Observation of Coherent Perfect Acoustic Absorption at an Exceptional Point.

Non-Hermitian systems have recently shown new possibilities to manipulate wave scattering by exploiting loss, yet coherent perfect absorption at an exceptional point (CPA EP) remains elusive in acoustics. Here, we demonstrate it based on a two-channel waveguide with compact lossy resonators. We realize imbalanced losses crucial for CPA EP by using active components to independently modulate the non-Hermiticity.

Reconstructing Satellites in 3D from Amateur Telescope Images.

Monitoring space objects is crucial for space situational awareness, yet reconstructing 3D satellite models from ground-based telescope images is super challenging due to atmospheric turbulence, long observation distances, limited viewpoints, and low signal-to-noise ratios. In this paper, we propose a novel computational imaging framework that overcomes these obstacles by integrating a hybrid image pre-processing pipeline with a joint pose estimation and 3D reconstruction module based on controlled Gaussian Splatting (GS) and Branch-and-Bound (BnB) search. We validate our approach on both synthetic satellite datasets and on-sky observations of China's Tiangong Space Station and the International Space Station, achieving robust 3D reconstructions of low-Earth orbit satellites from ground-based data.

[Identification of the sugarcane β-1,3-glucanase gene family and analysis of their expression under various stress conditions].

Sugarcane ( spp.) is an important sugar crop. Biotic and abiotic stresses such as diseases, cold, and drought are major factors limiting sugarcane production.

BSA-LDHs-cGAMP In Situ Sensitization of Osteosarcoma: Enhancing Antitumor Efficacy with CD40 Agonist Antibodies.

Osteosarcoma is a malignant bone tumor that is extremely aggressive and presents several therapeutic problems. Although CD40 agonist antibodies (αCD40) have demonstrated potential in improving T cell priming and reprogramming tumor-associated macrophages, osteosarcoma's poor immunogenicity leads to "cold" tumors that are challenging to cure. When it comes to triggering immunological responses, the STING pathway is essential.

Mangrove disturbance analysis over 30 years in Myanmar based on continuous change detection and classification algorithm.

Myanmar, recognized as a hotspot for global mangrove deforestation, has experienced rapid loss of these critical ecosystems due to extensive human activity and natural disturbances. However, limited research has addressed the long-term, detailed dynamics of mangrove disturbances in Myanmar. To bridge this gap, this study applied the continuous change detection and classification (CCDC) algorithm on Landsat images within the Google Earth Engine (GEE) platform to analyze mangrove disturbances (disturbance frequency, maximum disturbance years, and maximum disturbance degrees) and driving forces in Myanmar over 30 a (1990-2020).

The correlation between center of pressure and cerebral cortex activation characteristics in patients with stroke: A functional near-infrared spectroscopy study.

Balance impairment is common among patients with hemiplegia after stroke, yet the relationship between standing balance and cerebral cortex activation under eyes-open and eyes-closed conditions remains unclear. This study aims to explore these correlations to guide targeted neural regulation. Thirty-one stroke patients from Huashan Hospital, Fudan University (2021-2022), were assessed for the sway of center of pressure (COP) under the aforementioned conditions.

Non-invasive imaging with ICOS-targeting monoclonal antibody for preclinical diagnosis of rheumatoid arthritis in a humanized mouse model.

Background: Activated T cells play a pivotal role in rheumatoid arthritis (RA) pathogenesis, and imaging of activated T cells may provide a non-invasive tool for RA detection. Here, we first developed an optical probe targeting human inducible T cell co-stimulator (ICOS) and tested its capacity in RA diagnosis by capturing ICOS activated T cells in vivo in a humanized mouse model.

Methods: The humanized arthritis model, Human peripheral blood mononuclear cells- adjuvant induced arthritis (HuPBMC-AIA) was established, and flow cytometry and immunofluorescence were employed to determine ICOS expression in huPBMC-AIA model.

Placebo effects of repetitive transcranial magnetic stimulation on negative symptoms and cognition in patients with schizophrenia spectrum disorders: a systematic review and meta-analysis.

Background: Negative symptoms and cognitive impairments are highly frequent in schizophrenia spectrum disorders (SSD), associated with adverse functional outcomes and quality of life. Repetitive transcranial magnetic stimulation (rTMS) has been considered a promising therapeutic option in SSD. However, placebo effects of rTMS on these symptoms remained unclear.

Armed with IL-2 based fusion protein improves CAR-T cell fitness and efficacy against solid tumors.

Chimeric antigen receptor T (CAR-T) cell therapy is regarded as a potent immunotherapy and has made significant success in hematologic malignancies by eliciting antigen-specific immune responses. However, response rates of CAR-T cell therapy against solid tumors with immunosuppressive microenvironments remain limited. Co-engineering strategies are advancing methods to overcome immunosuppressive barriers and enhance antitumor responses.

Chemical Synthesis of a Branched Nonasaccharide Fragment from Lipopolysaccharide.

A chemical synthesis of a unique nanosaccharide fragment from lipopolysaccharide was achieved via a convergent glycosylation method. Challenges involved in the synthesis include the highly stereoselective construction of β-3-deoxy-d--oct-2-ulosonic acid (Kdo) and two 1,2--glycosidic linkages, as well as the formation of a branched 2,7-disubstituted heptose subunit. Hydrogen-bond mediated aglycone delivery strategy and benzoyl-directing remote participation effect were employed, respectively, for the efficient generation of the desired β-Kdo glycoside and 1,2--α-l-fucoside/d-glucoside.

Noninvasive Imaging OX40 Activated T Cells Provides Early Warning of Rheumatoid Arthritis.

Purpose: The goal of this study was to develop an imaging probe-IRDye-680RD-OX40 mAb-that can be used for noninvasive imaging and optical imaging of rheumatoid arthritis (RA). OX40/OX40 ligand (OX40L) interactions have been shown to exert potent costimulatory effects on T cell activation. Detectable change in T cell activation profiles was observed in early RA.

Low-cost high-speed rapidly reconfigurable integrated half-duplex optical transceiver front-end.

We present and demonstrate an integrated approach to make low-cost high-speed half-duplex optical transceiver with rapid reconfigurability. A single Distributed-Feedback (DFB) diode is employed as the unified E/O-O/E device, which is dynamically biased as laser or photodetector in transmitter or receiver mode. The bias for the DFB and the transmit/receive (T/R) signal path are provided by a custom-designed reconfigurable CMOS chip, which contains the biasing circuitry, a high-speed T/R switch and a burst-mode transimpedance amplifier (BM-TIA).

Astragaloside IV - mediated endothelial progenitor cell exosomes promote autophagy and inhibit apoptosis in hyperglycemic damaged endothelial cells via miR-21/PTEN axis.

Introduction: As one of the basic components of Astragalus, Astragaloside IV (AS-IV) has a protective effect on endothelial injury caused by diabetes. AS-IV stimulated endothelial progenitor cells (EPCs) to secrete exosomes loaded with miR-21. This study aimed to investigate the effects of AS-IV-mediated EPCs exosomal miR-21 (EPC-exos-miR-21) on high glucose (HG) damaged endothelial cells.

Fluorophore-conjugated 4-1BB antibody enables early detection of T-cell responses in inflammatory arthritis via NIRF imaging.

Purpose: We first developed a 4-1BB-targeted optical probe, named IRDye-680RD-4-1BB mAb (monoclonal antibody), and evaluated its value for the detection of 4-1BB activated T cells in vivo as well as the diagnosis of rheumatoid arthritis (RA) in an adjuvant-induced arthritis (AIA) mouse model.

Methods: The 4-1BB expression pattern was analysed by flow cytometry and immunofluorescence (IF) staining. The 4-1BB mAb was conjugated with IRDye-680RD NHS ester, and characterized via fluorescence spectrum.

The Effect of Cerebellar rTMS on Modulating Motor Dysfunction in Neurological Disorders: a Systematic Review.

The effectiveness of cerebellar repetitive transcranial magnetic stimulation (rTMS) on motor dysfunction in patients with neurological disorders has received increasing attention because of its potential for neuromodulation. However, studies on the neuromodulatory effects, parameters, and safety of rTMS implementation in the cerebellum to alleviate motor dysfunction are limited. This systematic review aimed to evaluate the effectiveness and safety of cerebellar rTMS treatment for motor dysfunction caused by neurological disorders and to review popular stimulation parameters.

Influences of Slenderness and Eccentricity on the Mechanical Properties of Concrete-Filled GFRP Tube Columns.

The existence of either eccentricity or slenderness has a significant effect on the mechanical properties of a structure or member. These properties can change the working mechanism, failure mode, and bearing capacity of the structure or member. A concrete-filled, glass fibre-reinforced, polymer tube composite column has the same problem.

[Representation, analysis and application of landscape graph based on graph theory].

Landscape structure and spatial pattern are the core issues in landscape ecology. The application of graph theory provides a research framework for landscape pattern analysis. Landscape graph based on graph theory is gradually applied to the connectivity modeling of biodiversity conservation and decision support of landscape planning.