Vitamin-Integrated PROTAC Nanoparticle for Combined Therapy of NSCLC.

Proteolysis-targeting chimeric (PROTAC) technology represents a groundbreaking approach with immense potential for treating a wide range of diseases. However, its clinical application is often limited by challenges in solubility and permeability. Herein, we have developed an innovative three-in-one nanoparticulate therapeutic agent tailored for non-small-cell lung cancer (NSCLC).

Construction of multifunctionalized (oxo)indoles via O-Selective interception of the zwitterionic intermediate with N=O.

A straightforward multi-component method is developed to construct multifunctionalized (oxo)indoles under Pd(II) catalysis via intramolecular or intermolecular reaction pathways between electron-rich arenes, diazo compounds, and nitrosoarenes. Under the catalysis of palladium, metal carbene, generated from diazo compound, reacts with electron-rich arene to form zwitterionic intermediate, which is trapped by activated nitrosobenzene to give the desired product. It is worth noting that indole and nitrosobenzene have a competitive relationship and react with diazo compounds to produce different two-component products.

Tuning the visible circularly polarized luminescence in highly emissive chiral terbium and europium chlorides.

Chiral hybrid metal halides have become increasingly popular due to their high structural tunability and exceptional optoelectronic properties. Incorporating rare-earth (RE) metals into the structural units and inheriting their pure emission characteristics are of great interest and importance. Here, we report two pairs of new isostructural chiral hybrid RE chlorides based on RE metals Tb and Eu, crystallizing in the non-centrosymmetric space group 222.

The preparation impairs the reinterpretation: insights from EEG-based multivariate pattern analysis.

Reinterpretation is one of the primary reappraisal tactics crucial for psychological well-being in emotion regulation (ER). However, it remains unclear how preparatory brain activity influences the temporal dynamics of ER during reinterpretation. Thirty-four young adults involving an adapted ER task, downregulated their negative emotional experiences through reinterpretation.

Bioassay-guided isolation of hepatoprotective lignans from : DeepSAT-driven structural elucidation and predictive mechanistic insights against drug-induced liver injury.

Three new dibenzylbutane lignans, vernolignans A-C (1-3), along with three known compounds (4-6), were isolated from through a bioactivity-guided isolation process. The planar structures of the new compounds (1-3) were elucidated through comprehensive analysis of HR-ESI-MS and 1D/2D NMR data, with the assistance of AI-based structure annotation tool DeepSAT. The absolute configurations of 1-3 were determined by comparing the experimental and calculated ECD spectra.

Ganoapplanilactone C from Ameliorates Metabolic Dysfunction-Associated Steatotic Liver Disease via AMPK/mTOR-Mediated Lipid Regulation in Zebrafish.

A phytochemical study of identified four predominant triterpenoids, with ganoapplanilactone C (GATC) exhibiting the most significant lipid-reducing effects in high-fat diet-fed zebrafish, surpassing atorvastatin at 5 μM. Histopathological analysis confirmed GATC's protective effects on the liver against high-fat diet-induced damage. The Enzyme-Linked Immunosorbent Assay (ELISA) results showed a positive correlation between GATC treatment and liver health markers, as well as antioxidant enzymes, while they revealed a negative correlation with triglycerides and inflammatory cytokines.

Comprehensive Stiffness Modeling and Evaluation of an Orthopedic Surgical Robot for Enhanced Cutting Operation Performance.

This study presents an integrated stiffness modeling and evaluation framework for an orthopedic surgical robot, aiming to enhance cutting accuracy and operational stability. A comprehensive stiffness model is developed, incorporating the stiffness of the end-effector, cutting tool, and force sensor. End-effector stiffness is computed using the virtual joint method based on the Jacobian matrix, enabling accurate analysis of stiffness distribution within the robot's workspace.

Intestinal flora metabolites indole-3-butyric acid and disodium succinate promote IncI2 carrying plasmid transfer.

Introduction: Plasmid-driven horizontal transfer of resistance genes in bacterial communities is a major factor in the spread of resistance worldwide. The gut microbiome, teeming with billions of microorganisms, serves as a reservoir for resistance genes. The metabolites of gut microorganisms strongly influence the physiology of their microbial community, but the role of the metabolites in the transfer of resistance genes remains unclear.

Aptamers for aflatoxin M1: from aptasensing technology to commercialization.

Aflatoxin M1 (AFM1) contamination in milk and dairy products poses a significant global concern due to its severe health risks to humans. Sensitive and specific detection of AFM1 has emerged as the most effective strategy for mitigating these health risks. Aptamers are regarded as ideal biorecognition elements for AFM1 monitoring owing to their small size, ease of production, excellent affinity and specificity, high stability, and low immunogenicity.

Penicipyrrolidines A-N, pyrrolidine derivatives with inhibitory effects on EMT and fibroblast activation from the mangrove-derived fungus sp. DM27.

Unlabelled: An investigation of the mangrove-derived fungus sp. DM27 led to the isolation of 19 new compounds, including three pairs of piperidinone enantiomers ( ±)-, ( ±)-, and ( ±)-, two pairs of pyrrolidinone enantiomers ( ±)- and ( ±)-, and nine pyrrolidine derivatives -. The structures of - were elucidated through NMR and HRESIMS analysis, coupled with experimental and calculated ECD spectroscopy and the modified Mosher method.

Hydroenergy Inspiring Large-Scale Piezoelectric Catalysis for Seawater Hydrogen Evolution.

The piezoelectric effect presents a promising avenue for harvesting and utilizing low-grade mechanical energy. However, challenges from lacking matched industrial equipment and maintaining catalytic performance during scaling up impede the engineering of piezo-catalysis. Here, utilizing mechanical energy of water to inspire piezoelectricity, a successful attempt at large-scale piezo-catalysis seawater H evolution was reported for the first time, exhibiting an efficiency of 36.

Lipid Nanoparticles-Mediated mRNA Delivery to the Eye Affected by Ionizable Cationic Lipid.

Ionizable lipid serves as the key functional component in lipid nanoparticles (LNPs) for efficient mRNA delivery. This study aims to systematically evaluate clinically approved ionizable lipid DLin-MC3-DMA and SM102-based LNPs for ocular mRNA delivery, with a comprehensive assessment of their physicochemical characteristics, delivery efficiency, and biodistribution patterns within the ocular microenvironment. Enhanced green fluorescence protein or Luc encoding mRNA-loaded LNPs were formulated using microfluidic mixing technology and characterized by dynamic light scattering, ζ-potential measurements, and cryogenic transmission electron microscopy imaging.

Bisabolane-type sesquiterpenoids and cyclic tetrapeptide from the marine fungus Aspergillus sp. WHUF05242.

Two new bisabolane-type sesquiterpenoids, aspergillolanoids A and B (1 and 2), along with a previously unreported cyclic tetrapeptide, aspergitertide A (5), and four known compounds (3, 4, 6 and 7), have been isolated from the deep-sea-derived fungus Aspergillus sp. WHUF05242. Structural elucidation of these compounds was accomplished through comprehensive spectroscopic analysis, including HR-ESIMS and 1D/2D NMR spectroscopic data.

Artificial regulation affects nitrate sources and transformations in cascade reservoirs by altering hydrological conditions.

Reservoirs are recognized as pivotal zones within the nitrate cycle, substantially modifying the source-sink dynamics of nitrate in fluvial systems. However, the impact of hydrological alterations induced by artificial regulation on nitrate sources and transformation processes in cascade hydropower reservoirs remains insufficiently comprehended. Consequently, we investigated the spatiotemporal characteristics of nitrate concentrations, δN, δO, δD, ΔO, relative water column stability (RWCS), runoff, and associated environmental factors within cascade reservoirs along the Wujiang River in Southwest China.

Disentangling Multiple pH-Dependent Factors on the Hydrogen Evolution Reaction at Au(111).

Understanding how the electrolyte pH affects electrocatalytic activity is a topic of crucial importance in a large variety of systems. However, unraveling the origin of the pH effects is complicated often by the fact that both the reaction driving forces and reactant concentrations in the electric double layer (EDL) change simultaneously with the pH value. Herein, we employ the hydrogen evolution reaction (HER) at Au(111)-aqueous solution interfaces as a model system to disentangle different pH-dependent factors.

Attachment styles and attachment (in)security priming in relation to emotional conflict control.

The functional neuro-anatomical model of attachment (NAMA) proposes that the balance between affective evaluation and cognitive control systems can be modulated by adult attachment styles and attachment priming. However, little is known about the characteristics of emotional conflict control that are modulated by attachment patterns. Accordingly, the present study adopted two experiments to investigate the associations between attachment styles, attachment (in)security priming, and emotional conflict control.

Integrative analysis of gene expression and chromatin dynamics multi-omics data in mouse models of bleomycin-induced lung fibrosis.

Background: Pulmonary fibrosis is a relentless and ultimately fatal lung disorder. Despite a wealth of research, the intricate molecular pathways that contribute to the onset of PF, especially the aspects related to epigenetic modifications and chromatin dynamics, continue to be elusive and not fully understood.

Methods: Utilizing a bleomycin-induced pulmonary fibrosis model, we conducted a comprehensive analysis of the interplay between chromatin structure, chromatin accessibility, gene expression patterns, and cellular heterogeneity.

Genomic diversity of mcr-carrying plasmids and the role of type IV secretion systems in IncI2 plasmids conjugation.

The rapid dissemination of colistin resistance via mcr-carrying plasmids (pMCRs) poses a significant public health challenge. This study examined the genomic diversity and conjugation mechanisms of pMCRs, with a particular focus on the role of type IV secretion systems (T4SS) in IncI2 plasmids. The 868 complete plasmid sequences revealed various replicon types of pMCRs, with IncI2 as the primary epidemic type, and the co-transfer risk of multidrug resistance genes associated with IncHI2.

Structurally diverse tetrahydroxanthone analogues from Paraconiothyrium sp. AC31 with pyroptosis induction through targeted inhibition of PARP1 in hepatocellular carcinoma cells.

This study reports the isolation and characterization of six novel tetrahydroxanthone derivatives, paraconixanthones A - F (1-6), a new diphenyl ether (7), and thirteen known compounds (8-20) from the endophytic fungus Paraconiothyrium sp. AC31. The chemical structures were elucidated using NMR, MS, X-ray diffraction, and ECD analyses.

Identification of Candidate Olfactory Genes in the Antennal Transcriptome of Trapped by Three Different Sex Pheromone Blends.

Insects sense intraspecific or interspecific information about the chemical substances in the habitat through the sensitive olfactory system to carry out foraging, mating, oviposition, and other activities. The antennae serve as the primary olfactory organs in insects. The olfactory process involves the participation of many proteins, such as odorant-binding proteins (OBPs) and odorant receptors (ORs), but ORs play a central role in olfactory specificity and sensitivity.

Resolving the relationship between capacity/voltage decay and the phase transition by accelerating the layered to spinel transition.

Lithium-rich cathode materials are some of the most promising choices for lithium-ion batteries due to their excellent energy density (>900 W h kg). However, severe voltage/capacity degradation during cycling has seriously hindered the further commercialization of lithium-rich cathode materials. Current research efforts are focused on enhancing their voltage and capacity retention.

Aculeapyridones A-Q, Pyranopyridone Alkaloids with Protective Effects against Acetaminophen-Induced Acute Liver Injury Discovered from a Coculture of WHUF0198 and a sp.

In the search for novel natural products with hepatoprotective effects against acetaminophen-induced acute liver injury, the marine-derived fungus WHUF0198 was investigated. Seventeen undescribed pyranopyridone alkaloids, aculeapyridones A-Q (-), were isolated by bioactivity-guided fractionation of an extract obtained by coculture of the WHUF0198 with the mangrove-associated fungus sp. DM27.

Clinical diagnosis of cerebral amyloid angiopathy related hemorrhage in China: Simplified Edinburgh criteria and Boston criteria version 2.0.

Background: Accurate diagnosis of cerebral amyloid angiopathy (CAA) in surviving patients is indispensable for making treatment decisions and conducting clinical trials. We aimed to evaluate the diagnostic value and clinical utility of the simplified Edinburgh computed tomography (CT) criteria for CAA-related hemorrhage in Chinese patients.

Methods: We analyzed 212 patients with lobar hemorrhage who underwent brain CT and magnetic resonance imaging (MRI) from a multicentre cohort.

Vernonolide A, a Sesquiterpene Lactone with a Unique Carbon Skeleton from .

A novel sesquiterpene lactone derivative, vernonolide A (), featuring an unprecedented carbon skeleton, along with its plausible biosynthetic precursor, vercinolide I (), and eight known sesquiterpene lactones (-) were isolated and characterized from the whole plants of (L.). The structures of and were elucidated using nuclear magnetic resonance spectroscopic analysis and calculated and experimental electronic circular dichroism spectra.