When buildings become barriers: assessing the impact of building height on the equality of emergency medical services accessibility-a dual-trip study in Wuhan, China.

Background: As urbanization accelerates, the height of urban buildings continues to rise, which may influence the provision of Emergency Medical Services (EMS). However, a current limitation is that related studies often neglect the impact of spatial variations in building height on EMS accessibility equality. Most scholars have focused primarily on EMS road travel-either the Departure Road Trip (DRT) or the Transport Trip (TT)-while overlooking the effects of building height on the in-building EMS trip, known as the Patient Access Trip (PAT).

Developing an Arene Binuclear Ruthenium(II) Complex to Induce Ferroptosis and Activate the cGAS-STING Pathway: Targeted Inhibiting Growth and Metastasis of Triple Negative Breast Cancer.

To effectively inhibit the growth and metastasis of triple-negative breast cancer (TNBC), we developed a high-efficiency and low-toxicity arene ruthenium (Ru) complex based on apoferritin (AFt). To achieve this, we optimized a series of Ru(II) 1,10-phenanthroline-2,9-diformaldehyde thiosemicarbazone complexes by studying their structure-activity relationships to obtain an arene binuclear Ru(II) complex (C5) with significant cytotoxicity and high accumulation in the mitochondria of tumor cells. Subsequently, a C5-AFt nanoparticle (NPs) delivery system was constructed.

Human Serum Albumin-Platinum(II) Agent Nanoparticles Inhibit Tumor Growth Through Multimodal Action Against the Tumor Microenvironment.

To overcome the limitations of traditional platinum (Pt)-based drugs and further improve the targeting ability and therapeutic efficacy in vivo, we proposed to design a human serum albumin (HSA)-Pt agent complex nanoparticle (NP) for cancer treatment by multimodal action against the tumor microenvironment. We not only synthesized a series of Pt(II) di-2-pyridone thiosemicarbazone compounds and obtained a Pt(II) agent [Pt(Dp44mT)Cl] with significant anticancer activity but also successfully constructed a novel HSA-Pt(Dp44mT) complex nanoparticle delivery system. The structure of the HSA-Pt(Dp44mT) complex revealed that Pt(Dp44mT)Cl binds to the IIA subdomain of HSA and coordinates with His-242.

Tunable Electrochemical Activity of P2-NaMnNiOF Microspheres as High-Rate Cathodes for High-Performance Sodium Ion Batteries.

As an important cathode candidate for the high-performance sodium ion batteries (SIBs), P2-type oxides with layered structures are needed to balance the specific capacities and cycling stability. As a result, a cation and anion codoped strategy has been adopted to tune the electrochemical activity of the redox centers and modulate the structure properties. Herein, a series of P2-NaMnNiOF ( = 0, 0.

Spatiotemporal access to emergency medical services in Wuhan, China: accounting for scene and transport time intervals.

Background: Access as a primary indicator of Emergency Medical Service (EMS) efficiency has been widely studied over the last few decades. Most previous studies considered one-way trips, either getting ambulances to patients or transporting patients to hospitals. This research assesses spatiotemporal access to EMS at the shequ (the smallest administrative unit) level in Wuhan, China, attempting to fill a gap in literature by considering and comparing both trips in the evaluation of EMS access.

[Ultrasonic atomization of Shaduolika and dexamethasone for pain relief in patients with foliate papillitis].

Purpose: To evaluate the effect of ultrasonic atomization of Shaduolika (a traditional Chinese herb), dexamethasone for pain relief in patients with foliate papillitis.

Methods: 84 patients with foliate papillitis were divided into two groups randomly with the single-blind method. Patients in the experimental group were treated with ultrasonic atomization of Shaduolika and dexamethasone, while patients in the control group were treated by taking Niuhuangjiedu tablets (mixed traditional Chinese medicine).