Development and Validation of a Pathomics-Based Prognostic Model for Patients with Lung Adenocarcinoma Undergoing First-Line EGFR-TKI Therapy.

Background: Accurate prognostic prediction is crucial for personalized treatment of patients with lung adenocarcinoma (LUAD) receiving epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors (TKIs). This study aims to develop and validate a pathomics-based prognostic model for EGFR-TKI-treated patients with LUAD.

Patients And Methods: Data from 122 patients with LUAD who underwent first-line EGFR-TKI therapy were retrospectively analyzed.

Upgrading Coal Gangue Waste into Molecular Sieves for Sustainable Wastewater Purification.

The disposal and management of coal gangue (CG) waste from coal mining pose significant environmental pollution challenges. Here, we propose utilizing CG as raw material to synthesize CG-based NaA-type molecular sieves (CG@NaA MS) through a high-temperature alkali fusion combined with a hydrothermal process. This approach enables the sustainable treatment of copper ions and methylene blue (MB) in wastewater.

Effects of preoperative psychological stress on selected parameters in older patients undergoing total hip arthroplasty.

Background: Total hip arthroplasty (THA) is an increasingly common treatment for older patients with hip osteoarthritis. Psychological stress is common before THA, although its clinical effects on selected parameters such as joint function, quality of life, and postoperative complications remain unclear.

Aim: To investigate the effects of preoperative psychological stress on selected parameters in older patients who underwent THA.

Retinal transduction profiling of diverse AAV serotypes via intravitreal injection.

Unlabelled: Optimizing adeno-associated virus (AAV) capsid and dosing selection is critical for the clinical translation of retinal gene therapy. This study aims to provide a comprehensive reference by comparing the transduction efficiency, cellular tropisms, and temporal retinal expression patterns of various AAV serotypes for intravitreal retinal gene therapy. A series of AAV vectors were intravitreally injected into C57BL/6J mice.

Design a bistable polymeric vascular stent (BPVS) and evaluate the biomechanical properties.

Background And Objectives: Polymeric vascular stents generally have the disadvantages of poor biomechanical properties, which may not achieve the therapeutic purpose of supporting the blocked vascular vessels to restore normal blood flow. The bistable structure depending on the two stable configurations seems to improve the weak strength of stents. This paper mainly designs a polymeric vascular stent with bistable structure to enhance the radial force, and reduce the radial recoil and wall shear stress.

Multi-DECT image-based radiomics with interpretable machine learning for preoperative prediction of tumor budding grade and prognosis in colorectal cancer: a dual-center study.

Purpose: This study evaluates the predictive ability of multiparametric dual-energy computed tomography (multi-DECT) radiomics for tumor budding (TB) grade and prognosis in patients with colorectal cancer (CRC).

Methods: This study comprised 510 CRC patients at two institutions. The radiomics features of multi-DECT images (including polyenergetic, virtual monoenergetic, iodine concentration [IC], and effective atomic number images) were screened to build radiomics models utilizing nine machine learning (ML) algorithms.

Meta-analysis of the efficacy and safety of rituximab in the treatment of primary Sjögren's syndrome.

Objective: To methodically assess the effectiveness and safety of rituximab in treating primary Sjögren's syndrome.

Methods: The search included databases such as PubMed, Embase, the Cochrane Library, and Web of Science, covering the period from the beginning until December 2023. A meta-analysis was conducted using Stata 14.

Risk factors for general complications after hip or knee replacement surgery in elderly patients: a single-center study.

Purpose: To determine the risk factors for complications after hip or knee replacement surgery in elderly patients.

Methods: In total, 401 elderly patients (aged ≥ 65 years) who underwent hip or knee replacement surgery at a hospital from January 2017 to December 2022 were retrospectively analyzed. Univariate analysis was performed to identify significant variables.

Application of spectral induced polarization technique in monitoring zinc removal by activated carbon as a permeable reactive barrier material.

Zinc accumulates in groundwater from mining operation and discarded batteries and poses a threat to environmental safety and human health. Activated carbon (AC), is an affordable media of permeable reactive barrier (PRB) for the in-situ zinc remediation. In this study, column breakthrough tests with spectral induced polarization technique monitoring, coupled with microscopic analyses, were utilized to investigate the zinc retention behaviors in activated carbon PRB.

Sustainable Closed-Loop Recycling of Polyester Waste Using Reconstructed Defective-Metal-Organic Frameworks.

Chemical recycling of polyester waste presents a promising strategy for achieving a sustainable circular economy. However, the development of efficient, low-cost recycling methods that minimize energy consumption and carbon emissions remains challenging. Here, we report an approach for depolymerization polyester waste to bis(hydroxyethyl)terephthalate (BHET) using a reconstructed metal-organic framework (r-Zn-MOF74-NT) catalyst under mild conditions.

Hydrogel Enhanced Organoid Multidirectional Differentiation via Yap/Tead4 Mechanotransduction for Accelerated Tissue Regeneration.

The repair of multiple organs in motor systems remains a major clinical challenge that necessitates bioactive grafts with a multidirectional differentiation ability. Hydrogel-based organoids implants have emerged as pivotal tools and attracted great attentions. However, strategies to unlock the multipotency of bone marrow mesenchymal stem cells (BMSCs) by precisely modulating the mechanical and structural characteristics of biomimetic extracellular matrix (ECM) during hydrogel-based organoid construction remain underexplored.

Mangrove disturbance analysis over 30 years in Myanmar based on continuous change detection and classification algorithm.

Myanmar, recognized as a hotspot for global mangrove deforestation, has experienced rapid loss of these critical ecosystems due to extensive human activity and natural disturbances. However, limited research has addressed the long-term, detailed dynamics of mangrove disturbances in Myanmar. To bridge this gap, this study applied the continuous change detection and classification (CCDC) algorithm on Landsat images within the Google Earth Engine (GEE) platform to analyze mangrove disturbances (disturbance frequency, maximum disturbance years, and maximum disturbance degrees) and driving forces in Myanmar over 30 a (1990-2020).

Increased dependence on mycorrhizal fungi for nutrient acquisition under carbon limitation by tree girdling.

Nutrient acquisition through symbiotic ectomycorrhizal fungi is carbon (C) costly but fundamental for plant growth, community, and ecosystem functioning. Here, we examined the functions of roots and mycorrhiza with respect to nutrient uptake after artificially inducing C limitation-seven months after girdling of an ectomycorrhizal tree, . Root physiological activity (measured as root nitrogen content and root exudation) declined after girdling and was accompanied with 110% and 340% increases in mycorrhizal colonization and extramatrical hyphal length, respectively.

Future Climate Change Increases the Risk of Suitable Habitats for the Invasive Macrophyte .

is an ornamental macrophyte native to North America that has been introduced to Europe and Asia, and having been established, has had detrimental effects on local aquatic ecosystems. In this study, we developed an optimized MaxEnt model to predict the global potential habitat suitability for under the influence of climate change. The model incorporated 20 relevant impact factors and occurrence record data for .

Prognostic value of baseline glucose levels for mortality in patients with cardiogenic shock: a systematic review and meta-analysis.

Background: Baseline glucose levels have been implicated in the prognosis of critically ill patients. However, the prognostic value of glucose in patients with cardiogenic shock (CS) has not been systematically evaluated. The current study aimed to provide evidence that baseline glucose levels can predict mortality in patients with CS.

Dynamic bidirectional regulation between Stk38 and rabies virus M protein coordinates apoptosis progression during neurotropic infection.

Rabies virus (RABV) causes fatal encephalitis in untreated humans, representing a critical global zoonotic threat. Although the viral matrix protein (M) is established as a mediator of mitochondrial apoptosis and enhancer of viral replication, its regulatory mechanisms remain incompletely characterized. This study reveals a reciprocal regulatory axis between RABV M protein and the host kinase Stk38.

Genetics of Childhood-onset Systemic Lupus Erythematosus (cSLE).

Objectives: Genome wide association studies (GWAS) have identified >100 loci for systemic lupus erythematosus (SLE). These loci may also impact age of diagnosis. We aimed to identify genetic variants for age of SLE diagnosis, and to complete a GWAS of childhood-onset SLE (cSLE) diagnosed <18 years of age.

Janus Nanoprobe with Dual-Modal NIR-II Fluorescence/Photoacoustic Imaging for Precision Cancer Radiosensitizing Therapy.

The use of radiotherapy sensitizers has proven to be effective in overcoming tumor radiotherapy resistance and improving treatment efficacy. However, challenges such as poor biocompatibility and difficulty in accurately guiding tumor radiotherapy with high efficiency still persist. Herein, we propose a radiosensitizer with Janus nanostructure to address these issues by enabling dual-modal fluorescence (FL)/photoacoustic (PA) imaging in the second near-infrared region (NIR-II, 900-1700 nm) for precise and efficient tumor radiotherapy guidance.

Epstein-Barr virus reactivation after haplo-peripheral blood stem cell transplantation in patients with hematological malignancies: immune reconstitution and influence on survival.

Background: Haploidentical hematopoietic stem cell transplantation (haplo-HSCT) is a common alternative for patients with hematological malignancies. Epstein-Barr virus (EBV) reactivation is a common complication post-transplantation, but its impact on immune reconstitution and survival remains unclear.

Objective: To compare immune reconstitution and survival between patients with and without EBV reactivation after haplo-HSCT.

Research trends of the aetiology of systemic lupus erythematosus in the past 10 years: a bibliometric analysis (2014-2023).

Objectives: Systemic lupus erythematosus (SLE) is a chronic autoimmune disease characterised by a complex aetiology that encompasses genetic, environmental, and immunological factors. A comprehensive understanding of SLE aetiology is essential for the development of effective therapeutic strategies and the enhancement of patient outcomes. This study aims to provide a thorough bibliometric analysis of research concerning the aetiology of SLE conducted over the past decade.

Demand analysis of transitional care for patients undergoing minimally invasive cardiac interventions with AI-driven solutions: a mixed-methods approach.

Aims: Minimally invasive cardiac intervention (MICI) patients remain at high risk of readmission and mortality during their post-discharge phase, with 30-day readmission rates of up to 10%. Although technological innovations, especially AI-driven solutions, hold promise for improving outcomes, there is a pressing need to clarify the full spectrum of patient demands during the transition from hospital to home. This study aimed to systematically identify these demands to guide the development of AI-driven solutions that reduce readmission rates and improve clinical outcomes.

Neferine reduces synovial inflammation and cardiac complications in a collagen-induced arthritis mouse model via inhibiting NF-κB/NLRP3 inflammasome axis.

For the treatment of rheumatoid arthritis (RA), there are limited options for drugs with fewer side effects. Neferine possesses anti-inflammatory, anti-fibrotic, and cardioprotective properties, but its effectiveness in the treatment of RA remains unclear. Our study aimed to explore the impact of neferine administration on ankle joint inflammation and cardiac complications of collagen-induced arthritis (CIA) mice.

Radio-Activated Selenium-Doped Janus Ag/AgSeS Nanoparticles for Precise Cancer NIR-II Fluorescence Imaging and Radiosensitization Therapy.

The efficacy of radiotherapy (RT) is often limited by insufficient tumor selectivity and suboptimal therapeutic responses. To overcome these problems, a new kind of selenium-doped Ag/AgS Janus nanoparticles (Ag/AgSeS JNPs) is presented as radio-responsive molecular probes for precise tumor imaging and enhanced radiosensitization. By adjusting the selenium precursor input, heterojunction nanoparticles with tunable doping ratios are synthesized, optimizing X-ray absorption and energy storage properties.

miR-216a-3p alleviates primary Sjögren's syndrome by regulating the STAT1/JAK signaling pathway.

Background: Sjögren's syndrome (SS) is a chronic systemic autoimmune It chiefly impacts the exocrine glands, specifically the salivary and lacrimal ones, causing manifestations such as dry mouth and eye. Sjögren's syndrome often coexists with other autoimmune diseases, making it difficult to study its pathogenesis. Mounting evidence suggests that microRNAs (miRNAs) play a pivotal role in the development of autoimmune diseases, yet the precise mechanisms underlying their involvement in SS remain to be fully elucidated.

DX-9 biocontrol against potato common scab involves significant changes in the soil microbiome and metabolome.

Unlabelled: Potato common scab (CS) is a worldwide disease, caused by spp., and its presence reduces the market value of potatoes. A nontoxic and potentially effective approach in many control strategies is the use of antagonistic microbes as biocontrol agents.