Using Machine Learning to Predict Advanced-Stage Progression of Intermediate-Stage Hepatocellular Carcinoma after Transarterial Chemoembolization.

Purpose To develop and test a machine learning (ML)-based model that integrates preoperative variables for prediction of advanced-stage progression (ASP) after transarterial chemoembolization (TACE). Materials and Methods This multicenter retrospective study (ResearchRegistry.com identifier no.

VISULYZE-Generated Nomogram-Assisted KLEx for Myopia and Astigmatism Correction: 3-Month Follow-Up Results.

Purpose: To evaluate the efficacy, safety, and predictability of Keratorefractive Lenticule Extraction (KLEx) surgery guided by a VISULYZE-generated nomogram for myopia and astigmatism correction.

Methods: This prospective cohort study included 130 consecutive patients (260 eyes) undergoing KLEx surgery using a VISULYZE-generated nomogram. Patients were followed for 3 months postoperatively.

A single-cell transcriptomic landscape characterizes the endocrine system aging in the mouse.

The endocrine system is crucial for maintaining overall homeostasis. However, its cellular signatures have not been elucidated during aging. Here, we conducted the first-ever single-cell transcriptomic profiles from eight endocrine organs in young and aged mice, revealing the activation of cell-type-specific aging pathways, such as loss of proteostasis, genomic instability and reactive oxygen species (ROS).

Recent Advances, Challenges, and Functional Applications of Protein Chemical Modification in the Food Industry.

Proteins serve as crucial functional components in food processing, with their unique physicochemical properties directly influencing the texture and stability of food products. Proteins exhibit a range of functional properties, including emulsification, foaming, gelation, and hydration. These properties arise from the structural differences in protein molecules.

Enalapril mitigates senescence and aging-related phenotypes in human cells and mice via pSmad1/5/9-driven antioxidative genes.

Aging increases the risk of a myriad of chronic diseases, which are expensive and difficult to treat owing to their various risk factors. Repurposing existing medications has accelerated the development of therapies aimed at slowing aging. In this study, using IMR90 cells and aged mice, we revealed that enalapril, a drug widely prescribed for hypertension, can improve both cellular senescence and individual health.

Differential diagnosis of acute myocardial infarction based on plasma Exosomal MicroRNA.

Object: The differentiation of acute myocardial infarction (AMI) has long been a challenging problem in clinical diagnosis and forensic identification. Recent studies have shown that microRNAs (miRNAs) in exosomes are involved in the development and progression of AMI. results indicated that plasma exosomal miRNAs can be considered as novel biomarkers for early AMI recognition.

Mucosal vaccination with long-form TSLP induces migratory cDC1-mediated adaptive immunity against SARS-CoV-2 infection.

Unlabelled: A combination of vaccination strategies will potentially be required for effective control of the virus pandemic. We report that mice intranasally immunized with commercial severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) subunit vaccines enriched with the human thymic stromal lymphopoietin (TSLP) variant, long-form TSLP (lfTSLP), but not the short-isoform TSLP (sfTSLP), induced robust antigen-specific systemic and mucosal antibody production. The adjuvant-enhancing activity of lfTSLP in mice requires functional TSLP receptor signals in migratory type 1 conventional dendritic cells (cDC1s).

Impact of exercise interventions on cardiotoxicity in patients with breast cancer undergoing chemotherapy: a study protocol for a quasi-randomised controlled trial.

Introduction: Agents used in antitumour therapy have toxic effects on the cardiovascular system of breast cancer (BC) patients, increasing the risk of cardiovascular disease, which has become the most common non-cancer cause of death in BC patients. Exercise can effectively prevent or reduce the occurrence of cardiotoxicity, however, most BC patients have low levels of physical activity. The Health Action Process Approach (HAPA) model has been successfully applied to encourage patients to adhere to physical exercise.

Etiology and efficacy of hysteroscopic management in cesarean scar pregnancy: a clinical study.

Objective: Cesarean scar pregnancy poses significant risks, including uterine scar rupture and increased postpartum hemorrhage. Effective diagnosis and treatment are critical to improving clinical outcomes. This study aimed to analyze the risk factors for cesarean scar pregnancy and evaluate the efficacy and safety of hysteroscopic diagnosis and treatment, providing a theoretical basis for clinical management.

15-Fold increase in solar thermoelectric generator performance through femtosecond-laser spectral engineering and thermal management.

Solar thermoelectric generators (STEGs) have recently gained increasing attention. However, their widespread adoption has been limited due to the lack of high-efficiency thermoelectric materials and compact heat sinks for effective heat dissipation. To address these issues, we develop a spectral engineering and thermal management strategy that significantly increases STEG power generation by 15 times with only a 25% increase in weight.

[Impact and action mechanisms of obesity on male reproductive function: An update].

The adverse effects of obesity on male reproductive function are mainly manifested as the abnormal development of the reproductive system, decrease of testosterone level, decline of sperm quality, and impact on the health of offspring, while its regulatory mechanism is far from being clarified. This paper expounds the influence of obesity on the male reproductive system in the aspects of population epidemiology and animal experiments, presents an overview on the action mechanisms of obesity from the perspectives of the hypothalamus-pituitary-testis axis, blood-testis barrier, inflammatory reaction, oxidative stress, testicular germ cell apoptosis, and impact of paternal obesity on the health of offspring, aiming to shed some light on the clinical treatment and prevention of obesity-related male reproductive dysfunction.

Refractive Predictability After Keratorefractive Lenticule Extraction Using a New Nomogram Creation Software Tool Compared to a Matched Control.

Purpose: The study aimed to assess the impact of VISULYZE nomogram software on refractive outcomes after lenticule extraction for myopia and myopic astigmatism correction.

Methods: This ambispective, single-site, matched case-control study was conducted at West China Hospital in Chengdu, China. Treatments using the VISULYZE nomogram were compared to a control group without it.

Rapid Access to Emergency Medical Services Within Historically Redlined Areas.

Importance: Inequities in rapid access to emergency medical services (EMS) represent a critical gap in prehospital care and the first system-level milestone for critically injured patients. As delays in EMS response are associated with increased mortality and known disparities within historically redlined areas are prevalent, this study sought to examine disparities in rapid access to EMS across the United States.

Objective: To assess the association between historically redlined areas and rapid EMS access (defined as ≤5-minute response time) across the United States.

Prediction efficiency and incremental processing strategy during spoken language comprehension in autistic children: an eye-tracking study.

Background: Language difficulties are common in autism, with several theoretical perspectives proposing that difficulties in forming and updating predictions may underlie the cognitive profile of autism. However, research examining prediction in the language domain among autistic children remains limited, with inconsistent findings regarding prediction efficiency and insufficient investigation of how autistic children incrementally integrate multiple semantic elements during language processing. This study addresses these gaps by investigating both prediction efficiency and incremental processing strategy during spoken language comprehension in autistic children compared to neurotypical peers.

Histone deacetylase 4: A therapeutic target for cardiovascular diseases (Review).

Cardiovascular disease (CVD) is a major global health threat, as its incidence and mortality rates continue to rise, highlighting the urgent need for effective therapeutic strategies. Histone deacetylase 4 (HDAC4), a member of class IIa HDACs, has attracted increasing attention in recent years for its role in CVD. Studies have shown that HDAC4 can influence the development and progression of CVD such as cardiac hypertrophy, hypertension and atherosclerosis by regulating key pathophysiological processes including inflammation, fibrosis and apoptosis.

Determination of changes in bioactive components and fatty acid compositions of olive fruits sonicated in different bitterness removal solutions in pickled olive production.

Unlabelled: The oil contents of olive fruits sonicated in different debittering solvents were defined to be between 46.45 (water) and 60.44% (NaOH).

Insights into toxic elements mobilization in Karstic paddy soil of southwest China: The overlooked significance of iron-organic matter colloids.

Due to their large specific surface area, variable surface charge, and abundant reactive functional groups, soil colloids are important "carriers" for the migration of HMs (heavy metals) in the soil. This study systematically investigates the migration-transformation mechanisms of colloidal As, Cd, Tl and their driving factors in paddy soils of the Karst region in southwest China. Results show that colloidal Fe and OM are the primary environmental factors influencing the formation and distribution of these three colloidal heavy metals, with significant positive correlations (correlation coefficients r = 0.

MRPL21-PARP1 axis promotes cisplatin resistance in head and neck squamous cell carcinoma by inhibiting autophagy through the PI3K/AKT/mTOR signaling pathway.

Background: Head and neck squamous cell carcinoma (HNSCC) constitutes a major clinical challenge that severely affects patient survival. Mitochondrial ribosomal protein (MRP) family plays an important role in energy metabolism by participating in mitochondrial oxidative phosphorylation. However, their roles in HNSCC and the underlying mechanisms are still unclear.

Functional and structural characterization of an aquaporin 5 from Pomacea canaliculata.

Aquaporins (AQPs) are crucial biomolecules involved in the transport of water and few solutes across the cell membranes of various organisms. In this study, we isolated and characterized PcAQP5 from Pomacea canaliculata to elucidate its contribution to development and stress tolerance. The PcAQP5 gene encodes a protein of 36.

Structural changes of cinnarizine-stabilizer core-shell nano- and micro-suspensions following freeze- and spray-drying determined from dynamic nuclear polarization enhanced NMR.

Developing potent drug molecules that are also highly soluble in aqueous media puts strong constraints on molecular design. As a result, there is intense interest today in developing drug formulation strategies that increase solubility. Specifically, nanosizing involves the reduction of the particle size of the active pharmaceutical ingredient (API) to the sub-micron range, which increases the surface area and dissolution rate.

Integrating pathomics and deep learning for subtyping uveal melanoma: identifying high-risk immune infiltration profiles.

Purpose: Uveal melanoma (UVM) is the most common primary intraocular malignancy in adults, characterized by high mortality despite its relatively low incidence. This study aimed to utilize unsupervised learning techniques to identify a high immune infiltration subtype of UVM and improve patient stratification based on mortality risk.

Methods: A total of 70 hematoxylin and eosin (H&E) stained whole-slide images (WSIs) of UVM were collected from the Genomic Data Commons (GDC) data portal, along with genomic and clinical data.

Complete plastome and mitogenome assembly of endangered tree reveals phylogenetic architecture for sensu lato (Rosaceae).

Introduction: The genus sensu lato ( s.l.) comprises over 260 species widely distributed across temperate regions of Asia, Europe, and North America.

Continuous noninvasive blood pressure estimation using tissue blood flow measured by diffuse correlation spectroscopy.

Blood pressure (BP) is an important parameter of human health, since hypertension is a major risk factor of the cardiovascular system. Nowadays, the continuous measurement of BP is only possible with an invasive measurement method using catheter as the gold standard. Diffuse correlation spectroscopy (DCS) is a powerful tool for assessing microvascular hemodynamics in deep tissues, which can reliably provide a blood flow index whose changes are proportional to relative changes in tissue blood flow (BF).

Molecular mechanism of flavonoid-induced iron oxide transformation and implication for phosphorus loss risk in paddy soils.

Phosphorus (P), a non-renewable resource essential for sustaining life, faces increasing environmental losses from agricultural systems. However, the effects of flavonoid-induced iron oxide on soil P behavior remain poorly understood, particularly in paddy soils. Here, we conducted a 7-year field trial under four fertilization regimes combined with laboratory incubations to reveal how flavonoid-modified iron oxides regulate P at the molecular scale.