Association between adjusted atherogenic index of plasma and major adverse cardiovascular events after percutaneous coronary intervention in patients with STEMI: a prospective observational study in China.

Objectives: The atherogenic index of plasma (AIP) has been reported as a biomarker for cardiovascular disease risks and clinical outcomes. However, few studies have investigated the relationship between the AIP and major adverse cardiovascular events (MACEs) after percutaneous coronary intervention (PCI) in patients with ST-segment elevation myocardial infarction (STEMI).

Design: Prospective observational study.

endometritis in a diabetic patient: MALDI-TOF MS overcomes diagnostic barriers in a non-IUD-associated case.

is a single-cell prokaryotic microorganism and a common component of the normal human oral flora. If it enters other parts and causes infection, it may lead to actinomycosis. We present the case of a 74-year-old female patient from Fuyang who developed bacterial endometritis due to .

Use of extracorporeal membrane oxygenation in adult trauma patients with refractory acute cardiopulmonary failure: guideline from the Chinese society of extracorporeal life support 2025.

Background: Adult trauma patients with refractory acute cardiopulmonary failure suffer from high morbidity and mortality. In the past decade, a growing body of researches has shown survival benefits of extracorporeal membrane oxygenation (ECMO) in trauma patients who fail to respond to optimal damage control resuscitation (DCR), and there is an opportunity to formulate clinical practice guidelines to guide clinicians in implementing trauma ECMO at the bedside.

Methods: The Chinese Society of Extracorporeal Life Support (CSECLS) convened a domestic panel of interdisciplinary experts to develop this guideline, adhering to the principles of the World Health Organization (WHO) Manual for Guideline Development and the policy of conflict of interest.

Disease spectrum of patients with hospital-acquired multidrug-resistant organism infections in the intensive care unit: a retrospective study.

Objective: To understand the infection status and disease spectrum distribution of patients with hospital-acquired Multidrug-resistant Organism (MDRO) Infections in an intensive care unit (ICU) before, during, and after the () Pandemic, and provide a basis for the prevention and control of hospital-acquired MDRO infections.

Methods: Data from the Second People's Hospital of Fuyang City's ICU was analyzed from three periods: pre- (January 1, 2018-December 8, 2019), during (December 9, 2019-December 7, 2022), and post- (December 8, 2022-December 31, 2023). The study compares the disease spectrum of MDRO infections patients across these periods.

MAP2K2 Knockdown Suppresses Phenotypic Transformation of Vascular Smooth Muscle Cells in Aortic Dissection by Inactivating the JAK/STAT Signaling Pathway.

Aortic dissection (AD) is a severe aortic disease characterized by high morbidity and mortality. However, the primary treatments for AD possess limited efficacy. The role and specific mechanisms of mitogen-activated protein kinase kinase 2 (MAP2K2) in AD are not elucidated.

Multigeneration Sublethal Chlorantraniliprole Treatment Disrupts Nutritional Metabolism and Inhibits Growth, Development, and Reproduction of .

, an important pest of tomato crops, has reportedly developed high levels of resistance to the insecticide chlorantraniliprole, which has a unique mode of action and high efficacy. This study evaluated the sustained multigenerational effects of chlorantraniliprole on , focusing on resistance development, growth, development, reproductive capacity, population parameters, and nutritional indicators. After continuous selection with sublethal chlorantraniliprole for eight generations (CX-Sub), bioassays showed that CX-Sub had 225.

Comparative efficacy and safety of oral hypoglycaemic drugs as adjunctive therapy in the management of type 1 diabetes mellitus: A systematic review and meta-analysis.

Aims: To evaluate the efficacy and safety of oral hypoglycaemic drugs (OHDs) as an adjunct to insulin therapy in patients with type 1 diabetes mellitus (T1DM), addressing the need for optimized glycaemic control and reduced insulin dependency.

Materials And Methods: A systematic literature search was conducted across PubMed, Embase and the Cochrane Library to identify randomized clinical trials (RCTs) published up to October 31, 2024. Primary outcomes included changes in glycated haemoglobin (HbA1c) and hypoglycaemia risk.

A machine learning-based glycolysis and fatty acid metabolism-related prognostic signature is constructed and identified ACSL5 as a novel marker inhibiting the proliferation of breast cancer.

Introduction: A new perspective on cancer metabolism suggests that it varies by context and is diverse. Cancer metabolism reprogramming can create a heterogeneous microenvironment that affects immune cell infiltration and function, complicating the selection of treatment methods. However, the specifics of this relationship remain unclear in breast cancer.

Time-resolved single-cell atlas identifies the spatiotemporal transcription dynamics in vernalization response in Brassica rapa.

Many temperate plants require vernalization, a prolonged low-temperature period, to accelerate flowering. Vernalization is a quantitative process whereby extended cold exposure establishes a stable transcriptional repression, with the degree of silencing correlating with the length of cold treatment. While much is known about the genes regulating this process, the expression dynamics at the single-cell level remain elusive.

Effects of L. on growth performance, biochemical indicators, immunity, and intestinal health of weaned piglets.

Introduction: Weaning stress syndrome in piglets seriously endangers the healthy development of the breeding industry. L. (Chinese yam, YAM) has activities such as boosting immunity and regulating gastrointestinal function.

Serum potassium is a critical risk factor for cardiac arrhythmias in acute heart failure patients treated with levosimendan: A retrospective study in a cohort of 250 patients.

Objectives: This study aimed to investigate the risk factors associated with developing cardiac arrhythmias in patients with acute heart failure treated with levosimendan.

Materials And Methods: A retrospective analysis was conducted in patients diagnosed with acute heart failure or acute exacerbation of chronic heart failure treated with levosimendan. The patients were divided into arrhythmia and non-arrhythmia groups based on the presence of rapid-type arrhythmias.

Exploring Novel Therapeutic Targets in Breast Cancer via Comprehensive Omics Profiling and Experimental Verification.

Background: Breast cancer is the leading cause of cancer-related deaths among women worldwide. Deciphering the molecular mechanisms of breast cancer is crucial for developing targeted therapeutic approaches.

Methods: This study analyzed gene expression profiles from the Gene Expression Omnibus (GEO) database to identify differentially expressed genes (DEGs) in breast cancer.

Genome sequence of the wild species, Spinacia tetrandra, including a phased sequence of the extensive sex-linked region, revealing partial degeneration in evolutionary strata with unusual properties.

Genetic degeneration is a striking feature of Y chromosomes, often involving losses of many genes carried on the X chromosome. However, the time course of gene losses remains unclear. Sex chromosomes of plants evolved more recently than animals' highly degenerated ones, making them ideal for studying degeneration timing.

Developmental landscape and asymmetric gene expression in the leaf vasculature of revealed by single-cell transcriptome.

Leaf vasculature not only acts as a channel for nutrients and signaling information but also influences leaf morphology. It consists of several distinct cell types with specialized functions. Cell type-specific characterizations based on single-cell RNA sequencing technology could aid in understanding the identities of vascular tissues and their roles in leaf morphogenesis in .

Switchable Nanophotosensitizers as Pyroptosis Inducers for Targeted Boosting of Antitumor Photoimmunotherapy.

Photodynamic therapy (PDT) has emerged as a promising modality for cancer treatment, but its clinical application is constrained by unexpected phototoxicity arising from nonspecific photosensitizer activation and their "always-on" nature. Herein, we developed a switchable nanophotosensitizer, poly(cation-π) nanoparticles (NP), which achieves supramolecular assembly through cation-π interactions. By coupling choline cationic moieties with aromatic photosensitizers (ZnPc), the polymer facilitates self-assembly driven by cation-π interactions for NP engineering.

Optimal extension time after initial endocrine therapy for postmenopausal hormone receptor-positive early-stage breast cancer: a systematic review and meta-analysis.

Background: The optimal duration of extended endocrine therapy (ET) for women with hormone receptor-positive (HR-positive) early-stage postmenopausal breast cancer remains uncertain. This meta-analysis systematically evaluated the optimal time to prolong aromatase inhibitors ( AIs) therapy for postmenopausal early stage breast cancer who received initial endocrine therapy.

Methods: PubMed, Web of Science, Ovid, Scopus, EmBase, and Cochrane Library were searched for randomized controlled trials (RCTs) using keywords related to breast cancer, HR-positive, AIs, and tamoxifen (TAM).

Causal association of breast cancer with immune cells: new evidence from bi-directional Mendelian randomization using GWAS summary statistics.

Background: The tumor microenvironment of breast cancer encompasses a broad spectrum of immune cell populations. These cell populations are biologically/clinically relevant to varying degrees. The causal relationship between these immune cells and breast cancer remains uncertain despite their relevance.

Efficacy of combined immunotherapy and targeted therapy in overcoming barriers to postoperative recurrence in squamous subtype anaplastic thyroid carcinoma with abscess: a case report and literature review.

Background: Molecularly targeted therapies and immunotherapy are increasingly being employed in the treatment of aggressive, recurrent thyroid cancer. Evidence from several studies indicates that a significant proportion of tumor patients derive limited benefit from immunotherapy as a monotherapy, with vascular abnormalities in solid tumors contributing to immune evasion. Numerous studies, both domestic and international, have assessed the efficacy of combining immune checkpoint inhibitors with antiangiogenic agents across various tumor types.

The role of estrogen in the sex difference for the risk factors of heart failure with preserved ejection fraction.

Heart failure with preserved ejection fraction (HFpEF) is a major subtype of heart failure, primarily characterized by a normal or mildly reduced left ventricular ejection fraction along with left ventricular diastolic dysfunction. Recent studies have shown that the prevalence of HFpEF is higher in women than that in men, particularly in postmenopausal women. Concurrently, it has been observed that the incidence of risk factors contributing to HFpEF (such as obesity, hypertension, diabetes, and atrial fibrillation) also notably increases post-menopause, affecting the incidence of HFpEF.

Ultrabithorax regulates Leptinotarsa decemlineata wing development along with insulin and ecdysteroid signaling pathways.

Leptinotarsa decemlineata (Say) (Colorado potato beetle, CPB) is a notorious pest of potatoes. Its hardened forewings, known as elytra, protect the hindwings and the abdomen against enemies and chemical pesticides. Ubx plays a crucial role in differentiating insect wings, but the molecular mechanism remains unclear.

Chromosome-level genome assembly of Z strain European corn borer Ostrinia nubilalis (Lepidoptera: Crambidae).

European corn borer Ostrinia nubilalis (Hübner) is the most important pest of maize around world, and an ideal model for the sympatric host races, evolutionary and speciation research. In this study, we assembled a chromosome-level genome of Z strain O. nubilalis by the integrated Illumina short reads, PacBio Revio long reads, and Hi-C sequencing data.

Combining molecular characteristics and therapeutic analysis of PDOs predict clinical responses and guide PDAC personalized treatment.

Background: The emergence of targeted therapies and immunotherapy has broadened treatment options for patients with pancreatic ductal adenocarcinoma (PDAC). Despite this, traditional drug selection, predominantly relies on tumor markers and clinical staging, has underutilized these drugs due to ignoring patient genomic diversity. Patient-derived organoids (PDOs) and corresponding patient-derived organoid xenograft (PDOX) models offer a way to better understand and address this.

PANoptosis-related genes in the prognosis and immune landscape of hepatocellular carcinoma.

In hepatocellular carcinoma (HCC) individuals, the influence of numerous variables on the HCC prognosis has gained widespread recognition. Nevertheless, there remains a need for further elucidation regarding the underlying mechanism of PANoptosis-related genes (PRGs) on HCC. A consensus clustering approach, based on the TCGA-LIHC data, was used to identify specific subtypes linked to PANoptosis in this study.