Designing 3D Nanoporous Cu/CuO (Bi) with Bimodal Porosity as a High-Rate and Capacity Zinc Anode Host.

We report a bimodal nanoporous Cu/CuO doped with bismuth (np-Cu/CuO (Bi)) by dealloying an Al-Cu-Bi-based two-phase precursor alloy. Different from the typically used unimodal porous Cu, the bimodal structure provides big pores (hundreds of nanometers) for enough Zn deposition (high capacity) and small pores (10 nm) with a high specific surface area for high rates. Moreover, the formation of the CuO surface with Bi doping significantly reduces the Zn deposition overpotential.

Restorative effects and perception of nature-themed artworks in indoor environments: an empirical study based on VR+EEG.

Background: While numerous studies have examined the restorative effects of natural elements in indoor environments, limited attention has been given to the role of natural analogues. This study investigates the restorative effects of nature-themed artwork, a common natural analogue in biophilic design.

Materials And Methods: Virtual reality (VR) was employed to simulate five work environments: rooms featuring nature-themed artwork, a blank foreground, an architectural window view, a natural window view, and a green plant wall, respectively.

Novel risk predictor of spontaneous rupture and hemorrhage of renal cell carcinoma based on clinical and radiographic characteristics.

Objectives: To evaluate and validate clinical and imaging predictors of spontaneous rupture and hemorrhage (SRH) in renal cell carcinoma (RCC), and to develop an individualized risk prediction nomogram.

Methods: A cohort of 914 RCC patients was analyzed. Clinical and imaging characteristics were compared between SRH and non-SRH groups, with baseline characteristics balanced using propensity score matching.

A rat Satb1 truncation causes neurodevelopmental abnormalities recapitulating the symptoms of patients with SATB1 mutations.

The special AT-rich sequence binding protein 1 (SATB1) has been linked to neurodevelopmental disorders (NDDs) including developmental delay, intellectual disabilities (ID) and autism spectrum disorder (ASD). But the underlying biological mechanisms are still not fully understood. In this study we generated a rat model with a truncated Satb1 protein.

A 12 μm-Thick, Mechanically Stable Ionogel Electrolyte with Directed Li Transport Channels for High-Performance Lithium Metal Batteries.

The ionogel polymer electrolyte (IGPE) has emerged as a promising polymer electrolyte for lithium metal batteries (LMBs) due to its high safety and a wide electrochemical window. To achieve an energy density comparable to that of liquid electrolyte (LEs)-based cells, ultrathin IGPE electrolytes with high Li conductance are desired. However, their development still suffers from intrinsically poor mechanical stability and the low Li transference number () of IGPEs.

Down-regulation of circMUC16 inhibited the progression of ALL via interaction with miR-1182 and TPPP3.

Circular RNA (circRNA) is crucial in various biological processes, particularly in the onset and progression of different diseases. Nevertheless, the function of circMUC16 in acute lymphoblastic leukemia (ALL) remains unclear. The expression of circMUC16, miR-1182 and TPPP3 was evaluated by qPCR.

Mechanical signal modulates prostate cancer immune escape by USP8-mediated ubiquitination-dependent degradation of PD-L1 and MHC-1.

The tumor environment of prostate cancer (PCa) tissues of high Gleason score has been proved to be more immune suppressive and has higher extracellular matrix (ECM) stiffness, but whether ECM mechanical stiffness is the cause of higher ability of invasiveness and immune escape of PCa with high Gleason score remains uncertain. In this study, we showed that higher polyacrylamide hydrogels (PAAG) stiffness resulted in the progression and immune escape of PCa via integrin β1/FAK/YAP axis. The translocation of YAP into cell nucleus to bind to TEAD2 promoted the transcriptional activation of USP8.

Integrated analysis of MIOX gene in prognosis of clear-cell renal cell carcinoma.

Clear-cell renal cell carcinoma (ccRCC) is a highly aggressive malignancy that originates in the kidney. It often exhibits a limited response or can be refractory to a wide range of anti-cancer therapies, including tyrosine kinase inhibitors (TKIs) and immune checkpoint inhibitors. Ferroptosis is a form of oxidative, iron-dependent cell death characterized by lipid peroxidation.

Bispecific antibodies targeting MPXV A29 and B6 demonstrate efficacy against MPXV infection.

Recently, the monkeypox virus (MPXV) outbreak was once again declared by the World Health Organization as a global health emergency, and currently, there is no specific drug against MPXV. During the replication cycle, MPXV produces two distinct forms of viral particles: extracellular enveloped virus (EEV), released via exocytosis, and intracellular mature virus (IMV), expelled through host cell lysis. A29 and B6 proteins are membrane proteins found on the IMV and EEV viral particles, respectively.

Central Med23 deficiency leads to malformation of dentate gyrus and ADHD-like behaviors in mice.

Attention-deficit hyperactivity disorder (ADHD) is a prevalent psychiatric disorder with high heritability, while its etiology and pathophysiology remain unclear. Med23 is a subunit of the Mediator complex, a key regulator of gene expression by linking transcription factors to RNA polymerase II. The mutations of Med23 are associated with several brain diseases including microcephaly, epilepsy and intellectual disability, but its biological roles in brain development and possible behavioral consequence have not been explored in the animal model.

Probing Berry Phase Effect in Topological Surface States.

We have observed the Berry phase effect associated with interband coherence in topological surface states (TSSs) using two-color high-harmonic spectroscopy. This Berry phase accumulates along the evolution path of strong field-driven electron-hole quasiparticles in electronic bands with strong spin-orbit coupling. By introducing a secondary weak field, we perturb the evolution of Dirac fermions in TSSs and thus provide access to the Berry phase.

Perceptions of Patients With Stroke Regarding an Immersive Virtual Reality-Based Exercise System for Upper Limb Rehabilitation: Questionnaire and Interview Study.

Background: With substantial resources allocated to develop virtual reality (VR)-based rehabilitation exercise programs for poststroke motor rehabilitation, it is important to understand how patients with stroke perceive these technology-driven approaches, as their perceptions can determine acceptance and adherence.

Objective: This study aimed to examine the perceptions of patients with stroke regarding an immersive VR-based exercise system developed to deliver shoulder, elbow, forearm, wrist, and reaching exercises.

Methods: A questionnaire was used to assess the perceptions of 21 inpatients who had experienced stroke (mean time from stroke onset: 37.

Radiomics of Periprostatic Fat and Tumor Lesion Based on MRI Predicts the Pathological Upgrading of Prostate Cancer from Biopsy to Radical Prostatectomy.

Rationale And Objectives: To assess the predictive value of MRI-based radiomics of periprostatic fat (PPF) and tumor lesions for predicting Gleason score (GS) upgrading from biopsy to radical prostatectomy (RP) in prostate cancer (PCa).

Methods: A total of 314 patients with pathologically confirmed prostate cancer (PCa) after radical prostatectomy (RP) were included in the study. The patients were randomly assigned to the training cohort (n = 157) and the validating cohort (n = 157) in a 1:1 ratio.

Development and Validation of an MRI-Based Radiomics Nomogram to Predict the Prognosis of De Novo Oligometastatic Prostate Cancer Patients.

Objective: We aimed to develop and validate a nomogram based on MRI radiomics to predict overall survival (OS) for patients with de novo oligometastatic prostate cancer (PCa).

Methods: A total of 165 patients with de novo oligometastatic PCa were included in the study (training cohort, n = 115; validating cohort, n = 50). Among them, MRI scans were conducted and T2-weighted imaging (T2WI) and apparent diffusion coefficient (ADC) sequences were collected for radiomics features along with their clinicopathological features.

Mendelian randomization studies in ankylosing spondylitis: A systematic review.

Introduction: Previous research has revealed connections between ankylosing spondylitis (AS) and comorbid conditions. However, observational studies frequently encounter difficulties in establishing definitive causal links between potential risk factors and AS. In contrast, Mendelian randomization (MR) offers a more robust approach to exploring causality by leveraging the random allocation of alleles at birth, thereby minimizing confounding factors.

Latent profiles of multi-dimensional sleep characteristics and association with overweight/obesity in Chinese preschool children.

Objectives: To examine the association between latent profiles of multi-dimensional sleep characteristics and overweight/obesity (OWO) in Chinese preschool children.

Study Design: The cross-sectional analysis included 3204 preschool children recruited from 24 kindergartens in Shanghai. Parents reported children's demographics and sleep characteristics, including sleep duration, timing and disturbances.

Effects of Anion Coadsorption on the Self-Assembly of 11-Acryloylamino Undecanoic Acid on an Au(111) Electrode.

11-acryloylamino undecanoic acid (AAUA) is a versatile polymerizable surfactant that has been applied to coat medical devices, and these applications can benefit from a fundamental understanding of its interaction with a metal substrate. Cyclic voltammetry and scanning tunneling microscopy (STM) were used to examine the adsorption configuration of AAUA molecules on an ordered Au(111) electrode and their mutual interactions, as AAUA was adsorbed from a methanol dosing solution. In addition to the van der Waals force between the aliphatic groups, the hydrogen bonding between the carboxylic acid and acrylamide groups was also important to guide the spatial arrangement of AAUA admolecules on the Au electrode.

Design, synthesis and antitumor activity of novel 4-oxobutanamide derivatives.

To find highly effective and low-toxicity antitumor drugs to overcome the challenge of cancer, we designed and synthesized a series of novel 4-oxobutanamide derivatives using the principle of molecular hybridization and tested the antiproliferative ability of the title compounds against human cervical carcinoma cells (HeLa), human breast carcinoma cells (MDA-MB-231) and human kidney carcinoma cells (A498). Among them, N-(4-methoxybenzyl)-N-(4-methoxyphenyl)-N-(3,4,5-trimethoxyphenyl) succinimide DN4 (IC = 1.94 µM) showed the best proliferation activity on A498, superior to the positive control paclitaxel (IC = 8.

DCC in the cerebral cortex is required for cognitive functions in mouse.

Schizophrenia (SZ) is a highly heritable mental disorder, and genome-wide association studies have identified the association between deleted in colorectal cancer (DCC) and SZ. Previous study has shown a lowered expression of DCC in the cerebral cortex of SZ patient. In this study, we identified novel single nucleotide polymorphisms (SNPs) of DCC statistically correlated with SZ.

Polyoxometalates and their composites for antimicrobial applications: Advances, mechanisms and future prospects.

The overuse of antibiotics can lead to the development of antibiotic-resistant bacteria, which can be even more difficult to treat and pose an even greater threat to public health. In order to address the issue of antibiotic-resistant bacteria, researchers currently are exploring alternative methods of sterilization that are both effective and sustainable. Polyoxometalates (POMs), as emerging transition metal oxide compounds, exhibit significant potential in various applications due to their remarkable tunable physical and chemical performance, especially in antibacterial fields.

LNP-mRNA vaccine prevents type 1 diabetes in non-obese diabetes mice.

Islet-antigen-specific tolerization is a key goal of experimental immunotherapies for type 1 diabetes. mRNA-based vaccines have demonstrated the feasibility of RNA delivery in inducing antigen tolerance in autoimmune diseases. In this study, mRNA vaccine, encoded tandem glutamic acid decarboxylase 65 (GAD65) epitopes and cholera toxin B subunit (CTB-GADIII), prepared by an in vitro transcription (IVT) system and encapsulated with lipid nanoparticles (LNP), was intramuscularly administered to non-obese diabetic (NOD) and cyclophosphamide (Cy)-NOD mice respectively.

Effects of Mung Bean Water Supplementation on Modulating Lipid and Glucose Metabolism in a Diabetic Rat Model.

Type 2 diabetes mellitus (T2DM) is often associated with chronic inflammation exacerbated by hyperglycemia and dyslipidemia. Mung beans have a longstanding reputation in traditional medicine for their purported ability to lower blood glucose levels, prompting interest in their pharmacological properties. This study aimed to explore the impact of mung bean water (MBW) on carbohydrate and lipid metabolism in a T2DM rat model induced by nicotinamide/streptozotocin.

Chitosan/agarose hydrogel dressing: pH response real-time monitoring and chemo-/photodynamic therapy synergistic treatment of infected wounds.

The early diagnosis and real-time monitoring of bacterial infections are of great significance for the establishment of integrated diagnosis and treatment systems. In this study, a pH-responsive smart hydrogel patch system, named CABP, was developed to monitor and treat wound infections. CABP has a sandwich structure, with non-woven fabric/chitosan (NF/CS) as the intermediate skeleton layer, Agarose/chitosan/Bromothymol Blue (AG/CS/BTB) hydrogel as the detection layer, and Agarose/chitosan/phthalocyanine (AG/CS/Pc) hydrogel as the treatment layer.

Magnetic resonance imaging-based radiomics nomogram for the evaluation of therapeutic responses to neoadjuvant chemohormonal therapy in high-risk non-metastatic prostate cancer.

Purpose: The aim of this study was to assess the potential application of a radiomics features-based nomogram for predicting therapeutic responses to neoadjuvant chemohormonal therapy (NCHT) in patients with high-risk non-metastatic prostate cancer (PCa).

Methods: Clinicopathologic information was retrospectively collected from 162 patients with high-risk non-metastatic PCa receiving NCHT and radical prostatectomy at our center. The postoperative pathological findings were used as the gold standard for evaluating the efficacy of NCHT.