Dynamic 3D chromatin organization and epigenetic regulation of gene expression in peanut nodules.

Root nodules are specialized organs formed by the symbiotic relationship between legumes and soil-borne rhizobia, facilitating an exchange of energy and nutrients essential for both organisms. This process is accompanied by dynamic changes in genomic organization and gene expression. While the three-dimensional (3D) architecture of the genome is known to influence gene regulation, its role in nodulation and symbiotic nitrogen fixation remains largely unexplored.

YTHDF2 regulates ACSL4-dependent ferroptosis of keratinocytes in diabetic wound healing.

Delayed diabetic wound healing is a global health issue with unclear pathogenesis. Ferroptosis, a form of cell death involving iron and lipid peroxidation, may contribute to delayed diabetic wound. This study investigates the role of ferroptosis in diabetic wound keratinocytes.

Galectin-3-integrin α5β1 phase separation disrupted by advanced glycation end-products impairs diabetic wound healing in rodents.

Diabetic foot ulcers are severe diabetic complications, and promoting impaired angiogenesis is essential for wound healing. Pro-angiogenic galectin-3 is elevated in diabetic serum and promotes systemic insulin resistance that may impair wound healing. However, the exact role of galectin-3 in the regulation of diabetic wound healing remains unclear.

Novel tryptophan 2,3-dioxygenase-targeted ruthenium(ii)-indole complex activates immunotherapy and .

Immunotherapy targeting immune checkpoints has emerged as a promising strategy in cancer treatment; however, the heterogeneous and dynamic tumor microenvironment (TME) imposes critical constraints on therapeutic outcomes. Tryptophan 2,3-dioxygenase (TDO), often dysregulated in malignant tissues, plays a pivotal role in shaping an immunosuppressive milieu by depleting tryptophan, thereby hindering anti-tumor immune response. To counteract this immune evasion mechanism, we designed a novel indole-coordinated ruthenium(ii) arene complex (In-Ru), aimed at bolstering tumor immunotherapy and thwarting immune evasion by targeting TDO expression.

Multi-Step Natural Gas Load Forecasting Incorporating Data Complexity Analysis with Finite Features.

Data complexity directly affects the dynamics of complex systems, which in turn influences the accuracy and robustness of forecasting models. However, the load data exhibit complex features such as self-similarity, long-term memory, randomness, and chaos. This study aims to quantify and evaluate the complexity features of natural gas loads and to develop a multi-step-ahead forecasting model that integrates data decomposition and ensemble deep learning while considering these complexity features.

New cytotoxic -hydroxybenzoic acid and sesquiterpene-derived amides from J2-22-1.

Two new amides (-) derived from -hydroxybenzoic acid and sesquiterpene, respectively, along with one known sesquiterpene (), were isolated from the desert soil-derived fungus J2-22-1. Structural characterisation was achieved through spectroscopic analysis, with absolute configurations confirmed comparative ECD spectra. The anticancer potential of these compounds was evaluated against four human tumour models: MCF-7, SGC-7901, MGC-803, and HepG2.

Assessment of lipid parameters and its association with risk of stage 1 hypertension: a cohort study in middle-aged and elderly Chinese.

Background: There is a correlation between dyslipidemia and elevated blood pressure, but the relationship between different lipid parameters and elevated blood pressure is inconsistent. Therefore, understanding the impact of dyslipidemia on blood pressure is significant for the prevention and control of ASCVD. Our study is aimed at assessing longitudinally the correlation between lipid parameters and the incidence of stage 1 hypertension in a large Chinese community population.

Association between the cardiometabolic index and all-cause and cardiovascular mortality in diabetes and prediabetes.

Background: The association between the cardiometabolic index (CMI) and mortality in individuals with diabetes or prediabetes remains unclear. This study sought to explore the association between the baseline CMI and all-cause mortality and cardiovascular disease (CVD) mortality in United States (U.S.

Screening and Validation of Rhizobial Strains for Improved Lentil Growth.

Lentil is a nutritionally valuable legume crop, rich in protein, carbohydrates, amino acids, and vitamins, and is also used as green manure. Symbiotic nitrogen fixation (SNF) plays a crucial role in lentil growth and development, yet there is limited research on isolating and identifying lentil rhizobia related to nodulation and nitrogen fixation. This study employed tissue block isolation, line purification, and molecular biology to isolate, purify, and identify rhizobial strains from lentils, analyzing their physiological characteristics, including bromothymol blue (BTB) acid and alkali production capacity, antibiotic resistance, salt tolerance, acid and alkali tolerance, growth temperature range, and drought tolerance simulated by PEG6000.

Stronger associations of abdominal obesity-related triglyceride-glucose indices with type 2 diabetes compared to general obesity-related indices in community-dwelling Chinese adults: a cross-sectional study.

Objectives: The relationships between the triglyceride-glucose (TyG) index, TyG-related parameters of different obesity phenotypes and the risk of type 2 diabetes (T2D) remain unclear. We aimed to determine associations between TyG index, obesity-related TyG parameters and T2D risk in Chinese adults.

Methods: This cross-sectional study included 9489 participants aged ≥40 years from a large scale, community-based cohort study.

Coordination-Driven Directional Construction of Mn/Co@Carbon Aerogels and Thermal Catalysis of Ammonium Perchlorate.

Previous studies have found that metal-doped carbon aerogels can effectively catalyze the thermal decomposition behavior of ammonium perchlorate (AP). In this study, a kind of carbon aerogel catalyst doped with Mn and Co was prepared by the bimetallic MOF (HMOF) precursor method through the key steps of gel and carbonization, and its thermal catalytic mechanism for AP was studied in detail. The results showed that Mn/Co@C aerogels had better catalytic performance than the monometal-doped carbon catalyst.

Synthesis and anticancer studies of Ru/Ir arene complexes bearing oleanolic acid in acute promyelocytic leukemia cells.

Acute leukemia, a cancer originating in the bone marrow and blood-forming tissues, poses a significant threat to human health. Chemotherapy may cause a range of side effects and further cause greater suffering to the patients. Thus, reducing the toxicity of the drugs for treating leukemia has become a significant challenge.

Nontargeted Analysis Reveals Organofluorine Pharmaceutical Compounds Responsible for Formation of Toxic Disinfection Byproducts in a Drinking Water Treatment Plant in China.

Toxic disinfection byproducts (DBPs) formed during chlorination are a significant concern for drinking water safety. These compounds were analyzed using nontargeted methods, and their chemical formulas and structures were determined through tandem mass spectrometry combined with a novel fragmental chain characterization (FCC) algorithm. This FCC algorithm significantly improved annotation rates, achieving a four-fold increase compared to traditional mass spectral matching strategies.

Cytotoxic polyketides from the desert soil-derived fungus H231.

Three new heterodimeric polyketides, fleisine A-C (1-3), were obtained from the fermentation product of the desert soil-derived fungus H231. The structures of 1-3 were elucidated through an integrated analysis of spectroscopic data, while the absolute configurations were established by chemical hydrolysis followed by calculated electronic circular dichroism (ECD). Biological evaluation revealed that compounds 1 and 2 exhibited potent cytotoxicity against multiple human tumor cell lines.

ISPO: An Integrated Ontology of Symptom Phenotypes for Semantic Integration of Traditional Chinese Medical Data.

Symptom phenotypes are crucial for diagnosing and treating various disease conditions. However, the diversity of symptom terminologies poses a significant challenge to analyzing and sharing of symptom-related medical data, particularly in the field of traditional Chinese medicine (TCM). This study aims to construct an Integrated Symptom Phenotype Ontology (ISPO) to support data mining of Chinese electronic medical records (EMRs) and real-world studies in the TCM field.

Atomic-Scale Simulations of Chemical Damage in Neoprene under Noble Gas Ion Irradiation.

The molecular simulation is an effective approach for investigating the effects of energetic ion irradiation on polymers. However, there is a lack of relevant studies on atomic structural changes and quantitative analysis. This study utilizes an inelastic thermal spike model and reactive molecular dynamics simulations to investigate the damage mechanisms of noble gas ion irradiation in neoprene rubber.

Systematic Review and Meta-Analysis of the Association Between Clinical Severity and Co-Infection of Human Adenovirus With Other Respiratory Pathogens in Children.

The correlation between the co-infection of human respiratory adenovirus (HAdV) and clinical severity has not been firmly established yet. We carried out a systematic review and meta-analysis. We scoured six databases for studies published up to 16 May 2024.

An interpreting machine learning models to predict amputation risk in patients with diabetic foot ulcers: a multi-center study.

Background: Diabetic foot ulcers (DFUs) constitute a significant complication among individuals with diabetes and serve as a primary cause of nontraumatic lower-extremity amputation (LEA) within this population. We aimed to develop machine learning (ML) models to predict the risk of LEA in DFU patients and used SHapley additive explanations (SHAPs) to interpret the model.

Methods: In this retrospective study, data from 1,035 patients with DFUs at Sun Yat-sen Memorial Hospital were utilized as the training cohort to develop the ML models.

Angiopoietin-Like 3 Antibody Therapy in Patients With Suboptimally Controlled Hyperlipidemia: A Phase 2 Study.

Background: Angiopoietin-like 3 (ANGPTL-3) inhibits the activity of lipoprotein lipase and endothelial lipase, increasing both serum low-density lipoprotein cholesterol (LDL-C) and triglyceride (TG) levels. SHR-1918 is a fully human monoclonal antibody against ANGPTL-3.

Objectives: The aim of this study was to assess the lipid-altering efficacy and safety of SHR-1918 in patients at moderate or higher risk of atherosclerotic cardiovascular disease (ASCVD) with suboptimally controlled hyperlipidemia.

Autotrophic Uranium (VI) bioreduction in groundwater by siderite: Comparison with sulfur and zero-valent iron.

Uranium (U), recognized as a significant health risk in groundwater, has become a key focus in environmental remediation efforts. While numerous electron donors have been investigated for the removal of U(VI) through microbial processes, the potential of abundant and economical Fe(II)-containing minerals remains unexplored. Here, a new inorganic electron donor, siderite (FeCO) was proposed.

Nonlinear association between hemoglobin glycation index and mortality in ischemic stroke Patients: Insights from the MIMIC-IV database.

Aims: Hemoglobin glycation index (HGI) is closely associated with adverse outcomes in several diseases. However, few studies have investigated the correlation between HGI and prognosis in patients with critical ischemic stroke.

Methods: A cohort of patients was established from the Medical Information Mart for Intensive Care IV (MIMIC-IV) database.

High-Brightness Perovskite Light-Emitting Diodes with Suppressed Efficiency Roll-off Using the Green Solvent γ-Valerolactone.

The application of promising perovskite light-emitting diodes (PeLEDs) faces a significant challenge known as efficiency roll-off, which refers to the decline in external quantum efficiency (EQE) at high current densities. This issue arises mainly from high trap densities in perovskite films and imbalanced carrier injection, which limit improvements in brightness and stability of PeLEDs. Here, we develop a green solvent strategy using γ-valerolactone (GVL) to suppress efficiency roll-off in PeLEDs.

Dysthyroid optic neuropathy treated with tocilizumab.

Summary: Dysthyroid optic neuropathy (DON) is the most serious complication associated with Graves' orbitopathy (GO). The primary treatment approach for DON is high-dose intravenous methylprednisolone infusion and decompression surgery. However, not all patients are suitable candidates for or can tolerate these two treatment options.

The Diminution of R-Loops Generated by LncRNA DSP-AS1 Inhibits DSP Gene Transcription to Impede the Re-Epithelialization During Diabetic Wound Healing.

Re-epithelialization constitutes a critical stage in the intricate process of wound healing, yet its mechanisms in the context of diabetic wounds remain elusive. In this study, the role of the mesenchymal-epithelial transition (MET) vis-à-vis the epithelial-mesenchymal transition (EMT) of keratinocytes in diabetic wound re-epithelialization is investigated. The findings reveal an impediment in the MET process, rather than EMT, which significantly compromised re-epithelialization in diabetic wounds.

Colloidally uniform single-crystal precursors enable uniform FAPbI films for efficient perovskite submodules.

With the unprecedented research development on lead halide perovskite photovoltaics, scaling up fabrication while comprehensively understanding the properties of cost-effective and highly uniform precursor films has become critical for their practical application. When enlarging the device area, good precursor purity serves as the first step in ensuring the uniformity of the perovskite film. Chemical purity and colloidal uniformity in the precursor solution both play important roles in dictating film uniformity and defect density.