Trophic transfer and potential human health risk assessment of heavy metals in food web from waters adjacent to Yanpu Bay, China.

This study investigated the trophic transfer of heavy metals and assessed their potential health risks in waters adjacent to Yanpu Bay, China, to elucidate their ecological and public health implications, integrating stable isotope analysis (δC, δN) and heavy metal concentration measurements across biotic and abiotic components. The δC values ranged from -24.85 (plankton) to -13.

Feasibility and priority strategies for diabetes prevention and control in Chinese demonstration areas.

Background: Diabetes is a leading global public health challenge with 537 million cases worldwide in 2021 and significant economic and societal burdens. Despite global initiatives, feasibility constraints limit widespread implementation of diabetes prevention/control measures. The key to facilitating the implementation of diabetes prevention and control measures lies in prioritise them.

Cumulative resting heart rate load and cardiovascular risk in patients with heart failure in sinus rhythm.

Introduction And Objectives: Resting heart rate is a readily available vital sign with important prognostic significance. However, traditional measures overlook both the magnitude and duration of elevated heart rate over time. This study assessed the association between cumulative resting heart rate load and adverse outcomes in patients with chronic heart failure (HF) in sinus rhythm.

Atomic-Level Design and Understanding of Hydroxyl-Mediated Ag Sites with Catalytic Versatility.

Regulating the size of active centers in catalysts exerts a profound effect on their activity and selectivity. Here, we demonstrate a strategy for precise control over the size of Ag species on AlO, enabling the 2%Ag/AlO catalyst to be tailored for various catalytic reactions. Building on the mechanism wherein hydroxyl groups serve as anchoring sites for Ag, we synthesized hydroxyl-rich AlO supports and subsequently reduced the hydroxyl content through roasting.

A novel thermo-activated one-pot RPA-CRISPR-Cas12b assay for Mycoplasma pneumoniae POCT.

Mycoplasma pneumoniae (M. pneumoniae), a major human respiratory pathogen, necessitates the development of rapid point-of-care testing (POCT) platforms for clinical management. However, current two-step workflows suffer from operational complexity and aerosol contamination risks.

Development and Evaluation of Antioxidant Postbiotics from Bacillus amyloliquefaciens C-1 to Alleviate DSS-Induced Colitis.

Bacillus amyloliquefaciens has been recognized as a next-generation probiotic with a qualified presumption of safety (QPS) status by the European Food Safety Authority (EFSA), indicating its promising application potential in postbiotic development. This study aimed to investigate the probiotic characteristics of B. amyloliquefaciens strain C-1, isolated from ready-to-eat fruit salads.

Bibliometric and Visualized Analysis of Gut Microbiota and Hypertension Interaction Research Published from 2001 to 2024.

A comprehensive bibliometric analysis of literature is imperative to elucidate current research landscapes and hotspots in the interplay between gut microbiota and hypertension, identify knowledge gaps, and establish theoretical foundations for the future. We used publications retrieved from the Web of Science Core Collection (WoSCC) and SCOPUS databases (January 2001-December 2024) to analyze the annual publication trends with GraphPad Prism 9.5.

Performance evaluation of four antibiotics using the BD Phoenix™ NMIC-413 antimicrobial susceptibility testing panel for carbapenem-resistant and carbapenem-resistant .

Background: The spread of antimicrobial resistance (AMR) poses significant threats to human health. In 2024, the World Health Organization (WHO) classified carbapenem-resistant (CRE) as a critical-priority pathogen and carbapenem-resistant (CRPA) as a high-priority pathogen. This study aimed to evaluate the performance of meropenem (MEM), imipenem (IPM), cefepime (FEP), and cefoperazone/sulbactam (SCF) using the BD Phoenix™ NMIC-413 antimicrobial susceptibility testing (AST) panel (NMIC-413 panel) for CRE and CRPA at Nanfang Hospital, China.

Phenotypic Traits, SSR Core Primer Screening, and Genetic Diversity Analysis of From Different Seed Sources in Yunnan, China.

Yunnan Province in China, with its unique natural conditions, has nurtured abundant yet fragile biodiversity resources. The is one of the important tree species in Yunnan, valued for its ecological, economic, and medicinal significance. However, due to a lack of related research and limited germplasm resources, breeding and propagation of the .

Prognostic Value of Plasma Big Endothelin-1 in Patients Hospitalized for Heart Failure.

Background And Objectives: Endothelin-1 (ET-1) is a potent vasoconstrictor and multifunctional neuroendocrine hormone that is closely associated with the pathophysiology of heart failure (HF). Currently, the evidence about the predictive value of big ET-1 in HF remains insufficient. This study aims to investigate the prognostic importance of big ET-1 in HF.

Serum uric acid fluctuations and cardiovascular outcomes in hospitalized acute heart failure patients.

Background And Aims: This study examined the association between serum uric acid (SUA) fluctuation patterns during hospitalization in acute heart failure (HF) patients and clinical outcomes, a relationship not fully understood.

Methods And Results: A cohort of 1403 acute HF patients was enrolled with a median follow-up of 20.5 months.

Gut microbiota and risk of heart failure in European population-A comprehensive Mendelian randomization study.

Aims: Gut dysbiosis is proven to be involved in the pathogenesis and progression of heart failure (HF). Hindering the detrimental effects of gut-heart axis is an emerging trend. Our goal is to investigate the causal relationship between gut microbiota and HF, with the aim of facilitating future exploration of microbiome-targeted approaches to prevent and delay the progression of HF.

The significance of the modified surgical apgar score in predicting postoperative acute kidney injury among patients undergoing hepatectomy.

Aim: The incidence of acute kidney injury (AKI) following hepatectomy ranges from 0.9 % to 21.6 %.

Resource utilization of electric arc furnace dust: Efficient wet desulfurization and valuable metal leaching kinetics investigation.

Electric arc furnace dust (EAFD) is hazardous solid waste containing valuable metals such as iron (Fe) and zinc (Zn) in large quantities. This presents a considerable recycling issue. This study proposes an integrated and efficient approach to solid waste management.

Two previously undescribed triterpenoid saponins from the roots and rhizomes of Maxim.

Since ancient times, plants have provided humans with important bioactive compounds for the treatment of various diseases. Nine compounds were isolated from the roots and rhizomes of Caulophyllum robustum (a plant in the family Panaxaceae), including two new saponins C. Spanion A and C.

Clinical implications of longitudinally assessed uric acid in heart failure.

Background And Aims: Numerous studies have evaluated the association between baseline uric acid (UA) and heart failure (HF) outcomes. The impact of longitudinal UA on HF survival remains unknown. We aim to investigate the association between different parameterizations of longitudinal UA measurements and survival outcomes in HF patients.

Genome-wide identification and expression analysis of the AS2/LOB gene family in physic nut.

Introduction: AS2/LOB genes, a class of transcription factors ubiquitously existing in plants, are vital for plant growth, development, and stress tolerance. Despite the availability of the physic nut genome, information regarding the expression profiles and evolutionary histories of its AS2/LOB genes remains scarce.

Methods: An elaborate exploration of the AS2/LOB gene family was conducted, including phylogeny, exon-intron structure, chromosomal location, conserved domain characteristics, conserved motifs, promoter cis-acting elements, protein interaction, and expression profiles under normal growth and abiotic stress conditions.

Incidence, progression, and outcomes of heart failure with improved ejection fraction: The added value of longitudinally assessed ejection fraction.

Background: The revised universal definition of heart failure (HF) established a standardized definition for HF with improved ejection fraction (HFimpEF) and emphasized the importance of longitudinally assessing left ventricular EF (LVEF). We aim to investigate the incidence, disease progression, and clinical outcomes of HFimpEF in a longitudinal cohort of hospitalized HF patients.

Methods: We retrospectively included HF patients with baseline LVEF ≤40 % and satisfactory echocardiographic follow-ups.

Association between RDW-SD and prognosis across glycemic status in patients with dilated cardiomyopathy.

Introduction: The prognostic significance of red cell distribution width-SD (RDW-SD) as a promising inflammatory biomarker in individuals with non-ischemic dilated cardiomyopathy (DCM) and varying glycemic status remains unexplored.

Research Design And Methods: Patients hospitalized for DCM in Fuwai Hospital from 2006 to 2021 were retrospectively included. The primary outcome encompassed all-cause mortality and heart transplantations.

Simultaneous removal of SO and NO by phosphate tailings-derived composite slurry: A study of phosphorus element migration and transformation.

In this study, we developed a composite slurry using industrial hazardous solid waste phosphate tailings and yellow phosphorus for the simultaneous removal of SO and NO. Additionally, the migration and transformation of the P element within the slurry were thoroughly investigated. The experimental results revealed that this composite slurry exhibited efficient removal of both SO and NO.

Effect of Cu/HZSM-5 sorbents with different Si/Al ratios on the adsorption and oxidation performance of HS.

This study employed a wet impregnation method to synthesize five types of Cu/HZSM-5 adsorbents with Si/Al ratios of 25, 50, 85, 200, and 300, used for the removal of HS in low-temperature, low-oxygen environments. The impact of different Si/Al ratios on the adsorption oxidative performance of Cu/HZSM-5-85 adsorbents was investigated. According to the performance test results, Cu/HZSM-5-85 exhibited the highest breakthrough capacity, reaching 231.

Stromal Reprogramming Optimizes KRAS-Specific Chemotherapy Inducing Antitumor Immunity in Pancreatic Cancer.

Pancreatic ductal adenocarcinoma (PDAC) is a clinically challenging cancer and is often characterized with rich stroma and mutated KRAS, which determines the tumor microenvironment (TME) and therapy response. Turning immunologically "cold" PDAC into "hot" is an unmet need to improve the therapeutic outcome. Herein, we propose a programmable strategy by sequential delivery of pirfenidone (PFD) and nanoengineered KRAS specific inhibitor (AMG510) and gemcitabine (GEM) liposomes.

Waste to Wealth: Discarded Cigarette Butt-Derived Metal-Free N-Rich Carbon Catalysts for the Selective Catalytic Oxidation of Hydrogen Sulfide to Sulfur.

The selective catalytic oxidation of toxic gas HS to elemental sulfur (HS-SCO) is a promising desulfurization process known for its dual benefits of recovering valuable sulfur resources and mitigating environmental pollution. Nevertheless, developing cost-effective and efficient catalysts for HS-SCO remains a significant challenge. In this study, we synthesized a low-cost and metal-free nitrogen-rich carbon catalyst (NrCC) by copyrolyzing discarded cigarette butts (organic solid wastes that are difficult to degrade naturally) with urea for the continuous HS-SCO process at a relatively low temperature.

Association among Gestational Weight Gain, Fucosylated Human Milk Oligosaccharides, and Breast Milk Microbiota─An Evidence in Healthy Mothers from Northwest China.

This study investigates the relationship among maternal secretor status, human milk oligosaccharides (HMOs), and the composition of breastmilk microbiota in a cohort of healthy mothers from Shaanxi province, China. The results demonstrated that 78.9% of the mothers were secretors, exhibiting an active fucosyltransferase 2 gene () and producing α-1,2 fucosylated HMOs, which significantly affected the HMO profile.