Biomechanical Effect of Chinese Manual Therapy for Cervical Spondylotic Radiculopathy After Percutaneous Endoscopic Cervical Foraminotomy and Diskectomy: A Finite Element Study.

Study Design: Finite element (FE) comparative study.

Objective: This study aims to assess the biomechanical effects of Chinese manual therapy (CMT) on the cervical spine following percutaneous endoscopic cervical foraminotomy and diskectomy (PECFD).

Summary Of Background Data: Cervical spondylotic radiculopathy (CSR) is a challenging condition that often recurs after cervical spine surgery, sparking interest in alternative treatment modalities such as CMT.

Potential predictive value of myocardial strain and strain rate for late gadolinium enhancement in children with a history of Kawasaki disease.

Background: Kawasaki disease (KD) is an acute pediatric vasculitis with significant implications for coronary arteries and myocardium, potentially leading to long-term myocardial fibrosis. With the advancements in speckle tracking echocardiography (STE), ultrasound parameters have been shown to be reliable in the early detection of structural and functional myocardial abnormalities, thus mitigating some limitations of cardiac magnetic resonance imaging (MRI). Despite its gold standard status for assessing myocardial fibrosis, the application of cardiac magnetic resonance (CMR) with late gadolinium enhancement (LGE) in pediatrics is restricted.

Inflammatory reaction in the acute phase of Kawasaki disease may better predict chronic cardiac dysfunction than coronary artery lesions.

Background: Kawasaki disease (KD) is a pediatric acute vasculitis affecting the coronary arteries and cardiac tissues. Research has been conducted on the assessment of acute cardiac function in KD; however, chronic cardiac dysfunction remains understudied, particularly in terms of coronary artery lesion (CAL) grading and acute-phase inflammatory markers. This study aimed to assess the effect of CAL grading on chronic cardiac function in KD patients, and explore the association between CAL grading and acute-phase inflammatory markers.

Invasive pulmonary aspergillosis in patients with lung cancer: Risk Factors for in-hospital mortality and Predictors of Clinical Outcomes.

Background: Invasive pulmonary aspergillosis (IPA) is a common complication in patients with hematological malignancies, and has also been reported in some solid tumors, but IPA in lung cancer patients has not been well described in recent years. This study aims to identify the risk factors for in-hospital mortality, and factors influencing antifungal efficacy in lung cancer patients with IPA.

Methods: We retrospectively collected data from all inpatients with positive aspergillus cultures or positive polymerase chain reaction(PCR) for aspergillus DeoxyriboNucleic Acid (DNA) in respiratory samples in the Third People's Hospital of Chengdu from January 2016 to December 2023.

Finite element analysis of pedicle screw fixation biomechanics and adjacent segment degeneration in varied bone conditions.

Pedicle screw fixation (PSF) has been extensively utilized in lumbar fusion surgeries to assist in stabilization. However, inappropriate implantation could accelerate the progression of adjacent segment degeneration (ASD). Current finite element studies are predominantly confined to single-segment fixation under conditions of normal bone mineral density and mechanical analyses of unidirectional adjacent vertebrae, failing to fully represent the diversity of clinical conditions.

The effects of glucocorticoids on cardiac function of patients with Duchenne muscular dystrophy: benefit or not?

Unlabelled: Duchenne muscular dystrophy (DMD) is a progressive, incurable X-linked neuromuscular disease caused by mutations in the dystrophin gene, resulting in functional dystrophin deficiency. Currently, cardiovascular complications are the leading cause of death in patients with DMD. Glucocorticoids are considered the gold standard treatment for children with DMD.

[Exploration and Practice of Performance Evaluation System for Large Medical Equipment Based on Internet of Things Technology].

Medical equipment, as an important indicator of smart hospital evaluation, plays a vital role in hospital operations. To ensure the safe and efficient operation of medical equipment, a reasonable performance evaluation system is indispensable. This study introduces a platform based on Internet of Things (IoT) technology that connects medical devices and collects data, achieving standardized and structured data processing, and supporting online operational supervision.

Immunomodulatory Effects of L-Arginine-Modified Silkworm Pupae Protein Enteral Nutrition on Murine Intestinal Morphology and Immunity.

L-arginine, a semi-essential amino acid, is well-documented for its role in nitric oxide (NO) synthesis, its anti-inflammatory properties, and its modulation of immune responses. Studies suggest it may improve gut barrier function and reduce inflammation in conditions such as colitis or sepsis. However, its specific efficacy in diabetic enteropathy (a complication of diabetes involving intestinal dysfunction, inflammation, and neuropathy) is less studied.

Cancer associated fibroblasts in cancer development and therapy.

Cancer-associated fibroblasts (CAFs) are key players in cancer development and therapy, and they exhibit multifaceted roles in the tumor microenvironment (TME). From their diverse cellular origins, CAFs undergo phenotypic and functional transformation upon interacting with tumor cells and their presence can adversely influence treatment outcomes and the severity of the cancer. Emerging evidence from single-cell RNA sequencing (scRNA-seq) studies have highlighted the heterogeneity and plasticity of CAFs, with subtypes identifiable through distinct gene expression profiles and functional properties.

tRNA-derived small RNAs in disease immunity.

Recently, members of a unique species of non-coding RNA, known as transfer RNA-derived small RNAs (tsRNAs) have been reported to serve multiple molecular functions, including in cells that mediate immunity. Because of their low molecular weights, tsRNAs were previously difficult to detect and were thus overlooked, until now. In this review, we delve into the biogenesis of tsRNAs and their diverse biological functions, ranging from transcriptional regulation to modulation of mRNA translation.

The Predictive Value of Fibrinogen-to-Albumin Ratio for Predicting Intravenous Immunoglobulin Resistance in Kawasaki Disease: A Prospective Cohort Study.

Background: Predicting resistance to intravenous immunoglobulin (IVIG) in the treatment of Kawasaki disease (KD) remains a focus of research. Fibrinogen and albumin in systemic inflammation play an important role. This study aims to investigate the predictive value of fibrinogen to albumin ratio (FAR) for initial IVIG resistance in patients with KD.

The Vectorcardiogram Characteristic and Its Predictive Value for Reduced Left Ventricular Ejection Fraction of Children with Duchenne Muscular Dystrophy.

Background: The prognosis of Duchenne muscular dystrophy (DMD) is poor once it develops to the stage of cardiac impairment. Recent studies have demonstrated that electrocardiogram (ECG), which consists of general ECG and vectorcardiogram (VCG), retains an extremely powerful role in the assessment of patients with reduced left ventricular (LV) systolic dysfunction. However, data regarding VCG recordings in DMD and its prognostic value for reduced left ventricular ejection fraction (LVEF) of DMD have never been reported.

[Clinical Evaluation of Dural (Spinal) Membrane Repair Materials].

Objective: To select high-quality and cost-effective dural (spinal) membrane repair materials, in order to reduce the cost of consumables procurement, save medical insurance funds, and optimize hospital operation and management.

Methods: Taking the BS06B disease group (spinal cord and spinal canal surgery without extremely severe or severe complications and comorbidities, mainly diagnosed as congenital tethered cord syndrome) as an example, a retrospective analysis was conducted on the relevant data of surgical treatment for congenital tethered cord syndrome conducted in our hospital from January 2021 to June 2023. Safety and efficacy indicators in clinical application (incidence of postoperative epidural hemorrhage, incidence of postoperative purulent cerebrospinal meningitis, incidence of cerebrospinal fluid leakage, surgical duration, and postoperative hospital stay) were compared.

Immunotherapeutic implications on targeting the cytokines produced in rhinovirus-induced immunoreactions.

Rhinovirus is a widespread virus associated with several respiratory diseases, especially asthma exacerbation. Currently, there are no accurate therapies for rhinovirus. Encouragingly, it is found that during rhinovirus-induced immunoreactions the levels of certain cytokines in patients' serum will alter.

Evaluation of left ventricular stiffness with echocardiography.

Half of patients with heart failure are presented with preserved ejection fraction (HFpEF). The pathophysiology of these patients is complex, but increased left ventricular (LV) stiffness has been proven to play a key role. However, the application of this parameter is limited due to the requirement for invasive catheterization for its measurement.

How to influence food waste behaviour of urban residents? The combined effect of network embeddedness and incentive measures.

Residents' food waste is a key part of environmental sustainability and food security. This study investigates influencing factors in reducing food waste by constructing a conceptual model examining the relationship between network embeddedness (NE) and food waste behaviour (FWB), using questionnaire data from 853 urban residents in eastern China, as well as the moderating role of incentive measures (IMs). We find that NE consists of three dimensions: structural embeddedness, relational embeddedness and functional embeddedness.

A new perspective to promote sustainable low-carbon consumption: The influence of informational incentive and social influence.

In the era of internet-based information, how to promote sustainable low-carbon consumption by residents through information incentives and social influence is a pressing question that needs to be solved urgently. This study develops an explanatory model to explain how information incentives and social influence affect sustainable low-carbon consumption by residents. Data were collected from residents by large-scale online surveys in China.

Chromatin Remodeling Induced by ARID1A Loss in Lung Cancer Promotes Glycolysis and Confers JQ1 Vulnerability.

Unlabelled: ARID1A is a key mammalian SWI/SNF complex subunit that is mutated in 5% to 11% of lung cancers. Although recent studies have elucidated the mechanism underlying dysregulation of the switch/sucrose non-fermentable (SWI/SNF) complexes in cancers, the significance of ARID1A loss and its implications in lung cancers remain poorly defined. This study investigates how ARID1A loss affects initiation and progression of lung cancer.

Hyperbaric Oxygen Therapy Represses the Warburg Effect and Epithelial-Mesenchymal Transition in Hypoxic NSCLC Cells the HIF-1α/PFKP Axis.

Background: Tumor cells initiate hypoxia-induced mechanisms to fuel cell proliferation, invasion, and metastasis, largely mediated by low O-responsive Hypoxia-Inducible Factor 1 Alpha (HIF-1α). Therefore, hyperbaric oxygen therapy (HBO) is now being studied in cancer patients, but its impact upon non-small-cell lung cancer (NSCLC) cell metabolism remains uncharacterized.

Methods: We employed the NSCLC cell lines A549 and H1299 for studies.

Exploring development and evolutionary trends in carbon offset research: a bibliometric perspective.

This study proposes a bibliometric measure to visualize and analyze the research status and development trend of carbon offset based on 1,581 articles over the period 1900-2019. The main findings include (1) carbon offset research turned into a rapid growth after 2009; (2) environmental studies, environmental science, economics, and energy fuels are the top four research domains in publication; (3) Energy Policy, Ecological Economics and Science are the top three journals in terms of citation impact; (4) climate change, impact, emission, CO emission, and policy are shown to be the most frequently used keywords; (5) the top 10 cited articles cover the following five essential aspects: individual carbon offset behavior; forest and land carbon offset; transportation carbon offset; international trade carbon offset; and eco-system service-related carbon offset; (6) eight research hotspots were identified including forest carbon sequestration program, understanding carbon and uncertainty market, policy design, biomass development, Chinese province, increasing adoption, and ecosystem service commodification. These findings suggest that the carbon offset research has been evolved from the theoretical exploration at the early stage to a more diversified conversion of research outputs at the practical level in recent years.

Tandem reassembly of split luciferase-DNA chimeras for bioluminescent detection of attomolar circulating microRNAs using a smartphone.

Detection of dysregulated circulating microRNAs (miRNAs) in human biofluids is a fundamental ability to determine tumor occurrence and metastasis in a minimally invasive fashion. However, the requirements for sophisticated instruments and professional personnel impede the translation of miRNA tests into routine clinical diagnostics, especially for resource-limited regions. Herein, we developed a DNA-guided bioluminescence strategy for the detection of circulating miRNAs.

Greenhouse Gas Emission Transfer of Inter-Provincial Electricity Trade in China.

Inter-regional electricity trade is an important way to mitigate the imbalance between regional electricity generation and consumption. With the increasing amount of inter-regional electricity trade in China, the emission transfer problem is more severe. By using Quasi-Input-Output model, which can consider the ripple effect of electricity trade network, this study analyzed embodied greenhouse gas emissions of electricity trade among 30 provinces in China.

[Study on the center-driven multiple degrees of freedom upper limb rehabilitation training robot].

With the aging of the society, the number of stroke patients has been increasing year by year. Compared with the traditional rehabilitation therapy, the application of upper limb rehabilitation robot has higher efficiency and better rehabilitation effect, and has become an important development direction in the field of rehabilitation. In view of the current development status and the deficiency of upper limb rehabilitation robot system, combined with the development trend of all kinds of products of the upper limb rehabilitation robot, this paper designed a center-driven upper limb rehabilitation training robot for cable transmission which can help the patients complete 6 degrees of freedom (3 are driven, 3 are underactuated) training.

Embodied carbon dioxide flow in international trade: A comparative analysis based on China and Japan.

Carbon dioxide embodied flow in international trade has become an important factor in defining global carbon emission responsibility and climate policy. We conducted an empirical analysis for China and Japan for the years 2000-2014, using a multi-region input-output model and considering the rest of the world as a comparison group. We compared the two countries' direct and complete carbon dioxide emissions intensity and bilateral economic activities such as imports and exports, production and consumption to analyze the difference between China and Japan.

Analysis of an optimal public transport structure under a carbon emission constraint: a case study in Shanghai, China.

Along with the rapid development of the transportation industry, the problems of the energy crisis and transport emissions have become increasingly serious. The success of traffic emission reduction is related to the realization of global low-carbon goals. Placing priority on public transport is the internationally recognized traffic development model.