Effects of non-nutritive sweeteners on body weight: a systematic review and meta-analysis of randomized controlled trial (RCT) studies.

Purposes: Controversy has emerged regarding the impact of non-nutritive sweeteners (NNS) on body weight. This systematic review and meta-analysis of randomized controlled trials aims to assess the effect of NNS intake on body weight change.

Results: Of the 3327 studies retrieved, 19 met the eligibility criteria for inclusion in the meta-analysis.

Nano MgO loaded thermosensitive HPCH@HA hydrogel accelerates in situ bone repair through osteoimmunomodulation while enhancing angiogenesis and osteogenesis.

Bone defect repair is a complex physiological process, starting with early modulation by the inflammatory immune system, and involves multiple physiological events, including angiogenesis, osteogenic differentiation, and mineralization. Biomaterial can regulate inflammatory responses through relevant immune cells in the local immune microenvironment of the implant-bone interface which is a hot topic in the field of regenerative medicine. Currently, Mg regulates immune cells in the bone microenvironment to promote osteogenesis and angiogenesis mainly focuses on macrophages,but there is relatively little research on T cells.

Multi-view Contrastive Learning for Drug-Drug Interaction Event Prediction.

Drug-drug interactions (DDIs) represent a critical challenge in pharmacology, often leading to adverse effects and compromised therapeutic efficacy. Accurate prediction of DDI events, which involve not only identifying interacting drug pairs but also characterizing the specific nature and context of their interactions, is essential for drug safety and personalized medicine. In this study, we propose a novel Multi-view Contrastive Learning framework, namely MCL-DDI, for DDI Event Prediction by leveraging multi-view representations of drugs to enhance predictive performance.

[Qiwei No.3 combined with sildenafil inhibits Rho kinase activity and increases AKT/eNOS expressions in the penile cavernosum of rats with diabetic erectile dysfunction].

Objective: To explore the effects of Qiwei No.3 combined with sildenafil on Rho kinase activity and AKT/eNOS pathways in the penile cavernous tissue of male rats with diabetic erectile dysfunction (DED).

Methods: We constructed a model of DED in 24 SD male rats by intraperitoneal injection of streptozotocin solution and injecting apomorphine into the neck after 8 weeks of feeding, equally randomized the model rats into a model control (MC), a sildenafil (S), a low-dose Qiwei No.

Programmable metal ion-induced patterned multicolour carboxymethylcellulose-based fluorescent hydrogels for information encoding and encryption.

To enhance the usability, security, and data capacity of information encryption materials, an interpenetrating polymer network was developed through copolymerization of carboxymethyl cellulose and acrylamide. Using dimethyl sulfoxide as the solvent, gold nanoclusters and coumarin derivatives were introduced to produce three types of hydrogels that emit red, blue, and green fluorescence. These hydrogels exhibited fluorescence changes in response to Hg and Fe ions, enabling patterning.

Interpretability-guided RNA N-methyladenosine modification site prediction with invertible neural networks.

As one of the most common and abundant post-transcriptional modifications, N-methyladenosine (mA) has been extensively studied for its essential regulatory role in gene expression and cell functions. The location of mA RNA modification sites, however, remains a challenging problem, because of the inability to characterize mA modified sites at a multi-scale level in their native RNA context. Here, we introduce an interpretability-guided invertible neural network (mA-IIN), a deep learning model to accurately identify mA RNA modification sites by integrating both primary and secondary structure information under an invertible coupling framework.

Circadian rhythm genes and immune cell infiltration in myasthenia gravis: A comprehensive analysis.

The fluctuating weakness in myasthenia gravis (MG) is clinically described as the "morning improvement and evening worsening" pattern; MG is commonly associated with sleep disorders. However, there remains a paucity of research investigating the relationship between MG and circadian rhythms. This study seeks to identify pivotal circadian rhythm genes (CRGs) and characterize immune cell infiltration in MG, while exploring their potential roles in MG pathogenesis.

LLM-DDI: Leveraging Large Language Models for Drug-Drug Interaction Prediction on Biomedical Knowledge Graph.

Drug-drug interaction (DDI) refers to the interaction relationships between drugs. Discovering new DDIs is crucial for advancing drug development and enhancing clinical treatments. Given the significant progress achieved through graph neural networks (GNNs), network-based models have become a prevalent approach for tackling this challenge.

A learning behavior classification model based on classroom meta-action sequences.

The individual adaptive behavioral interpretation of students' learning behaviors is a vital link for instructional process interventions. Accurately recognizing learning behaviors and conducting a complete judgment of classroom meta-action sequences are essential for the individual adaptive behavioral interpretation of students' learning behaviors. This paper proposes a learning behavior classification model based on classroom meta-action sequences (ConvTran-Fibo-CA-Enhanced).

BAHCC1 binds H4K20me1 to facilitate the MCM complex loading and DNA replication.

Mono-methylation of histone H4 lysine 20 (H4K20me1) regulates DNA replication, cell cycle progression and DNA damage repair. How exactly H4K20me1 regulates these biological processes remains unclear. Here, we report that an evolutionarily conserved tandem Tudor domain (TTD) in BAHCC1 (BAHCC1) selectively reads H4K20me1 for facilitating replication origin activation and DNA replication.

Association between air pollution and allergic upper respiratory diseases: a meta-analysis.

The prevalence of allergic upper respiratory diseases is rising, and while air pollution may worsen them, study results vary, and comprehensive analyses are lacking. This study aimed to systematically evaluate the link between air pollution and these diseases (allergic rhinitis, asthma and chronic sinusitis (with/without nasal polyps)) to provide evidence for reducing their prevalence. A systematic search of PubMed, Embase, Web of Science and Scopus was conducted to find studies published up to 1 September 2024, regarding association between air pollution and allergic upper respiratory diseases.

Characterization of Homeodomain Proteins at the Aβ Sublocus in and Their Role in Sexual Compatibility and Development.

The A mating-type locus in , which encodes homeodomain (HD) transcription factors, is essential for regulating sexual compatibility and development. While the role of the Aα sublocus and its Y-Z HD protein complex is adequality understood, the function of HD proteins at the Aβ sublocus remains unclear. In this study, we analyzed the Aβ sublocus of eight monokaryotic strains derived from the parental dikaryotic strain 20R-7-Z01 and identified four HD genes, , , , and , located at the Aβ sublocus.

Valence state engineering in multi-heteroatom-doped PAHs: a strategy for tunable photophysical properties and phototheranostic potentials.

Precise modulation of the electronic structures in heteroatom-doped polycyclic aromatic hydrocarbons (hetero-PAHs) is essential for advancing organic optoelectronic materials. Herein, we report a facile synthetic strategy for hetero-PAHs co-doped with N, O, and S/Se, achieved acid-catalyzed Pictet-Spengler reactions and thermally induced -substitution. Systematic π-extension results in a large redshift in optical absorption/emission and enhances fluorescence quantum yield ( ) from 4.

Topical Ropivacaine Combined With Dexamethasone Spray Relieves Post-Tonsillectomy Pain in Adults.

Objective: To evaluate the efficacy of ropivacaine with dexamethasone spray for postoperative pain relief in adults undergoing tonsillectomy.

Methods: A total of 172 adult patients were randomly assigned to four groups: RD group (n = 43) received topical 1% ropivacaine with dexamethasone spray, RP group (n = 43) received topical 1% ropivacaine spray, Saline group (n = 43) received topical saline spray, and Control group (n = 43): not receive any interventions. The groups were compared on resting pain scores at 1, 2, 3, 5, 7, and 10 days, changes in pain scores over 10 days, adverse reactions (including dizziness, nausea, difficulty opening the mouth, and pharyngeal foreign body sensation), the time to first solid food intake, the time to first oral pain medication, and total pain medication dosage within 10 days postoperatively.

Eye-visible red-emitting photoluminescence of copper nanoclusters capped by 2-mercaptopyrimidine derivatives for promoting visualization of latent fingermarks.

Latent fingermarks (LFMs) are served as crucial evidence in screening of identification. There are only a limited number of phosphors with red emission. In this work, the copper nanoclusters (CuNCs) are prepared by chemical reduction of Cu(II) ions using 2-mercaptopyrimidine (MPY) derivatives (such as 4-methyl-2-mercaptopyrimidine (MMPY) and 4,6-dimethyl-2-mercaptopyrimidine (DMPY)), as named MMPY-CuNCs and DMPY-CuNCs, respectively.

A new genus and three new species of Lycoperdaceae (Agaricales) from Southern China revealed by molecular phylogeny and taxonomy.

Lycoperdaceae (Agaricales, Agaricomycetes) is a taxonomically significant fungal family based on the globally distributed and morphologically defined puffball structures. In the present study, one new genus, , and three new species, viz. , , and , collected from southern China are proposed based on a combination of morphological characteristics and molecular evidence.

Comparative efficacy and acceptability of novel biologics in the treatment of myasthenia gravis: systematic review and network meta-analysis of randomized trials.

Background: Myasthenia gravis (MG) is a chronic autoimmune disorder affecting the neuromuscular junction. The emergence of molecular therapies, such as monoclonal antibodies, B-cell-depleting agents, and chimeric antigen receptor T-cell-based therapies, has the potential to transform the treatment landscape for myasthenia gravis. The clinical efficacy of novel biologics in the treatment of individuals with myasthenia gravis is still a subject of debate.

The Role of Nitric Oxide in the Growth and Development of Under Anaerobic Conditions.

Nitric oxide (NO) is a widely recognized signaling molecule found across various organisms, yet its specific effects on fungal growth and development under anaerobic conditions remain underexplored. This study investigates how NO influences the growth and development of 20R-7-F01 under anaerobic environments. The results demonstrated an increase in endogenous NO levels during mycelial growth and basidiospore germination.

Occurrence and Molecular Characterization of spp. in Beef Cattle in Yunnan Province, China.

spp. are protozoan pathogens that are widespread within mammals. In recent years, extensive molecular epidemiology studies on in dairy cattle have been conducted in Yunnan and worldwide.

Evidence for the Existence of Mating Subtypes Within the : Mating Behavior and Genetic Divergence.

, a Basidiomycota fungus with a tetrapolar mating system, serves as a key model for studying sexual reproduction. In this study, two distinct mating subtypes (I and II) were identified in strain 20R-7-ZF01, isolated from subseafloor sediment, which exhibited eight different mating interaction phenotypes. Intra-subtypes exhibited colony-symmetric tetrapolar interactions (G1), whereas inter-subtype crosses yielded colony-asymmetric phenotypes (G2) and a reduced number of fruiting bodies.

Impacts of air pollutions on cardiovascular and cerebrovascular diseases through inflammation: a comprehensive analysis of one million Chinese and half million UK individuals.

Background: Epidemiological studies have found an association between air pollution and cardiovascular and cerebrovascular diseases (CACD) and its subtypes. However, there is a lack of individual-level data to explore the associations of air pollutants on CACD and its subtypes, the interaction among them, and the potential mechanism.

Methods: This study employed a two-stage design, combining a time-stratified case-crossover study with a cohort study, analyzing data from one million individuals from China and half million from the UK.

Substrate recognition and cleavage mechanism of the monkeypox virus core protease.

Poxviruses cause severe diseases, including smallpox and mpox, that pose major threats to human health. The poxvirus core protease (Core) is essential for viral maturation and is highly conserved in poxviruses, making it an attractive antiviral target. However, the structure of Core remains unknown, hampering antiviral development.

What role does social class play in the impact of social environment on residents' health.

This study aims to identify the role and pathways through which social class plays a part in the impact of the social environment on residents' health. Using data from the China General Social Survey 2021, we analyzed a sample of 2715 participants to assess the role and pathways of social class in the influence of the social environment on residents' health. We employed the Ordinary Least Squares model to quantify the impact of the social environment on residents' health and utilized the Karlson-Holm-Breen method along with the construction of product terms to estimate the mediating and moderating effects of social class.

Recombinant Antithrombin Alleviated Pulmonary Injury and Inflammation in LPS-Induced ARDS by Inhibiting IL17a/NF-κB Signaling.

Background: Recombinant antithrombin (rAT) has been shown to protect lungs from ARDS and modulate immune responses, but its anti-inflammatory mechanisms remain unclear. This study aimed to explore the immunomodulatory effects and mechanisms of rAT in LPS-induced ARDS mice.

Methods: ARDS mouse model was established by intraperitoneally administration of 20 mg/kg LPS.

Histone lactylation regulates early embryonic development through m6A methyltransferase METTL3 in goats.

Histone lysine lactylation (Kla) is a novel epigenetic modification that plays a crucial role in cellular processes driven by glycolysis and lactate production. However, the mechanisms of histone lactylation and its interaction with m6A RNA methylation during early embryonic development remain underexplored. This study systematically investigated the effects of oxygen levels-atmospheric oxygen (atmosO; 20% O) and physiological oxygen (physO; 5% O)-on hallmark events during early embryonic development, revealing that lactylation modification regulates early goat embryonic development through the m6A methyltransferase-like 3 (METTL3).