Elucidating the correlation between polychlorinated dibenzo-p-dioxins and prostate cancer progression: Insights from gene expression and molecular docking.

Objective: Polychlorinated dibenzo-p-dioxins (PCDDs) present a significant long-term threat to human health attributable to their toxicological properties, chemical stability and propensity for bioaccumulation. This study seeks to explore the correlation between PCDDs exposure and prostate cancer (PCa) through comprehensive analysis.

Methods: The multi-dimensional analysis was conducted based on various online databases.

Comparison of the therapeutic effects of three internal fixation methods for transverse fractures of the patella.

Background: This study aimed to evaluate the treatment effects of three internal fixation methods, including tension band with K-wires, tension band with cannulated screws and tension band with ring-pins on transverse fractures of the patella.

Methods: Patellar fracture patients treated in Shanghai Yangpu District Shidong Hospital from March 2016 to January 2023 were divided into three groups based on the internal fixation method: the ring-pins group (tension band with ring-pins), the K-wires group (tension band with K-wires), and the cannulated screws group (tension band with cannulated screws). Surgery duration, hemoglobin decrease, excellent rate of knee joint function evaluation at postoperative 3 months and 12 months, VAS scores before surgery and at 3 and 12 months after surgery, postoperative complication rate, and removal rate of internal fixation were compared among the three groups of patients.

Novel risk assessment strategy of co-exposure of arsenic and cadmium in seaweeds based on in vivo-in vitro correlation, bio-transformation and speciation.

In recent years, global consumption of seaweed has been on the rise, yet there is a lack of accurate methods for assessing the health risks associated with its consumption. This gap could pose a threat to public safety or lead to wasted resources by government regulatory bodies. In this study, animal models and an innovative PBET (IPBET) were used to determine the bioavailability and bioaccessibility of arsenic (As) and cadmium (Cd) in various seaweeds, followed by an in vivo-in vitro correlation (IVIVC) analysis.

Novel risk predictor of spontaneous rupture and hemorrhage of renal cell carcinoma based on clinical and radiographic characteristics.

Objectives: To evaluate and validate clinical and imaging predictors of spontaneous rupture and hemorrhage (SRH) in renal cell carcinoma (RCC), and to develop an individualized risk prediction nomogram.

Methods: A cohort of 914 RCC patients was analyzed. Clinical and imaging characteristics were compared between SRH and non-SRH groups, with baseline characteristics balanced using propensity score matching.

Key Transcription Factors: Avenue for Treating Alcoholic Liver Disease.

Alcoholic liver disease (ALD), which includes a range of diseases, ranging from alcoholic steatosis, hepatitis, and fibrosis to cirrhosis and hepatocarcinoma, is a process of epigenetic remodeling involving multiple genes and metabolic pathways. ALD is involved in various transcriptional regulatory mechanisms, including lipid metabolism disorders, inflammatory responses, autophagy, fibrogenesis, oxidative stress, fatty acid metabolism, iron metabolism, and endoplasmic reticulum stress. In the occurrence of ALD and its response to the microenvironment, various transcription factors (TFs) play important roles.

Plasma activated water (PAW) modification of PSE-like chicken protein isolate: Structural changes and enhanced film-forming properties.

The oxidative effects of plasma-activated water (PAW) on the structure, oxidation, and film-forming properties of heat-induced alkaline PSE-like chicken protein isolate (PPI) were investigated. The results demonstrated that the content of active substances in PAW significantly increased with longer preparation times. PAW treatment led to the unfolding of PPI structure in the film-forming solution, evidenced by the conversion of α-helices to β-sheet and β-turn, exposure of hydrophobic groups, increased surface hydrophobicity, and a significant reduction in fluorescence intensity.

Discovery and evaluation of a novel selective fluorescent substrate for CYP3A4 based on sulfoxidation characteristics.

This study for the first time reports the design and application of a novel type of selective fluorescent substrate NESF for cytochrome P450 3A4 (CYP3A4) based on sulfoxidation reaction. NESF has been successfully applied for imaging endogenous CYP3A4 in living cells and for high-throughput screening of CYP3A4 inhibitors.

Deficiency of NPR-C triggers high salt-induced thoracic aortic dissection by impairing mitochondrial homeostasis.

Aims: Thoracic aortic dissection (TAD) is a highly fatal disease lacking effective pharmacologic interventions in clinical practice. Emerging evidence indicates that the natriuretic peptide receptor C (NPR-C) plays a crucial role in the regulation of cardiovascular diseases. However, the precise involvement of NPR-C in TAD remains elusive.

Recent progress of proline endopeptidase ligands and their effects on protein-protein interactions.

Proline endopeptidase (PREP), as a serine protease, plays a crucial role in human physiology and pathology, and is intricately linked to the genesis and progression of a spectrum of illnesses. The fluorescent substrates currently used for PREP lack ideal specificity and are unable to specifically detect PREP activity under physiological conditions. This limitation, to some extent, hinders the in-depth investigation of its physiological and pathophysiological functions.

Identification of Selected Genes Associated With the Prediction of Prognosis in Bladder Cancer.

Background: Bladder cancer (BC) is one of the most common urological malignancies, ranking as the eleventh most common cause of cancer-related deaths worldwide. The lack of specific and sensitive prognostic biomarkers presents a significant challenge in the early diagnosis and treatment of BC.

Methods: We used the Gene Expression Omnibus (GEO) dataset GSE13507 and the Cancer Genome Atlas (TCGA) database to screen differentially expressed genes related to BC.

Endothelial KLF15/VASN Axis Inhibits Angiogenesis via Activation of Notch1 Signaling.

Background: Angiogenesis is a dynamic process fine-tuned by transcription factors in endothelial cells. The KLF15 (Krüppel-like factor 15)-mediated transcriptional regulation mechanism is critical for cardiovascular diseases. However, the role of KLF15 in governing angiogenesis remains unknown.

Artificial regulation affects nitrate sources and transformations in cascade reservoirs by altering hydrological conditions.

Reservoirs are recognized as pivotal zones within the nitrate cycle, substantially modifying the source-sink dynamics of nitrate in fluvial systems. However, the impact of hydrological alterations induced by artificial regulation on nitrate sources and transformation processes in cascade hydropower reservoirs remains insufficiently comprehended. Consequently, we investigated the spatiotemporal characteristics of nitrate concentrations, δN, δO, δD, ΔO, relative water column stability (RWCS), runoff, and associated environmental factors within cascade reservoirs along the Wujiang River in Southwest China.

Impact of particle-attached microbial denitrification on NO production in an agricultural-urban watershed.

Anthropogenically influenced rivers are key hotspots for nitrous oxide (NO) emissions. However, the seasonal and spatial heterogeneity of NO emissions in subtropical riverine systems, particularly the role of particle-attached microbes (PAM) in regulating NO production, remains poorly understood, contributing to uncertainties in global NO estimates. This study investigates the potential impacts of PAM-driven nitrogen transformations on NO production in the Dongjiang River under agricultural and urban influences.

Total or partial adrenalectomy for aldosterone-producing adenoma: can Ga-Pentixafor PET/CT predict surgical outcomes?

Objective: This study aimed to compare the accuracy of adrenal vein sampling (AVS) and Ga-Pentixafor positron emission tomography (PET)/computed tomography (CT) in predicting the functional outcome from adrenalectomy in patients with primary aldosteronism (PA), and to investigate the utility of Ga-Pentixafor PET/CT in laparoscopic partial adrenalectomy.

Methods: We prospectively enrolled patients diagnosed with PA. All patients underwent Ga-Pentixafor PET/CT and AVS.

Investigating the therapeutic potential of Ganoderma lucidum in treating optic nerve atrophy through network pharmacology and experimental validation.

Objective: The aim of this study is to employ network pharmacology to identify potential therapeutic targets for Ganoderma lucidum in the treatment of optic atrophy, and elucidate the underlying pharmacological mechanism.

Methods: This study is mainly divided into two parts. In the first part, the chemical composition and Target of Ganoderma lucidum compound were predicted by TCMSP and Swiss Target Prediction, and the crossover gene between OA and Ganoderma lucidum target gene was screened based on GeneCards and OMIM database.

Mitochondria transplantation transiently rescues cerebellar neurodegeneration improving mitochondrial function and reducing mitophagy in mice.

Cerebellar ataxia is the primary manifestation of cerebellar degenerative diseases, and mitochondrial dysfunction in Purkinje cells (PCs) plays a critical role in disease progression. In this study, we investigated the feasibility of mitochondria transplantation as a potential therapeutic approach to rescue cerebellar neurodegeneration and elucidate the associated mechanisms. We constructed a conditional Drp1 knockout model in PCs (PCKO mice), characterized by progressive ataxia.

[Effect of Duhuo Jisheng Decoction on knee osteoarthritis model rabbits through regulation of cell pyroptosis mediated by PI3K/Akt/mTOR signaling pathway].

This study aimed to investigate the underlying mechanisms of Duhuo Jisheng Decoction(DJD) in the prevention and treatment of knee osteoarthritis(KOA). Forty SPF New Zealand rabbits were randomly divided using SPSS 26.0 software into five groups: blank group, model group, low-dose DJD group, high-dose DJD group, and high-dose DJD+phosphatidylinositol 3-kinase(PI3K)/protein kinase B(Akt)/mammalian target of rapamycin(mTOR) signaling pathway activator group(high-dose DJD+740Y-P group), with eight rabbits in each group.

A high-quality chromosome-level genome assembly of the mulberry looper, Phthonandria atrilineata.

The mulberry looper (Phthonandria atrilineata), a geometrid moth, plays a pivotal role in the destruction of mulberry trees (Morus spp.). In China, P.

A comprehensive analysis-based study of Di-(2-ethylhexyl) phthalate (DEHP)-Environmental explanation of bladder cancer progression.

Di-(2-ethylhexyl) phthalate (DEHP) is widely utilized as a plasticizer in industrial manufacturing to enhance the durability and flexibility of plastics. Studies have depicted that DEHP exposure may be associated with multiple cancers, including colorectal, liver and prostate cancer. However, the effects and underlying mechanisms of DEHP on bladder cancer progression remain unspecific.

Identification of neutrophil extracellular traps (NETs)-related molecular clusters in prostate cancer: Implications for predicting biochemical recurrence.

Objective: To identify neutrophil extracellular traps (NETs)-related molecular clusters and establish a novel gene signature for predicting biochemical recurrence in prostate cancer (PCa).

Methods: The transcriptome and clinicaldata of PCa sampleswere obtained from The TCGA and GEO databases. To identify NET-related molecular clusters, consensus clustering analyses were performed.

Development and Validation of an MRI-Based Radiomics Nomogram to Predict the Prognosis of De Novo Oligometastatic Prostate Cancer Patients.

Objective: We aimed to develop and validate a nomogram based on MRI radiomics to predict overall survival (OS) for patients with de novo oligometastatic prostate cancer (PCa).

Methods: A total of 165 patients with de novo oligometastatic PCa were included in the study (training cohort, n = 115; validating cohort, n = 50). Among them, MRI scans were conducted and T2-weighted imaging (T2WI) and apparent diffusion coefficient (ADC) sequences were collected for radiomics features along with their clinicopathological features.

Direct activation of toll-like receptor 4 signaling in group 2 innate lymphoid cells contributes to inflammatory responses of allergic diseases.

Group 2 innate lymphoid cells (ILC2s) are key players in type 2 immunity, but whether they can be directly activated by microbial ligands remain uncertain. In this study, we observed a positive correlation between blood endotoxin (LPS) levels and circulating ILC2s in allergic patients. , LPS robustly induced ILC2 proliferation and production of type 2 effector cytokines.

Case report: A rare EBV-associated T/NK cell monomorphic posttransplant lymphoproliferative disorder.

Background: Kidney transplantation (KT) is the best treatment for patients with end-stage renal disease. However, postoperative complications remain the main issues faced during KT recovery period. Posttransplant lymphoproliferative disorders (PTLD) are one of the severe and life-threatening complications that occur after KT while the recipient is undergoing immunosuppressive therapy.