Highly Efficient CO Electroreduction in Artificial Seawater Electrolyte Catalyzed by Strong-Acid/Base-Resistant MOF.

NaCl, a primary component of seawater, is a cost-effective alternative electrolyte for CO electroreduction; however, suppressing competitive hydrogen evolution reaction (HER) remains a challenge for efficient CORR. Herein, a novel Zn-MOF {[Zn(tz)(HCOO)]·2HO} (1, Htz = 1,2,3-triazole) was prepared, exhibiting excellent stability in 0.5 M NaCl electrolyte for 16 weeks.

Identification of SEC16B as a novel regulator of glucose homeostasis.

Aims/hypothesis: Glucose homeostasis, essential for metabolic health, requires coordinated insulin and glucagon activity to maintain blood glucose balance. Dysregulation of glucose homeostasis causes hyperglycaemia and glucose intolerance, hallmark features of type 2 diabetes. While SEC16 homologue B (SEC16B), an endoplasmic reticulum export factor, has been linked to obesity, type 2 diabetes and lipid metabolism, its role in glucose regulation remains poorly defined.

MTCH2 Suppresses Thermogenesis by Regulating Autophagy in Adipose Tissue.

Stimulating adipose tissue thermogenesis has emerged as a promising strategy for combating obesity, with uncoupling protein 1 (UCP1) playing a central role in this process. However, the mechanisms that suppress adipose thermogenesis and energy dissipation in obesity are not fully understood. This study identifies mitochondrial carrier homolog 2 (MTCH2), an obesity susceptibility gene, as a negative regulator of energy homeostasis across flies, rodents, and humans.

Modulated Multicomponent Reaction Pathway by Pore-Confinement Effect in MOFs for Highly Efficient Catalysis of Low-Concentration CO.

The conversion of flue gas CO into high-value chemicals via multicomponent reactions (MCRs) offers the advantages of atom economy, bond-formation efficiency and product complexity. However, because of the competition between reaction sequences and pathways among substrates, the efficient synthesize the desired product is a great challenge. Herein, a porous noble-metal-free framework (Cu-TCA) was synthesized, which can highly effectively catalyze the multicomponent conversion of CO by modulating reaction pathways.

Sucralose uses reward pathways to promote acute caloric intake.

Non-nutritive sweeteners (NNSs) are used to reduce caloric intake by replacing sugar with compounds that are sweet but contain little or no calories. In this study, we investigate how non-nutritive sweetener sucralose to promote acute food intake in the fruit fly Drosophila melanogaster. Our results showed that acute exposure to NNSs sweetness induces a robust hyperphagic response in flies.

A rapid and reproducible method for generating germ-free .

Microbial communities exert a profound influence on various facets of animal behavior and physiology, making the comprehension of their interactions with hosts or the environment essential. , a widely recognized model organism, has been pivotal in elucidating host-microbe interactions. Despite the existence of several protocols for generating germ-free (GF) , their reproducibility has been constrained by the technical difficulty of maintaining airtight conditions in centrifuge tubes.

An Efficient Bifunctional Core-Shell ZIF-90@ZIF-67 Composite as a Stable Pickering Interfacial Catalyst for the Deacetalization-Knoevenagel Tandem Reaction.

Exploiting advanced solid particles is crucial to the construction of Pickering emulsions catalysis. Recently, metal-organic frameworks (MOFs) have been used as ideal emulsifiers stabilizing Pickering emulsions for interfacial catalysis. Although Pickering emulsions stabilized by core-shell MOFs have significant importance in practical studies, to date there have been very limited reports on this topic.

[Retrospective cross-sectional survey of clinical characteristics and syndrome elements distribution at different stages of coronary heart disease].

The clinical data of coronary heart disease(CHD) patients treated in the First Affiliated Hospital of Guangzhou University of Chinese Medicine and Shenzhen Hospital of Integrated Traditional Chinese and Western Medicine from January 2022 to March 2023 were retrospectively collected. This study involved the descriptive analysis of demographic characteristics, clinical symptoms, and tongue and pulse features. The χ~2 test was conducted to analyze the distribution of syndrome elements and their combinations at diffe-rent stages of CHD, so as to reveal the clinical characteristics and syndrome patterns at various pathological stages of CHD.

Portably and Visually Sensing Cytisine through Smartphone Scanning Based on a Post-Modified Luminescence Center Strategy in Zinc-Organic Frameworks.

Cytisine (CTS) is a useful medicine for treating nervous disorders and smoking addiction, and exploring a convenient method to detect CTS is of great significance for long-term/home medication to avoid the risk of poisoning, but it is full of challenges. Here, a modified metal-organic framework sensor Tb@Zn-TDA-80 with dual emission centers was prepared using a post-modified luminescence center strategy. The obtained Tb@Zn-TDA-80 can serve as a CTS sensor with high sensitivity and selectivity.

Biotoxicity of Halide Perovskites in Mice.

Halide perovskites are crystalline semiconductors with exceptional optoelectronic properties, rapidly developing toward large-scale applications. Lead (II) (Pb ) is the core element used to prepare halide perovskites. Pb can displace key 2+ elements, including calcium, zinc and iron, that regulate vital physiological functions.

Diffusion law of coal gangue slurry and the application of fluidized filling technology of gangue in caving area.

In order to deeply study the basic characteristics, diffusion laws, and flow laws of coal gangue and coal gangue slurry, the basic characteristic parameters of coal gangue and coal gangue slurry were obtained through particle size distribution test, electron microscope scanning test, X-ray diffraction test, X-ray fluorescence spectrum test, and angle of repose test. The conveying performance test of coal gangue slurry was carried out, and based on this, a simulation test of coal gangue slurry caving areas was designed. The diffusion and flow laws of coal gangue slurry under the same inclination angle were summarized, and the field test of fluidization filling in the caving areas was conducted.

A nomogram diagnostic cardiovascular disease in patients with erythrodermic psoriasis in Chinese.

Objective: Patients with erythrodermic psoriasis (EP) are associated with an increased risk of cardiovascular disease (CVD), because of the more severe inflammation in the skin areas. This study aimed to develop a diagnostic model for the risk of CVD in EP patients based on the available features and multidimensional clinical data.

Methods: A total of 298 EP patients from Beijing Hospital of Traditional Chinese Medicine were retrospectively included in this study from May 5, 2008, to March 3, 2022.

Identification of indocyanine green as a STT3B inhibitor against mushroom α-amanitin cytotoxicity.

The "death cap", Amanita phalloides, is the world's most poisonous mushroom, responsible for 90% of mushroom-related fatalities. The most fatal component of the death cap is α-amanitin. Despite its lethal effect, the exact mechanisms of how α-amanitin poisons humans remain unclear, leading to no specific antidote available for treatment.

Thermocatalytic Conversion of CO to Valuable Products Activated by Noble-Metal-Free Metal-Organic Frameworks.

Thermocatalysis of CO into high valuable products is an efficient and green method for mitigating global warming and other environmental problems, of which Noble-metal-free metal-organic frameworks (MOFs) are one of the most promising heterogeneous catalysts for CO thermocatalysis, and many excellent researches have been published. Hence, this review focuses on the valuable products obtained from various CO conversion reactions catalyzed by noble-metal-free MOFs, such as cyclic carbonates, oxazolidinones, carboxylic acids, N-phenylformamide, methanol, ethanol, and methane. We classified these published references according to the types of products, and analyzed the methods for improving the catalytic efficiency of MOFs in CO reaction.

Dynamic tensile properties, deformation, and failure testing of impact-loaded coal samples with various water content.

Disc coal samples with different water content were tested using the split Hopkinson press bar test system. Their dynamic tensile failure process was monitored via an ultra-high-speed digital image correlation system. The deformation trend and failure characteristics as a function of the water content were analyzed, and the water content effect on dynamic mechanical properties was investigated.

Nuclear Factor-κB Signaling Mediates Antimony-induced Astrocyte Activation.

Objective: Antimony (Sb) has recently been identified as a novel nerve poison, although the cellular and molecular mechanisms underlying its neurotoxicity remain unclear. This study aimed to assess the effects of the nuclear factor kappa B (NF-κB) signaling pathway on antimony-induced astrocyte activation.

Methods: Protein expression levels were detected by Western blotting.

2,3,7,8-Tetrachlorodibenzo-p-dioxin Promotes Proliferation of Astrocyte Cells via the Akt/STAT3/Cyclin D1 Pathway.

Objective: The compound 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD), a persistent organic pollutant, is harmful to the nervous system, but its effects on the brain are still unclear. This study aimed to investigate the effects of TCDD on astrocytes proliferation and underlying molecular mechanism.

Methods: The cell proliferation was measured by EdU-based proliferation assay and PI staining by flow cytometry.

Increased PIT1 and PIT2 Expression in Streptozotocin (STZ)-induced Diabetic Mice Contributes to Uptake of iAs(V).

Objective: This study aimed to investigate the susceptibility of mice with streptozotocin(STZ)-induced diabetes mellitus (TIDM) to the uptake of pentavalent inorganic arsenic (iAsV) and the possible molecular mechanism.

Methods: TIDM was induced in mice by STZ. TIDM and normal mice were treated with 15.