Analysis of influencing factors and construction of predictive model for major gastrointestinal bleeding after receiving VTE prophylactic anticoagulants in non-tumor patients.

Objective: This study explored the factors associated with major gastrointestinal bleeding (MGB) after the use of prophylactic anticoagulants in patients with high risk of venous thromboembolism (VTE) and developed a predictive model to more accurately identify patients at high risk of MGB.

Methods: We collected related data on patients with a high risk of VTE and a low risk of bleeding between January 2020 and December 2024. Propensity score matching (PSM) was conducted to balance the important factors related to the disease status between the non-MGB and MGB groups.

Microplastics and Soil Greenhouse Gas Emissions: A Critical Reflection on Meta-Analyses.

Microplastics (MPs) are widespread in agricultural soils and may influence emissions of greenhouse gases (GHGs), though their specific impacts remain uncertain. This study utilized conventional and network meta-analysis to evaluate the effects of long-term exposure to environmentally relevant MP concentrations. Results showed that, compared with uncontaminated soil, polypropylene increased CH emissions by 2.

Trap loss spectroscopy of ultra-cold Rydberg atoms involved in microwave fields.

Trap loss spectroscopy, based on fluorescence detection, provides a real-time measurement technique that is advantageous for ultra-cold atomic systems, to monitor the interaction between microwave fields and Rydberg atoms. By employing the polarization combinations of excitation lasers and microwave fields, we achieve trap loss spectroscopy of multi-path transitions in magnetic Rydberg hyperfine states and observe Zeeman broadening. The contributions of laser power, Zeeman effect, and collision effects to the broadening of the trap loss spectrum were comprehensively analyzed.

Early immunotherapy in a patient with myelin oligodendrocyte glycoprotein antibody-associated disease with syphilis and acquired immunodeficiency syndrome: a case report.

This is the case of a 41-year-old man who presented with blurred vision, unconsciousness, and fever with a positive Babinski sign on both sides. Blurred vision, unconsciousness, and fever are commonly seen in neurology and emergency settings, with a wide range of potential etiologies. Myelin oligodendrocyte glycoprotein antibody-associated disease (MOGAD) often occurs after infection, but cases of syphilis and human immunodeficiency virus as precursors are rarely reported.

Cu-based dual-metal site catalysts for efficient alkaline hydrogen evolution reaction.

We synthesized a CuRhCr DMSC with isolated Rh and Cr single atoms in Cu nanoparticles a spark ablation in liquid (SAL) method. The isolated Rh and Cr single atoms have different coordination environments and can synergistically drive the catalytic process. The alkaline HER electrocatalytic performance of the CuRhCr DMSC is comparable to that of commercial Pt/C.

Clock gene ARNTL2 enhances 5-fluorouracil resistance in colon cancer by upregulating SLC7A11 to suppress ferroptosis.

Colorectal cancer, a leading cause of global cancer-related morbidity and mortality, poses a significant challenge with its incidence rising. 5-fluorouracil (5-FU), a key chemotherapy agent, faces the challenge of drug resistance. Clock genes, which regulate circadian rhythms, are linked to tumor occurrence, progression, and treatment responses, and are often abnormally expressed in many tumors.

Glial Fibrillary Acidic Protein Astrocytopathy Based on a Two-Center Chinese Cohort Study.

Objective: Glial fibrillary acidic protein astrocytopathy (GFAP-A) is a recently defined nosological form belonging to the class of autoimmune inflammatory disorders affecting the central nervous system (CNS). Here, we report the clinical and MRI characteristics, treatment, and prognosis of a GFAP-A cohort from two centers in China.

Methods: We retrospectively analyzed the data from 38 adult patients with positive GFAP antibodies and diagnosed as GFAP-A between June 2019 and September 2024.

Surgical Outcomes in Metastatic Mismatch Repair-Deficient/Microsatellite Instability-High Colorectal Cancer After Disease Control With Immune Checkpoint Inhibitors: A Retrospective Observational Study.

Background: Surgical intervention after systemic therapy improves prognosis in metastatic colorectal cancer. However, surgical outcomes after immune checkpoint inhibitor therapy remain controversial in patients with mismatch repair-deficient/microsatellite instability-high disease.

Objective: This study aimed to demonstrate the outcomes of patients with metastatic mismatch repair-deficient/microsatellite instability-high colorectal cancer who underwent curative surgery after achieving disease control with immune checkpoint inhibitors.

EDTA-Mediated Electrodeposition of Ag-Ni Dual-Atom on the Cu Substrate for Enhanced Alkaline Hydrogen Evolution.

Dual-atom catalysts (DACs) are designed to enhance catalytic activity through synergy among adjacent heteroatoms. Herein, we report the synthesis of an CuAgNi-DAC, where AgNi dual atoms are complexed with ethylenediaminetetraacetic acid and electrodeposited onto a copper nanoparticles deposited on copper substrates. The presence of AgNi dual atoms was confirmed by electron energy loss spectrometer and high-angle annular dark field-scanning transmission electron microscopy.

Effects of Cu Addition on the Microstructures and Properties of WC-12Co Cemented Carbides Additively Manufactured by Laser Powder-Bed Fusion.

The preparation of WC-Co cemented carbides by laser-based additive manufacturing (AM) is challenging, as the resulting products are often plagued by crack and pore defects. In this study, Cu-doped WC-12Co cemented carbides were successfully prepared by laser powder-bed fusion (LPBF). The effects of LPBF parameters and Cu doping on the defects, microstructures, and properties of the WC-12Co cemented carbides were analyzed.

Time delay of mean-field interaction in thermal Rydberg atomic gases.

Mean-field theory is commonly employed to study nonequilibrium dynamics in hot Rydberg atomic ensembles, but the fundamental mechanism behind the generation of the mean-field interactions remains poorly understood. In this work, we experimentally observe a time-delay effect in the buildup of mean-field interaction, which reveals the key role of collision ionization. We analyze the relevant collision channels and propose a microscopic mechanism that quantitatively explains the hysteresis window observed in optical bistability.

Large power dynamic range microwave electric field sensing in a vapor cell.

Sensing of the microwave (MW) electric field with high accuracy and large power dynamic range has assisted in the implementation of metrology and communication. Here, an atom-based MW sensing system with a large linear power dynamic range for an electric field in the C band of 6.835 GHz is demonstrated in a vapor cell.

Triple-Cue-Guided Multichannel Hydrogel Conduit to Synergistically Enhance Peripheral Nerve Repair.

Multichannel nerve guidance conduits (NGCs) have demonstrated superior efficacy in the regeneration of large nerve defects. Here, we present the incorporation of three synergistic guiding cues into a single multichannel hydrogel conduit: topographical guidance, a conductivity gradient, and a nerve growth factor (NGF) gradient. The aligned hydrogel conduit is fabricated through directional lyophilization of a graphene oxide (GO)/poly(vinyl alcohol) (PVA) solution.

Tumefactive demyelination as the first presentation of MOG ab-associated disease.

Tumefactive demyelination is a rare but clinically significant manifestation of myelin oligodendrocyte glycoprotein antibody-associated disease (MOGAD), often posing diagnostic challenges due to its resemblance to neoplastic lesions. We report a case of a 45-year-old woman presenting with a 3-week history of limb weakness, slowed responsiveness, and aphasia. Neurological examination revealed confusion and sensory aphasia.

Biochar alleviates adverse effects of polystyrene microplastics on anaerobic digestion performance of food waste and antibiotic resistance gene propagation.

This study systematically evaluated the efficacy of feedstock-derived biochars (maize straw, rice husk, bamboo) in mitigating polystyrene microplastic (PSMP)-induced inhibition of food waste anaerobic digestion performance and antibiotic resistance gene (ARG) dissemination. Biochar addition increased cumulative methane production by 4.3%-8.

Efficacy of tranexamic acid application in gynecology and obstetrics procedures: a umbrella review of systematic reviews of randomized trials.

Objective: This umbrella review aimed to synthesize evidence from systematic reviews of clinical trials on the efficacy of tranexamic acid in gynecology and obstetrics procedures.

Methods: We searched Medline, Embase, SciELO and Cochrane Database of Systematic Reviews on March 11, 2024, using the term "tranexamic acid". Four reviewers independently select studies and extract data.

Irisin restrains neuroinflammation in mouse experimental autoimmune encephalomyelitis via regulating microglia activation.

Introduction: Multiple sclerosis is a chronic autoimmune demyelinating disorder predominantly affecting the white matter of the central nervous system, with experimental autoimmune encephalomyelitis (EAE) serving as its classical animal model. Irisin, a glycosylated protein derived from the proteolytic cleavage of fibronectin type III domain-containing protein 5, plays a significant role in metabolic regulation and inflammatory modulation within the organism.

Methods: In this study, we systematically investigated the therapeutic effects and underlying mechanism of Irisin on EAE and BV2 microglial cells through comprehensive methodologies including quantitative real-time polymerase chain reaction, immunofluorescence staining and western blot.

DDX3 Regulates the Cap-Independent Translation of the Japanese Encephalitis Virus via Its Interactions with PABP1 and the Untranslated Regions of the Viral Genome.

The translation of global cellular proteins is almost completely repressed in cells with flavivirus infection, while viral translation remains efficient. The mechanisms of flaviviruses evade host translational shutoff are largely unknown. Here, it is found that Japanese encephalitis virus (JEV) can adopt cap-independent (CI) translation to escape the host translational shutoff.

A novel hydroxytyrosol derivative HT-3 enhances antioxidant and neuroprotective activity through efficient molecular conjugation.

Molecular conjugation is a promising strategy for drug development, which could enhance the efficacy, selectivity, and bioavailability of high-potency compounds through precise structural modifications. Our previous studies demonstrated that hydroxytyrosol (HT) provides excellent neuroprotection in PC12 cells, which is derived from olive oil, and now widely used as a natural food additive. In this study, we rationally designed and synthesized a string of HT derivations by coupling caffeic acid skeletons, and found that HT-3 exhibited the strongest antioxidant activity and superior neuroprotective efficacy via the Keap1/Nrf2/ARE pathway among the HT analogue.

Transfer Learning Empowered Multiple-Indicator Optimization Design for Terahertz Quasi-Bound State in the Continuum Biosensors.

Terahertz metasurface biosensors based on the quasi-bound state in the continuum (QBIC) offer label-free, rapid, and ultrasensitive biomedical detection. Recent advances in deep learning facilitate efficient, fast, and customized design of such metasurfaces. However, prior approaches primarily establish one-to-one mappings between structure and optical response, neglecting the trade-offs among key performance indicators.

Dual Transverse Arch Foot Orthosis Improves Gait Biomechanics in Females with Flexible Flatfoot.

(1) Background: Flexible flatfoot is characterized by medial arch collapse, leading to musculoskeletal impairments. We examined the effects of single-arch foot orthosis (SFO) and dual-arch foot orthosis (DFO) on arch height, kinematics, and kinetics in young females during walking and jogging. (2) Methods: Healthy females (n = 19) with flexible flatfoot were tested under three conditions: regular shoes, SFO, and DFO.

Redox dyshomeostasis-driven prodrug strategy for enhancing camptothecin-based chemotherapy: Selenization of SN38 as a case study.

Harnessing the modulation of redox homeostasis represents a promising anticancer strategy. Here, we design and evaluate Se-SN38, a prodrug of the camptothecin (CPT) derivative 7-ethyl-10-hydroxycamptothecin (SN38) with a cyclic five-membered diselenide moiety for redox-triggered activation. We demonstrate that Se-SN38 exhibits superior cytotoxicity in various cancer cell lines over the parent drug SN38 or the control prodrug S-SN38, a sulfur analogue of Se-SN38.

Active-Site-Switching in Medium-Entropy Metal Sulfides for Wide-Temperature High-Power Zn-Air Pouch Cells.

Quasi-solid-state Zn-air pouch cells (QZPCs) promise a high energy-to-cost ratio while ensuring inherent safety. However, addressing the challenges associated with exploring superior energy-wise cathode catalysts along with their activity origin, and the super-ionic electrolytes remains a fundamental task. Herein, the realistic high-performance QZPCs are contrived, underpinned by a robust NiVFeCo medium-entropy metal sulfides (MESs) bifunctional air cathode with a record-low potential polarization of 0.

Juvenile hormone and energy metabolism shape the optimal timing of flight to reproduction transition in migratory locusts.

Migratory insects are capable of long-distance flight and strong fecundity, but often have finite amounts of resources available for these energy-demanding traits. Although the trade-off between flight and reproduction has been reported in migratory insects, the optimal timing of flight to reproduction transition remains largely unknown. Here, using the gregarious phase of migratory locust Locusta migratoria, we report that 4-d-old adult females possessed the strongest flight capacity in the first gonadotrophic cycle.

Decoding the Plastic Patch: Exploring the Global Microplastic Distribution in the Surface Layers of Marine Regions with Interpretable Machine Learning.

The marine environment is grappling with microplastic (MP) pollution, necessitating an understanding of its distribution patterns, influencing factors, and potential ecological risks. However, the vast area of the ocean and budgetary constraints make conducting comprehensive surveys to assess MP pollution impractical. Interpretable machine learning (ML) offers an effective solution.