Circ_0005372 targets the miR-153-3p/ITGB3 axis to stimulate the PI3K/AKT signaling pathway to facilitate the occurrence and development of congenital heart disease and pulmonary arterial hypertension in children.

Background: Congenital heart disease (CHD) is the most common and highest incidence of congenital malformations in newborn infants. Pulmonary arterial hypertension (PAH) is the most serious complication associated with CHD. It is a great threat to the safety and health of newborns.

Accessing Metal-Containing Species in Tin-Lead Perovskite Precursor Solutions via Molecular Strategies Guided by the Hard-Soft Acid-Base Principle.

The properties of metal-centred species in metal halide perovskite precursor solutions substantially influence the formation and evolution of colloidal particles, which in turn dictate the crystallisation process and the film quality. In this work, we assess the "hard" and "soft" Lewis acid characteristics of Sn and Pb cations as a strategy to modulate the chemical environment of these metal-containing species in mixed-metal tin-lead perovskite precursor solutions. We observe enhanced simultaneous access to both metal centres upon adding compounds with functional groups suggested by the hard-soft acid-base principle.

Hydrogen-Sulfide-Mediated PpAOS3-JA Module Provides Insight into Salt Stress Resistance in Peach.

Salt stress is one of the main abiotic stresses that affects peach growth. Hydrogen sulfide has an important role in regulating plant resistance to salt stress. However, the mechanism by which hydrogen sulfide regulates salt stress resistance is currently unclear in peach.

Tailored Crystallization Dynamics for Efficient and Stable DMSO-Free Tin Perovskite Solar Cells.

Tin perovskite solar cells are emerging as a sustainable lead-free alternative in thin film photovoltaics. DMSO-free processed tin perovskites are gaining interest due to the detrimental effects of DMSO on tin oxidation. However, replacing DMSO with other solvents remains challenging due to the accelerated crystallization dynamics in non-DMSO systems.

Heat-Triggered Dynamic Self-Healing Framework for Variable-Temperature Stable Perovskite Solar Cells.

Metal halide perovskite solar cells (PSCs) are promising as the next-generation photovoltaic technology. However, the inferior stability under various temperatures remains a significant obstacle to commercialization. Here, a heat-triggered dynamic self-healing framework (HDSF) is implemented to repair defects at grain boundaries caused by thermal variability, enhancing PSCs' temperature stability.

Chemical Reaction Mechanism of Proton Irradiation to Polyimide Materials under Low Earth Orbit Using ReaxFF MD Methods.

Proton irradiation in the inner radiation belt significantly degrades the thermal stability and mechanical properties of aerospace polymer materials, but the involved reaction mechanism remains elusive. In this work, we systematically investigate the chemical reactions and performance degradation mechanisms of polyimide materials under proton irradiation using ReaxFF MD methods. The reactions between proton H and polyimide can be classified into substitution, hydrogenolysis, and hydrogenation reactions, while the latter two can create unsaturated reaction sites that trigger additional reactions with proton H.

Resistance risk asssement and molecular basis of metconazole in Fusarium pseudograminearum.

The fungicide metconazole, which acts as a sterol 14α-demethylation inhibitor (DMI), can exhibit strong inhibitory effects on Fusarium pseudograminearum. However, the resistance mechanism as well as the risk that F. pseudograminearum develops resistance to metconazole is yet to be fully assessed.

High-Efficiency Sn-Pb Perovskite Solar Cells via Nucleation and Crystallization Control.

The rapid crystallization of mixed tin-lead (Sn-Pb) perovskites and their dependence on antisolvent processes limit the development of large-area Sn-Pb perovskite solar cells (PSCs). Vacuum-flash-assisted solution processing (VASP) has emerged as a promising technique for large-scale fabrication. However, achieving consistent control over crystallization parameters remains a limitation.

Tailored Lattice-Matched Carbazole Self-Assembled Molecule for Efficient and Stable Perovskite Solar Cells.

Self-assembled monolayer molecules have been widely employed as interfacial transport materials in inverted perovskite solar cells (PSCs), demonstrating high efficiency and improved device stability. However, self-assembling monolayer (SAM) molecules often suffer from aggregation and weak interactions with the perovskite layer, resulting in inefficient charge transfer and significant energy losses, ultimately limiting the power conversion efficiency and long-term stability of perovskite solar cells. In this work, we developed a series of novel skeleton-matching carbazole isomer SAMs based on the following key design principles: (1) introducing a benzene ring structure to distort the molecular skeleton of the SAM, thereby preventing aggregation and achieving a uniform distribution on fluorine-doped tin oxide (FTO) substrates; (2) strategically incorporating methoxy groups onto the benzene ring at different positions (ortho, meta, and para).

MRI to digital medicine diagnosis: integrating deep learning into clinical decision-making for lumbar degenerative diseases.

Introduction: To develop an intelligent system based on artificial intelligence (AI) deep learning algorithms using deep learning tools, aiming to assist in the diagnosis of lumbar degenerative diseases by identifying lumbar spine magnetic resonance images (MRI) and improve the clinical efficiency of physicians.

Methods: The PP-YOLOv2 algorithm, a deep learning technique, was used to design a deep learning program capable of automatically identifying the spinal diseases (lumbar disc herniation or lumbar spondylolisthesis) based on the lumbar spine MR images. A retrospective analysis was conducted on lumbar spine MR images of patients who visited our hospital from January 2017 to January 2022.

Buried hole-selective interface engineering for high-efficiency tin-lead perovskite solar cells with enhanced interfacial chemical stability.

Mixed Sn-Pb perovskites are attracting significant attention due to their narrow bandgap and consequent potential for all-perovskite tandem solar cells. However, the conventional hole transport materials can lead to band misalignment or induce degradation at the buried interface of perovskite. Here we designed a self-assembled material 4-(9H-carbozol-9-yl)phenylboronic acid (4PBA) for the surface modification of the substrate as the hole-selective contact.

pH Nonlinearly Dominates Soil Bacterial Community Assembly along an Altitudinal Gradient in Oak-Dominant Forests.

Soil bacteria, the predominant microbiota in soil, are subject to the law of minimum and the law of tolerance, but the assembly patterns of soil bacteria in response to environmental factors remain far from clear. Here, we took advantage of an altitudinal gradient (1020-1770 asl) in oak-dominant forests and assessed whether soil bacteria linearly or nonlinearly respond to environmental properties through the changes in the community diversity and composition. We found that soil bacteria decreased with increasing altitude in terms of the species richness and phylogenetic structure, while they were unchanged with increasing altitude in terms of community composition.

Suppressed Defects by Functional Thermally Cross-Linked Fullerene for High-Efficiency Tin-Lead Perovskite Solar Cells.

Mixed tin-lead (Sn-Pb) perovskites have attracted the attention of the community due to their narrow bandgap, ideal for photovoltaic applications, especially tandem solar cells. However, the oxidation and rapid crystallization of Sn and the interfacial traps hinder their development. Here, cross-linkable [6,6]-phenyl-C-butyric styryl dendron ester (C-PCBSD) is introduced during the quenching step of perovskite thin film processing to suppress the generation of surface defects at the electron transport layer interface and improve the bulk crystallinity.

Inhibiting Interfacial Nonradiative Recombination in Inverted Perovskite Solar Cells with a Multifunctional Molecule.

Interface-induced nonradiative recombination losses at the perovskite/electron transport layer (ETL) are an impediment to improving the efficiency and stability of inverted (p-i-n) perovskite solar cells (PSCs). Tridecafluorohexane-1-sulfonic acid potassium (TFHSP) is employed as a multifunctional dipole molecule to modify the perovskite surface. The solid coordination and hydrogen bonding efficiently passivate the surface defects, thereby reducing nonradiative recombination.

Controlling Tin Halide Perovskite Oxidation Dynamics in Solution for Perovskite Optoelectronic Devices.

As a leading contender to replace lead halide perovskites, tin-based perovskites have demonstrated ever increasing performance in solar cells and light-emitting diodes (LEDs). They tend to be processed with dimethyl sulfoxide (DMSO) solvent, which has been identified as a major contributor to the Sn(II) oxidation during film fabrication, posing a challenge to the further improvement of Sn-based perovskites. Herein, we use NMR spectroscopy to investigate the kinetics of the oxidation of SnI, revealing that autoamplification takes place, accelerating the oxidation as the reaction progresses.

Hydrogen Production via Electrolysis of Wastewater.

The high energy consumption of traditional water splitting to produce hydrogen is mainly due to complex oxygen evolution reaction (OER), where low-economic-value O gas is generated. Meanwhile, cogeneration of H and O may result in the formation of an explosive H/O gas mixture due to gas crossover. Considering these factors, a favorable anodic oxidation reaction is employed to replace OER, which not only reduces the voltage for H production at the cathode and avoids H/O gas mixture but also generates value-added products at the anode.

Adaptive Force Field Parameter Optimization for Expanding Reaction Simulations within Wide-Ranged Temperature.

Large-scale and long-term simulation of chemical reactions are key research topics in computational chemistry. However, there are still difficulties in simulating high-temperature reactions, such as polymer thermal decomposition. Herein, we introduce an adaptive potential parameter optimization framework designed to automatically fine-tune parameters, and the application of it to optimize ReaxFF parameters enhances the accuracy of chemical reaction simulations conducted at experimental temperatures.

Resistance risk, resistance mechanism and the effect on DON production of a new SDHI fungicide cyclobutrifluram in Fusarium graminearum.

Fusarium head blight in wheat is caused by Fusarium graminearum, resulting in significant yield losses and grain contamination with deoxynivalenol (DON), which poses a potential threat to animal health. Cyclobutrifluram, a newly developed succinate dehydrogenase inhibitor, has shown excellent inhibition of Fusarium spp. However, the resistance risk of F.

Analysis of resistance risk and mechanism of the 14α-demethylation inhibitor ipconazole in Fusarium pseudograminearum.

Ipconazole is a broad-spectrum triazole fungicide that is highly effective against Fusarium pseudograminearum. However, its risk of developing resistance and mechanism are not well understood in F. pseudograminearum.

Anchoring Charge Selective Self-Assembled Monolayers for Tin-Lead Perovskite Solar Cells.

Self-assembled monolayers (SAMs) have displayed great potential for improving efficiency and stability in p-i-n perovskite solar cells (PSCs). The anchoring of SAMs at the conductiv metal oxide substrates and their interaction with perovskite materials must be rationally tailored to ensure efficient charge carrier extraction and improved quality of the perovskite films. Herein, SAMs molecules with different anchoring groups and spacers to control the interaction with perovskite in the p-i-n mixed Sn-Pb PSCs are selected.

Resistance risk assessment of mefentrifluconazole in Corynespora cassiicola and the control of cucumber target spot by a two-way mixture of mefentrifluconazole and prochloraz.

The cucumber target spot, caused by Corynespora cassiicola, is a major cucumber disease in China. Mefentrifluconazole, a new triazole fungicide, exhibits remarkable efficacy in controlling cucumber target spot. However, the resistance risk and mechanism remain unclear.

Mefentrifluconazole-Resistant Risk and Resistance-Related Point Mutation in FpCYP51B of .

Mefentrifluconazole, a triazole fungicide, exhibits remarkable efficacy in combating spp. The mean EC value of mefentrifluconazole against 124 isolates of was determined to be 1.06 μg/mL in this study.

One-Step Solution Deposition of Tin-Perovskite onto a Self-Assembled Monolayer with a DMSO-Free Solvent System.

We show for the first time DMSO-free tin-based perovskite solar cells with a self-assembled hole selective contact (MeO-2PACz). Our method provides reproducible and hysteresis-free devices with MeO-2PACz, having the best device PCE of 5.8 % with a of 638 mV.