, particularly in the Chinese paediatric population, is limited. The lactate-albumin ratio (LAR) is a potential prognostic indicator for adverse outcomes in critical illness, and its correlation with survival with the native liver (SNL) in PALF patients requires further study.

Soft water exposure increases the effect of genetic susceptibility on the risk of rheumatoid arthritis.

Background: Rheumatoid arthritis (RA) is influenced by both genetic and environmental factors. The mineral content of domestic water plays an essential role in human health. However, the relationship between water mineral content, genetic predisposition, and RA risk remains unclear.

Heterogeneity of tumor-associated macrophages in colorectal cancer: Origins, classification, and immunotherapeutic implications.

Tumor microenvironment (TME) plays an important role in the occurrence, progression, and therapeutic response of malignant tumor. As the main immune cells in TME, tumor-associated macrophages (TAMs) are considered to be potential key targets for cancer diagnosis and treatment. However, the functional roles and clinical significance of TAMs in colorectal cancer (CRC) remains controversial.

Plastics tracking strategy: Plastic-related small molecules as chemical fingerprints.

•Plastic-related small molecules provide information about plastic's past life.•Small molecular chemical fingerprints could become plastic identifiers.•Current challenges and recommendations for chemical fingerprints are identified.

Associations of Handgrip Strength and Testosterone With Cerebral White Matter Hyperintensity and Microstructural Injury.

Background: White matter hyperintensity (WMH) is one of the key imaging markers of cerebral small vessel disease (CSVD) and white matter microstructural injury may occur earlier than WMH. However, the associations of handgrip strength (HGS) and serum total testosterone (STT) with WMH and microstructural injury have not been thoroughly investigated. Therefore, we aimed to explore the associations of HGS and STT with WMH and microstructural injury, measured by fractional anisotropy (FA), mean diffusivity (MD), intracellular volume fraction (ICVF), and isotropic volume fraction (ISOVF).

Microvascular functional and structural changes in early-stage CADASIL.

Background: Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) is the most common monogenic form of hereditary cerebral small vessel disease (CSVD). While studies have demonstrated heterogeneous alterations in cerebrovascular reactivity (CVR) and gray matter structure in CADASIL patients, the diagnostic utility of CVR and brain structural imaging in identifying CADASIL remains uncertain.

Methods: This study investigated CVR and gray matter density (GMD) in 22 CADASIL patients compared to 21 age- and sex-matched healthy controls.

Impact of gene-environment interactions on atrial fibrillation and cardiac structure.

Environmental pollution is a major burden of cardiovascular disease. The aim of the study was to investigate the interactions between combined environmental factors and genetic susceptibility on atrial fibrillation (AF) and cardiac structures. The study included 374,495 participants from the UK Biobank, utilizing genetic data and environmental variables (including air pollution, noise, greenspace and water quality).

Joint effect of modifiable risk factors on Parkinson's disease: a large-scale longitudinal study.

Introduction: Previous researches have often underestimated the diversity and combined effects of risk factors for Parkinson's disease (PD). This study aimed to identify how multiple modifiable risk factors collectively impact PD.

Methods: The study included 452,492 participants from the UK Biobank, utilizing genetic data and 255 phenotypic variables.

Effects of obesity on aging brain and cognitive decline: A cohort study from the UK Biobank.

Objective: To investigate the impact of obesity on brain structure and cognition using large neuroimaging and genetic data.

Methods: Associations between body mass index (BMI), gray matter volume (GMV), whiter matter hyper-intensities (WMH), and fluid intelligence score (FIS) were estimated in 30283 participants from the UK Biobank. Longitudinal data analysis was conducted.

Association of systemic inflammatory markers with white matter hyperintensities and microstructural injury: an analysis of UK Biobank data.

Background: White matter damage is closely associated with cognitive and psychiatric symptoms and is prevalent in cerebral small vessel disease (CSVD); although the pathophysiological mechanisms involved in CSVD remain elusive, inflammation plays a crucial role. We sought to investigate the relationship between systemic inflammation markers and imaging markers of CVSD, namely white matter hyperintensity (WMH) and microstructural injury.

Methods: We conducted a study involving both cross-sectional and longitudinal data from the UK Biobank Cohort.

Extracorporeal membrane oxygenation for catecholaminergic polymorphic ventricular tachycardia: a case report and literature review.

Background: Catecholaminergic polymorphic ventricular tachycardia (CPVT) is an inherited ion channelopathy characterized by a structurally normal heart sensitive to catecholamines. It primarily presents as Bidirectional ventricular tachycardia (BiVT) and is a significant cause of sudden cardiac death in children.

Case Presentation: We report our experience with central Extracorporeal Membrane Oxygenation (ECMO) therapy in a 4-year-old boy with CPVT.

Imaging Transcriptomics of Brain Functional Alterations in MS and Neuromyelitis Optica Spectrum Disorder.

Background And Purpose: The underlying transcriptomic signatures driving brain functional alterations in MS and neuromyelitis optica spectrum disorder (NMOSD) are still unclear.

Materials And Methods: Regional fractional amplitude of low-frequency fluctuation (fALFF) values were obtained and compared among 209 patients with MS, 90 patients with antiaquaporin-4 antibody (AQP4)+ NMOSD, 49 with AQP4- NMOSD, and 228 healthy controls from a discovery cohort. We used partial least squares (PLS) regression to identify the gene transcriptomic signatures associated with disease-related fALFF alterations.

Association between BNP and all-cause mortality in critically ill children: a cohort study.

Background: There is evidence that a high level of BNP is associated with poorer outcomes in patients with cardiac diseases, but few data are available concerning BNP and all-cause mortality in pediatric population.

Methods: Using the 2010-2018 pediatric intensive care database, we conducted a retrospective study on patients aged 28 days to 18 years, analyzing post-admission BNP measurements. Through two-piecewise regression to identify inflection points, and multivariable logistic regression, we investigated BNP's association with all-cause mortality.

[Research advances in the response of soil nitrogen emissions from peatlands to climate warming and drying].

Climate warming and drying has led to a sharp increase in nitrogen (N) emissions from the boreal peatland soils, but the underlying microbial-mediated mechanism is still unclear. We reviewed the responses of soil N transformation and emission in alpine peatland to temperature increases and water table changes, the interaction between soil anaerobic ammonia oxidation (Anammox) and NO dissimilatory reduction processes, and soil NO production pathways and their contributions. There are several knowledge gaps.

Copper and cadmium co-contamination increases the risk of nitrogen loss in red paddy soils.

The microbiome plays a crucial role in soil nitrogen (N) cycling and in regulating its bioavailability. However, the functional and genomic information of microorganisms encoding N cycling in response to copper (Cu) and cadmium (Cd) contamination is largely unknown. Here, metagenomics and genome binning were used to examine microbial N cycling in Cu and Cd co-contaminated red paddy soils collected from a polluted watershed in southern China.

Predictive factors of stress response of nursing student repeaters under the background of abolishing the final supplementary examination in China.

Background: Academic pressure and frustration stimulation are significant stressors in college students, and response to the prolonged stimuli would cause adverse mental and physical outcomes. However, more is needed to know about the stress response and its predictors among undergraduate nursing students retaking failed course under the background of the abolition of the Final Supplementary Examination in China. This study aimed to investigate the stress response and its predictive factors of nursing student repeaters who are retaking at least one failed course.

The investigation of the enrichment behavior of identified PFAS and unknown PFAA-precursors in water and suspended particulate matter of the surface microlayer: A case study in Tianjin (China).

The surface microlayer (SML) is an important air water interface layer, known as the skin of the ocean, which has chemical enrichment properties. Chemical enrichment in the SML can affect the occurrence of pollutants in the underlying water and air samples. Although the enrichment of per- and polyfluorinated substances (PFAS), a class of persistent organic pollutants of high concern, has been reported in the SML, information on the behavior of unknown PFAA-precursors in SML is lacked, and it is not clear whether there is a similar PFAS enrichment in suspended particulate matter (SPM) in the SML.

Association between household size and risk of incident dementia in the UK Biobank study.

Currently, the relationship between household size and incident dementia, along with the underlying neurobiological mechanisms, remains unclear. This prospective cohort study was based on UK Biobank participants aged ≥ 50 years without a history of dementia. The linear and non-linear longitudinal association was assessed using Cox proportional hazards regression and restricted cubic spline models.

Distinct virtual histology of grey matter atrophy in four neuroinflammatory diseases.

Grey matter (GM) atrophies are observed in multiple sclerosis, neuromyelitis optica spectrum disorders [NMOSD; both anti-aquaporin-4 antibody-positive (AQP4+) and -negative (AQP4-) subtypes] and myelin oligodendrocyte glycoprotein antibody-associated disease (MOGAD). Revealing the pathogenesis of brain atrophy in these disorders would help their differential diagnosis and guide therapeutic strategies. To determine the neurobiological underpinnings of GM atrophies in multiple sclerosis, AQP4+ NMOSD, AQP4- NMOSD and MOGAD, we conducted a virtual histology analysis that links T1-weighted image derived GM atrophy and gene expression using a multicentre cohort of 324 patients with multiple sclerosis, 197 patients with AQP4+ NMOSD, 75 patients with AQP4- NMOSD, 47 patients with MOGAD and 2169 healthy control subjects.

Spinal cord and brain atrophy patterns in neuromyelitis optica spectrum disorder and multiple sclerosis.

Background: Spinal cord and brain atrophy are common in neuromyelitis optica spectrum disorder (NMOSD) and relapsing-remitting multiple sclerosis (RRMS) but harbor distinct patterns accounting for disability and cognitive impairment.

Methods: This study included 209 NMOSD and 304 RRMS patients and 436 healthy controls. Non-negative matrix factorization was used to parse differences in spinal cord and brain atrophy at subject level into distinct patterns based on structural MRI.

Exploring the dynamics of antibiotic resistome on plastic debris traveling from the river to the sea along a representative estuary based on field sequential transfer incubations.

The environmental risks arising from ubiquitous microplastics or plastic debris (PD) acting as carriers of antibiotic resistance genes (ARGs) have attracted widespread attention. Enormous amounts of plastic waste are transported by rivers and traverse estuaries into the sea every year. However, changes in the antibiotic resistome within the plastisphere (the biofilms formed on PD) as PD travels through estuaries are largely unknown.

Joint Exposure to Ambient Air Pollutants, Genetic Risk, and Ischemic Stroke: A Prospective Analysis in UK Biobank.

Background: Our primary objective was to assess the association between joint exposure to various air pollutants and the risk of ischemic stroke (IS) and the modification of the genetic susceptibility.

Methods: This observational cohort study included 307 304 British participants from the United Kingdom Biobank, who were stroke-free and possessed comprehensive baseline data on genetics, air pollutant exposure, alcohol consumption, and dietary habits. All participants were initially enrolled between 2006 and 2010 and were followed up until 2022.