A water-soluble phenothiazine-based fluorescent probe for selective detection and bioimaging of hypochlorite.

A hydrophilic phenothiazine-based fluorescent probe (PTZMN) was developed for the selective and sensitive detection of hypochlorite (ClO) in pure water. Upon ClO stimulation, PTZMN exhibited a distinct colorimetric shift and a "turn-on" fluorescence response at 496 nm, with a low detection limit of 5.2 × 10 mol/L and excellent linearity (R = 0.

Nano MgO loaded thermosensitive HPCH@HA hydrogel accelerates in situ bone repair through osteoimmunomodulation while enhancing angiogenesis and osteogenesis.

Bone defect repair is a complex physiological process, starting with early modulation by the inflammatory immune system, and involves multiple physiological events, including angiogenesis, osteogenic differentiation, and mineralization. Biomaterial can regulate inflammatory responses through relevant immune cells in the local immune microenvironment of the implant-bone interface which is a hot topic in the field of regenerative medicine. Currently, Mg regulates immune cells in the bone microenvironment to promote osteogenesis and angiogenesis mainly focuses on macrophages,but there is relatively little research on T cells.

Head-tail carboboration of multisubstituted alkenes enabled by chain recognition.

Precision in site-selective functionalization of molecules bearing multiple potentially reactive positions is a longstanding challenge in organic synthesis. Although migratory difunctionalization offers a powerful strategy for programmed functional group installation along carbon chains, its implementation with multisubstituted alkenes has been impeded by the increased complexity of site-selectivity. Here we report a head-tail carboboration of multisubstituted alkenes with exceptional site-selectivity, enabled by ligand steric exclusion in a nickel-catalysed chain-walking system.

Helicobacter pylori, peptic ulcer disease, and colorectal cancer: a prospective study with genome-wide interaction analysis and Mendelian randomization.

Introduction: Helicobacter pylori (HP) is a well-established gastric carcinogen. But it shows inconsistent association with colorectal cancer (CRC) across diverse study populations.

Methods: We investigated participants from the UK biobank.

Graft PD-L1 as a predictive marker for rejection in PD-1 inhibitor therapy for recurrent liver tumors post-transplant: A prospective pilot trial.

The safety of immunotherapy in transplant patients remains unclear due to rejection risks. This study assessed the safety and efficacy of programmed death-1 (PD-1) inhibitors in post liver-transplantation patients with recurrent tumors, emphasizing the value of using graft programmed death-ligand 1 (PD-L1) expression as a predictor of rejection to guide patient selection. This single-center, open-label, prospective, single-arm study was conducted from July 2019 to May 2024 at Zhongshan Hospital, Fudan University (Shanghai, China).

Three-dimensional craniofacial morphology predicts periodontal tissue dimensions using the facial scanner.

Background: Despite growing interest in dentofacial interactions, evidence linking three-dimensional (3D) craniofacial morphology to periodontal phenotypes remains sparse. This cross-sectional study aimed to investigate correlations between maxillary anterior periodontal parameters and 3D craniofacial morphology in a Chinese population.

Methods: Participants underwent cone-beam computed tomography (CBCT) and intraoral scans to quantify bone thickness (BT) (at 2 mm [BT] and 4 mm [BT] apical to the alveolar crest), gingival thickness (GT) (at cemento-enamel junction [GT] and bone crest [GT]), and periodontal supra-crestal tissue height (PSTH).

Long-term oncological outcomes of indocyanine green fluorescence imaging-guided laparoscopic lymphadenectomy for gastric cancer: 5-year outcomes from the FUGES-012 randomized clinical trial.

Background: The clinical use of indocyanine green (ICG) in laparoscopic radical gastrectomy for gastric cancer remains at an exploratory stage.

Methods: Participants with resectable gastric adenocarcinoma were randomly allocated in a 1:1 ratio. The primary outcome is the number of retrieved lymph nodes (LNs) and has been reported.

Association between adjusted atherogenic index of plasma and major adverse cardiovascular events after percutaneous coronary intervention in patients with STEMI: a prospective observational study in China.

Objectives: The atherogenic index of plasma (AIP) has been reported as a biomarker for cardiovascular disease risks and clinical outcomes. However, few studies have investigated the relationship between the AIP and major adverse cardiovascular events (MACEs) after percutaneous coronary intervention (PCI) in patients with ST-segment elevation myocardial infarction (STEMI).

Design: Prospective observational study.

Ultralow Shrinkage 3D Transparent Nanoporous Glass Printing through Low-Temperature Sintering for Micro-Optical Applications.

Current glass additive manufacturing relies on high-temperature processing to achieve optical transparency accompanied by significant structural shrinkage. These factors significantly restrict the micro-optical applications of three-dimensional (3D) glass microstructures in microsystems. Here, a low-temperature, low-shrinkage 3D printing strategy for transparent nanoporous glass microstructures is presented using a molecular cross-linker-free resin containing methacrylic acid-functionalized nanoparticles (MAA-NPs).

The predictive value of D-dimer combined with systemic immune-inflammation index for the presence of pulmonary thromboembolism in AECOPD patients.

Objective: This study aims to evaluate the predictive potential of D-dimer levels and the systemic immune-inflammatory index (SII) for identifying concurrent pulmonary thromboembolism (PTE) in patients with acute exacerbations of chronic obstructive pulmonary disease (AECOPD).

Methods: We conducted a case-control study involving 75 patients with AECOPD and concurrent PTE, admitted to the Affiliated Hospital of Guangdong Medical University between June 2017 and December 2020. A control group comprising 76 AECOPD patients without PTE was included for comparison.

FTO degrader impairs ribosome biogenesis and protein translation in acute myeloid leukemia.

Targeting ribosome biogenesis and protein translation has emerged as a promising avenue for cancer therapy. The fat mass and obesity-associated protein (FTO), an RNA -methyladenosine (mA) eraser, has been identified as an oncogenic factor in acute myeloid leukemia (AML). Here, we present the development of an FTO degrader that selectively degrades FTO in AML cells, demonstrating superior efficacy both in vitro and in vivo.

Bioarchitectonics-inspired soft grippers with cutaneous slip perception.

The growing demand for dexterous and autonomous robotic manipulation highlights the need for advanced sensing and control strategies, particularly for slip prevention. Although soft grippers provide intrinsic compliance and adaptability, their effectiveness is often limited by the lack of real-time sensory feedback and the complexity of soft actuator dynamics. Inspired by human tactile perception, we developed a bioarchitectonics-inspired soft slip sensor with a three-dimensional structure that leverages crack and stress concentration to enhance sensitivity to incipient slip and shear force.

ALKBH1 drives tumorigenesis and drug resistance via tRNA decoding reprogramming and codon-biased translation.

Cancer cells utilize codon-biased translation to fuel tumorigenesis and drug resistance, but underlying mechanisms remain poorly understood. Here, we show ALKBH1 is overexpressed in acute myeloid leukemia (AML) and essential for leukemia stem/initiating cell (LSC/LIC) self-renewal and AML development/maintenance, whereas dispensable for normal hematopoiesis. ALKBH1 enhances mitochondrial assembly/function and oxidative phosphorylation (OXPHOS), crucial for AML survival/proliferation and resistance to venetoclax, a potent BCL2 inhibitor and widely-used first-line targeted therapy for AML in clinic.

Collapse of density wave and emergence of superconductivity in pressurized-LaNiO evidenced by ultrafast spectroscopy.

Recent discoveries of superconductivity in Ruddlesden-Popper nickelates realize a rare category of superconductors. However, the use of high-pressure diamond anvil cells limits spectroscopic characterization of the density waves and superconducting gaps. Here, we systematically studied the pressure evolution of LaNiO using ultrafast optical pump-probe spectroscopy.

Genome-wide association study identifies FUT2 rs601338 polymorphism linking intra-pancreatic fat deposition to chronic pancreatitis.

Background: Pancreas fat deposition, measured by pancreatic proton density fat fraction (PDFF) in the MRI, has emerged as a critical area of research within the metabolic field. However, its genetic basis and how genetic predisposition impacts the pancreatic disorders remain poorly understood.

Methods: We conducted a genome-wide association study (GWAS) in 20,040 European individuals (excluding those with acute/chronic pancreatitis and pancreatic cancer) from the UK Biobank.

Transcriptomic Analysis Reveals C-C Motif Chemokine Receptor 1 as a Critical Pathogenic Hub Linking Sjögren's Syndrome and Periodontitis.

Compelling evidence has demonstrated a bidirectional relationship between Sjögren's syndrome (SS) and periodontitis (PD). Nevertheless, the underlying mechanisms driving their co-occurrence remain unclear, highlighting the need for finding the hub gene. This study sought to examine the common genes and any connections between SS and PD.

Global colorectal cancer screening programs and coverage rate estimation: an evidence synthesis.

Screening is effective in reducing the disease burden of colorectal cancer, with participation and coverage rates being key determinants of its effectiveness. This systematic review aims to provide a comprehensive assessment of colorectal cancer screening program characteristics and global screening coverage rates. We conducted a systematic literature search in the PubMed and Embase databases from inception to March 2025.

Hypertriglyceridemic pancreatitis: perspectives from China.

Purpose Of Review: This review aims to summarize the recent developments in hypertriglyceridemic acute pancreatitis (HTG-AP) research in China, focusing on its increasing prevalence, pathophysiology, prognosis, and novel treatment strategies, emphasizing the relevance of these findings in clinical practice and research.

Recent Findings: Recent studies have highlighted a rising incidence of HTG-AP in China, especially among young males, linked to dietary and lifestyle changes. Key research has identified lipoprotein metabolism abnormalities and genetic factors as predictors of recurrence.

Evaluation of a novel approach for colorectal cancer screening using an intelligent tool (INTEL-PATH CRC): a protocol for a multicentre, real-world, cohort study.

Introduction: Traditional colorectal cancer (CRC) screening programmes in China face two major challenges: low screening coverage and poor adherence. Mobile health shows promise for cancer prevention, and a WeChat-based intelligent tool has been developed to support full-cycle CRC screening, including risk assessment, individualised screening recommendation, appointment management, result processing and health education. This study aims to evaluate the feasibility and effectiveness of this tool-based screening strategy in a multicentre, prospective cohort.

Efficacy and safety of intensive triglyceride-lowering therapy on reducing recurrence of hypertriglyceridemia-associated pancreatitis (REDUCE): protocol for a multicentre, randomised controlled trial.

Introduction: Recurrence of hypertriglyceridaemia-associated acute pancreatitis (HTG-AP) is common. Uncontrolled HTG after hospital discharge is an important risk factor for recurrence. However, the optimal triglyceride (TG) goal of lipid-lowering therapy for outpatients remains unclear.

High Performance Amphibious Light-Driven Soft Actuators Realized by Biomimetic Superhydrophobic Micropillars.

Light-driven amphibious soft actuators have been a research focus in soft robotics for their superior environmental adaptability and remote controllability. However, achieving amphibious motion in millimeter-scale light-driven soft actuators remains challenging, as designing and fabricating land-water compatible structures is difficult. In this study, we develop femtosecond-laser-fabricated tilted superhydrophobic microstructures to enable amphibious capabilities in soft actuators.

circ-0001875 downregulation is associated with M1 macrophage activation and lung inflammation in severe asthma.

Background: Asthma is a heterogeneous group of diseases. The mechanism by which dysregulated circRNAs affect severe asthma by regulating macrophage polarization remains unclear.

Methods: High-throughput RNA sequencing technology was used to analyze circRNA expression in peripheral blood mononuclear cells (PBMCs) from patients with severe asthma.

Exosomal SPRY4 from adipogenic BMSCs impairs angiogenesis via the PTPRB/TIE2/PI3K axis in Steroid-induced osteonecrosis of the femoral head.

Background: Steroid-induced osteonecrosis of the femoral head (SONFH) drives irreversible bone collapse, yet current therapies inadequately target the disrupted angiogenic-osteogenic coupling central to its pathogenesis. Although pathological adipocyte hyperplasia is a hallmark of SONFH, the mechanisms by which adipogenic bone marrow mesenchymal stem cells (BMSCs) suppress angiogenesis remain unresolved. Emerging evidence implicates exosomes as mediators of adipose-vascular crosstalk, yet their role in SONFH-associated vasculopathy remains unexplored.

Microglia replacement halts the progression of microgliopathy in mice and humans.

Colony-stimulating factor 1 receptor () is primarily expressed in microglia. Its monoallelic mutation causes CSF1R-associated microgliopathy (CAMP), a major form of adult-onset leukoencephalopathy with axonal spheroids and pigmented glia (ALSP) and a fatal neurological disease without clinical cure. We developed mouse models harboring human hotspot mutations of CAMP and replaced CSF1R-deficient microglia with CSF1R-normal cells through microglia replacement by bone marrow transplantation (Mr BMT), which attenuated pathology in mice.