Adolescent executive function as a resilience factor in the family stress model among Mexican-origin families.

Mexican-origin families often face economic hardship due to systemic oppression, increasing the likelihood of adolescent marijuana use. While the family stress model provides insight into the mechanism of the association between family economic hardship and adolescent marijuana use, resilience factors are relatively unknown. The present study uses a three-wave longitudinal data set of Mexican immigrant families in the United States (Wave 1-adolescents: = 12.

Retinal transduction profiling of diverse AAV serotypes via intravitreal injection.

Unlabelled: Optimizing adeno-associated virus (AAV) capsid and dosing selection is critical for the clinical translation of retinal gene therapy. This study aims to provide a comprehensive reference by comparing the transduction efficiency, cellular tropisms, and temporal retinal expression patterns of various AAV serotypes for intravitreal retinal gene therapy. A series of AAV vectors were intravitreally injected into C57BL/6J mice.

Language Brokering Conditions the Indirect Association Between Mexican-Origin Adolescents' Academic Discrimination and Educational Expectations.

Mexican-origin adolescents, a significant portion of the US Latino population, often experience a decline in educational expectations from early to late adolescence. Contextual factors such as academic discrimination and language brokering for parents may contribute to this decline. This study investigates the indirect effect of academic discrimination experienced in middle school on educational expectations in young adulthood through high school grades and engagement, and the moderating role of language brokering experiences in these relations.

Urinary and plasma donor-derived cell-free DNA for noninvasive monitoring of BK polyomavirus-associated nephropathy in kidney transplant recipients: a prospective cohort study.

Background: BK polyomavirus-associated nephropathy (BKPyVAN) is a major cause of allograft injury and dysfunction in kidney transplant recipients. Current monitoring tools, including viremia and biopsy, have limitations in sensitivity, invasiveness, and timing.

Objective: To evaluate donor-derived cell-free DNA (dd-cfDNA) in urine and plasma as a dynamic, noninvasive biomarker for monitoring treatment response and predicting rejection risk in patients with biopsy-proven BKPyVAN.

Transplant Ureteral Stenosis Caused by Polyomavirus Ureteritis in Allograft Kidney Transplantation: Two Cases Report and a Literature Review.

Background: Polyomavirus ureteritis is a rare but increasingly recognized complication in kidney transplantation, with the potential to cause ureteral stenosis and graft loss. We report two pathologically confirmed cases of polyomavirus ureteritis presenting as ureteral stenosis, successfully treated with ureterovesical reimplantation surgery and adjustments in immunosuppressive therapy.

Case Presentation: The first case describes a 41-year-old male renal transplant recipient, who presented with progressive hydronephrosis and an elevated serum creatinine (Scr) level of 308 μmol/L 5 months post-transplant.

Noninvasive diagnosis and classification of kidney transplantation rejection by F-FAPI-04 PET/CT.

Purpose: Rejection, especially chronic rejection is a key factor influencing the prognosis of kidney transplantation patients. While F-fibroblast activation protein inhibitor (FAPI)-04 PET/CT has been widely utilized for diagnosing various diseases, its diagnostic efficacy in kidney transplant rejection remains unexplored.

Methods: In this study, 24 kidney transplant recipients were prospectively enrolled and divided into a control cohort and a rejection cohort (KTR), which were further classified into acute rejection (AR), mixed rejection (MR), and chronic rejection (CR) subgroups.

Familial Educational Factors and COVID-19 Vaccine Beliefs Among Mexican-Origin Youth.

Mexican-origin youth, a substantial and expanding demographic among U.S. youth, were disproportionately affected by COVID-19.

Cross-Modality Distillation for Multi-Modal Tracking.

Contemporary multi-modal trackers achieve strong performance by leveraging complex backbones and fusion strategies, but this comes at the cost of computational efficiency, limiting their deployment in resource-constrained settings. On the other hand, compact multi-modal trackers are more efficient but often suffer from reduced performance due to limited feature representation. To mitigate the performance gap between compact and more complex trackers, we introduce a cross-modality distillation framework.

Local Delivery of Ginger Extract a Nanofibrous Membrane Suppresses Human Skin Melanoma B16F10 Cells Growth Targeting Ras/ERK and PI3K/AKT Signaling Pathways: An Study.

Background: Metastatic melanoma poses a significant threat globally, with a distressingly low ten-year survival rate of only 10%. While FDA-approved treatments such as dacarbazine and high-dose IL-2 have been employed in clinical settings, their limitations underscore the urgent need for more effective therapies.

Aims: This study aimed to develop a potential anticancer local treatment through the extraction of various amounts of ginger extract loaded unto Poly(vinyl alcohol) (PVA) nanofibers.

Neuroprotective Effects of Astragalus Polysaccharide on Retina Cells and Ganglion Cell Projection in NMDA-Induced Retinal Injury.

Purpose: Astragalus polysaccharide (APS), a water-soluble heteropolysaccharide, possesses immunomodulatory, anti-inflammatory, and cardioprotective properties. This study investigates the neuroprotective potential of APS in a model of -Methyl-aspartic acid (NMDA)-induced retinal neurodegeneration, aiming to explore its potential as a treatment for retinal degenerative diseases.

Methods: Retinal function was evaluated using electroretinography (ERG), optomotor reflex (OMR), and flash visual evoked potentials (FVEP).

Role of Elavl-like RNA-binding protein in retinal development and signal transduction.

RNA-binding proteins (RBPs) play central roles in post-transcriptional gene regulation. However, the function of RBP in retinal progenitor cell differentiation and synaptic signal transmission are largely unexplored. Previously we have shown that Elavl2 regulates amacrine cell (AC) differentiation during retinogenesis, by directly binding to Nr4a2 and Barhl2.

Development of Bivalent Aptamer-DNA Carrier-Doxorubicin Conjugates for Targeted Killing of Esophageal Squamous Cell Carcinoma Cells.

Esophageal cancer ranks the seventh in cancer incidence and the sixth in cancer death. Esophageal squamous cell carcinoma (ESCC) accounts for approximately 90% of the total cases of esophageal cancer. Chemotherapy is the most effective drug-based method for treatment of esophageal cancer.

Exploring Multi-Modal Spatial-Temporal Contexts for High-Performance RGB-T Tracking.

In RGB-T tracking, there exist rich spatial relationships between the target and backgrounds within multi-modal data as well as sound consistencies of spatial relationships among successive frames, which are crucial for boosting the tracking performance. However, most existing RGB-T trackers overlook such multi-modal spatial relationships and temporal consistencies within RGB-T videos, hindering them from robust tracking and practical applications in complex scenarios. In this paper, we propose a novel Multi-modal Spatial-Temporal Context (MMSTC) network for RGB-T tracking, which employs a Transformer architecture for the construction of reliable multi-modal spatial context information and the effective propagation of temporal context information.

Selective inhibition of c-Met signaling pathways with a bispecific DNA nanoconnector for the targeted therapy of cancer.

Hepatocyte growth factor receptor (c-Met) is a suitable molecular target for the targeted therapy of cancer. Novel c-Met-targeting drugs need to be developed because conventional small-molecule inhibitors and antibodies of c-Met have some limitations. To synthesize such drugs, we developed a bispecific DNA nanoconnector (STPA) to inhibit c-Met function.

Deciphering three predominant biopsy-proven phenotypes of IgG4-associated kidney disease: a retrospective study.

Background: IgG4-associated kidney disease (IgG4-RKD) encompasses a spectrum of disorders, predominantly featuring tubulointerstitial nephritis (TIN) and membranous glomerulonephropathy (MGN). The limited understanding of the co-occurrence of IgG4-RD-TIN with anti-neutrophil cytoplasmic antibodies (ANCA)-associated vasculitis (AAV) poses a diagnostic and therapeutic challenge.

Methods: We examined 49 cases, comprising 21 cases of IgG4-RD-TIN (group A), 10 cases of IgG4-RD-TIN accompanied with MGN (group B), and 18 cases of IgG4-RD-TIN concurrent with AAV (group C), at the First Affiliated Hospital of Zhejiang University, China, from June 2015 to December 2022.

Microbial bionic nano-aromatic drugs for prevention of depression induced by chronic stress.

Depression is a mood disorder mainly clinically characterized by significant and persistent low spirits. Chronic stress is the leading cause of depression. However, traditional medicine has severe side effects in treating depression, ineffective treatment, and easy recurrence.

Cell Membrane-Anchored DNA Nanoinhibitor for Inhibition of Receptor Tyrosine Kinase Signaling Pathways via Steric Hindrance and Lysosome-Induced Protein Degradation.

Receptor tyrosine kinase (RTK) plays a crucial role in cancer progression, and it has been identified as a key drug target for cancer targeted therapy. Although traditional RTK-targeting drugs are effective, there are some limitations that potentially hinder the further development of RTK-targeting drugs. Therefore, it is urgently needed to develop novel, simple, and general RTK-targeting inhibitors with a new mechanism of action for cancer targeted therapy.

Effects of the Fibrous Root of Hua on Growth Performance, Meat Quality, Immunity, Antioxidant Capacity, and Intestinal Morphology of White-Feathered Broilers.

This study was designed to evaluate the effects of different doses of the fibrous roots of Hua on the growth performance, slaughter parameters, meat quality, immune function, cytokines, antioxidant capacity, and intestinal morphology of white-feathered broilers. Also, the mechanism to improve immune functions of broilers was explored through network pharmacology and molecular docking technology. A total of 360 AA-white-feathered broilers were randomly divided into six groups (not separated by sex), with six repetitions per group ( = 10).

A Biomimic Nanobullet with Ameliorative Inflammatory Microenvironment for Alzheimer's Disease Treatments.

Aβ oligomers, formed prior to diagnostic marker-amyloid β (Aβ) plaques, can damage neurons and trigger neuroinflammation, which accelerate the neuronal injury in Alzheimer's disease (AD). Herein, the combination of eliminating the Aβ oligomers and alleviating the inflammation is a promising therapeutic strategy for AD. However, the presence of the blood-brain barrier (BBB) and the intrinsic deficiencies of the drugs severely restrict their therapeutic effects.

Smart antioxidant function enhancing (SAFE) nucleic acid therapy for ROS-related chronic diseases and comorbidities.

Reactive oxygen species (ROS)-mediated oxidative stress exacerbates chronic diseases such as organ damage and neurodegenerative disorders. The Keap1-Nrf2-ARE pathway is a widely distributed endogenous antioxidant system. However, ROS under redox homeostasis regulates a wide range of life activities.

Engineered Extracellular Vesicles for Delivery of an IL-1 Receptor Antagonist Promote Targeted Repair of Retinal Degeneration.

Retinal degeneration (RD) is an irreversible blinding disease that seriously affects patients' daily activities and mental health. Targeting hyperactivated microglia and regulating polarization are promising strategies for treating the disease. Mesenchymal stem cell (MSC) transplantation is proven to be an effective treatment due to its immunomodulatory and regenerative properties.

Identifying TNF and IL6 as potential hub genes and targeted drugs associated with scleritis: A bio-informative report.

Background: Scleritis is a serious inflammatory eye disease that can lead to blindness. The etiology and pathogenesis of scleritis remain unclear, and increasing evidence indicates that some specific genes and proteins are involved. This study aimed to identify pivotal genes and drug targets for scleritis, thus providing new directions for the treatment of this disease.

Nucleic acid drug vectors for diagnosis and treatment of brain diseases.

Nucleic acid drugs have the advantages of rich target selection, simple in design, good and enduring effect. They have been demonstrated to have irreplaceable superiority in brain disease treatment, while vectors are a decisive factor in therapeutic efficacy. Strict physiological barriers, such as degradation and clearance in circulation, blood-brain barrier, cellular uptake, endosome/lysosome barriers, release, obstruct the delivery of nucleic acid drugs to the brain by the vectors.

Effects of L. Fruit Extract on Growth Performance, Meat Quality, Immunity, Antioxidant, Intestinal Morphology and Flora of White-Feathered Broilers.

This study aimed to determine whether adding Kadsura coccinea fruit extract to the diet of broilers could replace antibiotics. For this study, 300 one-day-old AA white feathered broilers were divided into five groups (no sex separated), with six repetitions per group (n = 10), as follows: blank control group (basal feed, CK group), positive drug (basal feed + 300 mg/kg aureomycin, PD group), and Kadsura coccinea low-dose, medium-dose, and high-dose groups (basal feed + 100 mg/kg, 200 mg/kg, and 300 mg/kg of Kadsura coccinea fruit extract, LD group, MD group and HD group). The experiment period was divided into early (1−21 days) and late (22−42 days) stage.

Does similarity trigger cooperation? Dyadic effect of similarity in social value orientation and cognitive resources on cooperation.

Unlabelled: Although a considerable amount of research has demonstrated a robust relationship between social value orientation and cooperation, these studies may be limited by focusing solely on the individual. Building on the growing literature documenting the effect of group formation on cooperation and personality similarity on negotiation, the present study explored whether similarity in social value orientation (both being pro-social or pro-self) leads to more cooperation in social dilemmas among dyad members. Drawing from expectancy theory and the concept of cognitive resources, we further predicted that the relationship between similarity in social value orientation and cooperation uniquely depends on whether the individual is cognitively busy.