Dual-Functional Nanoliposome with High BPA Loading for Targeted MRI-Guided BNCT of Glioblastoma.

Glioblastoma is a highly malignant brain tumor with few available therapeutic options, for which boron neutron capture therapy (BNCT) has emerged as a promising precision radiotherapy approach. However, its efficacy remains suboptimal due to inadequate tumor targeting of boron agents and lack of in vivo visualization. Herein, a gadolinium-boron integrated lipid nanocarrier (BPA-F&DOTA-Gd@LIPO-ANG) was developed for targeted boron delivery and MRI-guided BNCT.

Prediction evaluation of the Tp-Te interval in patients with vasovagal syncope.

Purpose: Vasovagal syncope (VVS) involves autonomic dysregulation affecting cardiac electrical activity. The Tp-Te interval, reflecting transmural repolarization dispersion, may help predict positive head-up tilt test (HUTT) responses in patients with suspected VVS.

Methods: A total of 179 patients with suspected VVS were included in the study.

is a novel symbiont of marine invertebrates that exhibits broad patterns of phylosymbiosis.

Despite growing insights into the composition of marine invertebrate microbiomes, our understanding of their ecological and evolutionary patterns remains poor, owing to limited sampling depth and low-resolution datasets. Previous studies have provided mixed results when evaluating patterns of phylosymbiosis between marine invertebrates and marine bacteria. Here, we investigated potential animal-microbe symbioses in , an overlooked bacterial genus consistently identified as a core microbiome taxon in diverse invertebrates.

Flexible Living Artificial Dura Mater for Efficient Therapy of Central Nervous System Injury Based on Neuronal Differentiation and Neuroprotective A2 Astrocyte Activation.

Central nervous system (CNS) injury is one of the most serious public health problems worldwide. To prevent secondary cascade damages to CNS caused by dural defects, the repair of dural defects is an essential step in CNS injury treatment. Although various artificial dura maters have been developed, unfortunately, no one exerting positive therapeutic effects for CNS injury repair.

Comparison of educational needs and priorities for work-related laws between hospital and community-based nurses.

Purpose: This study aimed to examine the practical utilization of work-related laws in nursing practice and to prioritize educational needs to provide foundational data for improving nurses' legal competencies.

Methods: A descriptive survey was employed using an online self-reported questionnaire. Participants included 275 nurses with over 3 years of clinical experience, categorized into hospital and community-based.

Investigation of an EPID-based dose verification system for patient-specific quality assurance in a harmony device.

Background: Precise patient-specific quality assurance (PSQA) is critically important in advanced treatments.

Purpose: This study aimed to evaluate the performance of the RadCalc software's electronic portal imaging device (EPID)-based patient specific QA function, focusing on its ability to accurately reconstruct doses from EPID images acquired on the Elekta Harmony Pro linear accelerators (LINACs).

Methods: Beam modeling was conducted for 6-MV and 6-MV flattening filter-free (FFF) photon beams on the recently released Harmony Pro LINAC system in RadCalc.

TRIM31 triggers colorectal carcinogenesis and progression by maintaining YBX1 protein stability through ubiquitination modification.

Colorectal cancer (CRC) is one of the most common gastrointestinal tumors, and one of the leading causes of cancer-related deaths worldwide. However, the molecular mechanisms underlying CRC development and progression have not been fully elucidated until now. Emerging studies have shown that post-translational modifications of proteins, especially ubiquitination modifications, play an important role in tumorigenesis and progression.

Feasibility study for dose calculation with a radiation treatment planning system using a fixed-size electron cone applicator for small electron fields.

Objective: This study aims to evaluate the feasibility of radiation treatment planning using a commercial treatment planning system (TPS) for small fixed-size electron cone electron applicators not natively supported by the TPS.

Methods: Dosimetric characteristics, including beam profiles and output factors (OFs), were compared between a 6 MeV electron beam collimated by a small fixed-size electron cone applicator and a cerrobend cutout-based general applicator. Measurements were performed using a micro-diamond detector in a water phantom for field sizes of 2, 3, 4, and 5 cm.

Enhancing political competency among nurses and nursing students: A scoping review.

Aims: To examine research trends on strengthening political competency among nurses and nursing students by mapping key concepts and exploring enhancement strategies.

Background: Political competency is essential for nurses to influence healthcare policies and advocate systemic change. However, research on nursing education and practice remains fragmented, highlighting the need for a more cohesive understanding.

Small molecular chelator for comprehensive regulation of tumor lactate levels in synergy with photodynamic therapy for cancer treatment.

An increasing number of studies have focused on depleting lactate and modulating the tumor's lactic microenvironment to interfere with tumor progression, particularly in breast cancer. Lactate accumulation in tumors contributes to a highly acidic microenvironment that promotes cancer cell survival and resistance to therapies. However, existing lactate depletion agents, primarily enzymes and macromolecules, fall short of clinical applications due to poor stability and their ability to only perform solitary lactate depletion without interfering with the transport process.

RNF144A and RNF144B: Important molecules for health.

RNF144 family proteins, including RNF144A and RNF144B, members of the RING-between-RING domain-containing ubiquitin E3 ligase family, serve as critical regulators of protein ubiquitination. Despite increasing research attention in recent years, particularly regarding their distinct functional roles in pathophysiological processes, a comprehensive synthesis of existing findings remains absent. To address this knowledge gap, we conducted a systematic literature search in PubMed using the following query terms: "RNF144," "RNF144A," "RNF144B," "PIR2," "IBRDC2," and "P53RFP.

A Comprehensive Review on Botany, Ethnopharmacology, Phytochemistry, Biosynthesis, Pharmacology, Toxicity, Quality Control and Metabolomics of Coptidis Rhizome.

Coptidis Rhizome (CR), referred to as Huanglian in Chinese, is the dry rhizome of Franch., C.Y.

Unraveling yield heterosis in Chinese cabbage hybrid by comparative transcriptomic analysis and gene function analysis.

Background: Changes in gene expression in plant hybrids are closely related to heterosis. Currently, few reports on key genes that promote yield advantage formation in Chinese cabbage hybrids exist.

Methods: We conducted a comparative transcriptomic analysis between a Chinese cabbage hybrid (weichunbaiNo.

Seizure in Pediatric Patients With SARS-CoV-2 or Influenza A Infections and Fever.

This study aimed to compare the frequency and clinical characteristics of seizures with fever (SWF) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and influenza A. Data of patients below 18 years of age diagnosed with either SARS-CoV-2 or influenza A infections in our hospital were retrospectively analyzed. Approximately 83 (14.

Multivariate analysis of soil particle size distribution and Spatial correlation with soil moisture characteristics in different vegetation types of Mu Us Sandy Land.

In this paper, the fractal mechanism of soil improvement by vegetation was revealed by analyzing the soil characteristics under four typical vegetation types: Salix cheilophila, Caragana korshinskii, Hippophae rhamnoides, and Corethrodendron fruticosum in Mu Us Sandy Land. The results showed that (1) the soil of each vegetation type was mainly composed of sand (> 90%), and the content of clay and silt was less than 10%. CF had the least heterogeneity of soil particles in the 0-120 cm soil layer, HR was uniformly distributed in the 120-200 cm soil layer, and the change trend of particle composition in the 140-200 cm soil layer was consistent.

CAD-based Monte Carlo dose calculation system for evaluating geometrical effect of inserted materials in carbon-ion radiation therapy.

Purpose: Carbon-ion radiation therapy (CIRT) achieves potent tumor control by leveraging the unique physical and biological properties of carbon ions, such as the Bragg peak and high relative biological effectiveness. However, the presence of implanted markers or embolization coils can alter the beam range; therefore, clinical planning becomes complex. This study developed and validated a computer-aided design (CAD)-based Monte Carlo (MC) dose calculation system to accurately assess the geometric effects of materials inserted in CIRT.

Simple and High-Throughput Fluorescence Assay Method for DNA Damage Analysis in Single-Stranded DNA-Encoded Library Synthesis.

The fluorescent dye-based simple and high-throughput DNA damage assay method was developed for the single-stranded DNA-encoded library (ssDEL) synthesis. The extent of DNA hybridization between single-stranded DNA (ssDNA) and its complementary DNA is influenced by the damage ratio of ssDNA. This damage can be quantified by measuring the change in the fluorescence of PicoGreen, providing valuable insights into the overall ssDNA integrity and facilitating the screening of DNA-compatible conditions for ssDEL synthesis.

Tuning the Aggregate Emission Behavior of Phenothiazine-Derived Coumarin for Ratiometric Sensing of Hypochlorous Acid.

Despite significant progress in the design of fluorescent probes, the development of ratiometric fluorescent hypochlorous acid (HOCl) probes with high specificity still remains a challenge. Phenothiazine-derived-coumarin (PTZC) fluorophores have been shown to respond to HOCl with high specificity; however, their faint fluorescence in aqueous media presents a barrier to their utility in the design of ratiometric HOCl fluorescent probes. To tackle this issue, we herein demonstrate a molecular design strategy of step-by-step increasing the steric hindrance of the substituent at the 3-position of the PTZC fluorophore to improve the emission behavior of the formed aggregates.

Algorithm for using dual energy computed tomography to determine chemical composition: A feasibility study.

Using dual-energy computed tomography (CT), this study aims to develop an algorithm to identify the chemical constituents of an unknown material (compound or mixture) and improve the accuracy of material discrimination. The algorithm requires mass attenuation coefficients (MAC) that were obtained using a dual energy CT as an input, identifies the elemental composition, and then calculates its weight fraction. To evaluate the functionality of the developed algorithm, it was used to determine the chemical constituents for human tissues.

Exosomal miRNA-188-3p derived from cancer-associated fibroblasts promotes ferroptosis in cervical cancer: Medical biothermal image analysis.

The study aimed to explore the potential mechanism of action of extracellular miRNA-188-3p derived from CAFs in cervical cancer. In this study, CAFs were isolated from patients with cervical cancer, and exosomes were extracted by ultrafast centrifugation method to detect the expression level of miRNA-188-3p in exosomes. Subsequently, the exosomes were co-cultured with cervical cancer cells, and the temperature changes of the cells were monitored by medical thermal image analysis technology to evaluate the metabolic activity of the cells.

Trop-2 expression as a biomarker of response to sacituzumab govitecan in patients with HER2-negative metastatic breast cancer: A pilot study.

Background: Sacituzumab govitecan (SG) is an anti-Trop-2 antibody-drug conjugate (ADC) approved for use in HER2-negative metastatic breast cancer (MBC). This study explores whether Trop-2 expression serves as a biomarker of excellent response versus non-response to sacituzumab govitecan (SG) in HER2-negative MBC.

Methods: Trop-2 expression was determined from patients with HER2-negative MBC categorized as non-responders and excellent responders to SG.

Sexual Risk Compensation and Retention in PrEP Care in Korea: An HIV PrEP Demonstration Study.

Background: Pre-exposure prophylaxis (PrEP) with tenofovir disoproxil fumarate and emtricitabine (TDF-FTC) is effective in preventing human immunodeficiency virus (HIV), however, its feasibility has not been evaluated in the Republic of Korea (Korea). Therefore, this study aimed to assess the feasibility of PrEP in men who have sex with men (MSM) in Korea. This is the first demonstration study in Korea, in which PrEP medication, laboratory tests, and clinic visit fees were provided without charge to participants.

N4BP3 Activates TLR4-NF-κB Pathway in Inflammatory Bowel Disease by Promoting K48-Linked IκBα Ubiquitination.

Purpose: N4BP3 is a ubiquitination-related gene that plays a pivotal role in neurology and neoplasia. Studies have demonstrated its essential function in axonal and dendritic branching, promoting hepatocellular carcinoma and breast cancer. Our previous research reveals that N4BP3 enhances inflammatory responses by modulating the NOD2 signaling pathway.

Comparative assessment of antitumor effects between doxorubicin and mitochondria-targeted doxorubicin in combination with radiotherapy.

Objectives: Triphenylphosphine (TPP) and Doxorubicin (DOX) were conjugated to obtain Triphenylphosphine-Doxorubicin (TPP-DOX), which was applied in tumor cells for enhancement of DOX in mitochondria targeting. The study focused on investigating the anti-tumor effect of TPP-DOX in combination with radiotherapy throughout and studies.

Methods: TPP-DOX was synthesized using the carbodiimide method.