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http://dx.doi.org/10.1111/pbi.13245 | DOI Listing |
Nat Prod Rep
August 2025
Department of Medicinal Chemistry, Center for Natural Products, Drug Discovery and Development, University of Florida, Gainesville, FL 32610, USA.
Covering: 2014 to 2024Cyanobacteria are prolific producers of bioactive natural products, including promising drug leads for FDA-approved cancer therapeutics. Advances in genome sequencing and computational tools have revealed a wealth of cyanobacterial biosynthetic gene clusters (BGCs). However, progress in genome-driven discovery has been hindered by challenges in manipulating native hosts and the limited availability of efficient heterologous expression platforms.
View Article and Find Full Text PDFCommun Biol
August 2024
School of Marine Sciences, Ningbo University, Ningbo, Zhejiang, 315211, China.
Cyanobacteria are important primary producers, contributing to 25% of the global carbon fixation through photosynthesis. They serve as model organisms to study the photosynthesis, and are important cell factories for synthetic biology. To enable efficient genetic dissection and metabolic engineering in cyanobacteria, effective and accurate genetic manipulation tools are required.
View Article and Find Full Text PDFPhysiol Plant
March 2024
Department of Life Technologies/Molecular Plant Biology, University of Turku, Turku, Finland.
Application of cyanobacteria for bioproduction, bioremediation and biotransformation is being increasingly explored. Photoautotrophs are carbon-negative by default, offering a direct pathway to reducing emissions in production systems. More robust and versatile host strains are needed for constructing production strains that would function as efficient and carbon-neutral cyanofactories.
View Article and Find Full Text PDFJ Environ Manage
April 2024
Botany Department, Faculty of Science, Tanta University, Tanta, 31527, Egypt. Electronic address:
Microalgae represent a promising renewable feedstock for the sustainable production of biohydrogen. Their high growth rates and ability to fix carbon utilizing just sunlight, water, and nutrients make them well-suited for this application. Recent advancements have focused on improving microalgal hydrogen yields and cultivation methods.
View Article and Find Full Text PDFFront Plant Sci
February 2024
Biosciences Center, National Renewable Energy Laboratory, Golden, CO, United States.
Identification and manipulation of cellular energy regulation mechanisms may be a strategy to increase productivity in photosynthetic organisms. This work tests the hypothesis that polyphosphate synthesis and degradation play a role in energy management by storing or dissipating energy in the form of ATP. A polyphosphate kinase () knock-out strain unable to synthesize polyphosphate was generated in the cyanobacterium sp.
View Article and Find Full Text PDF