Beneath a silent attack: Unraveling lung and brain injuries in a surviving monoamniotic twin.

Pregnancy with monochorionic monoamniotic twins is highly rare and frequently results in complications. Nevertheless, in monochorionic monoamniotic twin pregnancies, there are no reports of lung injury in the surviving fetus after single intrauterine fetal death. To the best of our knowledge, we present the first report of lung and brain injuries in a surviving fetus after single intrauterine fetal death in a monochorionic monoamniotic twin pregnancy.

Janus Nanoprobe with Dual-Modal NIR-II Fluorescence/Photoacoustic Imaging for Precision Cancer Radiosensitizing Therapy.

The use of radiotherapy sensitizers has proven to be effective in overcoming tumor radiotherapy resistance and improving treatment efficacy. However, challenges such as poor biocompatibility and difficulty in accurately guiding tumor radiotherapy with high efficiency still persist. Herein, we propose a radiosensitizer with Janus nanostructure to address these issues by enabling dual-modal fluorescence (FL)/photoacoustic (PA) imaging in the second near-infrared region (NIR-II, 900-1700 nm) for precise and efficient tumor radiotherapy guidance.

Radio-Activated Selenium-Doped Janus Ag/AgSeS Nanoparticles for Precise Cancer NIR-II Fluorescence Imaging and Radiosensitization Therapy.

The efficacy of radiotherapy (RT) is often limited by insufficient tumor selectivity and suboptimal therapeutic responses. To overcome these problems, a new kind of selenium-doped Ag/AgS Janus nanoparticles (Ag/AgSeS JNPs) is presented as radio-responsive molecular probes for precise tumor imaging and enhanced radiosensitization. By adjusting the selenium precursor input, heterojunction nanoparticles with tunable doping ratios are synthesized, optimizing X-ray absorption and energy storage properties.

Ultrasound-Activated Theranostic Materials and Their Bioapplications.

Ultrasound (US) is a promising external excitation modality for bioapplications, offering significant advantages over X-rays or lasers due to its low cost, high biosafety, and ideal tissue penetration depth. US-activated theranostic materials, comprising organic, inorganic, and hybrid-based compounds, hold particular value in synergistic cancer therapeutic and diagnostic applications. These materials exhibit excellent imaging properties, high drug delivery and release efficiency, and enhanced reactive oxygen species (ROS) production, making them suitable for clinical diagnostic imaging and therapeutic interventions.

Genetically Supported Causality Between Micronutrients and Sleep Behaviors: A Two-Sample Mendelian Randomization Study.

Background: Sleep behaviors, defined by the total duration of sleep and chronotype, significantly influence overall health. Compromised sleep quality, which is often manifested through reduced sleep duration and the prevalence of insomnia, has been found to be associated with micronutrient deficiencies. Nonetheless, the existence of a causal relationship between micronutrient levels and sleep behaviors remains to be established.

Data pharmacovigilance analysis of medroxyprogesterone-related adverse events in the FDA adverse event reporting system.

Objectives: Medroxyprogesterone acetate (MPA), a steroid progesterone, is widely used to treat endometriosis, menstrual disorders, and uterine bleeding in clinical practice. However, the safety profile of MPA requires comprehensive evaluation.

Methods: This study performed a retrospective analysis using real-world data extracted from the US Food and Drug Administration Adverse Event Reporting System (FAERS) database.

Intracranial Structural Malformations in Children in Tibet: CT and MRI Findings in a Single Tertiary Center.

Objectives: The objective of this study was to summarize the findings of children's intracranial congenital or developmental malformations found during imaging procedures in the Tibetan plateau.

Methods: We retrospectively reviewed the imaging data of the suspected patients who presented with the central nervous system (CNS) malformations and were enrolled either through the clinic or after ultrasound examinations between June 2019 and June 2023 in our institution. All imaging data were interpreted by two experienced radiologists through consensus reading.

Genetically Supported Causality between Brain Structural Connectome and Sleep Duration in Children: A Two-Sample Mendelian Randomization Study.

Certain structural brain connections have been confirmed to influence sleep duration in children. However, the causal relationships between all brain regions and children's sleep duration remain unclear. A two-sample Mendelian randomization analysis was conducted using data from genome-wide association studies (GWAS) to examine the relationships between 206 structural connections and sleep duration in children.

Mendelian randomization study reveals a causal relationship between body mass index in children and risk of autoimmune diseases.

Newly emerging evidence indicates that body mass index (BMI) is a potential risk factor for autoimmune diseases (ADs). Nevertheless, the exact causal connection between ADs and BMI in children remains uncertain. To investigate the relationship between BMI in children and ADs, a 2-sample Mendelian randomization (MR) analysis was conducted.

Proportion of confluent B-Lines predicts respiratory support in term infants shortly after birth.

Objective: To develop and evaluate the predictive value of a simplified lung ultrasound (LUS) method for forecasting respiratory support in term infants.

Methods: This observational, prospective, diagnostic accuracy study was conducted in a tertiary academic hospital between June and December 2023. A total of 361 neonates underwent LUS examination within 1 h of birth.

Quantitative Electroencephalography in Term Neonates During the Early Postnatal Period Across Various Sleep States.

Background: Neonatal sleep is pivotal for their growth and development, yet manual interpretation of raw images is time-consuming and labor-intensive. Quantitative Electroencephalography (QEEG) presents significant advantages in terms of objectivity and convenience for investigating neonatal sleep patterns. However, research on the sleep patterns of healthy neonates remains scarce.

LANMAO sleep recorder versus polysomnography in neonatal EEG recording and sleep analysis.

Background: The field of neonatal sleep analysis is burgeoning with devices that purport to offer alternatives to polysomnography (PSG) for monitoring sleep patterns. However, the majority of these devices are limited in their capacity, typically only distinguishing between sleep and wakefulness. This study aims to assess the efficacy of a novel wearable electroencephalographic (EEG) device, the LANMAO Sleep Recorder, in capturing EEG data and analyzing sleep stages, and to compare its performance against the established PSG standard.

Knowledge mapping of neonatal electroencephalogram: A bibliometric analysis (2004-2022).

Background: Electroencephalography (EEG), a widely used noninvasive neurophysiological diagnostic tool, has experienced substantial advancements from 2004 to 2022, particularly in neonatal applications. Utilizing a bibliometric methodology, this study delineates the knowledge structure and identifies emergent trends within neonatal EEG research.

Methods: An exhaustive literature search was conducted on the Web of Science Core Collection (WoSCC) database to identify publications related to neonatal EEG from 2004 to 2022.

Immune control in Kawasaki disease knowledge mapping: a bibliometric analysis.

Background: Kawasaki disease is a systemic vascular disease with an unclear pathophysiology that primarily affects children under the age of five. Research on immune control in Kawasaki disease has been gaining attention. This study aims to apply a bibliometric analysis to examine the present and future directions of immune control in Kawasaki disease.

A publicly available newborn ear shape dataset for medical diagnosis of auricular deformities.

Early and accurate diagnosis of ear deformities in newborns is crucial for an effective non-surgical correction treatment, since this commonly seen ear anomalies would affect aesthetics and cause mental problems if untreated. It is not easy even for experienced physicians to diagnose the auricular deformities of newborns and the classification of the sub-types, because of the rich bio-metric features embedded in the ear shape. Machine learning has already been introduced to analyze the auricular shape.

Ultrasound activated probe for disease imaging and therapy In-Vivo.

Sonodynamic therapy (SDT) is the use of ultrasound (US) to excite sonosensitizers to produce reactive oxygen species (ROS) to induce tumor cell death, thereby achieving therapeutic purposes. Based on the strong tissue penetration ability of ultrasound, SDT can realize the treatment of deeper tumors, and it is targeted, can be specifically concentrated at the tumor site, and has little impact on surrounding normal tissues. It has broad clinical transformation prospects.

Genetic analysis of potential biomarkers and therapeutic targets associated with ferroptosis from bronchopulmonary dysplasia.

Ferroptosis is a recently identified form of cell death that is distinct from the conventional modes such as necrosis, apoptosis, and autophagy. Its role in bronchopulmonary dysplasia (BPD) remains inadequately understood. To address this gap, we obtained BPD-related RNA-seq data and ferroptosis-related genes (FRGs) from the GEO database and FerrDb, respectively.

Perinatal characteristics and neonatal outcomes of singletons and twins in Chinese very preterm infants: a cohort study.

Background: The prevalence of preterm birth has been rising, and there is a paucity of nationwide data on the perinatal characteristics and neonatal outcomes of twin deliveries of very preterm infants (VPIs) in China. This study compared the perinatal characteristics and outcomes of singletons and twins admitted to neonatal intensive care units (NICUs) in China.

Methods: The study population comprised all infants born before 32 weeks in the Chinese Neonatal Network (CHNN) between January 2019 and December 2019.

Identification and immunological characterization of endoplasmic reticulum stress-related molecular subtypes in bronchopulmonary dysplasia based on machine learning.

Bronchopulmonary dysplasia (BPD) is a life-threatening lung illness that affects premature infants and has a high incidence and mortality. Using interpretable machine learning, we aimed to investigate the involvement of endoplasmic reticulum (ER) stress-related genes (ERSGs) in BPD patients. We evaluated the expression profiles of endoplasmic reticulum stress-related genes and immune features in bronchopulmonary dysplasia using the GSE32472 dataset.

Genome-wide exploration of a pyroptosis-related gene module along with immune cell infiltration patterns in bronchopulmonary dysplasia.

Pyroptosis plays a crucial role in bronchopulmonary dysplasia (BPD) and is associated with various lung injury illnesses. However, the function of pyroptosis-related genes (PRGs) in BPD remains poorly understood. The gene expression omnibus (GEO) database was searched for information on genes associated with BPD.

[Perinatal risk factors for the occurrence of singleton apparently stillborn infants].

Objectives: To identify the perinatal risk factors for the occurrence of singleton apparently stillborn infants.

Methods: This was a case-control study. A total of 154 singleton neonates with gestational age ≥28 weeks and Apgar score of 0-1 who were subsequently successfully resuscitated in the Obstetrics and Gynecology Hospital of Fudan University from January 2006 to December 2015 were enrolled as the case group (apparently stillborn group).

Characterization of Fatty Acid Metabolism-Related Genes Landscape for Predicting Prognosis and Aiding Immunotherapy in Glioma Patients.

Glioma is a highly malignant brain tumor with a poor survival rate. The involvement of fatty acid metabolism in glioma was examined to find viable treatment options. The information was gathered from the Cancer Genome Atlas (TCGA) and the Chinese Glioma Genome Atlas (CGGA) databases.

Carbon Dioxide Conversion Synergistically Activated by Dielectric Barrier Discharge Plasma and the CsPbBr@TiO Photocatalyst.

Carbon dioxide utilization activated by the integration of plasma and photocatalyst is a promising approach to achieve the mitigation of the greenhouse effect. In this paper, for the first time, the dielectric barrier discharge (DBD) plasma and halide perovskite photocatalysts were synergistically used to facilitate the carbon dioxide conversion. After introducing the photocatalyst into the plasma reactor, the plasma discharge characteristics were improved by the photocatalyst while the active photons, electrons, and vibrationally excited molecules in plasma also enhanced the photocatalytic activity of the photocatalyst.

Biallelic p.V37I variant in GJB2 is associated with increasing incidence of hearing loss with age.

Purpose: This study aimed to quantitatively assess the incidence of hearing loss in relation to age in individuals with biallelic p.V37I variant in GJB2.

Methods: Population screening of the biallelic p.

Maternal-Neonatal Serum Albumin Level and Neonatal Respiratory Distress Syndrome in Late-Preterm Infants.

To determine the correlation between maternal-neonatal serum albumin level and respiratory distress syndrome (RDS) in late-preterm infants. This case-control study included 112 late-preterm newborns admitted to the neonatal intensive care unit of our hospital between January 2018 and July 2019. Those infants were divided into the RDS group ( = 56) and the non-RDS group ( = 56).