Lipid metabolites as biomarkers and therapeutic targets in oral squamous cell carcinoma.

This study explores the association of lipid metabolism disruption and Oral Squamous Cell Carcinoma (OSCC). We aim to identify specific lipid biomarkers and therapeutic targets for OSCC. We included 78 OSCC patients and 80 healthy controls, and applied non-target lipidomics and transcriptomics for comprehensive analysis.

Feasibility and priority strategies for diabetes prevention and control in Chinese demonstration areas.

Background: Diabetes is a leading global public health challenge with 537 million cases worldwide in 2021 and significant economic and societal burdens. Despite global initiatives, feasibility constraints limit widespread implementation of diabetes prevention/control measures. The key to facilitating the implementation of diabetes prevention and control measures lies in prioritise them.

Homologous heteropolyaromatic covalent organic frameworks for enhancing photocatalytic hydrogen peroxide production and aerobic oxidation.

The development of robust catalysts that can work under harsh conditions bring promise but a challenge for photocatalytic hydrogen peroxide production. Here, we report the design of thiazole-based homologous heteropolyaromatic COFs (TTT-COF) via post-cyclization reaction for photocatalytic HO production and aerobic oxidation of C(sp)-H bonds. Our studies demonstrate that the elemental S heteroatom enables modified COF materials with high chemical stability, continuous π-conjugation, efficient electron and energy transfer, and an enhanced donor-acceptor (D-A) structure and charge separation, thus boosting their intrinsic photocatalytic activities and stability.

Hypo-electronegativity Atoms Induce Bader Charge Enrichment on the Pt Surface to Promote Ampere-Level Electrocatalytic Ammonia Oxidation.

The efficient development of electrocatalysts for ammonia oxidation anodes represents a critical challenge which hinders the commercialization of direct ammonia fuel cells (DAFCs) and the realization of energy transition goals. Platinum (Pt)-based catalysts play a key role in ammonia oxidation reactions (AOR); however, their reaction kinetics are sluggish at low temperatures and are susceptible to toxicity from intermediate species such as *N, which limits their applicability at ampere-level currents. Drawing inspiration from the "stepwise dehydrogenation mechanism" and the concept of "Bader charge", we have designed a hypo-electronegativity atom mediated Pt-based high-entropy alloy regulation strategy.

Recent advances in tumour microenvironment impact immunotherapy resistance in gastric cancer.

Gastric cancer (GC) is one of the most common malignant tumours worldwide, and its high morbidity and mortality are closely related to insignificant early symptoms, diagnosis mostly at an advanced stage and immunotherapy resistance. In recent years, the application of immunotherapy, especially immune checkpoint inhibitors, has brought new hope for treating GC; however, the problem of drug resistance is still a major challenge. The clinical need for effective immunotherapy in GC is still unmet, as the majority of patients do not respond to current treatments or develop resistance over time.

Aspirin-Inspired 6-O-Carboxymethyl-N-Acetylglucosamine: A potent antitumor agent with enhanced efficacy.

Aspirin, widely recognized for its anti-inflammatory and cardioprotective effects, has also shown potential as a cancer therapeutic. However, its clinical application is hindered by severe adverse effects. Here, we explore 6-O-Carboxymethyl-N-Acetylglucosamine (CM-NAG) a novel derivative of N-acetylglucosamine, designed to mimic the structural and functional properties of aspirin.

Dysfunction of PDE4DIP contributes to LVNC development by regulating cell polarity, skeleton, and energy metabolism via Rho-ROCK pathway.

Left ventricular non-compaction (LVNC), is a hereditary cardiomyopathy with limited treatments. Our previous study linked phosphodiesterase 4D interacting protein (PDE4DIP) to LVNC development. To explore the functional role of PDE4DIP activation in regulating cell polarity, skeleton, and energy metabolism, and to elucidate its mechanisms driving LVNC development, bioinformatics analysis was performed to compare its expression in LVNC patients and normal subjects.

Bader Charge Balance Mechanism Realizes Industrial-Grade Current Hydrogen Production.

The hydrogen production technology of water splitting under a high current density is the key to solve the efficient utilization of hydrogen energy. However, it is difficult for existing catalysts to exhibit bifunctional high-current activity in the same electrolyzer, considering that the bimetallic site can endow the catalytic material asymmetry and heterogeneity and then change the intrinsic electronic structure. Herein, we constructed a La-Fe dual-site coupled self-assembled membrane electrode (D-LaFe-SAME), and the introduction of the dual site reduced the Bader charge value of the La site from 0.

Migration and morphological transformation of Mn and its effect on microbial community in the AO process.

Manganese ion (Mn) was generated from metallurgical, steel making and chemical industries. It could affect microbial activity and community structure after entering sewage treatment plant. The effect of Mn on the pollutant removal, metal distribution patterns and composition of microbial communities were investigated in a an anaerobic/anoxic/oxic (AO) process.

Molecular signatures of invasive and non-invasive pituitary adenomas: a comprehensive analysis of DNA methylation and gene expression.

Background: Pituitary adenomas (PAs) are benign tumors in the pituitary gland. However, 30-40% of these tumors are invasive, complicating diagnosis and treatment. Invasive pituitary adenomas (IPAs) often respond poorly to conventional therapies, emphasizing the need for better diagnostic and therapeutic strategies.

Electrochemical glycoproteins sensor for sensitive diagnosis of PD: Ag@MSNs-MPBA as a specific signal amplifier and reporter.

Glycoprotein non-metastatic melanoma protein B (GPNMB) is a candidate biomarker of Parkinson's disease (PD). The development of a novel method for highly sensitive and specific detection of GPNMB is essential for PD's early and accurate diagnosis. An electrochemical biosensor was developed utilizing silver nanoparticle-loaded mesoporous silica (Ag@MSNs) with 4-mercaptophenylboronic acid (4-MPBA) modification for the sensitive and selective detection of GPNMB.

Dapagliflozin improves cardiac function and reduces adverse events in myocardial infarction: a meta-analysis in diabetic and non-diabetic populations.

Background: Myocardial infarction (MI) remains a leading cause of morbidity and mortality worldwide, frequently driven by acute coronary occlusion resulting from atherosclerosis and arrhythmias. Type 2 diabetes mellitus (T2DM) is a major risk factor for atherosclerotic progression and is associated with worsened cardiovascular outcomes in post-MI patients. Dapagliflozin, a sodium-glucose co-transporter 2 (SGLT2) inhibitor, has emerged as a novel antidiabetic agent with additional cardiovascular benefits.

ROS confer resistance to 3TC in p53 mutant colorectal cancer by promoting autophagy and ER stress.

Colorectal cancer (CRC) is among the most frequently diagnosed cancers globally. Lamivudine (3 TC), a nucleoside reverse transcriptase inhibitor (NRTI) commonly used for treating Human Immunodeficiency Virus (HIV) and Hepatitis B Virus (HBV), has recently demonstrated anticancer activity against p53-mutant CRC in Phase 2 clinical trials. However, the underlying mechanisms remain elusive.

Activation of pyroptosis impairs basal cell differentiation in the nasal epithelium in chronic rhinosinusitis with nasal polyps.

Chronic rhinosinusitis with nasal polyps (CRSwNP) is a chronic inflammatory sinus disease, which is categorized into eosinophilic CRSwNP (ECRSwNP) and non‑ECRSwNP (nECRSwNP), affecting 2‑4% of the population. Pyroptosis is implicated in the pathogenesis of CRSwNP, although the underlying molecular mechanisms driving pyroptosis and its role in the onset and progression of CRSwNP remain incompletely understood. Nasal tissue specimens from ECRSwNP and nECRSwNP were collected and analyzed by hematoxylin and eosin, immunohistochemical (IHC) staining of pyroptosis‑related markers, including NLRP3 and IL‑1β.

METRNL represses beta-to-alpha cell trans-differentiation to maintain beta cell function under diabetic metabolic stress in mice.

Aims/hypothesis: In type 2 diabetes mellitus, beta cell failure is associated with pancreatic beta cell dedifferentiation and trans-differentiation into other types of islet cells. However, the mechanisms underlying this process remain unclear. Recently, meteorin-like (METRNL) protein, a newly discovered secretory protein, has demonstrated beneficial effects in obesity and insulin resistance.

Impact of digital health management on clinical outcomes during post-PCI outpatient care in patients with acute coronary syndrome: study protocol for a multicentre, randomized controlled trial.

Introduction: Coronary heart disease is becoming more common in developing nations. Acute coronary syndrome (ACS) poses a major challenge to global health; however, access to cardiac rehabilitation and preventative measures is limited. There is an urgent need for affordable and widely accessible alternative delivery models to resolve this treatment gap.

Multi-level inhibition of SARS-CoV-2 invasion by cannabidiol and epigallocatechin gallate.

The global pandemic coronavirus disease 2019 (COVID-19) attributable to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The current study aimed at combination therapies with natural polyphenolic compounds, such as cannabidiol (CBD), green tea polyphenols (Tea-poly), epigallocatechin gallate (EGCG) and theaflavin (TF), to investigate in vitro their inhibitory effects on virus invasion and viral spike (S) protein expression. Among the compounds tested, CBD and Tea-poly exhibited the most significant inhibitory effects on virus entry, comparable to the positive control chloroquine (CQ).

Novel receptor-binding protein from phage PJNS004 for sensitive detection of Salmonella.

The detection of Salmonella, a key foodborne pathogen, is essential for maintaining food safety and safeguarding public health. Here, we have identified a novel receptor-binding protein (RBP), encoded by ORF33 of phage PJNS004, that specifically targets lipopolysaccharide on the host strain surface. To utilize this RBP for Salmonella detection, we expressed and purified the recombinant protein, designated as proSM and proM.

Neuroblastoma-Targeting π-Conjugated COP Nanostructure with Multiple Enzyme-Mimetic Actions for Sonochemodynamic Immunotherapies.

Sonodynamic therapy (SDT) has emerged as a promising strategy for neuroblastoma treatment, leveraging ultrasound to induce the production of reactive oxygen species (ROS) at tumor sites, thereby enhancing the efficacy of immunotherapy. However, a major challenge in SDT is the efficiency of ROS generation, particularly in the context of hypoxia within the tumor microenvironment. Herein, inspired by the natural peroxidase, an imide-linked metal-phthalocyanine-based conjugated organic polymer (COP) (COP) has been designed with a well-defined π-conjugated nanostructure and peroxidase-mimetic atomic Fe-N sites for sonochemodynamic immunotherapy against neuroblastoma.

Post-translational modifications in DNA damage repair: mechanisms underlying temozolomide resistance in glioblastoma.

Temozolomide (TMZ) resistance is one of the critical factors contributing to the poor prognosis of glioblastoma (GBM). As a first-line chemotherapeutic agent for GBM, TMZ exerts its cytotoxic effects through DNA alkylation. However, its therapeutic efficacy is significantly compromised by enhanced DNA damage repair (DDR) mechanisms in GBM cells.

Network pharmacology and in vitro analyses reveal EGCG inhibits breast cancer progression via suppression of the EGFR/Src pathway.

Breast cancer (BRCA) has emerged as a significant threat to women's health. Epigallocatechin gallate (EGCG) has shown promising therapeutic potential. However, its mechanisms of action are not yet fully understood.

Low-level expression of Cmyc in mature neurons: maintaining neuronal function and preventing neurodegeneration.

Cmyc , a proto-oncogene, is expressed at extremely low levels in mature neurons and is traditionally thought to have no function in these cells. However, recent studies suggest that Cmyc may play a crucial role in maintaining the health and function of mature dopaminergic neurons. This study assessed the role of Cmyc in dopaminergic neurons and its significance in Parkinson's disease.

In situ oxidation coating of copper bismuth oxide with polypyrrole to construct rice-like core-shell structures: Revealing prospects for high-performance asymmetric supercapacitor anodes.

Enhancing the energy density of asymmetric supercapacitors (ASCs) requires developing high-performance anode materials that pair well with cathode materials. In this study, rice-like structured CuBiO was synthesized using a simple and cost-effective wet-chemical method. Subsequently, the conductive polymer polypyrrole (PPy) was polymerized on the surface of CuBiO.

Changes in cancer mortality in Shandong Province, China: a large population based study.

Objective: To analyze the trend of major malignant tumor mortality in Shandong Province, eastern China from 1970 to 2021, and to provide the scientific basis for malignant tumor prevention and control.

Methods: Cancer mortality data were sourced from three nationwide cause-of-death surveys and the Shandong Death Registration System. Trends in overall mortality and major causes of death were elucidated through indicators such as mortality rates and age-adjusted death rates, by comparing findings from the three comprehensive mortality surveys and the Shandong Death Registration System.

Clinical Effect of Button Plate Fixation in the Treatment of Anterior Sternoclavicular Joint Dislocations.

Objective: Multiple reconstruction approaches for the anterior sternoclavicular joint have been described. No gold standard technique has been established. Owing to the well-established role of open reduction and internal fixation by means of plates and/or screws, rigid fixation is associated with the risk of implant failure, migration, and need for removal.