Synergistic Chalcogenate and Fluorine Engineering on Metal Oxyhydroxides Breaks the OER Scaling Relationship.

The oxygen evolution reaction (OER), a bottleneck in electrochemical water splitting, is fundamentally limited by a scaling relationship between the binding energies of key intermediates (OH* and OOH*), imposing a minimum theoretical overpotential of 0.37 eV. Breaking this scaling relationship is crucial for enhancing OER activity, yet effective strategies remain scarce.

Analysis of the effectiveness of combined CT angiography, MMP-9, and PAF testing in the assessment of vascular restenosis in acute coronary syndromes after atorvastatin combined with tirofiban therapy.

Background: Acute Coronary Syndrome (ACS) is a very common cardiovascular disease in clinical practice with a very high risk of death. In this study, we observed the effectiveness of CT angiography (CTA), matrix metalloproteinase-9 (MMP-9) and platelet-activating factor (PAF) in the assessment of ACS.

Methods: A total of 124 patients with ACS admitted to our hospital from June 2022 to March 2024 were enrolled as study subjects.

Chemically modified CRISPR-Cas9 enables targeting of individual G-quadruplex and i-motif structures, revealing ligand-dependent transcriptional perturbation.

The development of selective ligands to target DNA G-quadruplexes (G4s) and i-motifs (iMs) has revealed their relevance in transcriptional regulation. However, most of these ligands are unable to target individual G4s or iMs in the genome, severely limiting their scope. Herein, we describe a new Approach to Target Exact Nucleic Acid alternative structures (ATENA) that relies on the chemical conjugation of established G4 and iM ligands to a catalytically inactive Cas9 protein (dCas9), enabling their individual targeting in living cells.

High selectivity production of light aromatics via CO hydrogenation by tuning the crystal size of plate-like zeolite.

Direct hydrogenation of CO to high-value chemicals, especially aromatics, is an effective strategy for the alleviation of carbon emissions. Tremendous progress has been made in the direct conversion of CO into aromatics recently, but the highly selective synthesis of light aromatics (C-C) remains a huge challenge due to the complex role of Brønsted acid sites (BAS) and pore properties of zeolite in aromatic synthesis. Herein, a combination of the Na-modified ZnFeO and plate-like ZSM-5 (pZ5) with different b-axis thicknesses, which shows excellent performance for CO hydrogenation to light aromatics.

WormNet: A Multi-View Network for Silkworm Re-Identification.

Re-identification (ReID) has been widely applied in person and vehicle recognition tasks. This study extends its application to a novel domain: insect (silkworm) recognition. However, unlike person or vehicle ReID, silkworm ReID presents unique challenges, such as the high similarity between individuals, arbitrary poses, and significant background noise.

FAP Promotes Pulmonary Artery Hypertension via Activation of the PTEN/PI3K/Akt Pathway.

Pulmonary arterial hypertension (PAH) is a severe disease characterized by significant pulmonary vascular remodeling and right ventricular dysfunction. Activated fibroblasts can induce collagen deposition around blood vessels, thereby promoting vascular hardening and PAH development. Fibroblast activation protein (FAP) is a proline-specific serine protease expressed in active fibroblasts that is closely associated with tissue remodeling, inflammation, fibrosis, tumor growth, and cellular proliferation.

RBP7 knockdown inhibits proliferation of human hepatocellular carcinoma and activates the p38 MAPK pathway.

Background: Retinoid metabolism is critical for maintaining liver homeostasis, and its dysregulation is closely associated with liver diseases. Retinol binding protein 7 (RBP7) involves in retinoids transport, particularly in liver, indicating its importance in hepatic functions. However, its specific role in hepatocellular carcinoma (HCC) tumorigenesis remains unclear and needs to further investigation.

Research on visual design of urban multimedia portal.

In the digital multimedia era, city portal websites significantly impacted urban identity representation. This study addresses the complex challenge of selecting color schemes that authentically reflect cities' unique characteristics. We developed a decision model integrating Fuzzy Analytic Hierarchy Process and Gray Relational Analysis (FAHP-GRA) to evaluate color preferences.

Nature of the Active Sites and Reaction Mechanism during Methanol Steam Reforming over Cu/ZnO: An Isotopic Modulated Excitation Diffuse Reflectance Infrared Fourier Transform Spectroscopy Study.

Hydrogen production with high efficiency and low CO selectivity is the objective of developing methanol steam reforming (MSR) catalysts. The nature of the active sites and reaction mechanisms, however, has not been fully resolved, hampering the rational design of improved catalysts. Herein, we apply the isotope modulation excitation-phase sensitive detection-diffuse reflectance infrared Fourier transform spectroscopy (ME-PSD-DRIFTS) method to identify active surface species and determine the reaction pathway of the dynamic processes.

Enantioselective Synthesis of 2,3-Disubstituted Azetidines via Copper-Catalyzed Boryl Allylation of Azetines.

Disclosed here is a highly enantioselective difunctionalization of azetines for convenient access to chiral 2,3-disubstituted azetidines, a family of important scaffolds previously lacking general access. With Cu/bisphosphine as a catalyst, two versatile functionalities (boryl and allyl) were installed on azetine with concomitant construction of two new stereogenic centers. This represents a rare demonstration of Cu-catalyzed asymmetric boryl alkylation of electron-rich olefins and C═C bonds in strained heterocycles.

Development of a High-Efficacy and Low-Toxicity Cobalt(II) Agent for Targeting Inhibition of Tumor Growth through Mitochondrial Damage-Mediated Chemotherapy and Immunotherapy.

To overcome the deficiencies of platinum agents and the targeted inhibition of tumor growth, we proposed to develop a high-efficacy and low-toxicity cobalt (Co) agent multiacting on tumor cells based on the properties of the tumor microenvironment and liposomes (Lip). To this end, we optimized a series of Co(II) α-N-heterocyclic thiosemicarbazone complexes to obtain a Co(II) complex (C3) with significant cytotoxicity against tumor cells through an investigation of their structure-activity relationships and then constructed a C3-Lip delivery system. results showed that, on the one hand, C3/C3-Lip effectively inhibits tumor growth with almost no toxic side effects; on the other hand, C3-Lip improves the therapeutic efficiency and targeting ability of C3.

Electrochemically synthesized Cu-Mg mesh catalysts for methanol steam reforming.

Methanol steam reforming (MSR) represents a cost-effective method for hydrogen production. Structured catalysts, which exhibit strong resistance to frequent mechanical vibrations and suitability for on-board MSR, are somewhat complicated to fabricate. Herein, we synthesized and investigated copper-magnesium (Cu-Mg) mesh-type structured catalysts by a modified cycling chronopotentiometry method.

High internal phase Pickering emulsions stabilized by tea residue protein: Application in β-carotene encapsulation.

The increasing production and consumption of tea drinks has led to the generation of large amounts of discarded extracted tea residues. As a result, researchers have attempted to extract tea water-insoluble protein (TP) from discarded tea residues to produce food emulsifiers. Thus, in this study, high-internal-phase Pickering emulsions (HIPPEs) stabilized by TP were developed and characterized.

Single-atom catalysts confined in shell layer achieved by a modified top-down strategy for efficient CO reduction.

High-temperature pyrolysis is a primary method for synthesizing single-atom catalysts (SACs). However, this method accelerates the migration of metal atoms within the solid support, leading to low atom utilization. Herein, we report a novel top-down synthesis strategy wherein surface-sintered nickel sulfide (NiS) nanoparticles (NPs) are in situ atomized into single atoms, achieving confinement of the single-atom catalyst within the shell layer and synthesizing a high-performance single-atom catalyst.

Histone lactylation regulates early embryonic development through m6A methyltransferase METTL3 in goats.

Histone lysine lactylation (Kla) is a novel epigenetic modification that plays a crucial role in cellular processes driven by glycolysis and lactate production. However, the mechanisms of histone lactylation and its interaction with m6A RNA methylation during early embryonic development remain underexplored. This study systematically investigated the effects of oxygen levels-atmospheric oxygen (atmosO; 20% O) and physiological oxygen (physO; 5% O)-on hallmark events during early embryonic development, revealing that lactylation modification regulates early goat embryonic development through the m6A methyltransferase-like 3 (METTL3).

Tuning the Formation Kinetics of *OOH Intermediate with Hollow Bowl-Like Carbon by Pulsed Electroreduction for Enhanced HO Production.

The electrochemical synthesis of hydrogen peroxide (HO) via the two-electron oxygen reduction reaction (2e ORR) is a promising alternative to the conventional anthraquinone method. However, due to local alkalinization near the catalyst surface, the restricted oxygen replenishment and insufficient activated water molecule supply limit the formation of the key *OOH intermediate. Herein, a pulsed electrocatalysis approach based on a structurally optimized S/N/O tridoped hollow carbon bowl catalyst has been proposed to overcome this challenge.

Orbital Matching Mechanism-Guided Synthesis of Cu-Based Single Atom Alloys for Acidic CO Electroreduction.

Recent advancements in alloy catalysis have yield novel materials with tailored functionalities. Among these, Cu-based single-atom alloy (SAA) catalysts have attracted significant attention in catalytic applications for their unique electronic structure and geometric ensemble effects. However, selecting alloying atoms with robust dispersion stability on the Cu substrate is challenging, and has mostly been practiced empirically.

CAUSAL ASSOCIATION BETWEEN MEDICATION USE AND SEPSIS: A TWO-SAMPLE MENDELIAN RANDOMIZATION STUDY.

Objective: This study aimed to explore the causal association between genetically predicted medication use and sepsis. Methods: Utilizing summary data from genome-wide association studies (GWAS) on selected medications use and sepsis, a two-sample Mendelian randomization (MR) design was employed. Analysis was conducted using the Inverse Variance Weighted (IVW), weighted median, weighted mode, and MR-Egger regression methods.

Identification of glycolysis-related gene signatures for prognosis and therapeutic targeting in idiopathic pulmonary fibrosis.

Background: Glycolysis plays a crucial role in fibrosis, but the specific genes involved in glycolysis in idiopathic pulmonary fibrosis (IPF) are not well understood.

Methods: Three IPF gene expression datasets were obtained from the Gene Expression Omnibus (GEO), while glycolysis-related genes were retrieved from the Molecular Signatures Database (MsigDB). Differentially expressed glycolysis-related genes (DEGRGs) were identified using the "limma" R package.

MFI-Net: multi-level feature invertible network image concealment technique.

The utilization of deep learning and invertible networks for image hiding has been proven effective and secure. These methods can conceal large amounts of information while maintaining high image quality and security. However, existing methods often lack precision in selecting the hidden regions and primarily rely on residual structures.

Accelerated Selective Electrooxidation of Ethylene Glycol and Inhibition of C-C Dissociation Facilitated by Surficial Oxidation on Hollowed PtAg Nanostructures via In Situ Dynamic Evolution.

Electro-upgrading of low-cost alcohols such as ethylene glycol is a promising and sustainable approach for the production of value-added chemicals while substituting energy-consuming OER in water splitting. However, the sluggish kinetics and possibility of C-C dissociation make the design of selective and efficient electrocatalysts challenging. Herein, we demonstrate the synthesis of a hollowed bimetallic PtAg nanostructure through an in situ dynamic evolution method that could efficiently drive the selective electrochemical ethylene glycol oxidation reaction (EGOR).

Advances in understanding ferroptosis mechanisms and their impact on immune cell regulation and tumour immunotherapy.

Ferroptosis is a novel mode of iron-dependent non-apoptotic cell death that occurs mainly due to excessive accumulation of lipid peroxides. Numerous studies in recent years have shown that ferroptosis plays a vital role in the organism and has important interactions with immune cells. Ferroptosis has been shown to have great potential in tumour therapy through studying its mechanism of action.

Platinum/(Carbon-Nanotube) Electrocatalyst Boosts Hydrogen Evolution Reaction in Acidic, Neutral and Alkaline Solutions.

Widely used catalysts for electrocatalytic hydrogen (H) evolution reaction (HER) have high platinum (Pt) contents and show low efficiencies in neutral and alkaline solutions. Herein, a carbon nanotube (CNT) supported Pt catalyst (Pt/CNT45) with 1 wt.% Pt is fabricated.

Photodynamic therapy with a novel photosensitizer inhibits DSS-induced ulcerative colitis in rats via the NF-κB signaling pathway.

Introduction: Ulcerative colitis (UC) is an inflammatory bowel disease characterized by inflammation and ulceration of the digestive tract.

Methods: Photodynamic therapy (PDT) with a novel photosensitizer LD was used to treat UC rat models to explore the therapeutic effect and mechanism of LD-PDT on UC. 16S ribosomal RNA was used to detect the composition of Gut microbiota.