Unraveling the GHG emission patterns of inland waters in China: impact of water body types, aquatic plant life forms, and water temperature.

Inland water ecosystems play key roles in the production, transportation, transformation, storage, and consumption of global greenhouse gases (GHG). Different water body types exhibit spatial and temporal differences after considering factors such as season and aquatic plant life forms. The results revealed that the annual global warming potential (GWP) (Tg CO-eq yr) from swamps, rivers, lakes, and reservoirs in China were 1382.

Efficacy of bleomycin and sirolimus in inhibiting CD31 endothelial cell proliferation in noninvoluting congenital hemangiomas.

Objective: Congenital hemangiomas are rare vascular anomalies that manifest at birth. Noninvoluting congenital hemangiomas present significant clinical challenges due to their persistence and associated complications. The mechanisms underlying congenital hemangiomas remain poorly understood, and current treatments have shown limited efficacy.

Case Report: Hydronephrosis and nephrogenic adenoma secondary to Stevens-Johnson syndrome.

Introduction: Stevens-Johnson syndrome is a rare, severe cutaneous adverse reaction. There is a lack of literature reporting the complications of the bladder and ureter caused by Stevens-Johnson syndrome. In this case, we describe a 10-year-old boy with hydronephrosis and nephrogenic adenoma secondary to Stevens-Johnson syndrome.

Conserved mycobacterial sRNA B11 regulates lipooligosaccharide synthesis at posttranscriptional level in .

Extractable glycolipids of mycobacteria, such as lipooligosaccharides (LOSs), play crucial roles in responding to environmental stress and modulating the host immune response. Although the biosynthesis of LOS is likely regulated at multiple levels to ensure proper composition of the cell wall, the key regulators remain unknown. In this study, we investigated B11, a conserved mycobacterial small RNA (sRNA), and found that it post-transcriptionally regulates LOS synthesis in .

Comprehensive assessment of patients with Kawasaki disease without coronary artery aneurysm.

Background: In the current guidelines, the management algorithm for patients with Kawasaki disease (KD) without coronary artery (CA) aneurysms primarily depends on the clinical experience of pediatricians. It is necessary to conduct a comprehensive evaluation of these patients to provide a higher level of evidence for their management. Therefore, our study aimed to assess patients with KD using multidimensional data and investigate their prognosis.

How does an external electric field in the normal-direction affect the cyclo[18]carbon molecule?-a DFT study.

This investigation explores the impact of an external electric field (EEF) in the normal-direction on cyclo[18]carbon, scrutinizing changes in molecular conformation, electronic structure, reactivity, and spectroscopic properties. Utilizing Gaussian16 and Multiwfn, we modeled the molecule under EEF conditions. The EEF induced an expansion of the cyclo[18]carbon ring and increased bond lengths.

Biochar-Immobilized Enhances Copper Remediation and Growth of Chinese Milk Vetch ().

Heavy metal-contaminated soil poses a severe threat to environmental quality and human health, calling for eco-friendly and efficient remediation strategies. This study explored the use of biochar-immobilized copper-resistant to remediate copper-contaminated soil and promote growth of Chinese milk vetch ( L.).

Integrated multi-omics analysis identifies lipid metabolism biomarkers in ONFH and reveals therapeutic potential of retinoic acid.

Osteonecrosis of the femoral head (ONFH) is a debilitating condition frequently associated with dysregulation in lipid metabolism. The objective of this study was to identify potential biomarkers for ONFH through various analytical methods and experimental verification, thereby providing a robust reference for disease treatment. Utilizing public datasets, differential analysis was conducted and integrated with weighted gene co-expression network analysis to pinpoint key genes.

Predicting the potential distribution areas of under current and future climate change.

Background: a confirmed vector of scrub typhus, was historically restricted to southeastern coastal China but has recently been detected in southwestern regions. Species distribution modeling was applied to predict its current and future potential distribution areas under multiple climate scenarios, identify high-priority surveillance areas, and determine key environmental drivers. The results may facilitate a transition from passive to proactive vector monitoring.

Feasibility and accuracy of targeted axillary dissection by carbon tattooing in biopsy-proven node-positive breast cancer: A prospective study.

Introduction: Targeted axillary dissection (TAD) is used for less-invasive axillary staging in patients with initially node-positive breast cancer undergoing neoadjuvant chemotherapy (NACT). However, the efficacy of TAD using carbon suspension remains unclear. Here, the aim was to evaluate the feasibility and accuracy of TAD, combining sentinel lymph node biopsy (SLNB) using a single blue dye tracer with target lymph node biopsy (TLNB) using carbon suspension.

Does a combined intervention of diet and exercise lead to a more positive impact on neurocognitive function? A systematic review and meta-analysis.

Background: Recent studies have shown that lifestyle modifications, including diet and exercise, can help prevent cognitive decline. However, there are currently no comprehensive systematic reviews of the combined effects of diet and exercise on cognitive function.

Methods: A systematic review of the literature identified randomized controlled trials that examined the effects of combined diet and exercise interventions on neurocognitive function compared with either intervention alone.

The role of infraclavicular and supraclavicular lymph nodes in breast cancer patients receiving neoadjuvant chemotherapy: implications for regional lymph node classification.

Background: Metastasis to the infraclavicular and supraclavicular lymph nodes (ISLNs) is an important factor that predicts poor survival in patients with breast cancer; however, pathological nodal staging does not traditionally include ISLNs because of their non-routine surgical dissection. This study aimed to evaluate the prognostic impact of ISLN metastasis and propose a refined nodal staging system tailored for patients undergoing neoadjuvant chemotherapy (NAC).

Methods: We retrospectively reviewed 1,072 patients with breast cancer with or without ISLN metastasis who received NAC at two institutions (Fujian cohort and Hebei cohort) from 2010 to 2022.

Potential predictive value of myocardial strain and strain rate for late gadolinium enhancement in children with a history of Kawasaki disease.

Background: Kawasaki disease (KD) is an acute pediatric vasculitis with significant implications for coronary arteries and myocardium, potentially leading to long-term myocardial fibrosis. With the advancements in speckle tracking echocardiography (STE), ultrasound parameters have been shown to be reliable in the early detection of structural and functional myocardial abnormalities, thus mitigating some limitations of cardiac magnetic resonance imaging (MRI). Despite its gold standard status for assessing myocardial fibrosis, the application of cardiac magnetic resonance (CMR) with late gadolinium enhancement (LGE) in pediatrics is restricted.

Inflammatory reaction in the acute phase of Kawasaki disease may better predict chronic cardiac dysfunction than coronary artery lesions.

Background: Kawasaki disease (KD) is a pediatric acute vasculitis affecting the coronary arteries and cardiac tissues. Research has been conducted on the assessment of acute cardiac function in KD; however, chronic cardiac dysfunction remains understudied, particularly in terms of coronary artery lesion (CAL) grading and acute-phase inflammatory markers. This study aimed to assess the effect of CAL grading on chronic cardiac function in KD patients, and explore the association between CAL grading and acute-phase inflammatory markers.

Liver X receptor agonists in central nervous system disorders: From neuroprotection to clinical challenges.

Central nervous system (CNS) disorders, which include both neurodegenerative and neuroinflammatory conditions, present significant therapeutic challenges due to their complex pathological mechanisms, limited treatment options, and difficulties in drug delivery across the blood-brain barrier (BBB). Therefore, exploring therapeutic targets capable of overcoming these obstacles is of paramount importance. The liver X receptor (LXR) plays a crucial role in lipid homeostasis, inhibition of neuroinflammation, and promotion of neurogenesis, making it a promising therapeutic target for CNS diseases.

Development and Evaluation of a Multi-Epitope Vaccine Based on P22 Virus-Like Particles Targeting Helicobacter pylori.

Background: The current first-line treatment for Helicobacter pylori (H. pylori) infection is bismuth-based quadruple therapy. However, the widespread use of antibiotics has contributed to the emergence of antibiotic-resistant strains, thereby increasing the likelihood of treatment failure.

Neuronal Reg3β/macrophage TNF-α-mediated positive feedback signaling contributes to pain chronicity in a rat model of CRPS-I.

Complex regional pain syndrome type I (CRPS-I) develops after an initial injury. It causes prolonged pain that persists beyond the usual expected time for tissue healing. Mechanisms underlying pain chronicity of CRPS-I remain unknown.

Effect of a machine learning prediction model on the false-negative rate of sentinel lymph node biopsy for clinically node-positive breast cancer after neoadjuvant chemotherapy.

Background: Machine learning (ML) models can be used to predict axillary pathological complete responses (pCRs) in clinically node-positive (cN+) breast cancer after neoadjuvant chemotherapy (NAC). We developed an ML model combining clinicopathological characteristics and axillary ultrasound features before and after NAC to predict the possibility of axillary pCR in NAC-treated cN + breast cancer.

Methods: Patients with cN + breast cancer who received NAC were categorized into training and verification cohorts (7:3 ratio).

Global research trends in surgical management of choledochal cysts: a bibliometric analysis from 2000 to 2024.

Introduction: Choledochal cysts (CCs), which are congenital biliary anomalies prevalent in Asia, predominantly affect children and carry the risk of severe complications, including malignancy. Surgical intervention, evolving from open to minimally invasive (laparoscopic/robotic) techniques, remains the cornerstone of management. Despite growing research, no bibliometric analysis has mapped the global trends in CCs surgical studies.

PREDAC-FluB: predicting antigenic clusters of seasonal influenza B viruses with protein language model embedding based convolutional neural network.

Influenza poses a significant global public health threat, with vaccination being the most effective and economical preventive measure. However, these punctuated antigenic changes, particularly in HA, result in escape from the immunity that was induced by prior infection or vaccination. Accurately predicting antigenic variation and understanding the antigenic dynamics of influenza viruses are crucial for selecting appropriate vaccine strains, but no established methods exist for influenza B viruses.

Assessment of lipid parameters and its association with risk of stage 1 hypertension: a cohort study in middle-aged and elderly Chinese.

Background: There is a correlation between dyslipidemia and elevated blood pressure, but the relationship between different lipid parameters and elevated blood pressure is inconsistent. Therefore, understanding the impact of dyslipidemia on blood pressure is significant for the prevention and control of ASCVD. Our study is aimed at assessing longitudinally the correlation between lipid parameters and the incidence of stage 1 hypertension in a large Chinese community population.

Role of ALOX5AP in the pathogenesis of cerebral small vessel disease: impact of inflammation and lipid metabolism dysregulation.

Cerebral small vessel disease (CSVD) is a neurological disorder characterized by dysfunction of the brain's microvasculature. It serves as a key pathological basis for cognitive impairment and stroke. The pathogenesis of CSVD is closely associated with inflammatory responses and lipid metabolism abnormalities.

Predictive value of lymphocyte-to-C-reactive protein ratio for predicting initial and repeated intravenous immunoglobulin resistance in a large cohort of Kawasaki disease: a prospective cohort study.

Lmphocyte-to-C-reactive protein ratio (LCR) has tremendous predictive power for diseases with similar pathogenesis to Kawasaki disease (KD). The evidence on the prognostic value of LCR for IVIG resistance, especially for repeated IVIG resistance in KD, remains scarce. We conducted a prospective cohort study comprising 1607 individuals with KD to evaluate the predictive value of LCR for both the initial and repeated IVIG resistance.

Mesoporous silica nanoparticles loaded Au nanodots: a self-amplifying immunotherapeutic depot for photothermal immunotherapy.

Introduction: Photothermal therapy (PTT) has emerged as a highly promising approach for cancer treatment due to its advantages of localized treatment, controllable irradiation, and non-invasive nature. This study presents a multifunctional platform for tumor PTT based on Au nanoparticles-decorated mesoporous silica nanoparticles (MSN@Au), aiming to synergize photothermal ablation with immune modulation.

Methods: MSN@Au nanoparticles were engineered as the PTT agent.

Clinical TP53 genetic testing is recommended for HER2-positive breast cancer patients aged 35 or younger.

Limited information is available for TP53 pathogenic variants (PVs) in early-onset breast cancer patients in China. We investigated the prevalence and clinical relevance of TP53 PVs among 1492 BRCA1/2-negative early-onset breast cancer patients. Peripheral blood samples were collected for TP53 genetic testing through next-generation sequencing.