Stage-Specific Impacts of Climate Change on Greater White-Fronted Geese Along the East Asian Flyway.

Migratory flyways sustain waterbird populations by linking critical habitats across their annual cycle. However, stage-specific impacts of climate change on these habitats remain poorly understood. We integrated species distribution models with annual migration data from 30 Greater White-fronted Geese () to assess changes in habitat suitability, distributional shifts, and suitability fluctuations across breeding, stopover, and wintering stages under mid-century (2040-2060) climate scenarios.

Tumour necrosis factor alpha-inducing protein 3 (TNFAIP3) can independently predict coronary heart disease (CHD).

Background: Multiple indicators of inflammation are significantly associated with coronary heart disease (CHD). Tumour necrosis factor alpha-inducible protein 3 (TNFAIP3) is an anti-inflammatory protein that inhibits inflammatory responses. However, the relationship between TNFAIP3 and CHD is currently unknown.

Epidemiology of Hypertension in Psoriasis: An Analysis of Trends from 2006 to 2023.

Background: Psoriasis and hypertension (HTN) are known to be closely related. However, at present, no study has systematically examined the epidemiology of this disease pattern on a global scale.

Methods: We examined six databases from their inception until November 1, 2023 and used the Agency for Healthcare Research and Quality and the Newcastle-Ottawa Scale to assess the quality of observational studies.

Dual-Ligand Metal-Organic Framework for Ultrasensitive Fluorescence Detection of Uranium: An In Situ Trace Enrichment Strategy to Overcome Concentration Limitations.

The development of trace analysis technology for uranium pollution has become crucial for ecological protection, owing to the extensive utilization of uranium in the nuclear industry. Fluorescence method has been widely used for the detection of uranium in water, but current research still suffers from insufficient sensitivity, sluggish detection speed, and interference from coexisting ions. This is mainly due to the poor selective enrichment ability of the sensors for trace uranium.

Mussel-inspired photothermal antibacterial multi-network hydrogel for cascade-enhanced infected wound healing.

The clinical treatment of infected skin injuries caused by exogenous bacteria presents significant challenges, and traditional therapies struggle to achieve multiple therapeutic effects simultaneously. Herein, a mussel-inspired photothermal antibacterial self-repairing hydrogel (BA-PDZn-N) was designed for accelerating infected wound healing. Multi-network structures were constructed through free radical polymerization and dynamic borate bonding between acrylamide, 3-acrylamidophenylboronic acid, and polydopamine (PDA), as well as metal ligand chelation between PDA and Zn for uniform porosity.

A Fluorinated Conjugated Polymer Allows for Enhanced NIR-II Fluorescence Imaging-Guided Photothermal Therapy.

Precision cancer diagnosis is instrumental in optimizing photothermal anti-tumor therapy protocols. Powerful motivations have been expressed to construct conjugated polymers with near-infrared fluorescence and phototherapeutic behavior. However, it is a dilemma to simultaneously materialize a favorable fluorescence quantum yield (QY) and impressive photothermal conversion efficiency (PCE) as determined by the contradictory photophysical processes.

Large-scale protein interactome reveals lineage-specific genes driving plant-parasitic nematode adaptive innovations.

Mounting evidence suggests that lineage-specific genes drive phenotype diversity. Plant-parasitic nematodes (PPNs), among the most destructive plant pathogens, have evolved innovated traits required for plant parasitism, yet the genetic basis remains unclear. Here, we identify PPN lineage-specific genes (PPNLSGs) and analyze the large-scale protein interactome of their encoded proteins (PPNLSPs).

Ecological connectivity of genomic markers of antimicrobial resistance in Escherichia coli in Hong Kong.

Antibiotic-resistant Escherichia coli (E. coli) is a major contributor to the global burden of antimicrobial resistance (AMR). While the One Health concept emphasizes the connection of human, animal, and environmental health, genome-resolved and quantitatively integrated analyses of microbial exchange across ecological compartments remain limited.

Biopharmaceutical Switching in Psoriasis Treatment: A Systematic Review and Meta-Analysis.

Importance: Patients with psoriasis may require a switch to another therapy due to high treatment costs, primary effectiveness failure, biologic fatigue, or adverse effects associated with the initial biologic treatment; however, the availability of evidence for the effectiveness and safety of interclass biologic switching for the treatment of psoriasis is unknown.

Objective: To investigate the effectiveness and safety of psoriasis treatment after the failure of initial biologic therapy, particularly when patients switch to a second biologic.

Data Sources: PubMed, Embase, and the Cochrane Library were searched from inception through January 25, 2025.

Qilianshupi Decoction Alleviate Epithelial-mesenchymal Transition to Treat Chronic Atrophic Gastritis.

Introduction: Chronic atrophic gastritis (CAG) is an important stage in the occurrence and development of gastric cancer, and the morbidity of CAG is increasing year by year. Qilianshupi Decoction (QLSP) is a Chinese herbal compound which has been proved to reverse CAG, but its mechanism remains unknown. We wanted to identify the main components of QLSP by mass spectrometry and liquid phase analysis, and investigate their potential pathways for CAG treatment in combination with network pharmacology.

Side-stream anaerobic membrane bioreactor system for energy-positive sewage treatment.

Anaerobic membrane bioreactors (AnMBRs) present a promising solution for developing energy-neutral wastewater treatment systems. However, their application in mainstream settings, where they treat sewage directly, faces challenges such as dissolved methane loss and performance deterioration at low temperatures. To address these issues, this study developed a side-stream mode AnMBR system by integrating chemically enhanced primary treatment (CEPT) with AnMBR.

Enhancing fruity aroma of Cabernet Sauvignon wine by mixed culture fermentation with Schizosaccharomyces japonicus, Saccharomyces cerevisiae, and Starmerella bacillaris.

The mixed culture fermentation of Saccharomyces cerevisiae and non-Saccharomyces yeast has been reported to bring a higher diversity of volatile compounds and presumably a greater aromatic complexity to wine. This study mainly focuses on the performance of specific indigenous yeasts isolated from local grapes in Guizhou, including killer active S. cerevisiae FBKL2.

Inhibiting heme piracy by pathogenic Escherichia coli using de novo-designed proteins.

Iron is an essential nutrient for most bacteria and is often growth-limiting during infection, due to the host sequestering free iron as part of the innate immune response. To obtain the iron required for growth, many bacterial pathogens encode transporters capable of extracting the iron-containing cofactor heme directly from host proteins. Pathogenic E.

Abnormal peripheral microcirculation by nailfold videocapillaroscopy reveals severity of atherosclerosis in coronary heart disease.

Background Peripheral microangiopathy occurs in various diseases. However it is not known whether changes in the peripheral microcirculation are present in patients with coronary heart disease (CHD). Methods Two hundred and nineteen patients were enrolled.

Targeting indigenous for genotype exploration and organic acid degradation analysis.

belongs to fermentative non- yeast, which has been reported to be predominant in the late stage of natural wine fermentation, and can coexist with . This study targeted the indigenous strains found in Guizhou, China, to explore their genotype diversity, and to further analyze their fermentation properties especially on the degradation capacity of malic acid. Seven microsatellite loci were developed including GA1, CG3, SyGAA2, C11, SaGAA1, C12, and TG2, and 43 genotypes were identified from 63 strains.

Chaperone-Tag System for Activity Improvement of RNA Polymerase in Thermophiles.

Thermophilic microorganisms hold advantages including resistance to contamination, reduced cooling costs, and enhanced enzyme activity, positioning them as promising candidates for next-generation industrial biotechnology. However, the inactivity of tools developed for mesophiles hampered the development of thermophiles. By investigating the expression of the T7 RNA polymerase (T7RNAP) in Parageobacillus thermoglucosidasius, we found that the low expression levels of heat-shock proteins in thermophiles contribute to the inactivity.

ZNF432 suppresses endometrial cancer progression by promoting UPF1 ubiquitination and inducing apoptosis.

Endometrial cancer (EC) is a malignant tumor originating from the uterine epithelial lining and is one of the most common gynecologic malignancies worldwide. Ubiquitination, as a crucial regulatory mechanism in cell physiology, plays a key role in processes such as cell cycle control, DNA repair, and tumorigenesis. UPF1, a critical regulator of ubiquitination, is involved in the development of various diseases, including cancer, due to its influence on mRNA stability and protein degradation.

Effects of metformin on serum miRNA expression and target gene regulation in prediabetic patients.

Background: Prediabetes, also known as impaired glucose tolerance (IGT), is a common metabolic disorder and is often considered a risk factor for the development of diabetes. Metformin (MET) is a widely used medication for the treatment of diabetes and has the potential to improve insulin sensitivity and blood sugar control. This work aimed to investigate the impact of MET treatment on serum miRNA expression in IGT patients and explore the quantitative changes in miRNA after MET treatment.

Advances in Magnetically Controlled Medical Robotics: A Review of Actuation Systems, Continuum Designs, and Clinical Prospects for Minimally Invasive Therapies.

Magnetically controlled micro-robots hold immense potential for revolutionizing advanced medical applications, garnering significant research interest. This potential is underscored by the dual focus on magnetic control systems-both as driving forces and manipulation field sources-and magnetic continuums that have demonstrated clinical therapeutic efficacy. This comprehensive review delves into the actuation characteristics of permanent magnet systems, electromagnetic systems, and commercially available magnetic control systems.

QRICH1 regulates ATF6 transcription to affect pathological cardiac hypertrophy progression.

Background: Many studies have shown that pathological cardiac hypertrophy is associated with active endoplasmic reticulum (ER) stress. Glutamine-rich protein 1 (QRICH1), as a transcriptional regulator, belongs to the caspase recruitment domain (CARD)-containing gene family. QRICH1 has been shown to influence the outcomes of endoplasmic reticulum stress by regulating the transcription of proteostasis-related genes.

The HALP Index Is Associated with the Recurrence of Persistent Atrial Fibrillation Following Radiofrequency Catheter Ablation.

Purpose: To evaluate the relationship between the HALP Index and the recurrence of persistent atrial fibrillation (AF) following radiofrequency catheter ablation (RFCA).

Methods: We retrospectively analyzed 471 patients with persistent AF treated with RFCA between January 2019 and June 2022 at Yantai Yuhuangding Hospital of Qingdao University. The relationship between the Hemoglobin, Albumin, Lymphocyte, and Platelet (HALP) Index and AF recurrence outcomes was assessed using Kaplan-Meier survival curve analysis and multifactorial Cox proportional hazards regression modeling.

Association Between Neutrophil Percentage to Serum Albumin Ratio and in-Hospital Mortality of Patients with Chronic Obstructive Pulmonary Disease in Intensive Care Unit: A Retrospective Cohort Study.

Objective: This study aimed to investigate the potential correlation between the neutrophil percentage to serum albumin ratio(NPAR) and in-hospital mortality in critically ill patients with Chronic Obstructive Pulmonary Disease (COPD).

Patients And Methods: This study employed a retrospective cohort design. A total of 599 COPD patients were included in this research.

Protected areas mitigate the reduction in habitat suitability for swans under climate change: A case study in the Yellow River Basin.

Changes in migratory birds' habitats are important indicators of the health of global ecosystems. However, the habitat dynamics of the flagship swan species in China's major river basins and the adaptive strategies these species employ to respond to climate change have remained unclear. Using citizen science data, survey data, and species distribution models, we explored how three future climate scenarios for 2040-2060 affect habitat suitability for migratory swans in the Yellow River Basin.

Metabolic Segregation and Functional Gene Clusters in Anaerobic Digestion Consortia.

A combined enrichment experiment and genome-centric meta-omics analysis demonstrated that metabolic specificity, rather than flexibility, governs the anaerobic digestion (AD) ecosystem. This study provides new insights into interspecies electron transfer in the AD process, highlighting a segregation in the metabolism of H and formate. Our findings show that H acts as the primary electron sink for recycling redox cofactors, including NAD and oxidised ferredoxin (Fd), during primary fermentation, while formate is the dominant electron carrier in secondary fermentation, especially under conditions with elevated H concentrations.