Single-cell transcriptomic analysis reveals metastatic and immunosuppressive characteristics in meningioma brain-tumor interface.

Background: Meningioma is a common primary intracranial tumor with high recurrence and metastasis rate. Delineating the pathological ecosystem at the brain-tumor interface (BTI) of meningioma is critical for understanding the mechanisms of tumor metastasis and developing effective new therapies.

Methods: To identify biomarkers of early metastasis and discover potential therapeutic targets, we integrated single-cell transcriptome datasets of meningioma, and identified the cell populations and molecular signatures uniquely present at the BTI.

Social jet lag and mental health outcomes: A systematic review and meta-analysis.

In modern society, social jet lag has become increasingly prevalent due to the diversification of work, study, and social activities. While growing evidence suggests a link between social jet lag and mental health, findings remain inconsistent and lack a comprehensive synthesis. This meta-analysis aimed to systematically integrate existing evidence by analyzing 25 observational studies from five electronic databases.

Development and validation of a prediction model based on a nomogram for tuberculous pleural effusion.

Background: Diagnosing tuberculous pleural effusion (TPE) is challenging. There is a lack of cross-sectional lateral comparisons among TPE prediction models.

Objectives: We aimed to develop and validate a novel TPE prediction model and compare its diagnostic performance with that of existing models.

Transformable self-assembling peptide nanoplatforms with tumor microenvironment responsiveness for tumor stem cell suppression and immunomodulation.

Breast cancer stem cells (BCSCs) drive tumor formation and growth via self-renewal, differentiation, and high tumorigenic potential, and the persistence of BCSCs is an important cause of treatment failure in patients with breast cancer. In addition, the tumor microenvironment promotes the maintenance of BCSC stemness, inhibits immune cell activity, and forms an immune escape "barrier". In this study, we developed an amphiphilic peptide nanocarrier system, PA/Pep1, with an RGD-targeting sequence.

Linking obstructive sleep apnea with pulmonary hypertension via pooled prevalence and causal association: A systematic review, meta-analysis and Mendelian randomization.

Background: The coexisting prevalence and causal associations between obstructive sleep apnea (OSA) and pulmonary hypertension (PH) warranted further investigations.

Objectives: To investigate the prevalence of PH in patients with OSA and OSA in patients with PH and reveal the bidirectional causal association between OSA and PH via Mendelian randomization (MR).

Methods: Eligible records were selected from PubMed, Web of Science and Scopus.

NHP2 and PRPF4 are hub genes associated with the prognosis of colorectal cancer.

Background: There is an urgent need to identify more accurate and practical prognostic markers for improving the diagnosis and treatment outcomes of colorectal cancer (CRC). This study aimed to identify hub genes of CRC and to evaluate their clinical significance.

Methods: Proteomics analysis was performed on human CRC tissues and adjacent normal tissues, with bioinformatic screening applied to identify hub genes.

Semaphorin 3A protects against thoracic aortic aneurysm dissection by suppressing aortic angiogenesis.

Thoracic aortic aneurysm (TAA) is life-threatening once developing to sudden dissection (TAAD) or rupture. The pathogenesis of TAA remains poorly understood and there is no effective pharmacologic therapy. Increased aortic angiogenesis has been recognized as a key factor contributing to TAA formation, yet the regulatory mechanisms governing this process remain unclear.

Mitochondrial deoxyguanosine kinase depletion induced ROS causes melanocyte stem cell exhaustion and hair greying.

Hair pigmentation is regulated by melanocyte stem cells (MeSCs) within the hair follicle. Mitochondrial dysfunction is associated with hair depigmentation, primarily due to defects in melanogenesis. However, the mechanisms by which mitochondria support MeSCs during hair pigmentation remain obscure.

Linking Chronic Obstructive Pulmonary Disease and Asthma with Gallstones: Evidence from a Cross-Sectional Study and Mendelian Randomization.

Objective: To investigate whether chronic obstructive pulmonary disease (COPD) and asthma increase the risk of gallstones based on the National Health and Nutrition Examination Survey (NHANES) and Mendelian randomization (MR).

Methods: Data from the NHANES 2017-2023 were included in the cross-sectional study. Diagnoses of COPD, asthma and gallstones were obtained from self-report questionnaires.

Viral Infections in Elderly Individuals: A Comprehensive Overview of SARS-CoV-2 and Influenza Susceptibility, Pathogenesis, and Clinical Treatment Strategies.

As age increases, the immune function of elderly individuals gradually decreases, increasing their susceptibility to infectious diseases. Therefore, further research on common viral infections in the elderly population, especially severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and influenza viruses, is crucial for scientific progress. This review delves into the genetic structure, infection mechanisms, and impact of coinfections with these two viruses and provides a detailed analysis of the reasons for the increased susceptibility of elderly individuals to dual viral infections.

Work addiction in nurses: a cross-sectional correlational study of latent profile analysis and burnout.

Background: The nursing profession is known for its high intensity and high pressure, and burnout is prevalent among nurses.In recent years, work addiction has attracted attention as an emerging occupational psychological problem.However, there is a relative lack of research on nurses' work addiction, especially in the case of its underlying features and its relationship with burnout.

The effect of preparation process on combustibility of Robinia pseudoacacia charcoal and its structure-performance relationship.

Using Robinia pseudoacacia (RP) branches as raw materials, charcoal was prepared in a nitrogen atmosphere. The optimal conditions for preparing charcoal were determined based on energy yield, mass yield, and combustion characteristics (R), ignition characteristic index (D), comprehensive combustion index (S), flame stability combustion index (F), and combustion time (t) in co-combustion with anthracite, which turned out to be a pyrolysis temperature of 500 °C, a heating rate of 4 °C/min, and an isothermal residence time of 60 min. Elemental analysis, X-ray Diffraction (XRD), and Raman fitting were used to analyze the microstructure of the RP Charcoal (RPC).

Characterizing HLA-A2-restricted CD8 T-cell epitopes and immune responses to Omicron variants in SARS-CoV-2-inactivated vaccine recipients.

Introduction: Recent surveillance has identified the emergence of the SARS-CoV-2 Omicron ariant, which exhibits the ability to evade multiple neutralizing antibodies generated by prior infection or vaccination. However, significant knowledge gaps remain regarding the CD8 T-cell immune reactivity to the Omicron variant. This study aims to evaluate the characteristics of HLA-A2-restricted CD8 T-cell epitopes from the Omicron variant and analyze epitope-specific CD8 T-cell responses to SARS-CoV-2 inactivated vaccines.

Ligand-Modulated Nickel/Photoredox-Catalyzed -Arylalkylation of Alkynes.

A ligand-modulated synergetic nickel/photoredox-catalyzed -arylalkylation of unactivated alkynes was developed that was strikingly different from the known -arylalkylation of activated arylacetylenes. The unique arylalkylation pathway was due to the formation of a π-allyl-Ni complex from alkyne where the nickel species was engaged in a distinctive dual-catalytic cycle. The nickel/photoredox-catalyzed -alkenylation was applied to the divergent synthesis of tryptamines and benzofurylethylamines.

Altered face perception in amnestic mild cognitive impairment: Evidence from representational similarity analysis of event-related potential.

BackgroundStructural changes in medial temporal lobes including the fusiform gyrus, a critical area in face recognition, precede the progression of amnestic mild cognitive impairment (aMCI) to Alzheimer's disease (AD). However, how the neural correlates of face processing altered in aMCI, as well as their association with cognitive impairments, remain unclear.ObjectiveUsing electroencephalogram (EEG), we explored the electrophysiological markers of face-specific visual processing alterations in aMCI and examined their relationship with cognitive deficits.

Exosomal PD-L1 and lactate versus tissue PD-L1 as biomarkers for clinical outcomes of PD-1 Blockade plus chemotherapy in metastatic esophagogastric signet ring cell carcinoma.

In this investigator-initiated, prospective, exploratory study, biomarkers predictive of clinical outcomes of first-line immune checkpoint inhibitor (ICI, nivolumab or pembrolizumab) plus XELOX(oxaliplatin and capecitabine) were identified in human epidermal growth factor receptor 2 (HER2)-negative patients with metastatic esophagogastric signet ring cell carcinoma. The findings showed an objective response rate (ORR) of 51.5% and a disease control rate of 86.

Discovering new hub genes of dilated cardiomyopathy.

Aims: Dilated cardiomyopathy (DCM) has a poor prognosis and exhibits a complex and diverse aetiology and genetic profile. The genes responsible for the pathogenesis of DCM have not been fully identified. The present study aimed to explore new hub genes of DCM by mining the human DCM databases and further by experimental validation.

The Role of Deregulated MicroRNAs in Immune Cells of Sjögren's Disease.

The 2024 Nobel Prize in Physiology or Medicine, awarded for the discovery of microRNAs (miRNAs) as essential regulators of gene expression, has spotlighted their pivotal roles in disease processes, including autoimmune conditions such as Sjögren's disease (SD). SD is a chronic autoimmune disease marked by lymphocytic infiltration of exocrine glands, resulting in significant glandular dysfunction and diverse systemic effects. Recent research has revealed that miRNAs play crucial roles in SD pathogenesis, orchestrating immune cell activity, epithelial cell integrity, and the regulation of inflammatory pathways.

Machine learning-based myocardial infarction bibliometric analysis.

Purpose: This study analyzed the research trends in machine learning (ML) pertaining to myocardial infarction (MI) from 2008 to 2024, aiming to identify emerging trends and hotspots in the field, providing insights into the future directions of research and development in ML for MI. Additionally, it compared the contributions of various countries, authors, and agencies to the field of ML research focused on MI.

Method: A total of 1,036 publications were collected from the Web of Science Core Collection database.

Quzhou Aurantii Fructus Flavonoids Ameliorate Inflammatory Responses, Intestinal Barrier Dysfunction in DSS-Induced Colitis by Modulating PI3K/AKT Signaling Pathway and Gut Microbiome.

Purpose: To explore the protective effect and underlying mechanism of Quzhou Aurantii Fructus flavonoids (QAFF) on Ulcerative colitis (UC).

Methods: The constituents of QAFF were accurately determined by ultra-performance liquid chromatography-tandem mass spectrometry (UPLC-MS/MS). The therapeutic impacts of QAFF were assessed in dextran sulfate sodium (DSS)-induced UC mice, focusing on the changes in body weight, disease activity index (DAI), colon length, histological assessment of colonic tissues, levels of pro-inflammatory cytokines, and expression of tight junction proteins.

Trimethylamine oxide promotes myocardial fibrosis through activating JAK2-STAT3 pathway.

Myocardial infarction is often accompanied by symptoms of myocardial fibrosis, causing myocardial systolic and diastolic dysfunction. High levels of TMAO are considered to be strongly connected to cardiovascular diseases occurrence. The objective of this investigation was to determine whether formal TMAO affects the development of cardiac muscle fibers.

Synaptotagmin-1 attenuates myocardial programmed necrosis and ischemia/reperfusion injury through the mitochondrial pathway.

Programmed necrosis/necroptosis greatly contributes to the pathogenesis of cardiac disorders including myocardial infarction, ischemia/reperfusion (I/R) injury and heart failure. However, the fundamental mechanism underlying myocardial necroptosis, especially the mitochondria-dependent death pathway, is poorly understood. Synaptotagmin-1 (Syt1), a Ca sensor, is originally identified in nervous system and mediates synchronous neurotransmitter release.