The associations between female fecundability and postpartum breastfeeding: A prospective cohort study.

Objective: This study aimed to investigate the relationship between women's fecundability and postpartum breastfeeding.

Methods: We used a prospective cohort study design to recruit pregnant women who came to the hospital for antenatal checkups before 20 weeks' gestation between April 2019 and March 2020 at the Maternal and Child Health Hospital of Gulou District, Nanjing, China. Women were categorized into prolonged time to pregnancy (TTP) group (>3 months) and shorten TTP (≤3 months) groups.

The Impact of Metal Exposure, Vaginal Microbiota, and Their Interactions on Fertility: A Prospective Cohort Study.

To explore the effects of metal exposure, vaginal microbiota, and their interactions on time to pregnancy (TTP). A total of 200 couples were recruited in Nanjing. Ultimately, 150 women from whom prepregnancy blood samples and vaginal swabs were collected by trained clinicians were included.

A combined enteric neuron-gastric tumor organoid reveals metabolic vulnerabilities in gastric cancer.

The discrepancy between organoid and immortalized cell line cultures for cancer target discovery remains unclear. Here, our multi-tiered clustered regularly interspaced short palindromic repeats (CRISPR) screens reveal in vivo-relevant metabolic dependencies and synthetic lethal pairs that can be uncovered with tumor organoids but not cell lines or even three-dimensional (3D) spheroids. These screens identify lanosterol synthase and acetyl-coenzyme A (CoA) carboxylase inhibitors as effective treatments that impede xenografted tumor growth in mice.

Molecular Pharmacological Interventions for Endometrial Cancer: A Comprehensive Review.

Endometrial cancer, a common malignancy of the female reproductive system, has a rising incidence and complex clinical management due to its diverse molecular subtypes. This review examines the molecular mechanisms underlying EC, particularly the roles of the Bcl-2 family in apoptosis regulation and estrogen receptor signaling in tumor progression. We explore pharmacological interventions targeting these pathways, including BH3 mimetics and selective estrogen receptor modulators, which show promise but face challenges such as resistance and adverse effects.

Partner involvement and emotional and informational support gaps as predictors of postpartum birth trauma symptoms: a multi-center cross-sectional study of 230 women at 42 days postpartum.

Background: Postpartum birth trauma symptoms, encompassing psychological and physical sequelae related to childbirth experiences, pose a significant threat to maternal well-being. These symptoms, as measured in this study, are not equivalent to a clinical diagnosis of post-traumatic stress disorder (PTSD) but reflect self-reported experiences based on the City Birth Trauma Scale.

Methods: This multi-center cross-sectional survey enrolled 230 women at 42 days postpartum from four hospitals in Shanghai between February and July 2024.

The impact of maternal chronic stress on spontaneous preterm birth: evidence from a Chinese cohort study.

Background: This study aimed to examine the relationship between maternal chronic stress, measured as allostatic load (AL), and the subsequent risk of spontaneous preterm birth (sPTB).

Methods: This analysis was based on a prospective, single-center cohort study conducted in China. Eligible women were recruited during their second trimester and followed up until giving birth.

Study on the Relationship Between Postpartum Birth Trauma Symptoms and the Gap in Social Support Expectations at 42 Days Postpartum.

Objective: Birth trauma affects 9% to 44% of postpartum women and significantly impacts maternal health. In China, changes in social structures have led to discrepancies between expected and actual social support, yet few studies have explored the relationship with birth trauma. This study examines the association between birth trauma symptoms at 42 days postpartum and the gap between expected and received social support.

Exploring the association between vitamin D levels and dyslipidemia risk: insights from machine learning and generalized additive models.

Introduction: Vitamin D is a necessary nutrient that is important for calcium homeostasis and bone health. Dyslipidemia is thought to be a risk factor for the development of atherosclerotic illnesses. Recent research suggests that vitamin D may influence lipid metabolism, specifically the levels of circulating lipids in the blood.

Prognostic Potential of Clinical Factors, Serological Indicators, and Pelvic Floor Ultrasound Parameters in Women With Postpartum Stress Urinary Incontinence.

Numerous studies have assessed factors influencing stress urinary incontinence (SUI); however, their findings are somewhat inconsistent. Therefore, this study aimed to explore the predictive potential of clinical characteristics and serological indicators combined with pelvic floor ultrasound parameters for postpartum SUI. Furthermore, the analysis was intended to determine the prevalence and factors affecting postpartum SUI among women in China.

Construction of a 3D bioprinted skin model for psoriasis research and drug evaluation.

Psoriasis is a chronic inflammatory skin disease involving complex genetic, immune, and environmental interactions. Currentmodels fail to fully replicate the human psoriatic microenvironment, while animal models are limited by species differences and ethical concerns, restricting their applicability in pathogenesis studies and drug screening. Here, we present a human-derivedpsoriasis model constructed via 3D bioprinting.

Revealing the dynamic changes in the metabolites and sensory quality of Citri Reticulatae Pericarpium during aging using feature-based molecular networks and metabolomics.

The contribution of non-volatile metabolites to the unique flavor formation in Citri Reticulatae Pericarpium (CRP) during aging remains poorly characterized. This study employed sensory evaluation, electronic tongue (E-tongue) assessment, untargeted metabolomics in conjunction with feature-based molecular networks (FBMN) to elucidate flavor differentials and metabolic mechanisms during the aging process of CRP. The results showed that extended aging time enhanced the bitterness, astringency, aftertaste-bitterness, aftertaste-astringency, and sweetness of the CRP.

A comprehensive in silico and invitro analysis revealed the diagnostic, prognostic and therapeutic potential of GNAI family genes in colon adenocarcinoma (COAD).

Introduction: Guanine nucleotide-binding protein alpha inhibiting activity polypeptides (GNAI1, GNAI2, and GNAI3) play critical roles in cell cycle regulation, intracellular signaling, and immune modulation. However, their contribution to colorectal adenocarcinoma (COAD) pathogenesis remains poorly defined. This study aimed to comprehensively evaluate the diagnostic, prognostic, and therapeutic relevance of GNAI genes in COAD through integrated in silico and in vitro analyses.

Precision replication and quality analysis of the molded glass cylindrical lens array.

Precision glass molding (PGM) is a well-established and cost-effective manufacturing process used to fabricate high-quality and high-precision optical elements with complex geometries, such as aspherical lens, microlens array, and microprisms. This study focuses on the replication quality of molded glass cylindrical lens arrays, which is critical for achieving exceptional precision and consistency in optical applications. The effect of process parameters on replication quality of the molded cylindrical lens array was studied.

CRTH2 is critical for IL-1β-producing B cells during experimental autoimmune encephalomyelitis in mice via p38 signaling.

B cells play a critical role in the pathogenesis of autoimmune inflammatory diseases such as multiple sclerosis (MS). As a receptor of prostaglandin D, chemoattractant receptor homologous molecule expressed on TH2 cells (CRTH2) is known to be involved in Th2 cell activation, but its function in B lymphocytes is unclear. Here, we show that CRTH2 is critical for an IL-1β-producing B cell subset.

Regulating the exciton dissociation and charge carrier behavior of graphitic carbon nitride 3,9-perylenedicarboxylic acid for efficient photocatalytic hydrogen evolution.

Graphitic carbon nitride (GCN) is known as a promising photocatalyst due to its suitable energy level, low cost and high stability. However, its deficient light-absorption capacity and charge transfer driving force hinder its further application. In this work, 3,9-perylenedicarboxylic acid (PA) was introduced into GCN during thermal polymerization to form a new photocatalyst, which was then applied in photocatalytic hydrogen evolution.

Unraveling the link: exploring what risk factor for sleep disorders among paediatric migraine.

Background: Migraine is closely related to sleep disorders. Vitamin D is known to regulate sleep, cell proliferation and differentiation. The aim of our study was to measure the predictive value of vitamin D for sleep disorders in paediatric migraine.

Possible Association Between Concomitant Use of SSRIs with NSAIDs and an Increased Risk of Adverse Events Among People with Depressive Disorders: Data Mining of FDA Adverse Event Reporting System.

: Depression, a major global health issue, is commonly treated with selective serotonin reuptake inhibitors (SSRIs). Given the link between depression and inflammation, nonsteroidal anti-inflammatory drugs (NSAIDs) may have adjunctive benefits. Clinically, SSRIs and NSAIDs are often co-prescribed for comorbid pain or inflammatory conditions.

Global Hotspots of Whale-Ship Collision Risk: A Multi-Species Framework Integrating Critical Habitat Zonation and Shipping Pressure for Conservation Prioritization.

The expansion of global maritime activities threatens marine ecosystems and biodiversity. Collisions between ships and marine megafauna profoundly impact vulnerable species such as whales, who serve as keystone predators. However, the specific regions most heavily affected by shipping traffic and the multi-species facing collision risk remain poorly understood.

Identification of SEC16B as a novel regulator of glucose homeostasis.

Aims/hypothesis: Glucose homeostasis, essential for metabolic health, requires coordinated insulin and glucagon activity to maintain blood glucose balance. Dysregulation of glucose homeostasis causes hyperglycaemia and glucose intolerance, hallmark features of type 2 diabetes. While SEC16 homologue B (SEC16B), an endoplasmic reticulum export factor, has been linked to obesity, type 2 diabetes and lipid metabolism, its role in glucose regulation remains poorly defined.

Gonadal sex differentiation in Eleutheronema tetradactylum: Histological features and transcriptomic insights from mature gonads.

Plasticity in teleosts is a fascinating evolutionary strategy enables species to acclimate to environmental changes. However, the molecular mechanisms that underlie gonadal differentiation and reversal remain incompletely understood. The four-finger threadfin (Eleutheronema tetradactylum), a protandrous hermaphrodite belonging to the Polynemidae family, serves as an excellent model for studying genes and molecules involved in gonadal transformation.

Spatiotemporal patterns and influencing factors of genotypic resistance testing utilization among people living with HIV: A 10-year retrospective analysis at a tertiary care hospital in Beijing, China (2014-2023).

Prior research indicated low genotypic resistance testing (GRT) for human immunodeficiency virus (HIV) utilization in China due to partial cost coverage under national antiretroviral therapy policies, limited testing accessibility, and financial barriers. Temporal and spatial data on GRT trends were also scarce. We analyzed GRT patterns among 6,895 untreated individuals at a tertiary hospital using Joinpoint regression, multivariable logistic modeling, and spatial analysis (GeoDa/SatScan).

BCMA-targeted CAR T cell therapy can effectively induce disease remission in refractory lupus nephritis.

Objectives: This study aims to evaluate the safety and efficacy of anti-B cell maturation antigen (BCMA)-targeting chimeric antigen receptor (CAR) T cells in treating refractory lupus nephritis (LN).

Methods: This is an open-label, single-arm clinical trial assessing anti-BCMA CAR T cells in treating refractory LN patients. CAR T cells were infused following lymphodepletion therapy with cyclophosphamide and fludarabine.

Generation of Maillard reaction-derived flavour compounds in coffee analogues by an extrusion-based solid model system.

A solid food matrix (SFM) model system was established to replicate dry food processing environments and investigate how precursors and reaction parameters influence coffee flavour generation through Maillard reaction (MR). The model consisted of chickpea flour, oil, chlorogenic acid, amino acids, and sugars, and was processed through high-moisture extrusion, drying, and fluidized bed roasting. The inclusion of oil affected SFM physical characteristics, including bulk density, expansion ratio, and colour.

BRD4770 protects against DOX-induced cardiotoxicity by inhibiting apoptosis and ferroptosis.

Doxorubicin (DOX) is an effective anticancer drug, but its clinical utility is limited mainly by cardiotoxicity causing cardiomyocyte ferroptosis and apoptosis. While DOX-induced cardiotoxicity (DIC) involves epigenetic changes, no systematic epigenetic intervention studies have been reported. Here, we identified BRD4770 as a potential small molecule against DIC through the Epigenetics Compound Library screening.

Determinants of mid-term response to left bundle branch pacing in heart failure patients with left bundle branch block.

Background: Response to left bundle branch pacing (LBBP) varies in patients with left bundle branch block (LBBB). We aimed to investigate whether clinical response to LBBP was associated with ventricular electricity, volume, and myocardial glucose uptake in nonischemic cardiomyopathy (NICM) patients with LBBB.

Methods: Consecutive NICM patients who received LBBP with successful LBBB correction were prospectively enrolled.