Heavy Grazing Leads to Increased Dominance of Plant and Soil Nematode Communities.

Herbivore grazing plays a crucial role in grassland ecosystems, yet its comprehensive impact on plant and soil nematode diversity in desert steppe remains unclear. We assessed the impact of different grazing intensities (CK: no grazing, LG: light grazing, MG: moderate grazing, HG: heavy grazing, EG: extreme heavy grazing) on plant and soil nematode diversity in desert steppe. In the HG treatment, the diversity of plants and nematodes was the lowest and significantly lower than that in the CK treatment.

Effects of different grazing intensities on plant species diversity at different spatial scales in a desert steppe in Inner Mongolia.

The effect of grazing intensity on plant diversity has been widely studied. In this study, desert steppes with different grazing intensities (no grazing (CK), light grazing (LG), moderate grazing (MG), heavy grazing (HG), and extremely heavy grazing (EG)) in Inner Mongolia were selected to study the changes in species diversity at different spatial scales (α, β, and γ diversity) and the α diversity of different plant groups (dominant species, common species, and rare species).The results showed that the α, β, and γ diversity first decreased and then increased with increasing grazing intensity, and β diversity was observed to be the most sensitive index to the grazing intensity.

Response of the germinable soil seed bank of temperate meadows to mowing regimes.

Mowing is a primary practice in temperate meadows, which are severely degraded due to frequent mowing, overgrazing, and other factors, necessitating restoration and sustainable management. The natural recovery of these grasslands hinges on their germinable soil seed banks, which form the basis for future productivity. Thus, germinable soil seed banks are critical for restoring overexploited meadows.

The Impact of Exclosure Duration on Plant Species Diversity in a Desert Grassland and the Relative Contribution of Plant Groups.

Plant species diversity has long been a focal point in ecological studies. In order to study the changes in species diversity at different spatial scales (α, β, and γ diversities) in the restoration process of grassland vegetation in fragile desert steps, this study took desert steppe of Inner Mongolia as the research object and employed a two-factor experimental design that combined exclosure years (the years when an area was isolated to prevent grazing and other disturbances) with years of monitoring (the years when data were collected). It analyzed the plant groups (dominant species, common species, and rare species) and species diversity, and obtained the preliminary conclusions as follows: The optimal exclosure duration for promoting species diversity balance in desert steppe management is between 16 and 18 years.

Grazing effects on species diversity across different scales are related to grassland types.

Background: Community species in different grassland types exhibit unique ecological traits and adaptation strategies, influencing the impact of grazing on species diversity at various scales. This study aimed to elucidate the response characteristics and rules of species diversity in different grassland types to grazing intensity by analyzing plant groups and species diversity.

Results: Grazing intensity, grassland type, and their interaction significantly affected α, β, and γ diversity.

The relationships between structure and function of plant communities in the desert steppe.

Background: Assessing the relationships between spatial and temporal structures and functions of plant communities is an effective way to understand the changing dynamics of plant communities in specific environments. In this study, we investigated the response of structural and functional stabilities of plant communities to stocking rate in the desert steppe over a 16-year grazing period as the research background.

Methods: We used classical statistical methods to investigate the quantitative characteristics of plant communities over time (2014-2019) and space (2017-2019) at four stocking rates (control, CK, 0 sheep·ha·month; light grazing, LG, 0.

Long-term grazing changed the spatial distributions of dominant species in typical steppe of Inner Mongolia.

Dominant species occupy a pivotal role in plant community, influencing the structure and function of the ecosystem. The spatial distributions of dominant species can react to the effect of different grazing intensities, thereby reflecting their tolerance and adaptive strategies toward grazing. In this study, geostatistical methods were mainly used to study the spatial distribution characteristics of Stipa krylovii Roshev.

Nogo-A Drives Alzheimer's Disease Progression by Inducing Tauopathy Vulnerability.

Tauopathies, a group of neurodegenerative disorders, are characterized by disrupted homeostasis of the microtubule binding protein tau. Nogo-A mainly hinders axonal growth and development in neurons, but the underlying mechanism of tau vulnerability has not been determined. Here, to gain more comprehensive insights into the impact of Nogo-A on tau protein expression, we showed that Nogo-A induces tau hyperphosphorylation, synapse loss and cognitive dysfunction.

Effects of different grassland utilization methods on the germinable soil seed bank of the Hulunbuir meadow steppe.

Seed banks are crucial regenerative resources for aboveground vegetation. The pattern of their changes holds immense significance in understanding alterations in the belowground seed bank. This understanding is pivotal for uncovering both short-term and long-term shifts in plant communities.

Heavy grazing causes plant cluster fragmentation of sparse grasses.

, as a clustered grass, is the main grassland flora of the desert grassland. Some studies have shown that the constructive species of (sparse cluster type) is prone to cluster fragmentation; however, research on is relatively rare. Then will the plant population (dense cluster type) also have cluster fragmentation under the influence of intense grazing? To answer this question, we used variance analysis and geo-statistical methods.

EGFR-Activated JAK2/STAT3 Pathway Confers Neuroprotection in Spinal Cord Ischemia-Reperfusion Injury: Evidence from High-Throughput Sequencing and Experimental Models.

This study aimed to investigate the molecular mechanisms underlying spinal cord ischemia-reperfusion (SCI/R) injury. Through RNA-Seq high-throughput sequencing and bioinformatics analysis, we found that EGFR was downregulated in the spinal cord of SCI/R mice and may function via mediating the JAK2/STAT3 signaling pathway. In vitro cell experiments indicated that overexpression of EGFR activated the JAK2/STAT3 signaling pathway and reduced neuronal apoptosis levels.

Immune mechanism of low bone mineral density caused by ankylosing spondylitis based on bioinformatics and machine learning.

This study aims to find the key immune genes and mechanisms of low bone mineral density (LBMD) in ankylosing spondylitis (AS) patients. AS and LBMD datasets were downloaded from the GEO database, and differential expression gene analysis was performed to obtain DEGs. Immune-related genes (IRGs) were obtained from ImmPort.

Heavy grazing reduced the spatial heterogeneity of Artemisia frigida in desert steppe.

Background: Grazing disturbance plays an important role in the desert steppe ecosystem in Inner Mongolia, China. Previous studies found that grazing affected the spatial distribution of species in a community, and showed patchiness characteristics of species under different grazing treatments. Artemisia frigida is the dominant species and semi-shrub in desert steppe, and whether grazing interference will affect the spatial distribution of A.

Fluoxetine modifies circadian rhythm by reducing melatonin content in zebrafish.

Fluoxetine (FLX), a selective serotonin reuptake inhibitor (SSRI), increases the serotonin levels in the brain to treat depression. Antidepressants have been demonstrated to modulate circadian rhythm, but the underlying mechanisms by which antidepressants regulate circadian rhythm require more research. This study aimed to investigate the role of FLX on circadian rhythm by analyzing the movement behavior and internal circadian oscillations in zebrafish.

Muscarinic acetylcholine receptors regulate inflammatory responses through arginases 1/2 in zebrafish.

Muscarinic acetylcholine receptors (mAChRs) are widely expressed in various effector cells and have been proved to play vital roles in smooth muscle contraction and digestive secretion. However, there are relatively few literatures revealing the roles of mAChRs in inflammatory processes, and its underlying regulatory mechanisms have not been elucidated. Taking the advantages of live imaging of zebrafish, we found that inhibition of mAChRs resulted in increased neutrophils recruitment and proinflammatory cytokines expression, whereas activation of mAChRs led to opposite outcome.

Hypoxia regulates cytokines expression and neutrophils migration by ERK signaling in zebrafish.

Normal dissolved oxygen in water is essential for maintaining the physiological functions of fish, but environmental pollution, such as eutrophication can lead to a decrease in oxygen content in water. How this reduction of dissolved oxygen in water affects the immune functions of fish and the potential regulatory mechanisms have not been thoroughly elucidated. In this study, we made full use of the aquatic model animal zebrafish to explore this question.

Dominant species' dominant role and spatial stability are enhanced with increasing stocking rate.

Stipa breviflora Grisb. (S. breviflora) is a dominant species in the desert steppe of northern China.

Identification of foam cell biomarkers by microarray analysis.

Background: Lipid infiltration and inflammatory response run through the occurrence of atherosclerosis. Differentiation into macrophages and foam cell formation are the key steps of AS. Aim of this study was that the differential gene expression between foam cells and macrophages was analyzed to search the key links of foam cell generation, so as to explore the pathogenesis of atherosclerosis and provide targets for the early screening and prevention of coronary artery disease (CAD).

Study on the stability and cellular affinity of gelatin-polysaccharide composite films.

The gelatin film has great potential in biomedical applications, especially in wound healing. The combination of gelatin films and stem cells could further accelerate the skin regeneration. Although polysaccharide modification can improve the mechanical property and biological activity of gelatin films, information about the stability and cellular affinity is still limited.

Congenital unilateral proximal radioulnar synostosis: A surgical case report.

Rationale: Congenital proximal radioulnar synostosis is a rare genetic malformation of the upper limb. This deformity, which is found mainly in preschool-aged children, has no recognized diagnosis and treatment. Current diagnostic methods cannot effectively assess both bone structure and soft tissue abnormalities, and most surgical treatments introduce complications and do not prevent recurrence.

Differential distributions of parvalbumin-positive interneurons in the sulci and gyri of the adult ferret cerebral cortex.

Although accumulating evidence suggests that there are significant anatomical and histological differences between the sulci and gyri of the cerebral cortex, whether there is a difference in the distribution of interneurons between the two cortical regions remains largely unknown. In this study, we systematically compared the distributions of parvalbumin-positive interneurons among three neighboring gyrus and sulcus pairs-coronal gyrus and cruciate sulcus, anterior ectosylvian gyrus and rostral suprasylvian sulcus, and posterior ectosylvian gyrus and pseudosylvian sulcus-in the adult ferret cerebral cortex. We proposed a method to partition sulci and gyri into several specific subregions through the deepest points of the sulci and the highest points of gyri in the inner and outer cortical contours of coronal sections.

Grazing intensity enhances spatial aggregation of dominant species in a desert steppe.

Understanding how grazing activity drives plant community structure or the distribution of specific species in a community remains a major challenge in community ecology. The patchiness or spatial aggregation of specific species can be quantified by analyzing their relative coordinates in the community. Using variance and geostatistical analysis methods, we examined the quantitative characteristics and spatial distribution of in a desert steppe in northern China under four different grazing intensities (no grazing, NG, light grazing, LG, moderate grazing, MG, and heavy grazing, HG) at three small spatial scales (10 × 10 cm, 20 × 20 cm, 25 × 25 cm).

Syncope as the initial presentation of pulmonary embolism in a young adult with testicular tumor: A case report and literature review.

Rationale: Venous thrombus embolism (VTE) includes deep-vein thrombosis (DVT) and pulmonary embolism (PE) which may be an initial symptom for patients with cancer. PE has diverse clinical manifestations and is a rare complication of testicular tumor (TT).

Patient Concerns: Here, we report a 21-year-old man admitted to our hospital due to syncope.

Dihydroartemisinin induces apoptosis and downregulates glucose metabolism in JF-305 pancreatic cancer cells.

Cancer cell promotion of glycolysis provides a promising therapeutic target for cancer treatment. Dihydroartemisinin (DHA) displays cytotoxicity to multiple human tumor cells. However, its effects on pancreatic cancer cells are not well studied.