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Data complexity directly affects the dynamics of complex systems, which in turn influences the accuracy and robustness of forecasting models. However, the load data exhibit complex features such as self-similarity, long-term memory, randomness, and chaos. This study aims to quantify and evaluate the complexity features of natural gas loads and to develop a multi-step-ahead forecasting model that integrates data decomposition and ensemble deep learning while considering these complexity features. Firstly, the complexity features of the series are quantified by rolling the fractal dimension, Hurst exponent, sample entropy, and maximum Lyapunov exponent. The analysis contributes to understanding data characteristics and provides information on complex features. Secondly, the ensemble learning eXtreme Gradient Boosting (XGBoost) can effectively screen complexity features and meteorological factors. Concurrently, variational mode decomposition (VMD) provides frequency-domain decomposition capability, while the gated recurrent unit (GRU) captures long-term dependencies. This synergy enables effective learning of local features and long-term temporal patterns, resulting in precise predictions. The results indicate that compared to other models, the proposed method (XGBoost-VMD-GRU considering complex features) demonstrates superior performance in forecasting, with R of 0.9922, 0.9860, and 0.9679 for one-step, three-step, and six-step prediction, respectively. This study aims to bring innovative ideas to load forecasting by integrating complex features into the decomposition forecasting framework.
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http://dx.doi.org/10.3390/e27070671 | DOI Listing |
Clin Rheumatol
September 2025
The First College of Clinical Medical Science, Three Gorges University, Yichang, China.
Background: IgG4-related lung disease (IgG4-RLD) is a rare autoimmune condition. This study aims to systematically analyze the clinical characteristics of IgG4-RLD to enhance clinicians' awareness and improve patient outcomes.
Methods: This retrospective analysis investigates the clinical data of 20 patients diagnosed with IgG4-RLD at the Yichang Central People's Hospital between January 2019 and April 2025.
Biotechnol Lett
September 2025
Department of Chemical Engineering, Hongik University, Sangsu-dong, Mapo-gu, Seoul, 04066, Republic of Korea.
The cell surface display system employs carrier proteins to present target proteins on the outer membrane of cells. This system enables functional proteins to be exposed on the exterior of living cells without cell lysis, allowing direct interaction with the surrounding environment. A major limitation of conventional approaches is the difficulty in displaying large-sized enzymes or antibodies, despite their critical roles in applications requiring functional domains that must remain intact, such as catalytic or antigen-binding sites.
View Article and Find Full Text PDFLight Sci Appl
September 2025
State Key Laboratory of Flexible Electronics, Institute of Advanced Materials (IAM), Nanjing University of Posts & Telecommunications (NUPT), Nanjing, 210023, China.
As the demand for edge platforms in artificial intelligence increases, including mobile devices and security applications, the surge in data influx into edge devices often triggers interference and suboptimal decision-making. There is a pressing need for solutions emphasizing low power consumption and cost-effectiveness. In-sensor computing systems employing memristors face challenges in optimizing energy efficiency and streamlining manufacturing due to the necessity for multiple physical processing components.
View Article and Find Full Text PDFSignal Transduct Target Ther
September 2025
State Key Laboratory of Molecular Oncology & Department of Medical Oncology & Department of Pathology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
Small-cell lung cancer (SCLC), an aggressive neuroendocrine tumor strongly associated with exposure to tobacco carcinogens, is characterized by early dissemination and dismal prognosis with a five-year overall survival of less than 7%. High-frequency gain-of-function mutations in oncogenes are rarely reported, and intratumor heterogeneity (ITH) remains to be determined in SCLC. Here, via multiomics analyses of 314 SCLCs, we found that the ASCL1/MKI67 and ASCL1/CRIP2 clusters accounted for 74.
View Article and Find Full Text PDFOpen Biol
September 2025
National Brain Research Centre, Manesar, Haryana, India.
E3 ubiquitin ligases regulate the cellular proteome proteasome-dependent protein degradation; however, there exist limited studies outlining their non-canonical functions. RNA-binding ubiquitin ligases (RBULs) represent a subset of E3 ligases that harbour RNA-binding domains, making them uniquely positioned to function as both RNA-binding proteins and E3 ligases. Our initial microarray screen for E3 ligases from mouse cortical neural progenitor cells identified MEX3B, a known RNA-binding ubiquitin ligase, to be differentially expressed.
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