Agricultural propiconazole residues promote triazole cross-resistance in through and efflux pump overexpression.

Fluconazole remains a cornerstone for consolidation therapy in cryptococcal meningitis. However, resistance poses a significant risk of treatment failure in sub-Saharan Africa, where fluconazole monotherapy is common. Beyond clinical use, triazole fungicides are suspected drivers of resistance pathways.

Microneedle-based integrated pharmacokinetic and pharmacodynamic evaluation platform for personalized medicine.

Precision and personalized medicine for disease management necessitates real-time, continuous monitoring of biomarkers and therapeutic drugs to adjust treatment regimens based on individual patient responses. This study introduces a wearable Microneedle-based Continuous Biomarker/Drug Monitoring (MCBM) system, designed for the simultaneous, in vivo pharmacokinetic and pharmacodynamic evaluation for diabetes. Utilizing a dual-sensor microneedle and a layer-by-layer nanoenzyme immobilization strategy, the MCBM system achieves high sensitivity and specificity in measuring glucose and metformin concentrations in skin interstitial fluid (ISF).

Gastric cancer in children infected with .

Background: This retrospective study aimed to define associations between () in childhood and risk factors for gastric cancer with special emphasis on the role of family history of cancer.

Aim: To define associations between in childhood and risk factors for gastric cancer with special emphasis on the role of family history of cancer.

Methods: Details of 600 children who were subjected to upper gastrointestinal endoscopies at our institution are analyzed.

The Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of Single Subcutaneous Administration of a Novel Anti-NGF Monoclonal Antibody (AK115) in Healthy Participants: A Randomized, Double-Blind, Placebo-Controlled, Dose-Escalation Phase I Clinical Trial.

Objective: This study aimed to investigate the safety, tolerability, pharmacokinetics (PKs), and pharmacodynamics (PDs) of a novel anti-nerve growth factor (NGF) monoclonal antibody (mAb) (AK115) in healthy Chinese participants.

Methods: A randomized, double-blind, placebo-controlled, dose-escalation phase I clinical study was conducted as follows: eligible participants were divided into 6 dose groups, among which 0.5 mg group was administrated with AK115 injection and the remaining 5 groups were randomly assigned to AK115 injection or accompanying placebo at a ratio of 3:1.

Sustainable recovery CoO-based catalysts from spent lithium-ion batteries for preferential CO oxidation.

Retired Lithium-ion batteries (LIBs) present significant challenges related to environmental pollution, making the recycling of battery materials essential for environmental sustainability and energy recovery. Cobalt has been identified as an effective catalyst for oxidation reactions; accordingly, CoO was recovered from batteries directly for use in preferential CO oxidation (CO-PROX). To enhance the low-temperature catalytic activity, supported CuO/CoO catalysts were synthesized, resulting in a remarkable boost in catalytic performance, with thorough CO conversion (T) at 160 °C.

Significant changes in gut microbiota and SCFAs among patients with newly diagnosed acute myeloid leukemia.

The purpose of this study was to identify whether the gut microbiota and metabolites of newly diagnosed acute myeloid leukemia (AML) patients displayed specific characteristic alterations and whether these changes could be used as potential biomarkers for predicting the disease. Notably, the gut microbiota and metabolites of AML patients exhibited significant structural and quantitative alterations at the time of their initial diagnosis. Beneficial bacteria, including , , , and , as well as butyric acid and acetic acid, were found to be considerably reduced in newly diagnosed AML patients.

TOUSLED KINASE INTERACTING PROTEIN 1 (TKI1) interacts with SIN3-LIKES (SNLs) to promote flowering in Arabidopsis.

TOUSLED KINASE INTERACTING PROTEIN 1 (TKI1) is a SANT/Myb domain-containing protein, which binds DNA and may function as a transcription factor, and is characterized as an interacting protein with TOUSLED (TSL) in Arabidopsis. However, it remains largely unknown what biological functions of TKI1 for few reports about TKI1 in the literature. Here we first identified that TKI1 interacts with SIN3-LIKEs (SNLs) and the responsible interaction domains are the C-terminal domain of TKI1 and the PAH (Paired Amphipathic Helix) domains of SNLs respectively in yeast.

Construction of nanosensor based on cobalt phosphate-doped biochar for derivative voltammetric analysis of hydroquinone in environmental samples.

A nanosensing platform was designed based on environmentally friendly cobalt phosphate-doped biochar (CoCPBC) derived from bamboo leaves for derivative voltammetric determination of hydroquinone  (HQ) in water and soil samples. Highly ambient-stable CoCPBC is prepared by hydrothermal synthesis containing cobalt nitrate, phosphoric acid (HPO), cetyltrimethylammonium ammonium bromide (CTAB), and bamboo leaves. Benefiting from the high effective area, the CoCPBC displays more active sites for HQ recognition and simultaneously improving the conductivity of biochar.

Dihydrotanshinone I Attenuates Diet-Induced Nonalcoholic Fatty Liver Disease via Up-Regulation of IRG1.

Nonalcoholic fatty liver disease (NAFLD) is the most common chronic liver disease, but effective therapeutic drugs are still lacking. Dihydrotanshinone I (DHTS), a natural product isolated from Salvia miltiorrhiza , has been shown to have ameliorative effects on NAFLD. The aim of this study was to investigate the hepatoprotective effect of DHTS on NAFLD and its mechanism.

Bioavailability and phytotoxicity of clomazone to corn depend on soil characteristics and can be estimated by in situ pore water.

Background: The injury caused by residual herbicides in soils to subsequent crops has been frequently reported and is largely related to soil physicochemical properties. Elucidating the interactions between herbicide toxicity and soil properties could help assess its phytotoxicity based on local soil characteristics. Here, the influence of soil properties on the accumulation and toxicity of clomazone as a model compound to corn was explored to obtain a universal indicator for estimating the toxicity of herbicides against crops.

MOF-derived high oxygen vacancies CuO/CeO catalysts for low-temperature CO preferential oxidation.

The CO preferential oxidation reaction (CO-PROX) is an effective strategy to remove residual poisonous CO in proton exchange membrane fuel cells, in which oxygen vacancies play a critical role in CO adsorption and activation. Herein, a series of CuO/CeO catalysts derived from Ce-MOFs precursors were synthesized using different organic ligands via the hydrothermal method and the CO-PROX performance was investigated. The CuO/CeO-135 catalyst derived from homophthalic tricarboxylic acid (1,3,5-HBTC) exhibited superior catalytic performance with 100 % CO conversion at a relatively low temperature (T = 100 °C), with a wide reaction temperature range and excellent stability.

Ginkgolide C attenuated Western diet-induced non-alcoholic fatty liver disease via increasing AMPK activation.

Background: Non-alcoholic steatohepatitis (NASH) is a metabolic dysregulation-related disorder that is generally characterized by lipid metabolism dysfunction and an excessive inflammatory response. Currently, there are no authorized pharmacological interventions specifically designed to manage NASH. It has been reported that Ginkgolide C exhibits anti-inflammatory effects and modulates lipid metabolism.

Immunotherapeutic implications on targeting the cytokines produced in rhinovirus-induced immunoreactions.

Rhinovirus is a widespread virus associated with several respiratory diseases, especially asthma exacerbation. Currently, there are no accurate therapies for rhinovirus. Encouragingly, it is found that during rhinovirus-induced immunoreactions the levels of certain cytokines in patients' serum will alter.

Erratum to "Lipidome Atlas of the Developing Heart Uncovers Dynamic Membrane Lipid Attributes Underlying Cardiac Structural and Metabolic Maturation".

[This corrects the article DOI: 10.34133/research.0006.

Piperine attenuates hepatic ischemia/reperfusion injury via suppressing the TLR4 signaling cascade in mice.

Piperine, the major active substance in black pepper, has been shown to have anti-inflammatory and antioxidant effects in several ischemic diseases. However, the role of piperine in hepatic ischemia/reperfusion injury (HIRI) and its underlying mechanisms remain unclear. In this study, the mice were administered piperine (30 mg/kg) intragastric administration before surgery.

LXA4 protected mice from renal ischemia/reperfusion injury by promoting IRG1/Nrf2 and IRAK-M-TRAF6 signal pathways.

Excessive inflammatory response and increased oxidative stress play an essential role in the pathophysiology of ischemia/reperfusion (I/R)-induced acute kidney injury (IRI-AKI). Emerging evidence suggests that lipoxin A4 (LXA4), as an endogenous negative regulator in inflammation, can ameliorate several I/R injuries. However, the mechanisms and effects of LXA4 on IRI-AKI remain unknown.

Proportions and risk factors of chronic obstructive pulmonary disease and preserved ratio impaired spirometry, and association with small airway disease, in the positive screening older population from China: a cross-sectional study.

Background: Early diagnosing Chronic Obstructive Pulmonary Disease (COPD) is relatively difficult. Therefore, the concepts of preserved ratio impaired spirometry (PRISm) and small airway disease (SAD) were proposed to achieve early diagnosis for COPD. Besides, the occurrence of COPD is positively related to age.

Conventional and contrast-enhanced ultrasound in the differential diagnosis of recurrent dermatofibrosarcoma protuberans and postoperative scar.

Background: Dermatofibrosarcoma protuberans (DFSP) has a high recurrence rate after resection. Because of the lack of specific manifestations, recurrent DFSP is easily misdiagnosed as post-resection scar. A few series have reported ultrasound findings of recurrent DFSP; moreover, the usefulness of contrast-enhanced ultrasound in differentiating recurrent DFSP has not been studied.

Evaluation of a Novel Microfocused Ultrasound with Three-Dimensional Digital Imaging for Facial Tightening: A Prospective, Randomized, Controlled Trial.

Background: The excellent efficacy is mitigated by the limited safety profile of microfocused ultrasound procedures.

Objective: We sought to assess the safety and tightening efficacy of a novel microfocused ultrasound.

Methods: The randomized middle and lower face and submental region of the participants were treated with the novel device using the following transducers: M4.

Development of enzyme-inorganic hybrid nanoflower-modified electrodes and a smartphone-controlled electrochemical analyzer for point-of-care testing of salivary amylase in saliva.

Quantitation of salivary alpha-amylase (sAA) plays a significant role in not only theoretical studies but also clinical practice. This study reports a quantitative point-of-care testing (POCT) system for sAA quantitation anywhere, anytime and by anyone, which consists of customized electrodes and a smartphone-controlled electrochemical analyzer. Organic-inorganic hybrid nanoflowers (NFs) encapsulating α-glucosidase (AG) and glucose dehydrogenase (GDH) have been synthesized and modified onto screen-printed electrodes (SPCEs) to fabricate the customized electrodes.

Protectin D1 inhibits TLR4 signaling pathway to alleviate non-alcoholic steatohepatitis via upregulating IRAK-M.

Non-alcoholic steatohepatitis (NASH) is a prevalent metabolic disease, characterized by the hepatic steatosis, inflammation, and fibrosis, which is lack of effective treatment currently. Protectin D1 (PTD1), a lipid mediator from omega-3 fatty acid docosahexaenoic acid (DHA), has displayed wide pharmacological actions including anti-inflammation in a variety of diseases, but the role of PTD1 on NASH remains unclear. In this study, using the methionine and choline deficient (MCD) fed NASH model, we explored the effect and underlying mechanism of PTD1 on NASH in mice.