Healing Through Empowerment and Active Listening: Experience-Based Co-Design of a Nurse-Led Personalised Self-Care Support Intervention for Primary Care Patients With Diabetic Foot Ulcers.

Background: The rising prevalence of diabetic foot ulcers (DFUs) highlights the need for effective self-care interventions. Despite strong evidence supporting their effectiveness, patient engagement, uptake, and integration into routine care remain limited. Co-design approaches can enhance the relevance and adoption of interventions but are underutilized in DFU management.

CDKN2A alternations in non-small cell lung cancer: An evaluation using next-generation sequencing.

Background: Next-generation sequencing (NGS) is widely used for assessing CDKN2A status in cancers due to its high throughput and efficiency. However, discrepancies between NGS and fluorescence in situ hybridization (FISH)-the gold standard for detecting copy number variations (CNVs)-are occasionally observed. This study aimed to evaluate the accuracy of NGS in detecting CDKN2A deletions by comparing it with FISH.

Exploring genetic association of chronic kidney disease with sarcopenia among European population: a bidirectional Mendelian randomization study.

Background: This study aims to investigate the bidirectional causal relationship between chronic kidney disease (CKD) and sarcopenia using two-sample Mendelian randomization (MR) analysis.

Methods: A bidirectional MR analysis was performed using genetic data for CKD from the MEGASTROKE consortium and sarcopenia traits from the UK Biobank. SNPs associated with CKD and sarcopenia were used as instrumental variables.

"It is a constant battle": A qualitative study of the lived experience of individuals with diabetic foot ulcer and post-healing challenges in primary care.

Aim: To explore the lived experiences of primary care patients with active diabetic foot ulcer (DFU) and post-healing in remission (PHIR) to inform tailored interventions.

Methods: A qualitative interview study was conducted with primary care patients with DFU and PHIR in Singapore. In-depth interviews were held with 27 participants (15 with active DFU and 12 with PHIR) from April to July 2022.

Knowledge, attitudes, and practices of Chinese college students towards novel psychoactive substances.

Background: This study aimed to investigate the knowledge, attitudes, and practices (KAP) among Chinese college students regarding novel psychoactive substances (NPS), where practices specifically refer to behaviors related to NPS access and usage patterns.

Methods: An online questionnaire was used to collect demographic information and KAP scores from college students. A total of 1,543 participants were recruited using a combination of targeted and convenience sampling.

Patient and Health Care Provider Perspectives of Cognitive Difficulties in Dialysis.

Introduction: Cognitive impairments (CIs) are common among patients on dialysis, compromising functional capacity, decision-making, and quality of life. Previous work is dominated by quantitative studies, leaving the everyday experience of these impairments and their practical implications poorly understood. This qualitative study explored patients' and providers' perspectives on the lived experience of cognitive difficulties, impacts on daily living and care delivery, and associated needs.

Tumor vessel-adaptable adhesive and absorbable microspheres for sustainable transarterial chemoembolization therapy.

Transarterial chemoembolization (TACE) is a common clinical intervention used for unresectable liver tumors, but conventional embolic microspheres generally exhibit slack vascular stacking and suboptimal drug release. Here, we report tumor vessel-adaptable, adhesive, and absorbable microspheres (3Asphere) based on hyaluronic acid developed using microfluidic and radical polymerization techniques for sustained TACE therapy of liver tumors. 3Asphere presents uniform sizes, gradual degradation over two months, and fast encapsulation and sustained release of chemotherapeutics such as epirubicin, irinotecan, and cisplatin.

Safety and efficacy of TACE combined with immune checkpoint inhibitors plus molecular targeted therapies in older adults with unresectable hepatocellular carcinoma.

Objectives: To assess the efficacy and tolerability of transarterial chemoembolization (TACE) plus immune checkpoint inhibitors (ICIs) plus molecular targeted therapies (MTT) in elderly patients with hepatocellular carcinoma (HCC) (≥ 65 years).

Methods: This retrospective, multicenter study enrolled treatment-naïve HCC patients undergoing TACE combined with ICIs and MTT at three Chinese medical centers from June 2019 to December 2023. The study's primary endpoint was overall survival (OS), with secondary endpoints being the objective response rate (ORR), disease control rate (DCR) per modified RECIST criteria, and adverse events (AEs).

Liver function dynamics in advanced hepatocellular carcinoma receiving immune checkpoint inhibitors and anti-vascular endothelial growth factor antibody/tyrosine kinase inhibitors with or without transarterial chemoembolization.

Background: The efficacy and safety of transarterial chemoembolization (TACE) combined with immune checkpoint inhibitors (ICIs) and anti-vascular endothelial growth factor (anti-VEGF) antibody/tyrosine kinase inhibitors (TKIs) have been established. However, it remains unclear whether the addition of TACE to systemic therapies exacerbates liver function deterioration and increases mortality risk.

Objectives: To assess liver function changes and their impact on prognosis in patients with advanced hepatocellular carcinoma (HCC) treated with ICIs and anti-VEGF antibody/TKIs with or without TACE as first-line therapy.

Hypoparathyroidism induced by immune checkpoint inhibitors: a review of literature reports and real-world pharmacovigilance data.

Objective: This study aims to comprehensively assess the characteristics of immune checkpoint inhibitor (ICI)-induced hypoparathyroidism (HP) by analyzing published case reports and adverse event data from the U.S. Food and Drug Administration Adverse Event Reporting System (FAERS).

Mutational landscape and DNA methylation-based classification of squamous cell carcinoma and urothelial carcinoma.

Background: Identification of the tissue of origin is fundamental for cancer treatment. However, squamous cell carcinomas from different sites lack representative histological and immunohistochemical features. This study aimed to identify mutational profiles and further establish a DNA methylation-based classification for squamous cell carcinoma and urothelial carcinoma.

Management of Pharyngeal Perforation with Cervical Spine Injury Following Blunt Trauma on Electric Vehicle Accident.

BACKGROUND Cases of pharyngeal perforation (PP) associated with cervical spine injury following blunt trauma are extremely rare. CASE REPORT A 58-year-old woman was hit by a car while riding an electric bicycle. She presented with neck pain and dyspnea on admission to the hospital.

Development and validation of a prealbumin-bilirubin model for prognostic prediction in intermediate hepatocellular carcinoma undergoing transarterial chemoembolization.

To establish and validate a novel prognostic model to predict outcomes for intermediate hepatocellular carcinoma (HCC) patients undergoing transarterial chemoembolization (TACE). Clinical data from intermediate-stage HCC patients who underwent TACE between January 2007 and December 2020 were retrospectively analyzed. Patients were divided into a training cohort and a validation cohort.

Intelligent anatomic design of porous radial head prosthesis and microscopic-macro biomechanical finite element analysis in the long-term after replacement surgery.

Background: The microporous structure of porous titanium alloy may affect osteoblast differentiation and reduce effective elastic modulus (EEM) of the prostheses. Therefore, the biomechanics-based anatomic design of porous radial head prosthesis (PRHP) may help promote bone healing and reduce postoperative complications.

Methods: A microscopic-macro virtual testing platform (VTP) was built to design cells with excellent mechanical properties, further, to construct the PRHP.

Epidemic-induced changes in nursing students' professional identity: a qualitative investigation.

Objective: To explore the impact and mechanisms of COVID-19 on the professional identity of nursing students, providing theoretical and practical insights to inform nursing education reform.

Method: This study employed Colaizzi's descriptive phenomenological method to explore nursing students' experiences. Semi-structured interviews were conducted, and data collection continued until information saturation was achieved.

Research Progress of Traditional Chinese Medicine in Adjuvant Treatment of Type 1 Diabetes.

Type 1 diabetes (T1DM) is one of the most common chronic metabolic diseases in the world. Insulin replacement therapy and drug adjuvant therapy are the main means of modern medical treatment of T1DM; still, there are adverse reactions such as drug resistance, which seriously hinder the therapeutic effect. As a unique medical method in China, traditional Chinese medicine (TCM) has a significant effect on the treatment of T1DM.

Single-cell transcriptomics reveal the effects of chemoimmunotherapy on hypopharyngeal cancer and its tumor microenvironment.

Induction chemoimmunotherapy (ICIT) has emerged as a potential treatment option for resectable hypopharyngeal cancer (HPC), while its effectiveness remains limited to a significant portion of HPC cases, and a major challenge behind lies in the lack of reliable molecular markers to identify treatment-resistant patients. In this study, we analyzed biopsy samples of HPC patients collected before and after ICIT, classifying them based on treatment response. By investigating the tumor microenvironment (TME) at the single-cell level, we demonstrated that the heterogeneity within the TME is closely linked to different treatment outcomes.

A study on the safety and efficacy of a robotic-assisted navigation and positioning system in CT-guided percutaneous biopsy of thoracic and abdominal tumors.

Objective: To compare the safety, accuracy, and application efficacy of a computed tomography (CT)-guided robotic-assisted navigation system and conventional CT-guided percutaneous puncture biopsy techniques for thoracic and abdominal tumor puncture biopsies.

Methods: A total of 140 patients with thoracic or abdominal tumors who were scheduled to undergo CT-guided percutaneous puncture biopsy were randomly assigned to the robotic navigation system puncture group and the traditional step-by-step puncture group. Postoperative tissue specimens and pathological diagnosis results were obtained.

Clinical Effectiveness and Safety of Radiofrequency Ablation Combined with Percutaneous Osteoplasty in the Management of Pubic Skeletal Metastases.

Purpose: To evaluate the effectiveness and safety of combining radiofrequency (RF) ablation and percutaneous osteoplasty (POP) to relieve pain, enhance mobility, and improve the quality of life for patients with malignant pubic metastases.

Materials And Methods: A retrospective analysis was conducted on 29 patients with pain caused by pubic metastases who were treated between January 2014 and April 2024. All patients received RF ablation followed by POP, guided by biplane digital subtraction angiography (DSA) and performed under local anesthesia.

How to enhance student satisfaction in Chinese open education? A serial multiple mediating model based on academic buoyancy and flow experience.

With the rapid development of information technology and the widespread acceptance of the concept of sharing educational resources, open education has gradually become an important part of China's national education system as a flexible and efficient learning method. It is also playing a significant role in promoting educational equity and lifelong learning. However, how to effectively implement open education and improve the satisfaction of students who receive open education remains a crucial issue that needs to be addressed.

Transarterial chemoembolization for unresectable hepatocellular carcinoma: a comparative study between transradial and transfemoral approaches.

Background: While transarterial chemoembolization (TACE) has been performed using both the transfemoral approach (TFA) and the transradial approach (TRA) to date, the relative superiority of these techniques remains uncertain. This study aimed to evaluate the relative clinical efficacy, radiation exposure, and safety associated with TRA- and TFA-based TACE procedures in patients with inoperable hepatocellular carcinoma (HCC).

Methods: This study compared the relative outcomes of consecutive inoperable HCC patients who were treated via TFA- or TRA-based TACE between January 2020 and August 2024.

Role of therapeutic treatment with antiseptic solutions in the care of diabetic foot ulcers.

Background: Diabetic foot ulcers (DFUs) are a prevalent and severe complication of diabetes, leading to significant morbidity, impaired health-related quality of life (HRQoL) and economic burden on healthcare systems. The complexity of DFUs often results in prolonged healing and high recurrence rates. Effective management strategies are crucial for improving outcomes and reducing complications.

Negative Pressure Tube Drainage for the Management of Pharyngocutaneous Fistulas in Patients Following Total Laryngectomy.

: The treatment of a pharyngocutaneous fistula (PCF) is typically a lengthy and arduous process, often causing significant pain for patients. This study aims to introduce a new method of treating PCF, negative pressure tube drainage (NPTD). : A retrospective study was conducted on 43 patients who developed PCF after laryngectomy.