Dynamic Restructuring of Stacking-Fault-Rich Copper Catalysts.

Copper (Cu) catalysts with abundant defects are pivotal for converting CO into valuable multi-carbon products. However, the practical application of Cu catalysts is challenged by the thermodynamic instability of the defects, often leading to surface reconstruction during catalytic processes. Here, it is found that particle size and COO-containing intermediates are key factors driving reconstruction, as the defect stability is size-dependent and can be amplified by leveraging the highly reactive intermediates as the initial reactant.

A U-box E3 ubiquitin ligase CmPUB15 targets CmMYB73 to regulate anthocyanin biosynthesis in response to low temperatures in chrysanthemum.

During annual chrysanthemum production, low temperatures (10°C, the same below) can promote anthocyanin accumulation in petals. However, the specific mechanism behind this phenomenon remains unclear. In this study, we identified CmMYB73, an SG22 R2R3-MYB transcription factor, as a negative regulator of anthocyanin biosynthesis in chrysanthemum.

Fast deconvolved beamforming for arbitrary arrays based on off-grid sparse Bayesian learning.

The deconvolved beamforming (dCv) improves spatial resolution without expanding the array aperture but fails for the shift-variant beam pattern and the real targets, which are not located on the sampling grids. To solve them, this Letter extends the off-grid sparse Bayesian learning (OGSBL) to dCv because the generalized convolutional model considers the beam pattern at each angle in beam domain. OGSBL reduces modeling errors by parameterizing sampled locations in coarse grids.

Atomistic Insights into Fluorinated/Chlorinated Ether-Based LHCEs on Lithium Metal: Decomposition Mechanisms via Multiscale Simulations.

The interfacial stability of localized high-concentration electrolytes (LHCEs) with fluorinated (F2DEE) or chlorinated (Cl2DEE) ether solvents critically controls lithium metal battery performance. However, atomistic mechanisms driving their solid electrolyte interphase (SEI) formation remain unclear. We systematically compare the decomposition pathways of 1LiFSI-1.

Duhuo jisheng decoction alleviates osteoarthritis progression by mitigating ferroptosis in chondrocytes via the nuclear factor erythroid 2-related factor 2/glutathione peroxidase 4 axis.

Ethnopharmacological Relevance: Osteoarthritis (OA) is a leading cause of disability worldwide, imposing a substantial burden on global public health and healthcare systems. Currently, there are no viable strategies to halt the progression or reverse the course of this disease. Duhuo Jisheng Decoction (DHJSD) has been extensively employed in treating OA.

The role of healthy personality, psychological flexibility, and coping mechanisms in university students' mental health in China.

Background: Mental health issues such as anxiety and depression have become increasingly common among Chinese university students, especially after the COVID-19 pandemic. This study explores the relationships between personality health, psychological flexibility, coping styles, and mental health in this population.

Methods: A cross-sectional survey was conducted with 2,528 university students (aged 18-25, 53.

First case report in China of Gitelman syndrome associated with ileocecal polyps in a child: a case report.

Background: Gitelman syndrome (GS) is a rare autosomal recessive renal tubular disorder characterized by hypokalemia, metabolic alkalosis, and hypomagnesemia.While gastrointestinal polyps are common in children, their co-occurrence with GS is exceedingly rare. This report presents the first documented pediatric case in China of GS associated with ileocecal polyps.

Multi-module UNet++ for colon cancer histopathological image segmentation.

In the pathological diagnosis of colorectal cancer, the precise segmentation of glandular and cellular contours serves as the fundamental basis for achieving accurate clinical diagnosis. However, this task presents significant challenges due to complex phenomena such as nuclear staining heterogeneity, variations in nuclear size, boundary overlap, and nuclear clustering. With the continuous advancement of deep learning techniques-particularly encoder-decoder architectures-and the emergence of various high-performance functional modules, multi module collaborative fusion has become an effective approach to enhance segmentation performance.

Robust Fractional Low Order Adaptive Linear Chirplet Transform and Its Application to Fault Analysis.

Time-frequency analysis (TFA) technology is an important tool for analyzing non-Gaussian mechanical fault vibration signals. In the complex background of infinite variance process noise and Gaussian colored noise, it is difficult for traditional methods to obtain the highly concentrated time-frequency representation (TFR) of fault vibration signals. Based on the insensitive property of fractional low-order statistics for infinite variance and Gaussian processes, robust fractional lower order adaptive linear chirplet transform (FLOACT) and fractional lower order adaptive scaling chirplet transform (FLOASCT) methods are proposed to suppress the mixed complex noise in this paper.

Histone demethylase KDM5C is critical for cartilage development and protects against osteoarthritis by increasing HIF-1α to maintain mitochondrial function.

Objective: With age-related incidence and prevalence, osteoarthritis (OA) is becoming a major source of disability with an increased medical burden worldwide. Lysine Demethylase 5 C (KDM5C) mutation causes abnormalities of epilepsy and short stature. Our previous study has demonstrated KDM5C is indispensable for osteogenesis and bone formation.

Aroma-Driven Differentiation of Wuyi Shuixian Tea Grades: The Pivotal Role of Linalool Revealed by OAV and Multivariate Analysis.

Wuyi Shuixian tea, a premium oolong tea known for its complex floral-fruity aroma, exhibits significant quality variations across different grades. This study systematically analyzed the aroma characteristics and key fragrant compounds of four grades (Grand Prize SA, First Prize SB, Outstanding Award SC, and Non-award SD) using headspace solid-phase microextraction-gas chromatography-mass spectrometry (HS-SPME-GC-MS), odor activity value (OAV) analysis, and multivariate statistical methods. A total of 159 volatile compounds were identified, with similar compound categories but distinct concentration gradients between grades.

Female Perioral Aesthetic and Therapeutic Strategies of Chinese Population in China.

Background: With the increase in demand for lip aesthetics and antiaging solutions, coupled with advancements in medical aesthetic technology and changing beauty trends, there has been a growing focus on refining specific facial features. However, significant differences exist in the aesthetic perceptions of lips between Chinese and Western populations, and limited research has been conducted on the aesthetic preferences and personalized lip design for Eastern individuals. Therefore, understanding public preferences is essential for developing tailored treatment approaches.

WT1 directs normal progesterone receptor-chromatin binding essential for uterine receptivity at peri-implantation.

Progesterone receptor (PR)-mediated progesterone (P4) signaling plays a crucial role in the establishment of uterine receptivity which is the prerequisite for successful embryo implantation in mammals. However, detailed molecular mechanisms underlying PR-chromatin binding and transcriptional activity in the uterus remain largely elusive. Here, combining the P4-administrated ovariectomized mouse model and PR-chromatin immunoprecipitation sequencing, we identified transcription factor WT1 as a potential cooperator of PR in the uterus.

Fluorescent probes for the visualization of membrane microdomain, deformation, and fusion.

The cell membrane, a fluid interface composed of self-assembled phospholipid molecules, is a vital component of biological systems that maintains cellular stability and prevents the invasion of foreign toxins. Due to its inherent fluidity, the cell membrane can undergo bending, shearing, and stretching, making membrane deformation crucial in processes like cell adhesion, migration, phagocytosis, and signal transduction. Within the plasma membrane are highly ordered dynamic structures formed by lipid molecules, known as "lipid rafts," whose dynamic dissociation and reorganization are prerequisites for membrane deformation.

Endometrial stromal Menin supports endometrial receptivity by maintaining homeostasis of WNT signaling pathway through H3K4me3 during WOI.

Dysregulated endometrial receptivity is a well-established critical factor that contributes to recurrent implantation failure (RIF). Decidualization of stromal cells and differentiation of epithelial cells in the endometrium are crucial processes for achieving endometrial receptivity. Menin, the unique subunit of the H3K4 methyltransferase complex, exhibits cell-specific effects on gene expression through chromatin modification by histone 3 lysine 4 trimethylation (H3K4me3).

Household clusters of SARS-CoV-2 Omicron subvariants contemporaneously sequenced from dogs and their owners.

Monitoring the zoonotic potential of emerging SARS-CoV-2 variants in animals is a critical tool to protect public health. We conducted a longitudinal study in 47 households reporting people with COVID-19 in Texas from January to July 2022, during the first Omicron wave. We evaluated 105 people and 100 of their companion animals for SARS-CoV-2 infection at three sequential sampling events, starting 0-5 days after the first reported diagnosis of COVID-19 in the house.

EDTA-Mediated Electrodeposition of Ag-Ni Dual-Atom on the Cu Substrate for Enhanced Alkaline Hydrogen Evolution.

Dual-atom catalysts (DACs) are designed to enhance catalytic activity through synergy among adjacent heteroatoms. Herein, we report the synthesis of an CuAgNi-DAC, where AgNi dual atoms are complexed with ethylenediaminetetraacetic acid and electrodeposited onto a copper nanoparticles deposited on copper substrates. The presence of AgNi dual atoms was confirmed by electron energy loss spectrometer and high-angle annular dark field-scanning transmission electron microscopy.

Macropinocytosis: Molecular mechanisms and regulation.

Macropinocytosis is a conserved pathway for non-selective bulk uptake of extracellular fluid. It plays important roles in various cellular processes, including nutrient acquisition in Dictyostelium and cancer cells and antigen sampling by immune cells. This process is initiated by localized actin polymerization, which drives the formation of membrane protrusions that close to generate macropinosomes.

Multimodal analgesia in cardiac surgery: Impact on postoperative medication consumption and cognitive function.

Background: Patients who undergo cardiac surgery often face postoperative pain and potential cognitive issues. Multimodal analgesia may address these problems. We hypothesized that multimodal analgesia can reduce opioid use and improve cognitive recovery.

Mechanisms of Complications from Ear Filler Injections: A Cadaver Imaging and Anatomical Study.

Background: Our society's focus on facial beauty has recently expanded to ear beauty, with an increase in related complications. We aimed to elucidate the mechanisms underlying complications associated with ear filler injections by exploring the course of auricular blood vessels through cadaver anatomical and imaging examinations.

Methods: Thirty cadavers underwent arterial perfusion with red latex, and computed tomography was utilized for 3D reconstruction to analyze the relations between arteries, nerves, and lesions in the auricular area.

Dahongpao mother tree affects soil microbial community and nutrient cycling by increasing rhizosphere soil characteristic metabolite content.

Cuttings are an important way of propagating tea trees (). In this study, Dahongpao mother tree (MD) and cutting Dahongpao (PD) were used as research objects and their rhizosphere soil were collected and performed metabolomics analysis. At the same time, soil nutrient content, microbial physiological indexes, and microbial carbon source utilization were determined, which in turn obtained the effect of cuttings on metabolites, microorganisms, and nutrient cycling in rhizosphere soil of tea trees.

Impact of Anatomical Variations of Right Hepatic Artery on Biliary Obstruction and Liver Fibrosis in Pediatric Congenital Biliary Dilatation Patients: A Retrospective Analysis of 1464 Cases.

Background: The role of the ventrally positioned right hepatic artery (RHA) in congenital biliary dilatation (CBD) remains unclear.

Methods: We retrospectively analyzed 1464 pediatric CBD patients undergoing surgery from 2015 to 2023, comparing those with ventrally positioned versus normal RHA.

Results: Ventrally positioned RHA was identified in 10.

Alpinetin protects against iron overload related osteoarthritis via NRF2/HO-1 pathway.

Context: Alpinetin(APT) is a natural product with anti-inflammatory and antioxidant effects. Iron overload has been recognized in recent years as a new way to exacerbate osteoarthritis.

Objective: This study evaluated the effects of ATP on iron overload related osteoarthritis.

Hyperoside improves intestinal mucosal immunity against zearalenone-induced intestinal barrier damage by regulating intestinal flora.

Zearalenone (ZEA) is a mycotoxin that is immunotoxic and causes intestinal damage. Hyperoside (HYP) is a natural flavonol side with a wide range of sources and has a variety of pharmacological effects. The aim of this study is to investigate the effect and mechanism of HYP on ΖΕΑ-induced intestinal immunosuppression and intestinal injury in piglets.