Impact of Subthalamic Nucleus Deep Brain Stimulation on Gastrointestinal Symptoms and Gastric Emptying in Parkinson's Disease: A Systematic Review and Meta-Analysis.

Objective: This systematic review and meta-analysis evaluates the efficacy of bilateral subthalamic nucleus (STN) deep brain stimulation (DBS) in improving gastric motility in patients with Parkinson's disease (PD).

Materials And Methods: A systematic search was conducted in Scopus, Web of Science, PubMed, and Cochrane CENTRAL until December 15, 2024. Observational studies and clinical trials evaluating DBS effects on gastric motility and gastric emptying in patients with PD were included.

Concentration-dependent blood binding: assessing implications through physiologically based Pharmacokinetic modeling of tacrolimus as a case example.

Concentration-dependent binding to red blood cells is a characteristic of several drugs, complicating the understanding of how pathophysiological factors influence drug behavior. This study utilized user-friendly, physiologically-based pharmacokinetic (PBPK) models to compare concentration-dependent and independent blood-to-plasma drug concentration ratios (B/P), using tacrolimus as a case study. Two models were developed and validated for tacrolimus using clinical data from healthy volunteers; Model 1 accounted for saturable blood binding, and Model 2 used a constant B/P level.

Optimal estimation of power Chris-Jerry distribution parameters using ranked set sampling design with application.

Effective sample design has a major role in the quality of parameter estimation in statistical parameter estimation issues. The ranking set sampling (RSS) strategy is effective and a less costly option than simple random sampling (SRS). A novel mixture continuous lifetime distribution that has been proposed recently is the power Chris-Jerry distribution (PC-JD).

The potential relationship between Toxocara canis infection and epilepsy in a rat model.

Human toxocariasis presents in several forms, including visceral larva migrans, ocular larva migrans, covert toxocariasis, and neurotoxocariasis. Although several studies suggest a potential link between toxocariasis and epilepsy, this link is still debated. Additional mechanistic and experimental studies in animal models are essential for a better understanding of this association.

A comprehensive systematic review of randomized controlled trials on anesthetic agents in children's upper gastrointestinal endoscopy: highlighting safety concerns and efficacy.

Upper gastrointestinal endoscopy (GIE) is essential for diagnosing and treating gastrointestinal disorders in children aged 6-12 years, yet it often requires sedation due to the significant discomfort and pain involved. We conducted a PRISMA 2020-compliant systematic review of randomized controlled trials (RCTs) from PubMed, Web of Science, Scopus, and Ovid (inception to March 30, 2024). Inclusion criteria are as follows: RCTs comparing sedative regimens (e.

Sustainable valorization of olive by-products: environmental impact, biotechnological and probiotic approaches for bioactive recovery in alignment with circular bioeconomy.

The olive oil industry generates vast amounts of by-products, including olive pomace, olive mill wastewater, olive pits, and olive leaves, which pose serious environmental and economic challenges. However, these residues are rich in bioactive compounds such as polyphenols, dietary fibers, unsaturated fatty acids, and sugar derivatives, making them valuable resources for sustainable valorization. This review explores innovative biotechnological and probiotic-driven approaches to convert olive waste into high-value products, aligning with the United Nations Sustainable Development Goals (SDGs), particularly SDG 12 (Responsible consumption and production) and SDG 13 (Climate action).

Serum golgi protein-73 (GP-73) in children with autoimmune hepatitis.

Unlabelled: To assess the correlation between serum Golgi protein-73 (GP-73) and the degree of hepatic fibrosis in children with autoimmune liver diseases. This case-control study included 100 children. Group A involved 50 children with autoimmune hepatitis (AIH), aged 2-17 years (mean 11.

Integrated metabolomic profiling of olive oil, olive mill wastewater, and pomace from Egyptian cultivars based on UHPLC-MS/MS and NMR coupled with chemometrics.

Introduction: Olive oil and their by-products have long been regarded as valuable sources of health-promoting metabolites. Although the composition of olive oil has been widely studied, less attention has been given to olive mill wastewater (OMWW) and pomace across different cultivars (cvs.).

DECODE: An open-source cloud-based platform for the noninvasive management of peripheral artery disease.

Background And Objective: Peripheral artery disease (PAD) is a progressive vascular condition affecting >237 million individuals worldwide. Accurate diagnosis and patient-specific treatment planning are critical but are often hindered by limited access to advanced imaging tools and real-time analytical support. This study presents DECODE, an open-source, cloud-based platform that integrates artificial intelligence, interactive 3D visualization, and computational modeling to improve the noninvasive management of PAD.

Mutational profile of a Saudi patient with Familial adenomatous polyposis that progressed to colon cancer: A case report.

Background: Familial adenomatous polyposis (FAP) is an autosomal dominant syndrome that results from a germline mutation in the adenomatous polyposis coli gene. It is characterized by the early development of hundreds of adenomas in the colon during the second decade of life. If prophylactic colectomy is not performed, most patients eventually develop colorectal cancer (CRC).

Navigating gastrointestinal challenges in genetic myopathies: Diagnostic insights and future directions.

Background: Gastrointestinal (GI) manifestations are prevalent in genetic myopathies, posing significant diagnostic and management challenges.

Aim: To synthesize evidence on the diagnostic approaches, management strategies, patient perspectives, and future research directions regarding GI symptoms in genetic myopathies.

Methods: A systematic review followed the Preferred Reporting Items for Systematic Reviews and Meta-Analyses 2020 guidelines.

Epiploic appendagitis: An overlooked cause of acute abdominal pain.

Background: Epiploic appendagitis is a rare, often underrecognized cause of acute abdominal pain. Misdiagnosis can lead to unnecessary hospitalization, antibiotic use, or surgical intervention. Advances in imaging have improved the recognition of this self-limiting condition, but clinical awareness remains critical.

Differential NADP-Dependent Isocitrate Dehydrogenases Expression in Metabolically Healthy Obesity vs Metabolic Syndrome: A Probable Predictive Biomarker for Metabolic Deterioration.

Background: Nicotinamide adenine dinucleotide phosphate (NADP)-dependent isocitrate dehydrogenases, isocitrate dehydrogenase enzyme (IDH)1 and IDH2, are crucial to normal glucose and lipid metabolism and to oxidative species handling. This study aimed to assess the probability of utilizing NADP-dependent isocitrate dehydrogenases deficiency as a biomarker of the progression of metabolically healthy obesity (MHO) to metabolic syndrome (MetS).

Methods: The study enrolled 120 participants.

Multiple sclerosis patients' journey delay in diagnosis and treatment: a multicenter study.

Objective: To determine factors that contribute to delayed diagnosis and treatment of MS patients. Additionally, the study aimed to evaluate the correlation between diagnostic and therapeutic delay and disease outcome.

Methods: The current cohort observational multicenter study was performed at neurology clinics in four cities in Egypt.

Differential genetic and biochemical responses of Beta vulgaris and Beta maritima under salt stress.

Background: Screening and raising salt-tolerant crops on saline land is an affordable and environmentally friendly alternative. This study investigated the physiological and molecular processes in eight Beta vulgaris and Beta maritima accessions.

Results: A preliminary study was carried out to determine the sublethal concentration of NaCl.

MDL-800 protects against inflammatory and metabolic dysfunction: role of SIRT6 in the cross-regulation of NFκB, AMPK, and PPAR signaling in rats.

Metabolic syndrome (MetSyn) is a complex, multifactorial disorder characterized by insulin resistance, dyslipidemia, hepatic steatosis, oxidative stress, and chronic inflammation, contributing substantially to the global burden of cardiometabolic diseases. Despite extensive research, effective pharmacological strategies that address the diverse and interconnected pathophysiological mechanisms of MetSyn are lacking. Sirtuin 6 (SIRT6), a NAD-dependent epigenetic regulator, has emerged as a critical modulator of metabolic and inflammatory homeostasis.

Computational modeling of drug-eluting balloons in peripheral artery disease: Mechanisms, optimization, and translational insights.

Drug-eluting balloons (DEBs) represent a promising alternative to stent-based interventions for peripheral artery disease (PAD), and their therapeutic efficacy is dependent on optimizing drug transfer, mechanical deployment, and vessel-wall interactions. This review synthesizes current advancements in computational modeling; systematically analyzes studies identified through comprehensive ScienceDirect, Scopus, and PubMed (2015-2025) searches; and selects them according to PRISMA guidelines. Key strategies, including computational fluid dynamics (CFD), finite element analysis (FEA), fluid-structure interaction (FSI), and machine learning (ML), are critically examined to elucidate how drug kinetics, coating stability, and mechanical stress govern therapeutic outcomes.

An in vivo comparative study of pure Mg and Mg-Zn alloy plates implanted in the mandible of New Zealand rabbits.

Background: Biodegradable magnesium-based implants present significant potential for maxillofacial applications, particularly in mandible fixation, due to their osteoconductive properties and elimination of secondary removal surgeries.

Objective: The present study aimed to assess the in vivo biocompatibility and degradation behavior of pure magnesium (Mg) and Mg-Zn-Ca alloy plates implanted in the mandibles of New Zealand rabbits, providing insights into their clinical viability.

Materials And Methods: Twenty-four male New Zealand White rabbits were divided into two groups and received titanium, pure Mg, and Mg-Zn-Ca alloy plates passively implanted into the mandibular bone surface.

The Efficacy and Safety of Seladelpar for Primary Biliary Cholangitis: A Systematic Review and Meta-Analysis.

Background And Objective: Seladelpar is an oral, once-daily medication that improves cholestasis through its selective peroxisome proliferator-activated receptor (PPAR-δ) agonism. It shows promising efficacy in treating primary biliary cholangitis (PBC) patients.

Methods: A systematic review and meta-analysis synthesizing evidence from randomized controlled trials (RCTs) obtained from PubMed, Cochrane, Scopus, and WOS until July 19th, 2025.

Evaluating Myotomy Length in POEM for Achalasia: A Grade-Assessed Meta-Analysis of Randomized Controlled Trials.

Background: Peroral endoscopic myotomy (POEM) is a standard achalasia treatment, matching surgery in efficacy. However, myotomy length varies. Shorter myotomies are gaining attention for potential benefits.

Drug Repurposing Investigation for Combating Ebola Virus Disease: Database Mining, Docking Calculations, Molecular Dynamics, and Density Functional Theory Study.

Ebola virus (EBOV), one of the deadliest diseases, is responsible for infecting individuals with hemorrhagic fever syndrome, which remains an ongoing worldwide health concern. The extremely deadly nature and virulence of EBOV illness illuminate the imperative need to evolve effective curative agents. Viral protien (VP35) acts as an Achilles heel for EBOV reproduction and also interacts with numerous human proteins, which leads to impairing the immune system.

An Artificial Intelligence System for Staging the Spheno-Occipital Synchondrosis.

Objective: The aim of this study was to develop, test and validate automated interpretable deep learning algorithms for the assessment and classification of the spheno-occipital synchondrosis (SOS) fusion stages from a cone beam computed tomography (CBCT).

Study Design: The sample consisted of 723 CBCT scans of orthodontic patients from private practices in the midwestern United States. The SOS fusion stages were classified by two orthodontists and an oral and maxillofacial radiologist.

Forecasting mortality rates in hyponatremia: a statistical approach using Holt-Winters models.

Hyponatremia, characterized by a serum sodium concentration below 135 mEq/L, is a prevalent electrolyte imbalance associated with increased morbidity and mortality across various clinical conditions. This study employs the Holt-Winters seasonal method, a robust time series forecasting model, to predict mortality rates attributed to hyponatremia. Leveraging retrospective mortality data from a cohort of hospitals in the United States, our analysis aims to elucidate temporal patterns and trends in hyponatremia-related deaths.

Analgesic efficacy of different volumes in erector spinae plane block in patients undergoing single level lumbar spine fixation: a non-inferiority randomized trial.

Background: Using a lower volume (LVs) of local anaesthetic (LA) reduces the risk of toxicity, side effects, and cost. Our study assessed whether the lower LA volumes (10 or 15 ml) have the same analgesic efficacy as 20 ml of erector spinae plane block (ESPB) in single-level lumbar spine fixation.

Methods: Our non-inferiority, randomised, double-blind trial recruited sixty cases scheduled for single-level lumbar spine fixation.