Habitat imaging based on dual-energy computed tomography for predicting axillary lymph node metastasis in breast cancer.

BackgroundQuantitative analysis with habitat clustering represents an innovative, non-invasive approach to quantify tumor heterogeneity.PurposeTo characterize intratumoral spatial heterogeneity using dual-energy computed tomography (DECT) in breast cancer patients and investigate the performance of habitat imaging in predicting axillary lymph node (ALN) metastasis compared with radiomics.Material and MethodsA total of 135 patients were randomly assigned to a training group (n = 95) and a testing group (n = 40).

Identification of Mild Hepatic Encephalopathy Based on Multi-level Functional Connectivity Hypernetwork.

Early diagnosis of mild hepatic encephalopathy is important for the reversion of hepatic encephalopathy. Brain hyper-connectivity networks with hyperedges have showed good performance for diagnosis of neurological disorders. However, the previous hyper-connectivity networks is essentially low-level since the temporal synchronization of regional signal fluctuation is merely considered.

SIRT3 promotes mitophagy to attenuate fumonisin B1-induced chicken hepatocyte senescence and antagonism of lycopene.

Fumonisins are a class of mycotoxins produced by molds of the genus Fusarium, and fumonisin B1 (FB1) is the most toxic and common fumonisins. As a carotenoid with natural powerful antioxidant capacity found in plants, lycopene (LYC) can enhance immunity, modulate blood lipids, and prevent liver diseases. Sirtuin 3 (SIRT3) is a versatile molecule in modulating mitochondrial function with the significance in mitophagy and cellular senescence.

972 nm single-frequency distributed Bragg reflector Yb-doped silica fiber laser.

We demonstrated a 972 nm single-frequency distributed Bragg reflector (DBR) Yb-doped fiber laser core-pumped by a watt-level 915 nm Nd-doped fiber laser. A 9 mm long home-fabricated highly Yb-doped silica fiber was used to build the DBR cavity. The direct output power of the 972 nm single frequency fiber laser (SFFL) could reach 42.

Development and validation of a prognostic nomogram incorporating automated collateral score and computed tomography perfusion parameters for patients with acute ischemic stroke undergoing endovascular thrombectomy.

Background: Prognostic evaluation of patients with acute ischemic stroke (AIS) after endovascular thrombectomy (EVT) remains challenging. Traditional computed tomography angiography (CTA) and computed tomography perfusion (CTP) have limitations, whereas multiphase CTA (mCTA) allows for more accurate collateral circulation assessment. However, the predictive utility of automated collateral scoring remains underexplored.

Association of exposure duration, modality, and polycythaemia with hyperuricaemia among han male immigrants at high altitudes: a cross-sectional study.

Background: Hyperuricaemia is associated with increased metabolic syndrome, cardiovascular disease, and mortality risk in the adult population and is more common in plateau areas. Han male immigrants are a high-risk population and deserve more attention. The correlations between different altitude exposure durations and exposure modalities with hyperuricaemia have not yet been reported.

Stroke burden analysis attributable to ambient and household PM in China from 1990 to 2021 based on GBD 2021.

Driven by rapid urbanization and economic growth, PM pollution has emerged as a pressing issue exacerbating the stroke burden, especially in developing nations such as China. As a preventable and measurable risk factor, the stroke burden attributable to ambient and household PM has not yet received adequate attention. The data were collected from Global Burden of Disease (GBD) database from 1990-2021.

Development and Evaluation of Antioxidant Postbiotics from Bacillus amyloliquefaciens C-1 to Alleviate DSS-Induced Colitis.

Bacillus amyloliquefaciens has been recognized as a next-generation probiotic with a qualified presumption of safety (QPS) status by the European Food Safety Authority (EFSA), indicating its promising application potential in postbiotic development. This study aimed to investigate the probiotic characteristics of B. amyloliquefaciens strain C-1, isolated from ready-to-eat fruit salads.

Dynamic contrast-enhanced MRI-based radiomics model of intra-tumoral kinetic heterogeneity for predicting breast cancer molecular subtypes.

Objectives: This study aims to segment intra-tumoral subregions of breast cancer based on kinetic heterogeneity using dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI). It also aims to construct a radiomics model of the whole tumor and washout region to predict molecular subtypes and human epidermal growth factor receptor 2 (HER2) status.

Methods: A total of 124 patients with biopsy-confirmed breast cancer were randomly divided into training and test sets in a 7:3 ratio.

Revealing the influence of annealing on mid- and long-wave infrared dual-color HgCdTe p-n junctions at the nanometer scale.

Doping and activation in HgCdTe to form p-n junctions are prerequisites for achieving superior infrared detection performance. This process is complex and highly sensitive to heat treatment. Comprehensive understanding of this procedure is often impeded by the lack of electronic information in the material with high spatial resolution.

PFKFB2-Driven Glycolysis Promotes Dendritic Cell Maturation and Exacerbates Acute Lung Injury.

Acute lung injury (ALI) is a life-threatening condition with excessive immune activation and dysregulated inflammation. Dendritic cells (DCs) play a pivotal role in immune regulation; however, their exact contribution to ALI pathogenesis remains unclear. This study demonstrates that the upregulation of the glycolytic regulator 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 2 (PFKFB2) by hypoxia-inducible factor-1α (HIF-1α) enhances glycolysis, drives DC maturation, and exacerbates inflammation, contributing to the pathogenesis of ALI.

Possible Use in Soil Bioremediation of the Bacterial Strain Bacillus Sphaericus NM-1 Capable of Simultaneously Degrading Promethrin and Acetochlor.

Prometryn and acetochlor are herbicides used to control weeds in farmlands and other areas. They enter the soil through direct application, residual accumulation in crops, and atmospheric deposition. The pollution of their residues in the environment has attracted people's attention.

Bibliometric and Visualized Analysis of Gut Microbiota and Hypertension Interaction Research Published from 2001 to 2024.

A comprehensive bibliometric analysis of literature is imperative to elucidate current research landscapes and hotspots in the interplay between gut microbiota and hypertension, identify knowledge gaps, and establish theoretical foundations for the future. We used publications retrieved from the Web of Science Core Collection (WoSCC) and SCOPUS databases (January 2001-December 2024) to analyze the annual publication trends with GraphPad Prism 9.5.

Global burden of ischemic heart disease attributable to ambient and household PM exposure: a comprehensive analysis (1990-2021) from socioeconomics perspective.

Objectives: Socioeconomic status links to exposure of air pollutants. This study evaluates global PM-attributable ischemic heart disease (IHD) burden from 1990 to 2021.

Methods: Using Global Burden of Disease (GBD) 2021 data, PM-related IHD burdens were analyzed.

Restorative effects and perception of nature-themed artworks in indoor environments: an empirical study based on VR+EEG.

Background: While numerous studies have examined the restorative effects of natural elements in indoor environments, limited attention has been given to the role of natural analogues. This study investigates the restorative effects of nature-themed artwork, a common natural analogue in biophilic design.

Materials And Methods: Virtual reality (VR) was employed to simulate five work environments: rooms featuring nature-themed artwork, a blank foreground, an architectural window view, a natural window view, and a green plant wall, respectively.

Comparing Multi-Value Diffusion MRI Models for Predicting Pathologic Complete Response to Neoadjuvant Chemotherapy in Breast Cancer.

Background Multi-value diffusion MRI models have been used to predict pathologic complete response (pCR) to neoadjuvant chemotherapy (NAC) for breast cancer. However, there is a lack of longitudinal comparative research. Purpose To compare the performance of various diffusion MRI-derived longitudinal parameters during NAC for prediction of pCR in breast cancer.

Enhanced Image Quality and Comparable Diagnostic Performance of Prostate Fast Bi-MRI with Deep Learning Reconstruction.

Rational And Objectives: To evaluate image quality and diagnostic performance of prostate biparametric MRI (bi-MRI) with deep learning reconstruction (DLR).

Materials And Methods: This prospective study included 61 adult male urological patients undergoing prostate MRI with standard-of-care (SOC) and fast protocols. Sequences included T2-weighted imaging (T2WI), diffusion-weighted imaging (DWI), and apparent diffusion coefficient (ADC) maps.

Reservoir water-level operations to manage biogeochemical turnover.

Rapid decrease in temperature changes water stratification structure into an unstable state, reinforcing water convection and enhancing vertical biogeochemical fluxes, which might pose a threat to aquatic ecosystems, especially for drinking water use. At high latitudes, current research predominantly focuses on destratification systems to reduce the degradation of aquatic ecosystems. However, at low latitudes, the strategies of enhanced stratification through water level operation (WLO) provide a perspective for reservoir management.

Deep adaptive learning predicts and diagnoses CSVD-related cognitive decline using radiomics from T-FLAIR: a multi-centre study.

Early identification of cerebral small vessel disease related cognitive impairment (CSVD-CI) is crucial for timely clinical intervention. We developed a Transformer-based deep learning model using white matter hyperintensity (WMH) radiomics features from T-fluid-attenuated inversion recovery images to detect CSVD-CI. A total of 783 subjects (161 longitudinally followed) were enrolled from three centres for model development and external validation, using a domain adaptation strategy.

Parental preconception BMI and risk of adverse birth outcomes in 8 million parent-child triads: a nationwide population-based cohort study in China.

Background: Maternal obesity has been identified as a risk factor for adverse birth outcomes, but the role of paternal obesity (separately and in combination with maternal obesity) on perinatal outcomes remains to be determined. Therefore, this study aims to investigate the independent and joint associations of paternal and maternal BMI with adverse birth outcomes in the general population in China.

Methods: This population-based cohort study used data from the National Free Preconception Checkups Project between 2010 and 2020.

Four methods to identify sensitive periods of infant weight gain associated with adolescent BMI in a Chinese birth cohort.

Infant weight gain is strongly linked to a higher risk of childhood and adolescent obesity. However, limited growth assessments and inconsistent weight gain measures hinder the identification of sensitive early-life periods. This study aims to use various methods to quantify weight gain across different periods during the first two years of life and further identify sensitive periods of infant growth.

Distance of Hematoma Crossing the Midline as a Predictor of Obstructive Hydrocephalus and Poor Outcome in Patients with Small Amount of Thalamic Hemorrhage.

Objective: This study aimed to examine the association of distance of hematoma crossing the midline (DHCM) with obstructive hydrocephalus (OH) and 90-day neurological outcomes in patients with small amount of thalamic hemorrhage (SATH).

Methods: A retrospective analysis was conducted in patients with thalamic hemorrhage with a hematoma volume of ≤10 mL. The coronal section of brain computed tomography was used to measure the distance from the hematoma's distal end to the midline, and a cutoff value was determined to predict OH.

Dynamic evolution of microstructure in thalamic subregions of patients with cirrhosis: A study based on diffusion kurtosis imaging.

Objectives: To investigate the cross-sectional and longitudinal dynamics of the thalamic subregion microstructure in patients with liver cirrhosis by diffusion kurtosis imaging (DKI) and explore its relationship with cognitive function.

Materials And Methods: DKI was performed on 50 with hepatic encephalopathy (HE), 46 without hepatic encephalopathy (non-HE), and 41 healthy controls (HC). 61 of these cirrhotic patients underwent liver transplantation (LT) surgery and DKI again one month later to compare the diffusion parameters before and after surgery.

Subtype identification of clinical and thrombus imaging features in acute ischemic stroke: using clustering analysis and principal component analysis.

Acute ischemic stroke (AIS) presents significant heterogeneity in clinical and thrombus imaging characteristics, which can profoundly impact therapeutic decisions and outcomes. This study analyzed 520 AIS patients who underwent endovascular thrombectomy, integrating clinical variables and thrombus imaging features to identify potential subtypes through unsupervised clustering and principal component analysis. Three distinct subtypes emerged: Cluster 1, characterized by middle cerebral artery occlusion, shorter thrombus lengths, and favorable outcomes; Cluster 2, comprising predominantly male smokers and drinkers with no significant outcome differences; and Cluster 3, consisting of older patients with higher stroke severity, internal carotid artery occlusion, longer thrombus lengths, and poor outcomes.

Impact of negative-pressure ureteral access sheath on preventing "boiled ureter" during holmium laser lithotripsy.

Purpose: To evaluate the impact of negative-pressure ureteral access sheath (NP-UAS) on thermal effects during holmium laser lithotripsy.

Materials And Methods: A 3D-printed urinary model was used. A ureteroscope, traditional UAS (T-UAS) or NP-UAS, and a 200 µm hollium laser fiber were introduced into the model's proximal ureter, with the fiber activated for 90 s.