Light-controlled sequential nanoregulators for antibacterial and anti-inflammatory effects on promoting chronic wound healing.

The wound microenvironment (WME) of sustained immune inflammatory response and bacterial infection notably impede the process of tissue repair in chronic wound healing. Herein, the sequential nanoregulator (TiC@MnO-EPL/TA, TMPT) consisting of photothermal-catalytic heterostructure grafted with positive-potential antimicrobial peptides and inflammation-suppressing polyphenols were engineered. In WME, positively charged TMPT nanoregulator adhere to bacteria and mineralize them.

Dissolution Inhibition via Intramolecular N···I Halogen Bond Enables High-Loading Zn-Organic Battery.

The development of aqueous zinc-ion batteries faces persistent challenges in reconciling high mass-loading capabilities with extreme tolerance, particularly for organic cathodes prone to dissolution in aqueous electrolyte. Here, we present a halogen-bonded azo-based cathode material, 4,4'-azopyridine-iodide (AZPY-I), engineered through iodine-mediated molecular stabilization of pyridinic nitrogen sites. Analyses reveal that AZPY-I adopts a robust π-π conjugated framework stabilized by directional N···I halogen bonds, achieving ultralow solubility (<0.

TRIM31 triggers colorectal carcinogenesis and progression by maintaining YBX1 protein stability through ubiquitination modification.

Colorectal cancer (CRC) is one of the most common gastrointestinal tumors, and one of the leading causes of cancer-related deaths worldwide. However, the molecular mechanisms underlying CRC development and progression have not been fully elucidated until now. Emerging studies have shown that post-translational modifications of proteins, especially ubiquitination modifications, play an important role in tumorigenesis and progression.

An efficient and precise solution-vacuum hybrid batch fabrication of 2D/3D perovskite submodules.

The quickly processable solution deposition and accurately controllable vacuum deposition are the two competing mainstream fabrication techniques for perovskite films. However, the former may inevitably leave pinholes on film surface and calls for further treatment, the latter exhibits a generally low processing rate. In this work, we develop a solution-vacuum hybrid batch fabrication to precisely deposit nanoscale two-dimensional (2D) capping layer via all-vacuum evaporation on a solution-deposited three-dimensional bulk film.

A novel protein encoded by circUBE2G1 suppresses glycolysis in gastric cancer through binding to ENO1.

Gastric cancer (GC), a malignant neoplasm originating in the stomach epithelium, is characterized by substantial global incidence and mortality rates, posing a substantial threat to public health systems worldwide. The present study was designed to identify and validate a previously unannotated protein encoded by circular RNA (circRNA), with the principal objective of elucidating its functional significance and mechanistic basis in gastric carcinogenesis.CircUBE2G1 (hsa_circ_003239) was identified as a translationally active circRNA exhibiting significant downregulation in gastric cancer.

FOXM1 Protects Against Myocardial Ischemia-Reperfusion Injury in Rodent and Porcine Models by Suppressing MKRN1-Dependent LKB1 Ubiquitination.

Mitochondrial dysfunction is related to etiopathogenesis and progression of heart failure (HF). The underlying molecular mechanisms are not fully understood. Transcription factor FOXM1 plays an essential role in cardiovascular development.

Ultra high-speed 3D shape measurement technology for specular surfaces based on μPMD.

Phase measuring deflectometry (PMD) has been extensively applied to measure specular surfaces due to its non-contact, high-precision, full-field measurement capabilities. Liquid crystal display (LCD) screen is the most common structured light source in PMD. However, the response time of liquid crystal molecules limits its frame rate to around 100 frames per second (fps).

Targeting SPP1 macrophages via the SPP1-CD44 axis reveals a key mechanism of immune suppression and tumor progression in ovarian cancer.

Tumor-associated macrophages (TAMs) play a pivotal role in immune suppression, tumor progression, and metastasis within the tumor microenvironment (TME) of ovarian cancer. While TAMs are known to promote T-cell dysfunction, the precise molecular mechanisms governing this process remain poorly understood. Here, we performed an integrated analysis of six high-grade serous ovarian cancer (HGSOC) single-cell sequencing datasets to investigate the molecular and functional diversity of TAMs in HGSOC.

Puerarin relives inflammation, bone destruction and facilitates osteogenic differentiation in periodontitis by enhancing mitochondrial autophagy via activating mitochondrial Mitofusin 2.

Purpose: Puerarin (Pue) has recently been reported to have therapeutic effects on periodontitis (PD). However, there is insufficient evidence, and the mechanism involved has not yet been revealed. This work delved to explore the exact therapeutic effects and molecular mechanism of Pue in treating PD.

Who, What, and Where: Composite-Semantics Instance Search for Story Videos.

Who, What and Where (3W)are the three core elements of storytelling, and accurately identifying the 3W semantics is critical to understanding the story in a video. This paper studies the 3W composite-semantics video Instance Search (INS) problem, which aims to find video shots about a specific person doing a concrete action in a particular location. The popular Complete-Decomposition (CD) methods divide a composite-semantics query into multiple single-semantics queries, which are likely to yield inaccurate or incomplete retrieval results due to neglecting important semantic correlations.

Assessment of cellular dose and damage induced by radon and its progeny using the BEAS-2B cell mesh model.

The decay of radon and its progeny mainly produces α particles and β particles. Due to their short range and high linear energy transfer (LET) of α particles, it is necessary to evaluate the dose deposition at the cellular and subcellular levels so as to better assess their health effects on the human body. Given that the lung is the primary target organ for radon exposure, we utilized human bronchial epithelial cells (BEAS-2B cells) to construct a realistic mesh model.

Development of zebrafish (Danio rerio) mesh-type model at multi-life stages and Monte Carlo simulations of dosimetric parameters.

As socioeconomic development progresses, nuclear energy and technology advance rapidly. Concurrently, nuclear accidents may result in the release of additional radioactive isotopes into the environment. Groundwater and oceans are key pathways for radioactive nuclides in the environmental cycle, with aquatic organisms being particularly vulnerable to radiation exposure.

Efficient Carbon-Based Optoelectronic Synapses for Dynamic Visual Recognition.

The human visual nervous system excels at recognizing and processing external stimuli, essential for various physiological functions. Biomimetic visual systems leverage biological synapse properties to improve memory encoding and perception. Optoelectronic devices mimicking these synapses can enhance wearable electronics, with layered heterojunction materials being ideal materials for optoelectronic synapses due to their tunable properties and biocompatibility.

Acidic Engineering on Buried Interface toward Efficient Inorganic CsPbI Perovskite Light-Emitting Diodes.

Inorganic CsPbI perovskite has emerged as a promising emitter for deep-red light-emitting diodes (LEDs) due to its intrinsic thermal stability and suitable bandgap. However, uncontrollable CsPbI crystallization induced by an alkaline zinc oxide (ZnO) substrate in bulk film-based LEDs leads to insufficient external quantum efficiencies (EQEs) at high brightness, leaving obstacles in commercialization progress. Herein, we demonstrate an effective acidic engineering strategy with wide applicability to modify the surface property of ZnO and regulate CsPbI crystallization.

Restoration of mitochondrial function alleviates trigeminal neuropathic pain in mice.

Craniofacial pain is prevalent and a debilitating condition. Managing craniofacial pain is particularly challenging due to its multifaceted nature. Among the most severe forms of craniofacial pain is trigeminal neuralgia, often described as one of the most excruciating pain syndromes encountered in clinical practice.

Effects of Ciprofloxacin on the Production and Composition of Cellular Microcystins in .

Antibiotics can affect the photosynthetic system of , potentially altering the balance of carbon and nitrogen, which may influence the synthesis of different microcystin (MC) congeners. However, the regulatory mechanisms by which antibiotics affect the synthesis of various MC congeners in remain unknown. In this study, the effects of ciprofloxacin (CIP) on the growth, carbon and nitrogen balance, amino acid composition, gene expression, and production of different MC congeners were investigated in two toxin-producing strains of .

Hypoxic stabilization of RIPOR3 mRNA via METTL3-mediated mA methylation drives breast cancer progression and metastasis.

Dysregulated N-methyladenosine (mA) modification has been associated with breast cancer pathogenesis. Hypoxia which characterizes solid tumors is known to reprogram the mA epitranscriptome, but the underlying mechanisms of how this process contributes to breast cancer progression remain poorly understood. Through integrative analyses of mA-RIP sequencing and RNA sequencing databases, we reveal a cluster of mRNAs with upregulated mA methylation and expression under hypoxia, that are enriched by many oncogenic pathways, including PI3K-Akt signaling.

Exploratory research on the multi-life stages mesh-type model of Caenorhabditis elegans in radiation ecology.

To address the lack of effective dose quantification methods for the model organism Caenorhabditis elegans (C. elegans) in radiation ecology research, this study employs remeshing techniques to develop a comprehensive mesh-type model covering multi-life stages, from embryonic to larval (L1, L2, L3, L4) and adulthood. Using these models, Dose Coefficients (DC) for C.

Enhanced drug resistance suppression by serum-stable micelles from multi-arm amphiphilic block copolymers and tocopheryl polyethylene glycol 1000 succinate.

To develop a robust drug-delivery system using multi-arm amphiphilic block copolymers for enhanced efficacy in cancer therapy. Two series of amphiphilic polymer micelles, PEG-b-PCL and PEG-b-PCL/TPGS, were synthesized. Doxorubicin (DOX) loading into the micelles was achieved via solvent dialysis.

Thermally and Mechanically Stable Perovskite Artificial Synapse as Tuned by Phase Engineering for Efferent Neuromuscular Control.

The doping of perovskites with mixed cations and mixed halides is an effective strategy to optimize phase stability. In this study, we introduce a cubic black phase perovskite CsFAPb(BrI) artificial synapse, using phase engineering by adjusting the cesium-bromide content. Low-bromine mixed perovskites are suitable to improve the electric pulse excitation sensitivity and stability of the device.