Toward Lab-In-Fiber Liquid Biopsy: Graphene-Oxide Functionalized Anti-Resonant Optical Fiber for Single-Device Capture-Enrichment-Detection-Recovery of Circulating Tumor Cells.

Metastatic spread in aggressive cancers is often initiated by circulating tumor cells (CTCs) before primary tumor detection. Current CTC analysis faces fundamental limitations due to extreme cell scarcity (≈10 cells mL blood) and reliance on large sample volumes (>7.5 mL).

Healing Through Empowerment and Active Listening: Experience-Based Co-Design of a Nurse-Led Personalised Self-Care Support Intervention for Primary Care Patients With Diabetic Foot Ulcers.

Background: The rising prevalence of diabetic foot ulcers (DFUs) highlights the need for effective self-care interventions. Despite strong evidence supporting their effectiveness, patient engagement, uptake, and integration into routine care remain limited. Co-design approaches can enhance the relevance and adoption of interventions but are underutilized in DFU management.

Mechanism analysis of 2 µm thulium-doped picosecond laser ablation on myocardial tissue in minimizing thermal injury.

In this work, we introduced a fully fiber-integrated 2 µm thulium-doped laser system and conducted parametric analysis and mechanism studies on myocardial tissue ablation using this laser. Fresh porcine myocardial tissue served as the model, allowing precise adjustment of laser power (1.0-3.

Overexpression of Aquaporin-1 Promotes Epithelial-Mesenchymal Transition and Cancer Stem Cell Properties via Wnt/β-Catenin Signaling Pathway in Advanced Breast Cancer Cells.

Tumor metastasis and the persistence of cancer stem cells (CSCs) are the main factors contributing to tumor malignancy, particularly in breast cancer. Uncovering the critical molecular mechanisms and therapeutic targets is essential for addressing this challenge. The present study revealed that aquaporin-1 (AQP1) was highly expressed in breast cancer and was closely associated with poor patient prognosis.

Comparing Liposomal Bupivacaine and Ropivacaine in Serratus Anterior Plane Block for Thoracoscopic Lobectomy: A Randomized Controlled Trial.

Background: The optimal analgesic regimen after video-assisted thoracoscopic surgery (VATS) is unclear. We aimed to examine whether ultrasound-guided serratus anterior plane block (SAPB) with liposomal bupivacaine could provide continuous and effective analgesic effects for lung cancer patients undergoing VATS.

Methods: A total of 64 patients were randomly allocated to receive either the liposomal bupivacaine (LB group) or the ropivacaine (RO group).

Association of food insecurity with diet quality and anthropometric measurements among American elderly: results from 2017 to 2020 National Health and Nutrition Examination Survey.

Food insecurity (FIS) is a critical public health issue, particularly among older adults. This study investigates the association between FIS with diet quality and anthropometric indices in the US older adults. A cross-sectional analysis was conducted using NHANES data from 2017 to 2020, involving 2592 participants aged ≥ 60 years.

Self-neglect, anxiety and depression among empty nesters in China: A network analysis.

Previous studies have shown that anxiety and depression are important factors affecting self-neglect among empty nesters and are a prerequisite for the occurrence of self-neglect. However, there is still little data on the potential mechanism of influence between anxiety, depression and self-neglect. This study aimed to construct a network structure to investigate the connections between self-neglect, anxiety and depression in Chinese empty nesters, identifying core and bridge symptoms in the network and analyze the mechanisms that influence their connection.

Influenza A virus dissemination and infection leads to tissue resident cell injury and dysfunction in viral sepsis.

Background: Severe respiratory viral infections can lead to viral sepsis (VS), a life-threatening condition characterized by lung and extrapulmonary organ dysfunction. However, the pathology of VS is not clear. Specifically, it is unknown how the cytokine storm and direct virus infection contribute to the damage of extrapulmonary organs.

Accelerating multi-objective optimization of concrete thin shell structures using graph-constrained GANs and NSGA-II.

In architectural and engineering design, minimizing weight, deflection, and strain energy requires navigating complex, non-linear interactions among competing objectives, making the optimization of concrete thin shell constructions particularly challenging. Traditional multi-objective optimization (MOO) methods frequently encounter difficulties in effectively exploring design spaces, which often necessitate substantial computational resources and result in suboptimal solutions. This paper presents a novel approach for enhancing topology and thickness optimization.

IgA nephropathy, non-cirrhotic portal fibrosis, and POEMS syndrome: A rare combination in the long-term follow-up of Sjögren's syndrome.

Sjögren's syndrome is a heterogeneous autoimmune disorder that may be associated with systemic manifestations involving multiple organs. We herein reported a rare combination of immunoglobulin A nephropathy; non-cirrhotic portal fibrosis; and polyneuropathy, organomegaly, endocrinopathy, monoclonal plasma cell disorder, and skin changes (POEMS) syndrome in a 15-year follow-up of a female patient initially diagnosed with Sjögren's syndrome. The patient had excessive lymphoproliferation featured by lymphadenopathy and hyperglobulinemia.

ACSS3 promotes the tumorigenesis of non-small cell lung cancer via suppressing p53-mediated ferroptosis.

Non-small cell lung cancer (NSCLC) is a subtype of the most frequently diagnosed cancer, causing a considerable number of deaths globally. Mitochondrial dysfunction was found to promote malignant progression. However, the underlying mechanism remains unclear.

Causal analysis of dietary preferences and the risk of endometriosis using large-scale population data.

Dietary factors have recently been recognized as potentially influential in the pathogenesis of endometriosis (EM), yet studies on the causal relationship between dietary preferences and EM are limited. The present study aimed to explore the causal relationships between 187 dietary preferences and EM using Mendelian randomization (MR) methods. This study utilised genome-wide association study data from over 500,000 European participants for dietary preferences and 64,658 EM patients from Finland.

Optimizing concrete crack detection an echo state network approach with improved fish migration optimization.

There are numerous reasons for concrete buildings cracks, like stress loads, material flaws, and environmental impacts. It is important to find and investigate the concrete cracks during analyzing the safety and structural soundness of buildings, bridges, and other infrastructure. However, there are many models available for concrete crack detection, an efficient approach is needed because the existing methods often have flaws like overfitting, high computational complexity, and noise sensitivity, which can lead to accurate crack detection and classification.

Quantitative Histopathology Analysis Based on Label-free Multiphoton Imaging for Breast Cancer Diagnosis and Neoadjuvant Immunotherapy Response Assessment.

Accurate diagnosis and assessment of breast cancer treatment responses are critical challenges in clinical practice, influencing patient treatment strategies and ultimately long-term prognosis. Currently, diagnosing breast cancer and evaluating the efficacy of neoadjuvant immunotherapy (NAIT) primarily rely on pathological identification of tumor cell morphology, count, and arrangement. However, when tumors are small, the tumors and tumor beds are difficult to detect; relying solely on tumor cell identification may lead to false negatives.

Empowering women with fetal malpositions: enhancing childbirth experience and empowerment through educational interventions: a randomized controlled clinical trial.

Background: This study aims to determine the impact of a childbirth educational intervention, based on empowerment theory, on childbirth experience and empowerment in women with fetal occiput posterior and occiput transverse malpositions.

Methods: A randomized controlled trial was conducted from February 2022 to December 2022 involving pregnant women with fetal occiput posterior and occiput transverse malpositions. Eligible women were randomly assigned to either the control or study group.

A new subtype of papillary ductal carcinoma in situ with tall cell and reversed polarity morphology: a rare case report.

Background: According to previous studies, tall cell carcinoma with reversed polarity can be easily distinguished from ductal carcinoma in situ based on the absence of myoepithelium and a typical histologic feature. However, to the best of our knowledge, no cases of papillary ductal carcinoma exhibiting tall cell and reversed polarity features with intact myoepithelium have been reported, and thus its diagnosis and prognosis remain unclear.

Case Presentation: A 54-year-old female with a palpable lump in her right breast for 3 years.

Synergistic SDT/cuproptosis therapy for liver hepatocellular carcinoma: enhanced antitumor efficacy and specific mechanisms.

The efficacy of sonodynamic therapy (SDT), an emerging approach for tumor treatment, is hindered by the high levels of the antioxidant glutathione (GSH) in the tumor microenvironment (TME). In this study, we constructed nanobubbles loaded with the sonosensitizer HMME and the tumor-targeting peptide RGD (HMME-RGD@CF NBs) for synergistic SDT/cuproptosis therapy of liver hepatocellular carcinoma (LIHC) in combination with Elesclomol-Cu as cuproptosis inducers. Endogenous GSH is consumed by Cu to modulate the complex TME, thereby amplifying oxidative stress and further improving SDT performance.

Effects of maternal posture and cognitive-behavioral interventions on labor outcomes in primigravidas with abnormal fetal head position: a randomized controlled clinical trial.

Objective: Fetal head malposition can result in neonatal and maternal complications. Fetal head malposition occurs frequently in labor. Appropriate and timely managements are required.

Whispering Gallery Mode Micro/Nanolasers for Intracellular Probing at Single Cell Resolution.

Intracellular probing at single cell resolution is key to revealing the heterogeneity of cells, learning new cell subtypes and functions, understanding the pathophysiology of disease, and ensuring precise diagnosis and treatment. Despite the best efforts, an enormous challenge remains due to the very small size, extremely low content, and dynamic microenvironment of a single cell. Whispering gallery mode (WGM) micro/nanolasers (active WGM) offer unique advantages of small mode volume, high quality factors, bright and low threshold laser emission, and narrow line width, particularly suitable for integration within a single cell.

The association between Internet use and intrinsic capacity among older adults in China: The mediating role of social participation.

Objective: This study aims to explore the relationship between Internet use and intrinsic capability among Chinese older adults, and the potential mediating role of social participation.

Methods: We verified the correlation between Internet use and intrinsic capacity using multiple linear regression and verified the mediating role of social participation using the Sobel and Bootstrap tests.

Results: The results of multiple linear regression show that there is a significant positive association between Internet use and intrinsic capacity (B = 0.

Predictive factors of stress response of nursing student repeaters under the background of abolishing the final supplementary examination in China.

Background: Academic pressure and frustration stimulation are significant stressors in college students, and response to the prolonged stimuli would cause adverse mental and physical outcomes. However, more is needed to know about the stress response and its predictors among undergraduate nursing students retaking failed course under the background of the abolition of the Final Supplementary Examination in China. This study aimed to investigate the stress response and its predictive factors of nursing student repeaters who are retaking at least one failed course.

A serial mediation model reveals the association between parental over-protection and academic entitlement among nursing students.

The study aims to explore the influence of parental over-protection on academic entitlement of nursing students, and examine the mediating roles of external locus of control and psychological entitlement. The study sampled two medical universities in Guizhou and Yunnan provinces, China. Participants were nursing students in grades one to four (N = 1003; mean age = 19.

Somatosensory game intervention experience among prefrail older adults in the community: A qualitative study.

Background: Somatosensory game interventions have been used to rehabilitate hospitalized older adults. However, their application in prefrail older adults in the community is poorly understood, hindering the development of effective intervention strategies and exercise diversification.

Objectives: This study aimed to explore the experiences of prefrail Chinese older adults engaging in somatosensory gaming interventions and thus develop tailored intervention frameworks and support strategies.

Comparative effectiveness of eHealth interventions on the exercise endurance and quality of life of patients with COPD: A systematic review and network meta-analysis.

Aims: To compare the effectiveness of different types of eHealth interventions in improving exercise endurance and quality of life in chronic obstructive pulmonary disease (COPD) patients.

Background: COPD is a chronic airway disease characterized by persistent respiratory symptoms and airflow limitation. eHealth interventions have been accepted and recognized by healthcare professionals and COPD patients as an effective alternative to pulmonary rehabilitation.

Efficacy and safety of remimazolam versus propofol for intraoperative sedation during regional anesthesia: A phase II, multicenter, randomized, active-controlled, single-blind clinical trial.

This study aimed to evaluate the efficacy and safety of remimazolam for intraoperative sedation during regional anesthesia. It was a phase II-multicenter, randomized, single-blind, parallel-group, active-controlled clinical trial (No. ChiCTR2100054956).