Genome-wide identification and characterization of the ubiquitin-specific protease (USP) gene family in cattle: primary analysis of muscle-specific USP genes and their influence on myogenesis.

Background: The ubiquitin-proteasome system(UPS) is a critical biological pathway that regulates protein function and plays a pivotal role in muscle formation. Nevertheless, the current comprehension of the ubiquitin-specific protease (USP) family, an important component of the UPS, in relation to bovine myoblast development remains relatively limited. This study aims to characterize the bovine USPs and conduct a preliminary analysis of their function, to provide valuable insights for enhancing beef yield and quality.

CD7 CAR-T therapy: current developments, improvements, and dilemmas.

Chimeric antigen receptor (CAR) T-cell therapy is an epoch-making immunotherapy for the treatment of relapsed or refractory (r/r) blood tumors, as demonstrated by its successful implementation in r/r B cell-derived malignancies. However, replicating this success in T-cell leukemia or lymphoma remains challenging. Among the various potential target antigens, CD7 has garnered attention as a promising candidate.

Intracellular cholesterol: new functions and therapeutic approaches in NSCLC EGFR-TKI resistance.

Epidermal growth factor receptor tyrosine kinase inhibitors (EGFR-TKIs) have markedly enhanced survival rates among patients with advanced non-small cell lung cancer (NSCLC) exhibiting EGFR mutations. However, acquired resistance diminishes their therapeutic efficacy over time. Recent investigations have linked intracellular cholesterol with the emergence and advancement of various cancers.

Gonadal sex differentiation in Eleutheronema tetradactylum: Histological features and transcriptomic insights from mature gonads.

Plasticity in teleosts is a fascinating evolutionary strategy enables species to acclimate to environmental changes. However, the molecular mechanisms that underlie gonadal differentiation and reversal remain incompletely understood. The four-finger threadfin (Eleutheronema tetradactylum), a protandrous hermaphrodite belonging to the Polynemidae family, serves as an excellent model for studying genes and molecules involved in gonadal transformation.

Ginsenosides Rh2 and Rg3 exert their anti-cancer effects on non-small cell lung cancer by regulating cell autophagy and choline-phosphatidylcholine metabolism.

Background: Ginseng (Panax ginseng C. A. Meyer) herb itself and its derived preparations (e.

Transcriptome-based analysis of the immune response of the four-finger threadfin (Eleutheronema tetradactylum) to Vibrio harveyi infection.

The four-finger threadfin (Eleutheronema tetradactylum), an economically important fish species, has faced significant economic losses due to bacterial diseases, particularly Vibrio harveyi, a Gram-negative bacterium. In this study, we used RNA sequencing (RNA-seq) to analyze transcriptomic responses in the intestine and liver of E. tetradactylum post-V.

Metabolomics-Based Analysis of Adaptive Mechanism of to Low-Temperature Stress.

Temperature is a critical environmental factor that influences the growth, development, metabolism, and overall physiological performance of fish. is an economically significant fish species; however, its molecular mechanism's response to long-term cold stress is still unclear. In this study, we investigated the physiological responses of the liver in exposed to a constant temperature of 18 °C for durations of both 7 and 14 days, utilizing liquid chromatography-mass spectrometry (LC-MS), metabolomics, and conventional biochemical assays.

Effects of on Growth Performance, Digestive Enzyme Activity, and Intestinal Microbiota of the Juvenile Fourfinger Threadfin ().

The effects of (BC) T-21 on growth performance, intestinal digestive enzyme activity, intestinal morphology, and intestinal microbiota of juvenile fourfinger threadfin () were investigated in the present study. Healthy juvenile with an initial body weight of 4.2 ± 0.

A new class of higher-order topological insulators that localize energy at arbitrary multiple sites.

Z-classified topological phases lead to a larger-than-unity number of topological states. However, these multiple topological states are only localized at the corners in nonlocal systems. Here, first, we rigorously prove that the multiple topological states of nonlocal Su-Schrieffer-Heeger (SSH) chains can be inherited and realized by local aperiodic chains with only the nearest couplings.

ORANGE interplays with TCP7 to regulate endoreduplication and leaf size.

Leaf size is a crucial agronomic trait directly affecting crop yield, which is mainly determined by coordinated cell proliferation, growth, and differentiation. Although endoreduplication is known to be correlated with the onset of cell differentiation and leaf size, the underlying molecular mechanisms are largely unclear. The DnaJ-like zinc finger domain-containing protein ORANGE (OR) was initially demonstrated to confer the massive accumulation of carotenoids in cauliflower curds.

Experimental study on the methane explosion suppression by ultra-fine water mist containing bacteria under degradation for five times.

In a semi-closed visualization pipeline, this experiment studied the inhibitory effect of ultra-fine pure water mist, ultra-fine water mist containing inorganic salt and ultra-fine water mist containing bacteria-inorganic salt on 9.8% methane explosion under five different quality of spray volume. Combined with the methane explosion suppression experiment, the ability of methane-oxidizing bacteria to degrade 9.

Using the i-PARIHS theoretical framework to develop evidence implementation strategies for central venous catheter maintenance: a multi-site quality improvement project.

Introduction: Evidence-based nursing practice can reduce complications associated with central venous catheters (CVCs). In this project, the Integrated Promoting Action on Research Implementation in Health Services (i-PARIHS) framework was considered an ideal theoretical instrument to identify facilitators and barriers to implementing evidence-based practice.

Methods: The project was conducted in pediatric intensive care units in six Chinese tertiary children's hospitals.

The Research Progress on the Interaction between Mammalian Gut Microbiota and the Host's Metabolism Homeostasis during Hibernation.

Hibernating mammals confront seasonal and harsh environmental shifts, prompting a cycle of pre-hibernation feeding and subsequent winter fasting. These adaptive practices induce diverse physiological adjustments within the animal's body. With the gut microbiota's metabolic activity being heavily reliant on the host's diet, this cycle's primary impact is on this microbial community.

An Analytical Method for Elastic Modulus of the Sandwich BCC Lattice Structure Based on Assumption of Linear Distribution.

An analytical method to predict the elastic modulus of the sandwich body-centered cubic (BCC) lattice structure is presented on the basis of the assumption of a linearly changing elastic modulus. In the constrained region, the maximum of elastic modulus used the elastic moduli of the BCC lattice element with plate constraints and is calculated with Timoshenko beam theory, the minimum used without plate constraints. In the rest of the constrained region, a linear function along the thickness direction is proposed to calculate elastic modulus.

The functional evolution of architecturally different plant geranyl diphosphate synthases from geranylgeranyl diphosphate synthase.

Terpenoids constitute the largest class of plant primary and secondary metabolites with a broad range of biological and ecological functions. They are synthesized from isopentenyl diphosphate and dimethylallyl diphosphate, which in plastids are condensed by geranylgeranyl diphosphate synthases (GGPPSs) to produce GGPP (C20) for diterpene biosynthesis and by geranyl diphosphate synthases (GPPSs) to form GPP (C10) for monoterpene production. Depending on the plant species, unlike homomeric GGPPSs, GPPSs exist as homo- and heteromers, the latter of which contain catalytically inactive GGPPS-homologous small subunits (SSUs) that can interact with GGPPSs.

Emerging Synthesis Strategies of 2D MOFs for Electrical Devices and Integrated Circuits.

The development of advanced electronic devices is boosting many aspects of modern technology and industry. The ever-increasing demand for advanced electrical devices and integrated circuits calls for the design of novel materials, with superior properties for the improvement of working performance. In this review, a detailed overview of the synthesis strategies of 2D metal organic frameworks (MOFs) acquiring growing attention is presented, as a basis for expansion of novel key materials in electrical devices and integrated circuits.

The DnaJ-like Zinc Finger Protein ORANGE Promotes Proline Biosynthesis in Drought-Stressed Seedlings.

Orange (OR) is a DnaJ-like zinc finger protein with both nuclear and plastidial localizations. OR, and its orthologs, are highly conserved in flowering plants, sharing a characteristic C-terminal tandem 4× repeats of the CxxCxxxG signature. It was reported to trigger chromoplast biogenesis, promote carotenoid accumulation in plastids of non-pigmented tissues, and repress chlorophyll biosynthesis and chloroplast biogenesis in the nucleus of de-etiolating cotyledons cells.

Screening and Identification of Candidate GUN1-Interacting Proteins in .

Chloroplasts are semi-autonomous organelles governed by the precise coordination between the genomes of their own and the nucleus for functioning correctly in response to developmental and environmental cues. Under stressed conditions, various plastid-to-nucleus retrograde signals are generated to regulate the expression of a large number of nuclear genes for acclimation. Among these retrograde signaling pathways, the chloroplast protein GENOMES UNCOUPLED 1 (GUN1) is the first component identified.

Bi S -In S Heterostructures for Efficient Photoreduction of Highly Toxic Cr Enabled by Facet-Coupling and Z-Scheme Structure.

The construction of Z-scheme photocatalyst materials mimicking the natural photosynthesis system provides many advantages, including increased light harvesting, spatially separated reductive and oxidative active sites and strong redox ability. Here, a novel Bi S nanorod@In S nanoparticle heterojunction photocatalyst synthesized through one-pot hydrothermal method for Cr reduction is reported. A systematic investigation of the microstructural and compositional characteristics of the heterojunction catalyst confirms an intimate facet coupling between (440) crystal facet of In S and (060) crystal facet of Bi S , which provides a robust heterojunction interface for charge transfer.

General Control Non-derepressible 1 (AtGCN1) Is Important for Flowering Time, Plant Growth, Seed Development, and the Transcription/Translation of Specific Genes in .

We have previously demonstrated that General Control Non-derepressible 1 (AtGCN1) is essential for translation inhibition under cold stress through interacting with GCN2 to phosphorylate eukaryotic translation initiation factor 2 (eIF2). Here, we report that the flower time of the mutant is later than that of the wild type (WT), and some siliques of cannot develop and produce seeds. Total and polysomal RNA of and wild type (WT) after cold treatments were sequenced.

At3g53630 encodes a GUN1-interacting protein under norflurazon treatment.

Chloroplasts are semi-autonomous organelles, with more than 95% of their proteins encoded by the nuclear genome. The chloroplast-to-nucleus retrograde signals are critical for the nucleus to coordinate its gene expression for optimizing or repairing chloroplast functions in response to changing environments. In chloroplasts, the pentatricopeptide-repeat protein GENOMES UNCOUPLED 1 (GUN1) is a master switch that senses aberrant physiological states, such as the photooxidative stress induced by norflurazon (NF) treatment, and represses the expression of photosynthesis-associated nuclear genes (PhANGs).

WO in suit embed into MIL-101 for enhancement charge carrier separation of photocatalyst.

Compositing nanoparticles photo-catalyst with enormous surface areas metal-organic framework (MOF) will greatly improve photocatalytic performances. Herein, WO nanoparticles are partly embedded into pores of MIL-101 or only supported on the outside of representative MIL-101, which were defined as embedded structure WO@MIL-101@WO and coating structure WO&MIL-101 respectively. Different pH, concentration and loading percentage were researched.