Salicylic acid regulates biosynthesis of floral fragrance (E)-β-farnesene via NPR3-WRKY1 module in chrysanthemum.

Floral fragrance is essential for the attraction of pollinators and responses to biotic and abiotic stresses. It also enhances the quality and economic value of plants. Phytohormones, acting as key signaling molecules, are crucial roles in regulating plant growth and development.

Heavy Grazing Leads to Increased Dominance of Plant and Soil Nematode Communities.

Herbivore grazing plays a crucial role in grassland ecosystems, yet its comprehensive impact on plant and soil nematode diversity in desert steppe remains unclear. We assessed the impact of different grazing intensities (CK: no grazing, LG: light grazing, MG: moderate grazing, HG: heavy grazing, EG: extreme heavy grazing) on plant and soil nematode diversity in desert steppe. In the HG treatment, the diversity of plants and nematodes was the lowest and significantly lower than that in the CK treatment.

Timosaponin B- II Enhances Osteogenic Differentiation of Human Periodontal Ligament Stem Cells via PI3K/AKT/GSK3β Signaling Pathway.

Background: This investigation aims to elucidate the effects of Timosaponin B-II (TB-II) on the proliferation and osteogenic differentiation of human periodontal ligament stem cells (hPDLSCs) through both in vitro experiments and an in vivo orthodontic tooth movement model utilizing rats. The primary objective is to clarify the mechanisms by which TB-II influences the remodeling of periodontal tissue under biomechanical stress, thereby providing insights into its potential role in reducing relapses after orthodontic tooth movement.

Methods: hPDLSCs were isolated and characterized via flow cytometry and multilineage differentiation assays (osteogenic and adipogenic induction).

A Novel Therapeutic Strategy for Bone Marrow Failure: Niche Rejuvenation Using Costal Cartilage-Derived Stem Cells.

The bone marrow (BM) niche plays a critical role in maintaining hematopoietic stem cell function but is highly vulnerable to damage from chemotherapy and radiation. However, current therapeutic strategies for BM niche failure remain significantly limited. The previous study demonstrate that costal cartilage-derived stem cells (CDSCs) exhibit substantial self-renewal and bone-forming capacity; however, whether and how CDSCs contribute to BM microenvironment maintenance remains unknown.

Cysteine mediates the association of essential trace elements with polycystic ovary syndrome: Does ambient particulate matters exposure modify the mediation effect of cysteine.

Objective: In this study, we aimed to investigate the relationship between essential trace element levels in FF and PCOS and to determine whether this association was mediated by the antioxidant stress indicator cysteine (Cys). In addition, the effect of ambient PM exposure on the mediation effect of Cys was examined.

Methods: A case-control study was conducted, which involved 420 patients with PCOS and 408 controls.

Female predominance in nocturnal hypoxemia among elderly OSAS patients: hemoglobin mediates sex-specific hypoxic burden in Chinese cohorts.

Objectives: To explore the clinical characteristics and sex differences in relevant indicators of obstructive sleep apnea syndrome (OSAS) in elderly patients.

Methods: A total of 1290 elderly patients diagnosed with OSAS by polysomnography (PSG) from 2015 to 2017 were consecutively collected from multiple medical institutions. Detailed demographic data, laboratory indicators, and sleep breathing parameters were recorded for each patient.

RNA m6A methylation regulates CDH6 to promote epithelial-to-mesenchymal transition in cholangiocytes of biliary atresia.

Purpose: N6-methyladenosine (m6A) is involved in biliary atresia (BA), however the underlying mechanisms remain unknown. This study aims to explore the involvement of m6A modification and its role in epithelial-to-mesenchymal transition (EMT) in BA cholangiocytes.

Method: A published single-cell RNA sequencing dataset (HRA003163) was analyzed, focusing on cholangiocytes for differential gene expression, pathway enrichment, and correlation analyses.

NSD2 inhibitors rewire chromatin to treat lung and pancreatic cancers.

NSD2 catalyses the epigenetic modification H3K36me2 (refs. ) and is a candidate convergent downstream effector of oncogenic signalling in diverse malignancies. However, it remains unclear whether the enzymatic activity of NSD2 is therapeutically targetable.

A case of membranous nephropathy complicated by autoimmune hepatitis and primary biliary cholangitis.

Rationale: Membranous nephropathy (MN) is an important and common cause of nephrotic syndrome in adults. Overlap syndrome is an infrequent clinical subgroup characterized by the coexistence of autoimmune hepatitis, primary biliary cholangitis or primary sclerosing cholangitis. Coexistence of MN and autoimmune liver diseases is rare.

Hypoxia-Induced Creatine Uptake Reprograms Metabolism to Antagonize PARP1-Mediated Cell Death and Facilitate Tumor Progression in Hepatocellular Carcinoma.

Recently, a PARP1-dependent cell-death process termed "parthanatos" that is driven by DNA damage has emerged as a crucial regulator of tissue homeostasis and tumorigenesis. Hypoxia is a hallmark of solid tumors and profoundly affects the malignant phenotypes of cancer cells. Here, we investigated the crosstalk between parthanatos and hypoxia.

Establishment of predictive models for postoperative delirium in elderly patients after knee/hip surgery based on total bilirubin concentration: machine learning algorithms.

Background: With the aging demographic on the rise, we're seeing a spike in the occurrence of postoperative delirium (POD). Our research aims to delve into the connection between plasma bilirubin levels and postoperative delirium, with the goal of crafting ten machine learning (ML) models capable of predicting POD instances.

Methods: This study enrolled 621 elderly patients after knee/hip surgery.

Bibliometric and Visualized Analysis of Gut Microbiota and Hypertension Interaction Research Published from 2001 to 2024.

A comprehensive bibliometric analysis of literature is imperative to elucidate current research landscapes and hotspots in the interplay between gut microbiota and hypertension, identify knowledge gaps, and establish theoretical foundations for the future. We used publications retrieved from the Web of Science Core Collection (WoSCC) and SCOPUS databases (January 2001-December 2024) to analyze the annual publication trends with GraphPad Prism 9.5.

Genetic findings of children with congenital heart diseases using chromosomal microarray and trio-based whole exome sequencing.

Congenital heart disease (CHD) is the most common type of birth defects in humans. Genetic factors have been identified as an important contributor to the etiology of CHD. However, the underlying genetic causes in most individuals remain unclear.

Influence of biomass ashes on the structural evolution and oxygen-donating capacity of red mud during chemical looping gasification.

To efficiently convert the biomass wastes, chemical looping gasification has been proposed as a highly effective method to produce hydrogen-rich syngas. The lattice oxygens in oxygen carriers can supplant molecular oxygens, thereby improving syngas quality. However, the complex interactions between oxygen carrier and biomass ash are inevitable, obviously affecting reactivity of oxygen carrier.

Feasibility and Accuracy of an RTMPose-Based Markerless Motion Capture System for Single-Player Tasks in 3x3 Basketball.

Markerless motion capture (MMC) offers a non-invasive method for monitoring external load in sports where wearable devices are restricted; however, its validity in 3x3 basketball contexts remains unverified. The viability and measurement precision of a multi-camera RTMPose-based MMC system for single-player tasks in 3x3 basketball performance monitoring were evaluated in this study. Recorded on a standard half-court, eight cameras (60 fps) captured ten collegiate athletes executing basketball-specific activities including linear sprints, curved runs, T-tests, and vertical jumps.

Impact of different treatment strategies on therapeutic efficacy and biomarkers in children with IVIG-resistant Kawasaki disease: a retrospective cohort study.

Background: Intravenous immunoglobulin (IVIG) is the standard first-line treatment for Kawasaki disease (KD), although 10%-20% of patients are resistant to initial IVIG therapy. This study investigates retreatment strategies and associated biomarkers in IVIG-resistant KD patients.

Methods: This retrospective analysis included 68 IVIG-resistant KD patients from the Children's Hospital Affiliated to Shandong University.

Changes in serotype distribution and antimicrobial nonsusceptibility of among hospitalized children: Shenzhen, China, 2009-2019.

Background: This study assessed changes in Streptococcus pneumoniae serotype distribution and antimicrobial nonsusceptibility among hospitalized children with pneumonia in Shenzhen, China, from 2009 to 2019, under low pneumococcal conjugate vaccine (PCV) coverage.

Research Design And Methods: We analyzed 1,361 isolates (62 invasive, 1,299 noninvasive). Serotypes were identified by latex agglutination and Quellung reaction.

Variations in the clinical practice of blood pressure and sedo-analgesia management for intracerebral hemorrhage: a case-based survey of Chinese healthcare workers.

Background: Blood pressure (BP) management during the acute phase of intracerebral hemorrhage (ICH) is critical to improving patient prognosis. Besides routine antihypertensive medications, sedo-analgesia (i.e.

Mitochondrial deoxyguanosine kinase depletion induced ROS causes melanocyte stem cell exhaustion and hair greying.

Hair pigmentation is regulated by melanocyte stem cells (MeSCs) within the hair follicle. Mitochondrial dysfunction is associated with hair depigmentation, primarily due to defects in melanogenesis. However, the mechanisms by which mitochondria support MeSCs during hair pigmentation remain obscure.

CXCL6 Is a Novel Biliary Marker and a Downstream Target of MMP7 in Biliary Atresia.

Aim: MMP7 has been identified as a potential biomarker for biliary atresia (BA) diagnosis. However, the mechanism of MMP7 and its downstream signaling pathway remain unknown in the pathogenesis of BA. Herein, this study was performed to figure out MMP7's downstream target.

Elderly care needs and factors influencing negative emotions among first-generation only child parents in a Chinese city.

Background: China has recently encountered severe challenges associated with population aging. Parents of first-generation only children face significant challenges regarding elderly care needs and the associated negative emotions.

Aim: To analyze the elderly care needs of first-generation only child parents in China and identify factors that influence negative emotions.

Elucidating the role of stacking faults in TlGaSe on its thermoelectric properties.

Thermoelectric materials are of great interest for heat energy harvesting applications. One such promising material is TlGaSe, a 2D-layered, -type semiconducting ternary chalcogenide. Recent reports show it can be processed as a thin film, opening the door for large-scale commercialization.

Design and discovery of novel cyclic peptides as TSP1-CD36 interaction inhibitors for intestinal fibrosis treatment.

Intestinal fibrosis is a refractory complication of inflammatory bowel disease (IBD), arising from recurrent intestinal inflammation and excessive wound healing. Repeated strictures can lead to intestinal obstruction, with three-quarters of patients with strictures eventually requiring surgery, which severely impacts their quality of life. Thrombospondin-1 (TSP1) is a matricellular protein that regulates tissue fibrosis by binding to its cell membrane receptor, CD36, and activating transforming growth factor β (TGF-β).

Triglyceride-glucose index as a predictor of the risk of sarcopenia in elderly patients with OSA: a multicenter study.

Background: Given the clear association between obstructive sleep apnea (OSA) and metabolic disorders, coupled with a limited understanding of sarcopenia in patients with OSA, this study aimed to investigate the relationship between triglyceride-glucose (TyG) index and sarcopenia and in an elderly population with OSA.

Methods: Multiple hematological and sleep-breathing status were meticulously recorded in the cohorts. The SARC-F scale ≥ 4 was considered indicative of probable sarcopenia.

Ganoderic acid T, a novel activator of pyruvate carboxylase, exhibits potent anti-liver cancer activity.

Background: Ganoderic acid T (GAT), a lanostane triterpenoid isolated from the methanol extract of G. lucidum mycelia, has demonstrated potent antitumor activity against various human cancer types. However, the specific molecular targets of GAT in cancer cells remain largely unknown.