The link between systemic inflammation and mental disorders: a study on CLR, depression, and anxiety in a US cohort.

Background: Depression and anxiety are significant global health concerns, with systemic inflammation playing a critical role in their pathophysiology. Recent studies have highlighted the C-reactive protein to lymphocyte ratio (CLR) as a potential biomarker of inflammation that may be associated with these mental health conditions. However, the relationship between CLR and depression and anxiety, especially within a diverse population, remains underexplored.

Construction effect of fertile cultivated layer in albic soil. Ⅱ. Effects of deep tillage with organic materials on nutrient contents and pH in tillage layer of albic soil.

White slurry layer of albic soil has low fertility and poor nutrient availability. Organic material return to fields is a primary agricultural management practice for enhancing soil fertility. We examined the variations of soil nitrogen, phosphorus and potassium nutrient contents and pH of the topsoil layer (0-15 cm) and subsoil (15-35 cm) layers of albic soil under different treatments, including deep tillage at 35 cm without organic materials (T), straw deep mixing at 35 cm (T+S), organic fertilizer deep mixing at 35 cm (T+M), combined straw and organic fertilizer deep mixing at 35 cm (T+M+S), and conventional tillage at 15 cm without organic materials as the control (CK).

Hierarchical Text-Guided Refinement Network for Multimodal Sentiment Analysis.

Multimodal sentiment analysis (MSA) benefits from integrating diverse modalities (e.g., text, video, and audio).

Identifying Opponent's Neuroticism Based on Behavior in Wargame.

Traditional neuroticism assessments primarily rely on self-report questionnaires, which can be difficult to implement in highly confrontational scenarios and are susceptible to subjective biases. To overcome these limitations, this study develops a machine learning-based approach using behavioral data to predict an opponent's neuroticism in competitive environments. We analyzed behavioral records from 167 participants on the MiaoSuan Wargame platform.

Flexible Living Artificial Dura Mater for Efficient Therapy of Central Nervous System Injury Based on Neuronal Differentiation and Neuroprotective A2 Astrocyte Activation.

Central nervous system (CNS) injury is one of the most serious public health problems worldwide. To prevent secondary cascade damages to CNS caused by dural defects, the repair of dural defects is an essential step in CNS injury treatment. Although various artificial dura maters have been developed, unfortunately, no one exerting positive therapeutic effects for CNS injury repair.

Synergistic tumor microenvironment modulation enabled by a nanozyme-boosted biomimetic macrophage-derived nanovesicle for highly efficient antitumor therapy.

The tumor microenvironment (TME) plays a pivotal role in cancer progression, with tumor-associated macrophages (TAMs) serving as key contributors. Immunosuppressive M2-type TAMs are associated with poor prognosis and treatment resistance, highlighting the need for strategies to reprogram these cells into pro-inflammatory M1 phenotypes. To address this, we developed a TME-reshaping nanoplatform combining the tumor-targeting capability of M1 macrophage-derived nanovesicles (M1NVs) with the immunomodulatory and catalytic properties of hollow, virus-spiky hMnO nanozymes.

Thymic stromal lymphopoietin in leukemia: A double-edged sword?

Thymic stromal lymphopoietin (TSLP) is a cytokine expressed by various cell types. It is involved in the development of allergies, autoimmune diseases, and cancers. TSLP affects immune responses and disease pathogenesis by binding to a heterodimeric receptor complex.

The influence of audience's regulatory focus on the persuasive effect of different pro-vaccine messages.

The aim of this study was to investigate the influence of an audience's regulatory focus on the persuasive effect of different pro-vaccine messages. Study 1 (N = 169) examined attitude changes among audiences with different regulatory focus after reading pro-vaccine messages, and Study 2 (N = 201) added the exploration of message persuasiveness and vaccination intentions as well. The results of Study 1 and Study 2 showed that both high promotion fucus and high prevention focus could facilitate the attitude change elicited by messages emphasizing vaccine safety, official position and credibility.

Manganese exposure: a study on apoptosis and Ferroptosis in mouse Leydig and Sertoli cells.

Manganese (Mn), a vital trace element for biological functions, has raised health concerns due to potential toxicity. Excessive Mn impairs male reproduction by reducing testosterone, inducing oxidative stress, and disrupting spermatogenesis. However, its mechanisms targeting Leydig and Sertoli cells remain unclear.

A YOLOv11-based AI system for keypoint detection of auricular acupuncture points in traditional Chinese medicine.

Objective: This study aims to develop an artificial intelligence model and web-based application for the automatic detection of 21 commonly used auricular acupoints based on the YOLOv11 neural network.

Methods: A total of 660 human ear images were collected from three medical centers. The LabelMe annotation tool was used to label the images with bounding boxes and key points, which were then converted into a format compatible with the YOLO model.

Dihydrosanguinarine enhances tryptophan metabolism and intestinal immune function via AhR pathway activation in broilers.

Background: Tryptophan is essential for nutrition, immunity and neural activity, but cannot be synthesized endogenously. Certain natural products influence host health by modulating the gut microbiota to promote the production of tryptophan metabolites. Sanguinarine (SAN) enhances broiler immunity, however, its low bioavailability and underlying mechanisms remain unclear.

[Curative Efficacy Analysis of Allogeneic Hematopoietic Stem Cell Transplantation for Acute Myeloid Leukemia with Mutation].

Objective: To explore the efficacy and apoptosis of allogeneic hematopoietic stem cell transplantation (allo-HSCT) in the treatment of acute myeloid leukemia (AML) with mutation.

Methods: The clinical data of 80 AML patients with mutation treated in our hospital from January 2019 to December 2021 were retrospectively analyzed. The clinical characteristics of the patients were summarized, and the therapeutic effect and prognostic factors of allo-HSCT for the patients were analyzed.

Automated sparse feature selection in high-dimensional proteomics data via 1-bit compressed sensing and K-Medoids clustering.

Background: High-dimensional proteomics data present significant challenges in biomarker discovery due to technical noise, feature redundancy, and multicollinearity. Current feature selection methods, including filter, wrapper, and embedded approaches, struggle with stability, sparsity, and computational efficiency. To address these limitations, we propose Soft-Thresholded Compressed Sensing (ST-CS), a hybrid framework integrating 1-bit compressed sensing with K-Medoids clustering.

Tetrahydrazide-EDTA Cross-Linked Cellulose Hydrogels for Water Treatment by Heavy Metal Chelation.

Polluting heavy metals persist in the environment, leading to bioaccumulation and toxicity, which is a growing problem in developing countries. Various water filtration systems for heavy metal removal have been developed, with sorption being the simplest and most economically viable. However, many commercial sorbents are powders, leading to inefficient sorbent removal and secondary pollution.

Effects of Parameter Variations Generated by Pumping on LNAPL Migration in the Aquitard: An Analytical and Experimental Study.

The parameter variations in the aquitard have an important influence on the migration laws of contaminants in the aquitard. In order to study the influence of dynamic changes in parameters during pumping on the migration laws of Light Non-aqueous Phase Liquid (LNAPL) in the aquitard, the one-dimensional consolidation and groundwater flow equations for the aquitard were employed to derive the governing equations for the migration of LNAPL in the aquitard. A self-designed experimental platform was developed to investigate the effects of the pore water pressure, consolidation deformation, and pumping rate on LNAPL migration during pumping.

Trajectories of physical activity and influencing factors in patients with type 2 diabetes mellitus: a mixed-methods study.

Aim: To explore the different trajectories of physical activtity (PA) change in Type 2 diabetes mellitus (T2DM) patients and the factors affecting them, and to delve deeper into the PA experiences and needs of the different trajectory groups.

Design: An observational longitudinal study and a descriptive qualitative study.

Methods: 276 patients with T2DM were recruited from two tertiary hospitals and followed them up in this longitudinal study.

Evaluation of the toxic effects and midgut biological changes induced by low concentrations of cyantraniliprole in Bombyx mori.

Cyantraniliprole (Cya), a diamide insecticide, is widely utilised for the management of Lepidoptera pests owing to its potent insecticidal efficacy and broad spectrum of activity. The extensive use and prolonged environmental persistence of this insecticide pose a significant threat to the sustainable development of sericulture. This study firstly assessed the lethal toxicity of cyantraniliprole to the 5th instar larvae of Bombyx mori.

An ancient regulatory variant of ACSF3 influences the coevolution of increased human height and basal metabolic rate via metabolic homeostasis.

Anatomically modern humans (AMHs) exhibit a significant increase in basal metabolic rate (BMR) and height compared to non-human apes. This study investigates the genetic basis underlying these traits. Our analyses reveal a strong genetic correlation between height and BMR.

AP2M1 is a prognostic marker associated with cell cycle arrest and the tumor immune microenvironment in acute myeloid leukemia.

Acute myeloid leukemia (AML) is a heterogeneous clonal disease of hematopoietic progenitor cells and the most common malignant myeloid disease in adults. Although significant progress has been made in treatment, the outlook remains bleak, and new therapeutic targets need to be sought. AP-2 complex subunit mu (AP2M1) is a core component of the clathrin-mediated endocytic machinery, AP2M1 plays a critical role in cancer progression.

Spatial distribution analysis of secondary metabolites in bolted and unbolted Saposhnikovia divaricata by atmospheric pressure laser ablation carbon fiber ionization mass spectrometry imaging.

Background: Bolting severely affects the medicinal value and yield of Saposhnikovia divaricata. Currently, spatial distribution of secondary metabolites in bolted and unbolted Saposhnikovia divaricata remains unknown. The commercial Mass spectrometry imaging (MSI) platforms has high sensitivity to high-polar compounds, but suppresses signals of less polar compounds, generating a gap of understanding how spatial distributed of such metabolites that is less prone to ionize.

Healthy and moribund Zhikong scallops () developed different viral communities during a mass mortality event.

Unlabelled: Viral assemblages of scallops are still relatively unknown. Here, metagenomic analysis was used to study virus communities in the gut of scallops to establish the first scallop virome data set (SVD); this contains 7,447 viral operational taxonomic units. Protein-sharing networks and phylogenetic analyses demonstrated the high diversity and novelty of the SVD, which is very different from viromes from other habitats.

Screening of neurotransmitter receptor modulators reveals novel inhibitors of influenza virus replication.

Influenza presents a significant public health threat, as severe cases can lead to excessive inflammation and complications such as pneumonia or acute respiratory distress syndrome. Current antiviral agents targeting viral proteins may lead to the development of resistance, highlighting the need for new agents targeting host factors. Neurotransmitter receptors are vital for cellular signaling and cell cycle modulation, making them promising antiviral therapeutic targets.

The mechanism of chunk restructuring in the memory superiority effect of Insight: Dissociating the roles of decomposition and composition.

This study investigates the role of chunk restructuring, particularly its decomposition and composition processes, in the memory superiority effect of insight. Participants completed a Chinese character transformation task in three conditions: decomposition-focused (DE), composition-focused (CO), and control. Individuals made old/new judgments on Chinese characters and confidence judgments after 4 min or 24 h later.

Establishing Bovine Embryonic Stem Cells and Dissecting Their Self-Renewal Mechanisms.

Bovine pluripotent stem cells (PSCs) hold significant potential for diverse applications in agriculture, reproductive biotechnology, and biomedical research. However, challenges persist in establishing stable bovine PSC lines and understanding the mechanisms underlying their pluripotency maintenance. Here, we derived bovine embryonic stem cells (bESCs) from Holstein cattle embryos.

Ginseng and its functional components in non-alcoholic fatty liver disease: therapeutic effects and multi-target pharmacological mechanisms.

Background: Non-alcoholic fatty liver disease (NAFLD) is a common type of chronic liver disease and its incidence is increasing. Its disease progression is closely related to non-alcoholic steatohepatitis and liver fibrosis. Effective treatment is currently lacking.